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Shaping synaptic learning by the duration of the postsynaptic action potential 突触后动作电位持续时间对突触学习的影响
Pub Date : 2013-08-01 DOI: 10.1109/IJCNN.2013.6706960
Youwei Zheng, L. Schwabe
Most previous studies treated spikes as all-or-none events, and considered their duration and magnitude as negligible. Action potential (AP) duration varies across neuron types, but its consequences on synaptic plasticity remain largely unexplored. Here we study the effects of AP-duration on spike-timing dependent synaptic plasticity (STDP) by negatively shifting the temporal window, potentiating synapses with presy-naptic EPSPs occurring both before and during a postsynaptic AP. With this interpretation, we demonstrate that AP-duration controls the shape of weight distribution and the temporal fluctuations of the weights after the distribution reaches a steady-state.
大多数先前的研究将尖峰视为全有或全无的事件,并认为其持续时间和强度可以忽略不计。动作电位(AP)持续时间因神经元类型而异,但其对突触可塑性的影响在很大程度上尚未被研究。本研究通过负移时间窗口,研究了AP持续时间对spike-timing依赖性突触可塑性(STDP)的影响,增强了突触在突触后AP之前和期间发生的突触前突触epsp。通过这种解释,我们证明AP持续时间控制着权重分布的形状以及权重在分布达到稳态后的时间波动。
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引用次数: 0
A neural network based algorithm for gene expression prediction from chromatin structure 基于神经网络的染色质结构基因表达预测算法
Pub Date : 2013-08-01 DOI: 10.1109/IJCNN.2013.6706954
M. Frasca, G. Pavesi
Gene expression is a very complex process, which is finely regulated and modulated at different levels. The first step of gene expression, the transcription of DNA into mRNA, is in turn regulated both at the genetic and epigenetic level. In particular, the latter, which involves the structure formed by DNA wrapped around histones (chromatin), has been recently shown to be a key factor, with post-translational modifications of histones acting combinatorially to activate or block transcription. In this work we addressed the problem of predicting the level of expression of genes starting from genome-wide maps of chromatin structure, that is, of the localization of several different histone modifications, which have been recently made available through the introduction of technologies like ChIP-Seq. We formalized the problem as a multi-class bipartite ranking problem, in which for each class a gene can be under-or over-expressed with respect to a given reference expression value. In order to deal with this problem, we exploit and extend a semi-supervised method (COSNet) based on a family of Hopfield neural networks. Benchmark genome-wide tests performed on six different human cell lines yielded satisfactory results, with clear improvements over the alternative approach most commonly adopted in the literature.
基因表达是一个非常复杂的过程,在不同的水平上受到精细的调控。基因表达的第一步,即DNA转录成mRNA,反过来又在遗传和表观遗传水平上受到调控。特别是后者,涉及DNA包裹在组蛋白(染色质)周围形成的结构,最近已被证明是一个关键因素,组蛋白的翻译后修饰组合起激活或阻断转录的作用。在这项工作中,我们解决了从全基因组染色质结构图谱开始预测基因表达水平的问题,即几种不同组蛋白修饰的定位,这些修饰最近通过引入ChIP-Seq等技术得以实现。我们将该问题形式化为一个多类二部排序问题,其中对于每一类,基因可以相对于给定的参考表达值过表达或过表达。为了解决这一问题,我们开发并扩展了一种基于Hopfield神经网络的半监督方法(COSNet)。在六种不同的人类细胞系上进行的基准全基因组测试产生了令人满意的结果,与文献中最常用的替代方法相比,有明显的改进。
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引用次数: 16
A traffic sign detection pipeline based on interest region extraction 一种基于兴趣区域提取的交通标志检测管道
Pub Date : 2013-08-01 DOI: 10.1109/IJCNN.2013.6706808
Samuele Salti, A. Petrelli, Federico Tombari, Nicola Fioraio, L. D. Stefano
In this paper we present a pipeline for automatic detection of traffic signs in images. The proposed system can deal with high appearance variations, which typically occur in traffic sign recognition applications, especially with strong illumination changes and dramatic scale changes. Unlike most existing systems, our pipeline is based on interest regions extraction rather than a sliding window detection scheme. The proposed approach has been specialized and tested in three variants, each aimed at detecting one of the three categories of Mandatory, Prohibitory and Danger traffic signs. Our proposal has been evaluated experimentally within the German Traffic Sign Detection Benchmark competition.
本文提出了一种用于图像中交通标志自动检测的流水线。该系统可以处理交通标志识别应用中通常出现的高度外观变化,特别是强烈的照明变化和急剧的尺度变化。与大多数现有系统不同,我们的管道是基于兴趣区域提取而不是滑动窗口检测方案。所提议的方法已经过专门设计,并在三种变体中进行了测试,每种变体旨在检测强制、禁止和危险三类交通标志中的一种。我们的建议已经在德国交通标志检测基准竞赛中进行了实验评估。
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引用次数: 42
Robot coverage control by evolved neuromodulation 进化神经调节的机器人覆盖控制
Pub Date : 2013-08-01 DOI: 10.1109/IJCNN.2013.6706784
K. Harrington, E. Awa, Sylvain Cussat-Blanc, J. Pollack
An important connection between evolution and learning was made over a century ago and is now termed as the Baldwin effect. Learning acts as a guide for an evolutionary search process. In this study reinforcement learning agents are trained to solve the robot coverage control problem. These agents are improved by evolving neuromodulatory gene regulatory networks (GRN) that influence the learning and memory of agents. Agents trained by these neuromodulatory GRNs can consistently generalize better than agents trained with fixed parameter settings. This work introduces evolutionary GRN models into the context of neuromodulation and illustrates some of the benefits that stem from neuromodulatory GRNs.
进化和学习之间的一个重要联系是在一个多世纪前提出的,现在被称为鲍德温效应。学习是进化搜索过程的向导。在本研究中,训练强化学习代理来解决机器人覆盖控制问题。这些药物通过进化神经调节基因调节网络(GRN)来改善,影响药物的学习和记忆。由这些神经调节grn训练的智能体始终比用固定参数设置训练的智能体具有更好的泛化能力。这项工作将进化的GRN模型引入到神经调节的背景下,并说明了神经调节GRN的一些好处。
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引用次数: 11
Dynamics of Hodgkin and Huxley model with conductance based synaptic input 基于电导的突触输入的Hodgkin和Huxley模型动力学
Pub Date : 2013-08-01 DOI: 10.1109/IJCNN.2013.6706900
Priyanka Bajaj, A. Garg
The original Hodgkin and Huxley equations are landmark equations explaining the generation of action potential in a biological neuron. Moreover, many studies have been done on the Hodgkin and Huxley model with constant injected current. Here we present an Extended Hodgkin and Huxley model with conductance based excitatory and inhibitory synaptic inputs. It is asserted that the Hodgkin and Huxley model remains robust with the all kinds of synaptic inputs. Moreover, this model is more tractable to a biological neuron.
最初的霍奇金和赫胥黎方程是解释生物神经元中动作电位产生的里程碑式方程。此外,对恒注入电流的Hodgkin和Huxley模型也做了很多研究。在这里,我们提出了一个基于电导的兴奋性和抑制性突触输入的扩展霍奇金和赫胥黎模型。认为霍奇金和赫胥黎模型对各种突触输入仍然具有鲁棒性。此外,该模型对生物神经元更易于处理。
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引用次数: 1
Multi-valued neuron with new learning schemes 具有新学习方案的多值神经元
Pub Date : 2013-08-01 DOI: 10.1109/IJCNN.2013.6707132
Shin-Fu Wu, Shie-Jue Lee
Multi-valued neuron (MVN) is an efficient technique for classification and regression. It is a neuron with complex-valued weights and inputs/output, and the output of the activation function is moving along the unit circle on the complex plane. Therefore, MVN may have more functionalities than sigmoidal or radial basis function neurons. In some cases, a pair of weighted sums would oscillate between two sectors and the learning process can hardly converge. Besides, many weighted sums may be located around the borders of each sector, which may cause bad performance in classification accuracy. In this paper, we propose two modifications of multivalued neuron. One is involved with moving boundaries and the other one with targets at the center of sectors. Experimental results show that the proposed modifications can improve the performance of MVN and help it to converge more efficiently.
多值神经元(MVN)是一种有效的分类和回归技术。它是一个具有复值权值和输入/输出的神经元,激活函数的输出沿复平面上的单位圆运动。因此,MVN可能比s型基或径向基神经元具有更多的功能。在某些情况下,一对加权和会在两个扇区之间振荡,学习过程很难收敛。此外,许多加权和可能位于每个扇区的边界附近,这可能会导致分类精度下降。本文提出了多值神经元的两种修正方法。一种涉及移动边界,另一种涉及在扇区中心的目标。实验结果表明,所提出的改进方法可以提高MVN的性能,使其更有效地收敛。
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引用次数: 1
Towards predicting persistent activity of neurons by statistical and fractal dimension-based features 基于统计和分形维数的特征预测神经元的持续活动
Pub Date : 2013-08-01 DOI: 10.1109/IJCNN.2013.6707083
P. Petrantonakis, Athanasia Papoutsi, Panayiota Poirazi
Persistent activity is the prolongation of neuronal firing that outlasts the presentation of a stimulus and has been recorded during the execution of working memory tasks in several cortical regions. The emergence of persistent activity is stimulus-specific: not all inputs lead to persistent firing, only `preferred' ones. However, the features of a stimulus or the stimulus-induced response that determine whether it will ignite persistent activity remain unknown. In this paper, we propose various statistical and fractal dimension-based features derived from the activity of a detailed biophysical Prefrontal Cortex microcircuit model, for the efficient classification of the upcoming Persistent or Non-Persistent-activity state. Moreover, by introducing a novel majority voting classification framework we manage to achieve classification rates up to 92.5%, suggesting that selected features carry important predictive information that may be read out by the brain in order to identify `preferred' vs. `no-preferred' stimuli.
持续活动是神经元放电的延长,持续时间超过刺激的呈现,在执行工作记忆任务的过程中,在几个皮层区域记录了这种活动。持续活动的出现是刺激特异性的:不是所有的输入都会导致持续的放电,只有“首选”的才会。然而,决定刺激是否会引发持续活动的刺激或刺激引起的反应的特征仍然未知。在本文中,我们提出了各种基于统计和分形维数的特征,这些特征来源于详细的生物物理前额叶皮层微电路模型的活动,用于有效分类即将到来的持续或非持续活动状态。此外,通过引入一种新的多数投票分类框架,我们设法实现了高达92.5%的分类率,这表明所选择的特征携带着重要的预测信息,这些信息可能被大脑读出,以识别“偏好”vs。没有优先的刺激。
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引用次数: 2
Development of an efficient parameter estimation method for the inference of Vohradský's neural network models of genetic networks 开发了一种有效的参数估计方法来推断Vohradský遗传网络的神经网络模型
Pub Date : 2013-08-01 DOI: 10.1109/IJCNN.2013.6707079
Shuhei Kimura, Masanao Sato, Mariko Okada
Vohradský has proposed a neural network model to describe biochemical networks. Based on this model, several researchers have proposed genetic network inference methods. When trying to analyze large-scale genetic networks, however, these methods must solve high-dimensional function optimization problems. In order to resolve the high-dimensionality in the estimation of the parameters of the Vohradský's neural network model, this study proposes a new method. The proposed method estimates the parameters of the neural network model by solving two-dimensional function optimization problems. Although these two-dimensional problems are non-linear, their low-dimensionality would make the estimation of the model parameters easier. Finally, we confirm the effectiveness of the proposed method through numerical experiments.
Vohradský提出了一个神经网络模型来描述生化网络。基于这个模型,一些研究者提出了遗传网络推理方法。然而,当试图分析大规模遗传网络时,这些方法必须解决高维函数优化问题。为了解决Vohradský神经网络模型参数估计的高维性问题,本文提出了一种新的方法。该方法通过求解二维函数优化问题来估计神经网络模型的参数。虽然这些二维问题是非线性的,但它们的低维性使模型参数的估计更容易。最后,通过数值实验验证了该方法的有效性。
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引用次数: 0
Fast parking control of mobile robot based on multi-layer neural network on homogeneous architecture 基于同构多层神经网络的移动机器人快速停车控制
Pub Date : 2013-08-01 DOI: 10.1109/IJCNN.2013.6706922
Hanen Chenini, J. Derutin, T. Tixier
Today, the problem of designing suitable multiprocessor architecture tailored for a target Neural Networks applications raises the need for a fast and efficient MP-SOC (MultiProcessor System-on-Chip) design environment. Additionally, the implementation of such applications on multiprocessor designs will need to exploit the parallelism and pipelining in algorithms with the hope of delivering significant reduction in execution times. To take advantage of parallelization on homogeneous multiprocessor architecture and to reduce the programming effort, we provide new MP-SOC design methodology which offers more opportunities for accelerating the parallelization of Neural Networks algorithms. The efficiency of this approach is tested on many examples of applications. This work is devoted to the design and implementation of a complete intelligent controller parking system of autonomous mobile robot based on Multi-Layer Feed-Forward Neural Networks. To emphasize some specific requirements to be considered when implementing such algorithm, we propose new parallel pipelined architecture composed of several computational stages. Additionally, we especially suggest a parallel software skeleton “SCComCM” aimed at being employed by the developed multistage architecture. The experimental results show that the proposed parallel architecture has better speed-up, less communication time, and better space reduction factor than the hand tuned hardware design.
如今,为目标神经网络应用设计合适的多处理器架构的问题提出了对快速高效的MP-SOC(多处理器片上系统)设计环境的需求。此外,在多处理器设计上实现此类应用程序需要利用算法中的并行性和流水线,以期显著减少执行时间。为了利用同构多处理器架构的并行化优势,减少编程工作量,我们提供了新的MP-SOC设计方法,为加速神经网络算法的并行化提供了更多的机会。在许多应用程序示例中测试了该方法的效率。本文致力于基于多层前馈神经网络的自主移动机器人智能停车控制系统的设计与实现。为了强调在实现这种算法时需要考虑的一些具体要求,我们提出了由几个计算阶段组成的新的并行流水线架构。此外,我们特别建议一个并行软件骨架“SCComCM”,旨在被开发的多阶段体系结构所采用。实验结果表明,与手工调优硬件设计相比,所提出的并行架构具有更好的加速、更少的通信时间和更好的空间缩减系数。
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引用次数: 2
Cognitive computing building block: A versatile and efficient digital neuron model for neurosynaptic cores 认知计算构建块:神经突触核心的通用高效数字神经元模型
Pub Date : 2013-08-01 DOI: 10.1109/IJCNN.2013.6707077
A. Cassidy, P. Merolla, J. Arthur, Steven K. Esser, Bryan L. Jackson, Rodrigo Alvarez-Icaza, Pallab Datta, J. Sawada, T. Wong, V. Feldman, A. Amir, D. B. Rubin, Filipp Akopyan, E. McQuinn, W. Risk, D. Modha
Marching along the DARPA SyNAPSE roadmap, IBM unveils a trilogy of innovations towards the TrueNorth cognitive computing system inspired by the brain's function and efficiency. Judiciously balancing the dual objectives of functional capability and implementation/operational cost, we develop a simple, digital, reconfigurable, versatile spiking neuron model that supports one-to-one equivalence between hardware and simulation and is implementable using only 1272 ASIC gates. Starting with the classic leaky integrate-and-fire neuron, we add: (a) configurable and reproducible stochasticity to the input, the state, and the output; (b) four leak modes that bias the internal state dynamics; (c) deterministic and stochastic thresholds; and (d) six reset modes for rich finite-state behavior. The model supports a wide variety of computational functions and neural codes. We capture 50+ neuron behaviors in a library for hierarchical composition of complex computations and behaviors. Although designed with cognitive algorithms and applications in mind, serendipitously, the neuron model can qualitatively replicate the 20 biologically-relevant behaviors of a dynamical neuron model.
在DARPA SyNAPSE路线图的指引下,IBM公布了TrueNorth认知计算系统的创新三部曲,其灵感来自于大脑的功能和效率。明智地平衡功能能力和实现/运营成本的双重目标,我们开发了一个简单的,数字化的,可重构的,通用的峰值神经元模型,支持硬件和仿真之间的一对一等价,并且仅使用1272个ASIC门即可实现。从经典的泄漏集成-触发神经元开始,我们增加:(a)输入、状态和输出的可配置和可重复的随机性;(b)四种泄漏模式使内部状态动力学发生偏置;(c)确定性和随机阈值;(d)丰富有限状态行为的六种复位模式。该模型支持多种计算函数和神经编码。我们在一个库中捕获了50多个神经元的行为,用于复杂计算和行为的分层组合。尽管在设计时考虑了认知算法和应用,但偶然的是,神经元模型可以定性地复制动态神经元模型的20种生物相关行为。
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引用次数: 239
期刊
The 2013 International Joint Conference on Neural Networks (IJCNN)
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