D. Tsvetkova, I. Kostadinova, B. Landzhov, L. Vezenkov, Lyubomir Marinov, Ivalina Ivanova
The aim of the current study was the estimation of the radical-scavenging activity of Creatine lysinate against 0.05 mM methanol solution of DPPH radical by measuring the decrease in the absorbance at λ = 516 in methanol. The antiradical effect of the compound examined is presented with the following parameters calculated: radical scavenging activity in [%], IC 50 value; antioxidant power 1/IC 50 , and Trolox equivalent activity. relative radical scavenging activity (RRSA, [%]), and a relative decrease in radical scavenging activity (RDRSA, [%]).From the experimental results, it was observed that the DPPH binding ability of Creatine lysinate (IC 50 = 73.75 mM) is lower compared to the standard Trolox (IC 50 = 0.001154 mM), which antioxidant power (1/IC 50 = 8.67) is higher in comparison with Creatine lysinate (1/IC 50 = 0.014). The experimental data show that Creatine lysinate (IC 50 = 73.75 mM) is more active compared to Creatine monohydrate (IC 50 = 102.48 mM) due to lower IC 50 and higher scavenging activity. In comparison with mono application of alone antioxidant, the beneficial effect of the combination of Creatine monohydrate and Creatine lysinate with other antioxidants in form of food supplements could be an important strategy for a synergistic effect in the reduction of free radicals in the treatment of disorders resulted from oxidative stress.
{"title":"Application of DPPH assay for the evaluation of the antiradical activity of Creatine Lysinate","authors":"D. Tsvetkova, I. Kostadinova, B. Landzhov, L. Vezenkov, Lyubomir Marinov, Ivalina Ivanova","doi":"10.51847/guimkn4fkf","DOIUrl":"https://doi.org/10.51847/guimkn4fkf","url":null,"abstract":"The aim of the current study was the estimation of the radical-scavenging activity of Creatine lysinate against 0.05 mM methanol solution of DPPH radical by measuring the decrease in the absorbance at λ = 516 in methanol. The antiradical effect of the compound examined is presented with the following parameters calculated: radical scavenging activity in [%], IC 50 value; antioxidant power 1/IC 50 , and Trolox equivalent activity. relative radical scavenging activity (RRSA, [%]), and a relative decrease in radical scavenging activity (RDRSA, [%]).From the experimental results, it was observed that the DPPH binding ability of Creatine lysinate (IC 50 = 73.75 mM) is lower compared to the standard Trolox (IC 50 = 0.001154 mM), which antioxidant power (1/IC 50 = 8.67) is higher in comparison with Creatine lysinate (1/IC 50 = 0.014). The experimental data show that Creatine lysinate (IC 50 = 73.75 mM) is more active compared to Creatine monohydrate (IC 50 = 102.48 mM) due to lower IC 50 and higher scavenging activity. In comparison with mono application of alone antioxidant, the beneficial effect of the combination of Creatine monohydrate and Creatine lysinate with other antioxidants in form of food supplements could be an important strategy for a synergistic effect in the reduction of free radicals in the treatment of disorders resulted from oxidative stress.","PeriodicalId":37660,"journal":{"name":"Journal of Advanced Pharmacy Education and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70821608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of break hours on work quality among respiratory care providers in Saudi Arabia's eastern province","authors":"Heba Ahmed Albhair, B. Bugis","doi":"10.51847/jgzs6wxisu","DOIUrl":"https://doi.org/10.51847/jgzs6wxisu","url":null,"abstract":"","PeriodicalId":37660,"journal":{"name":"Journal of Advanced Pharmacy Education and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70825165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Drug-related problems in elderly patients with diabetes: A study in primary health care setting","authors":"I. Cahyaningsih, N. Hikmah, Nurul Maziyyah","doi":"10.51847/rgpup8aeb3","DOIUrl":"https://doi.org/10.51847/rgpup8aeb3","url":null,"abstract":"","PeriodicalId":37660,"journal":{"name":"Journal of Advanced Pharmacy Education and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70832718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of clerkship modification during the COVID-19 pandemic towards competency achievement in hospital pharmacy ","authors":"Nurul Maziyyah, Sri Tasminatun, Wahyu Prastyo Aji","doi":"10.51847/sxbq0i2ago","DOIUrl":"https://doi.org/10.51847/sxbq0i2ago","url":null,"abstract":"","PeriodicalId":37660,"journal":{"name":"Journal of Advanced Pharmacy Education and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70834437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Blood-ocular barrier-specialized morphological structures that regulate the transport of fluids and substances between the vascular bed and the tissues of the eye, prohibiting the penetration of foreign cells and molecules. The permeability of various substances into the non-vascular and vascular tissues of the eye is not the same. In conditions of pathology, the blood-ocular barrier can be permeable to various endogenous, exogenous, and other substances that are not correct with respect to the cells and tissues of the eye. In this article, the permeability of the blood-ocular barrier with fluoroquinolone group drugs in the pathologies of the visual organs is considered. For this purpose, a laboratory study was conducted, during which three groups of experimental rabbits were formed (5 individuals in each group). Clinically healthy animals were included in group 1, and sick animals with experimentally induced ophthalmopathology were included in groups 2 and 3. The treatment of individuals was carried out with a solution of ciprofloxacin. A comprehensive examination of animals was carried out: clinical examination, determination of the concentration of antibacterial drugs in biological fluids, histological examination of the blood-ocular barrier, biochemical studies; hematological studies
{"title":"Study of blood-ocular barrier permeability by Fluoroquinolone group drugs","authors":"Arzigul Hamidovna Yahyaeva, Margusheva Maryana Aslanovna, Kyamalya Azadovna Yariyeva, Artem Olegovich Pogosov, Nargiz Asadullaevna Ilyasova, Diana Rezuanovna Kokova","doi":"10.51847/tkubytphaq","DOIUrl":"https://doi.org/10.51847/tkubytphaq","url":null,"abstract":"Blood-ocular barrier-specialized morphological structures that regulate the transport of fluids and substances between the vascular bed and the tissues of the eye, prohibiting the penetration of foreign cells and molecules. The permeability of various substances into the non-vascular and vascular tissues of the eye is not the same. In conditions of pathology, the blood-ocular barrier can be permeable to various endogenous, exogenous, and other substances that are not correct with respect to the cells and tissues of the eye. In this article, the permeability of the blood-ocular barrier with fluoroquinolone group drugs in the pathologies of the visual organs is considered. For this purpose, a laboratory study was conducted, during which three groups of experimental rabbits were formed (5 individuals in each group). Clinically healthy animals were included in group 1, and sick animals with experimentally induced ophthalmopathology were included in groups 2 and 3. The treatment of individuals was carried out with a solution of ciprofloxacin. A comprehensive examination of animals was carried out: clinical examination, determination of the concentration of antibacterial drugs in biological fluids, histological examination of the blood-ocular barrier, biochemical studies; hematological studies","PeriodicalId":37660,"journal":{"name":"Journal of Advanced Pharmacy Education and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70834727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Khdair Sura Abbas, Abbas Shaymaa Hasan, Nafea Lubab Tareq
{"title":"Assessment of the impact of different rheumatoid arthritis stages on the quality of life of a sample of Iraqi patients","authors":"Khdair Sura Abbas, Abbas Shaymaa Hasan, Nafea Lubab Tareq","doi":"10.51847/41nl6ig253","DOIUrl":"https://doi.org/10.51847/41nl6ig253","url":null,"abstract":"","PeriodicalId":37660,"journal":{"name":"Journal of Advanced Pharmacy Education and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70812263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sofya Olegovna Budagova, Gregory Vadimovich Nadvodnyk, Polina Alexandrovna Belskaia, A. A. Obukhova, Ivan Gennadievich Lebedev, Ramazan Magomedgadjievich Osmanov, Gamzat Temurovich Dzhumaev, Maxim Mavludinovich Agarzaev
{"title":"Toxicity assessment of the selenium nanoparticles in vitro ","authors":"Sofya Olegovna Budagova, Gregory Vadimovich Nadvodnyk, Polina Alexandrovna Belskaia, A. A. Obukhova, Ivan Gennadievich Lebedev, Ramazan Magomedgadjievich Osmanov, Gamzat Temurovich Dzhumaev, Maxim Mavludinovich Agarzaev","doi":"10.51847/4i6jd9dehl","DOIUrl":"https://doi.org/10.51847/4i6jd9dehl","url":null,"abstract":"","PeriodicalId":37660,"journal":{"name":"Journal of Advanced Pharmacy Education and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70812705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Nurcahyo, A. B. Riyanta, Rizki Febriyanti, Heri Sutanto, Wiwin Herdwiani
{"title":"Hypolipidemic activity of Ceciwis ethanol extract on wistar rats induced by high fat in vivo","authors":"H. Nurcahyo, A. B. Riyanta, Rizki Febriyanti, Heri Sutanto, Wiwin Herdwiani","doi":"10.51847/enxiiqzxm1","DOIUrl":"https://doi.org/10.51847/enxiiqzxm1","url":null,"abstract":"","PeriodicalId":37660,"journal":{"name":"Journal of Advanced Pharmacy Education and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70819600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Elbashir, RaniaMohammed Ahmed, Awatif M. Omer, Marzoug A. Al, Elbashir A. Hussien, Eman M. Algorashi, S. Ali, Amel F. Alzain, Salwa Siddig
{"title":"Reference indicators for kidney dimensions in Sudanese children using Ultrasound","authors":"M. Elbashir, RaniaMohammed Ahmed, Awatif M. Omer, Marzoug A. Al, Elbashir A. Hussien, Eman M. Algorashi, S. Ali, Amel F. Alzain, Salwa Siddig","doi":"10.51847/hokhfdjpej","DOIUrl":"https://doi.org/10.51847/hokhfdjpej","url":null,"abstract":"","PeriodicalId":37660,"journal":{"name":"Journal of Advanced Pharmacy Education and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70823206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Interprofessional education in pharmacogenomics: perspective of pharmacy and nursing students","authors":"","doi":"10.51847/pi4ggrk1z0","DOIUrl":"https://doi.org/10.51847/pi4ggrk1z0","url":null,"abstract":"","PeriodicalId":37660,"journal":{"name":"Journal of Advanced Pharmacy Education and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70830160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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