{"title":"Topical interferon alpha-2b is a proper alternative for management of adenoviral keratitis: A case report","authors":"M. Akbari","doi":"10.51847/bhzyx16r2y","DOIUrl":"https://doi.org/10.51847/bhzyx16r2y","url":null,"abstract":"","PeriodicalId":37660,"journal":{"name":"Journal of Advanced Pharmacy Education and Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70816156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Safa Mustafa Najim, M. R. Abd, A. Fadhil, A. Hassan
{"title":"Fimasartan attenuates edema and systemic changes in egg albumin-induced paw inflammation in rats","authors":"Safa Mustafa Najim, M. R. Abd, A. Fadhil, A. Hassan","doi":"10.51847/edwlwyapjy","DOIUrl":"https://doi.org/10.51847/edwlwyapjy","url":null,"abstract":"","PeriodicalId":37660,"journal":{"name":"Journal of Advanced Pharmacy Education and Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70819542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lindita Agolli, Daniela Haxhihyeni, M. Fida, E. Janushaj, Dorina Demaj, E. Vasili, M. Krasniqi
Pemphigus Vulgaris is an autoimmune disease and is treated with immunosuppressive therapy. This reason but either the fact that the skin is not intact are predisposition factors why patients with Pemphigus vulgaris are predisposed to infections. We aimed to study the frequency of infections, categorical and numeric variables related to infection, in Pemphigus vulgaris s patients admitted to dermatology service. This retrospective study was conducted on 130 patients diagnosed with Pemphigus vulgaris and hospitalized at Dermatology Clinic during the year 2020-2022. The diagnosis of Pemphigus vulgaris was confirmed by biopsy and indirect/direct immunofluorescence findings. Data were collected through the charts in the Statistics Department, in UHC "Mother Teresa", Tirana, Albania. 130 patients (70 males, 60 females) were hospitalized in UHC " Mother Theresa) during the period 2020-20122. 48.69% of patients had infections. The occurrence of infection was significantly related to the severity of the disease, multiple admissions, and hospitalization duration. The most frequent infections encountered: are skin infections, urinary infections, pulmonary infections, and opportunistic infections (candida). The most common pathogenic germs isolated from cultures were Staphylococcus aureus and Escherichia coli. Infections are the most common complication among patients treated for Pemphigus vulgaris. Patients with longer duration disease and hospitalization have a higher probability to develop infections, mainly skin infections. Due to the limitations of a retrospective study, we recommend a prospective study.
{"title":"Pemphigus vulgaris and infections - A retrospective study","authors":"Lindita Agolli, Daniela Haxhihyeni, M. Fida, E. Janushaj, Dorina Demaj, E. Vasili, M. Krasniqi","doi":"10.51847/h3hazzyg7i","DOIUrl":"https://doi.org/10.51847/h3hazzyg7i","url":null,"abstract":"Pemphigus Vulgaris is an autoimmune disease and is treated with immunosuppressive therapy. This reason but either the fact that the skin is not intact are predisposition factors why patients with Pemphigus vulgaris are predisposed to infections. We aimed to study the frequency of infections, categorical and numeric variables related to infection, in Pemphigus vulgaris s patients admitted to dermatology service. This retrospective study was conducted on 130 patients diagnosed with Pemphigus vulgaris and hospitalized at Dermatology Clinic during the year 2020-2022. The diagnosis of Pemphigus vulgaris was confirmed by biopsy and indirect/direct immunofluorescence findings. Data were collected through the charts in the Statistics Department, in UHC \"Mother Teresa\", Tirana, Albania. 130 patients (70 males, 60 females) were hospitalized in UHC \" Mother Theresa) during the period 2020-20122. 48.69% of patients had infections. The occurrence of infection was significantly related to the severity of the disease, multiple admissions, and hospitalization duration. The most frequent infections encountered: are skin infections, urinary infections, pulmonary infections, and opportunistic infections (candida). The most common pathogenic germs isolated from cultures were Staphylococcus aureus and Escherichia coli. Infections are the most common complication among patients treated for Pemphigus vulgaris. Patients with longer duration disease and hospitalization have a higher probability to develop infections, mainly skin infections. Due to the limitations of a retrospective study, we recommend a prospective study.","PeriodicalId":37660,"journal":{"name":"Journal of Advanced Pharmacy Education and Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70822002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Molecular detection of some Gram-negative bacterial species using folp gene sequences","authors":"M. M. El-Sokkary","doi":"10.51847/2b4jraefdf","DOIUrl":"https://doi.org/10.51847/2b4jraefdf","url":null,"abstract":"","PeriodicalId":37660,"journal":{"name":"Journal of Advanced Pharmacy Education and Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70810731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yosi Febrianti, Muhammad Muhajir, Ulyatul Khoiroh, Fansyoska Claridho, Joep Ahmed Djojodibroto, Ninisita Srihadi
{"title":"Prevalence of potentially inappropriate medications in psychogeriatric patients in Indonesia based on the beers 2019 criteria ‎","authors":"Yosi Febrianti, Muhammad Muhajir, Ulyatul Khoiroh, Fansyoska Claridho, Joep Ahmed Djojodibroto, Ninisita Srihadi","doi":"10.51847/fqo4orkkfk","DOIUrl":"https://doi.org/10.51847/fqo4orkkfk","url":null,"abstract":"","PeriodicalId":37660,"journal":{"name":"Journal of Advanced Pharmacy Education and Research","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135800624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Albina Borisovna Kubanova, Madina Aslanovna Kogotyzheva, Zaurbek Jebrailovich Borov, Khadizhat Akhmedovna Rabadanova, Laura Zhadigerovna Gilzhanova, Elina Nikolaevna Kabisova, Madina Sergeevna Komarova, Marat Borisovich Uzdenov
{"title":"The clinical picture of the damage to the organs of the hepatobiliopancreatic area in hypothyroidism","authors":"Albina Borisovna Kubanova, Madina Aslanovna Kogotyzheva, Zaurbek Jebrailovich Borov, Khadizhat Akhmedovna Rabadanova, Laura Zhadigerovna Gilzhanova, Elina Nikolaevna Kabisova, Madina Sergeevna Komarova, Marat Borisovich Uzdenov","doi":"10.51847/iwlul3umlx","DOIUrl":"https://doi.org/10.51847/iwlul3umlx","url":null,"abstract":"","PeriodicalId":37660,"journal":{"name":"Journal of Advanced Pharmacy Education and Research","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135008869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aimed to attain a comparison in pharmacokinetic parameters of ondansetron after transdermal (as invasomes gel) and oral (as solution) routes. Ondansetron is a 5 ‐ hydroxytryptamine receptor antagonist used for chemotherapy and radiotherapy ‐ induced nausea and emesis. The study was performed using Wistar albino rats weighing 200 ±20 g divided into two groups (6 of each). A dose of 0.28 mg of ondansetron, equivalent to 140 µl, was administered as an oral solution for the first group. Ondansetron-loaded invasomes gel was prepared, optimized, and applied on rat skin at a dose of 0.1652 mg of ondansetron, equivalent to 41 mg weight of invasomes gel for the second group. In addition, ondansetron was determined in rat plasma using HPLC apparatus and applying a modified HPLC method after validation. A comparison of primary pharmacokinetic parameters for both routes was performed. Results showed that C max , T max , AUC 0-24, and AUC 0-∞ were 58±3.4 ng/ml, 2±0.2 h., 246.25±47.6 ng.h./ml, and 259.4±57.7, respectively, for oral solution and 36±2.9 ng/ml, 5±0.5 h., 390.5±5.2 ng.h./ml and 442.8±66.1 ng.h./ml., respectively for transdermal invasomes gel. Results showed that the time and concentration needed to achieve the maximum effect (C max and T max ) were significantly different between oral and transdermal routes ( p <0.05). The relative bioavailability for the transdermal route was 2.9 times that of the oral route after a single dose administered for 24 h. In conclusion, the prepared invasomes gel enhanced the bioavailability of ondansetron, and transdermal delivery could be considered a vital delivery system for ondansetron.
{"title":"Pharmacokinetic parameters of ondansetron in rats after oral solution and transdermal invasomes gel: A comparison study","authors":"Omar S. Salih, E. J. Al-Akkam","doi":"10.51847/hs5a27ei6o","DOIUrl":"https://doi.org/10.51847/hs5a27ei6o","url":null,"abstract":"This study aimed to attain a comparison in pharmacokinetic parameters of ondansetron after transdermal (as invasomes gel) and oral (as solution) routes. Ondansetron is a 5 ‐ hydroxytryptamine receptor antagonist used for chemotherapy and radiotherapy ‐ induced nausea and emesis. The study was performed using Wistar albino rats weighing 200 ±20 g divided into two groups (6 of each). A dose of 0.28 mg of ondansetron, equivalent to 140 µl, was administered as an oral solution for the first group. Ondansetron-loaded invasomes gel was prepared, optimized, and applied on rat skin at a dose of 0.1652 mg of ondansetron, equivalent to 41 mg weight of invasomes gel for the second group. In addition, ondansetron was determined in rat plasma using HPLC apparatus and applying a modified HPLC method after validation. A comparison of primary pharmacokinetic parameters for both routes was performed. Results showed that C max , T max , AUC 0-24, and AUC 0-∞ were 58±3.4 ng/ml, 2±0.2 h., 246.25±47.6 ng.h./ml, and 259.4±57.7, respectively, for oral solution and 36±2.9 ng/ml, 5±0.5 h., 390.5±5.2 ng.h./ml and 442.8±66.1 ng.h./ml., respectively for transdermal invasomes gel. Results showed that the time and concentration needed to achieve the maximum effect (C max and T max ) were significantly different between oral and transdermal routes ( p <0.05). The relative bioavailability for the transdermal route was 2.9 times that of the oral route after a single dose administered for 24 h. In conclusion, the prepared invasomes gel enhanced the bioavailability of ondansetron, and transdermal delivery could be considered a vital delivery system for ondansetron.","PeriodicalId":37660,"journal":{"name":"Journal of Advanced Pharmacy Education and Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70823197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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