V. Pokaichuk, O. Nykyforova, Sergey N. Komissarov, Vadym Fursa, Yevhen Bakhchevan
{"title":"Distance education in the higher educational institutions of the ministry of internal affairs","authors":"V. Pokaichuk, O. Nykyforova, Sergey N. Komissarov, Vadym Fursa, Yevhen Bakhchevan","doi":"10.51847/wptbj96hk9","DOIUrl":"https://doi.org/10.51847/wptbj96hk9","url":null,"abstract":"","PeriodicalId":37660,"journal":{"name":"Journal of Advanced Pharmacy Education and Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70838685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Patients’ and healthcare professionals’ experience with at-home parenteral therapy","authors":"Marko Puzovic, Hana Morrissey, Patrick Ball","doi":"10.51847/shh6wzi9tf","DOIUrl":"https://doi.org/10.51847/shh6wzi9tf","url":null,"abstract":"","PeriodicalId":37660,"journal":{"name":"Journal of Advanced Pharmacy Education and Research","volume":"103 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135261320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Brain relaxation score on craniotomy brain tumour removal with adjuvant thiopental and dexmedetomidine: A case report","authors":"Dewi Yulianti Bisri, Ignatia Karina Hallis, Tengku Addi Saputra, Tatang Bisri","doi":"10.51847/ctkvdusitr","DOIUrl":"https://doi.org/10.51847/ctkvdusitr","url":null,"abstract":"","PeriodicalId":37660,"journal":{"name":"Journal of Advanced Pharmacy Education and Research","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135502472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nedaa’ Husein, Amjad Al-Tarawneh, Shahed Rashad Al-Rawashdeh, K. Khleifat, M. Al-limoun, Ibrahim I. Alfarrayeh, Ahmad Eyal Awwad, Ahmad Z. Alsarayreh, Yaseen T Al-Qaisi
{"title":"Ruta graveolens methanol extract, fungal-mediated biosynthesized silver nanoparticles, and their combinations inhibit pathogenic bacteria","authors":"Nedaa’ Husein, Amjad Al-Tarawneh, Shahed Rashad Al-Rawashdeh, K. Khleifat, M. Al-limoun, Ibrahim I. Alfarrayeh, Ahmad Eyal Awwad, Ahmad Z. Alsarayreh, Yaseen T Al-Qaisi","doi":"10.51847/h8sagkiapx","DOIUrl":"https://doi.org/10.51847/h8sagkiapx","url":null,"abstract":"","PeriodicalId":37660,"journal":{"name":"Journal of Advanced Pharmacy Education and Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70822253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Importance of healthcare professional training on medication safety, medication error prevention, and reporting ","authors":"M. Saada, H. Morrissey, P. Ball","doi":"10.51847/nsvledyp4z","DOIUrl":"https://doi.org/10.51847/nsvledyp4z","url":null,"abstract":"","PeriodicalId":37660,"journal":{"name":"Journal of Advanced Pharmacy Education and Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70827578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Posaconazole (POCZ) is a triazole antifungal with poor solubility and low bioavailability, so this work is aimed to compare between bioavailability parameters of pure POCZ and the prepared lyophilized POCZ nano-micelles. In this study, twelve Wistar rats were used with a weight of 200±20g and divided into twice groups (each group with six animals). The dose of 10mg/kg of pure POCZ and POCZ nano-micelles was administered to rats by oral gavage after reconstitution with water. The determination of POCZ in the plasma of rats is done by using (HPLC) after the construction of a spiked calibration curve with plasma and internal standard itraconazole. The bioavailability parameters for pure POCZ and POCZ nano-micelles were determined. The results show that C max , T max , AUC 0-72, and AUC 0-∞ were 230±4ng/ml, 8±0.5hr, 8622±127 ng.h/ml,10050±110 ng.h/ml and 2107±7ng, 2±0.2hr, 27261. 2±233ng.h/ml, 30364±205 respectively for pure POCZ suspension and POCZ nano-micelles. The obtained results from this work are that the time T max required for maximum concentration C max was statistically different from pure POCZ and POCZ nano-micelles ( p< 0.05). The POCZ nano-micelles show relative bioavailability 3.02 times than pure Posaconazole. In conclusion, the prepared POCZ nano-micelles enhance the oral absorption and bioavailability of the drug.
泊沙康唑(Posaconazole, POCZ)是一种溶解度差、生物利用度低的三唑类抗真菌药物，因此本研究旨在比较纯POCZ与制备的冻干POCZ纳米胶束的生物利用度参数。实验选用Wistar大鼠12只，体重200±20g，分为两组，每组6只。将纯POCZ和POCZ纳米胶束分别以10mg/kg的剂量经水复溶后灌胃给大鼠。用血浆和内标伊曲康唑建立加标曲线，采用高效液相色谱法测定大鼠血浆中POCZ的含量。测定了纯POCZ和纳米POCZ胶束的生物利用度参数。结果表明，cmax、tmax、AUC 0-72、AUC 0-∞分别为230±4ng/ml、8±0.5hr、8622±127 ng.h/ml、10050±110 ng.h/ml和2107±7ng、2±0.2hr、27261。纯POCZ悬浮液浓度为2±233ng.h/ml，纳米胶束浓度为30364±205 ng /ml。得到的结果是，获得最大浓度C max所需的时间与纯POCZ和POCZ纳米胶束有统计学差异(p< 0.05)。POCZ纳米胶束的相对生物利用度是泊沙康唑的3.02倍。综上所述，制备的POCZ纳米胶束增强了药物的口服吸收和生物利用度。
{"title":"Bioavailability study of Posaconazole in rats after oral Poloxamer P188 Nano-micelles and oral Posaconazole pure drug","authors":"Alaa Abdulelah Abdulqader, N. Rajab","doi":"10.51847/q59uyvrmy3","DOIUrl":"https://doi.org/10.51847/q59uyvrmy3","url":null,"abstract":"Posaconazole (POCZ) is a triazole antifungal with poor solubility and low bioavailability, so this work is aimed to compare between bioavailability parameters of pure POCZ and the prepared lyophilized POCZ nano-micelles. In this study, twelve Wistar rats were used with a weight of 200±20g and divided into twice groups (each group with six animals). The dose of 10mg/kg of pure POCZ and POCZ nano-micelles was administered to rats by oral gavage after reconstitution with water. The determination of POCZ in the plasma of rats is done by using (HPLC) after the construction of a spiked calibration curve with plasma and internal standard itraconazole. The bioavailability parameters for pure POCZ and POCZ nano-micelles were determined. The results show that C max , T max , AUC 0-72, and AUC 0-∞ were 230±4ng/ml, 8±0.5hr, 8622±127 ng.h/ml,10050±110 ng.h/ml and 2107±7ng, 2±0.2hr, 27261. 2±233ng.h/ml, 30364±205 respectively for pure POCZ suspension and POCZ nano-micelles. The obtained results from this work are that the time T max required for maximum concentration C max was statistically different from pure POCZ and POCZ nano-micelles ( p< 0.05). The POCZ nano-micelles show relative bioavailability 3.02 times than pure Posaconazole. In conclusion, the prepared POCZ nano-micelles enhance the oral absorption and bioavailability of the drug.","PeriodicalId":37660,"journal":{"name":"Journal of Advanced Pharmacy Education and Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70830979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A ntibacterial activity of Hylocereus polyrhizus Britton & Rose peel against Staphylococcus epidermidis bacteria ","authors":"N. Dn, Liza Yudhistira, A. Faizah","doi":"10.51847/w1llf9oarg","DOIUrl":"https://doi.org/10.51847/w1llf9oarg","url":null,"abstract":"","PeriodicalId":37660,"journal":{"name":"Journal of Advanced Pharmacy Education and Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70838174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Nguyen, Le My Khuu, Thành Kiên Nguyễn, Thuc Tri Nguyen
{"title":"Research on the treatment of settling sediments in the production process of Ich mau extracts","authors":"T. Nguyen, Le My Khuu, Thành Kiên Nguyễn, Thuc Tri Nguyen","doi":"10.51847/ytnxj9b9qo","DOIUrl":"https://doi.org/10.51847/ytnxj9b9qo","url":null,"abstract":"","PeriodicalId":37660,"journal":{"name":"Journal of Advanced Pharmacy Education and Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70841710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jian Zhou, Yueqing Lin, R. S. Dewey, Yuanyuan Zhou
{"title":"The distribution of Kolb’s learning style in college students from different family backgrounds","authors":"Jian Zhou, Yueqing Lin, R. S. Dewey, Yuanyuan Zhou","doi":"10.51847/zuo6u56w16","DOIUrl":"https://doi.org/10.51847/zuo6u56w16","url":null,"abstract":"","PeriodicalId":37660,"journal":{"name":"Journal of Advanced Pharmacy Education and Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70844215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ni Putu Udayana Antari, Rr. Asih Juanita, Ni Made Dharma Shantini Suena
{"title":"Panic buying behavior and Covid-19 handling knowledge of health workers and non-health workers in Bali &lrm;","authors":"Ni Putu Udayana Antari, Rr. Asih Juanita, Ni Made Dharma Shantini Suena","doi":"10.51847/csppa9xkk0","DOIUrl":"https://doi.org/10.51847/csppa9xkk0","url":null,"abstract":"","PeriodicalId":37660,"journal":{"name":"Journal of Advanced Pharmacy Education and Research","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135008858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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