Pub Date : 2023-01-11DOI: 10.5812/compreped-130133
Doaa M. Salah, A. Aoun, B. Fahmy, Asmaa Hasan Mahaseb Abu Zeid, Y. Fahmy
Background: Nephrotic syndrome (NS) is a common glomerular disease in children, for which there are currently no noninvasive markers for predicting responsiveness to steroid treatment. Objectives: This study aimed to analyze the relationship between clinical-laboratory presentations and subsequent response to steroid therapy and to evaluate the role of urinary vitamin D binding protein (uVDBP) as a predictor of steroid resistance (SR). Methods: This was a prospective longitudinal study on 60 children with active NS (30 patients with newly diagnosed NS and 30 with relapsed NS). In addition, 30 control subjects served as a reference group for uVDBP values. The patients were evaluated before starting steroid therapy, and response to steroid therapy was monitored 4 - 8 weeks later. Results: The levels of uVDBP were elevated in patients with NS (33.33 ± 15.6 ng/mL) compared to control subjects (17.35 ± 5.5 ng/mL, P < 0.001). Also, the levels of uVDBP were significantly higher in patients with relapsed NS (37.93 ± 16.2 ng/mL) than in newly diagnosed NS patients (28.73 ± 13.67 ng/mL, P = 0.014). The level of uVDBP on presentation did not significantly differ between patients who had steroid-sensitive nephrotic syndrome (SSNS) (34.91 ± 15.01 ng/mL) and patients who had steroid-resistant nephrotic syndrome (SRNS) after 4 - 8 weeks of steroid treatment (32.60 ± 15.94 ng/mL, P = 0.417). Steroid resistance was significantly associated with a younger age of onset, specifically below 2.1 years (P = 0.023), a longer duration of the illness (P = 0.007), having more relapses (P = 0.002), total leucocytic count on presentation > 8.05 × 103/mm3 (P = 0.031), and platelet counts on presentation > 516.5 × 103/mm3 (P = 0.044). Conclusions: In this study, we found that uVDBP levels could reflect disease severity rather than predict the pattern of steroid responsiveness. Younger age of onset, longer duration of illness, previous relapses, and increased total leukocyte and platelet counts on presentation were associated with SRNS.
{"title":"Does Urinary Vitamin D-Binding Protein Have a Role in the Prediction of Steroid Resistance in Nephrotic Syndrome? A Cohort Study on Egyptian Children","authors":"Doaa M. Salah, A. Aoun, B. Fahmy, Asmaa Hasan Mahaseb Abu Zeid, Y. Fahmy","doi":"10.5812/compreped-130133","DOIUrl":"https://doi.org/10.5812/compreped-130133","url":null,"abstract":"Background: Nephrotic syndrome (NS) is a common glomerular disease in children, for which there are currently no noninvasive markers for predicting responsiveness to steroid treatment. Objectives: This study aimed to analyze the relationship between clinical-laboratory presentations and subsequent response to steroid therapy and to evaluate the role of urinary vitamin D binding protein (uVDBP) as a predictor of steroid resistance (SR). Methods: This was a prospective longitudinal study on 60 children with active NS (30 patients with newly diagnosed NS and 30 with relapsed NS). In addition, 30 control subjects served as a reference group for uVDBP values. The patients were evaluated before starting steroid therapy, and response to steroid therapy was monitored 4 - 8 weeks later. Results: The levels of uVDBP were elevated in patients with NS (33.33 ± 15.6 ng/mL) compared to control subjects (17.35 ± 5.5 ng/mL, P < 0.001). Also, the levels of uVDBP were significantly higher in patients with relapsed NS (37.93 ± 16.2 ng/mL) than in newly diagnosed NS patients (28.73 ± 13.67 ng/mL, P = 0.014). The level of uVDBP on presentation did not significantly differ between patients who had steroid-sensitive nephrotic syndrome (SSNS) (34.91 ± 15.01 ng/mL) and patients who had steroid-resistant nephrotic syndrome (SRNS) after 4 - 8 weeks of steroid treatment (32.60 ± 15.94 ng/mL, P = 0.417). Steroid resistance was significantly associated with a younger age of onset, specifically below 2.1 years (P = 0.023), a longer duration of the illness (P = 0.007), having more relapses (P = 0.002), total leucocytic count on presentation > 8.05 × 103/mm3 (P = 0.031), and platelet counts on presentation > 516.5 × 103/mm3 (P = 0.044). Conclusions: In this study, we found that uVDBP levels could reflect disease severity rather than predict the pattern of steroid responsiveness. Younger age of onset, longer duration of illness, previous relapses, and increased total leukocyte and platelet counts on presentation were associated with SRNS.","PeriodicalId":37929,"journal":{"name":"Journal of Comprehensive Pediatrics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47390505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-06DOI: 10.5812/compreped-126319
Nasrin Ezatpanah, Masoome Nikoo, S. Arshi, Narges Gholami, L. Gachkar
Background: Developmental delay (DD) in children is a crucial issue in pediatric health. The most practical evaluation way for early detection of developmental delay is parent-completed tool by the Ages and Stages Questionnaire (ASQ). Objectives: The aim of this study was to estimate the prevalence of developmental delay in 12-month-old infants. Methods: In this cross-sectional study, 5,025 ASQs of 12-month-old children who presented in urban health centers of Shahid Beheshti University of Medical Sciences from 23 August 2018 to 23 August 2019, were evaluated. Total scores in five main domains and six final questions were extracted. Results: Fifty-one-point-five percent were boys. Also, 243 cases (4.8%) had problem in at least one out of the five domains, 68 cases (1.35%) had DD in two domains, five cases (0.09%) in three domains, four cases (0.07%) in four domains, and two cases (0.03%) had an essential delay in all five domains. Developmental delay was seen more in gross motor (1.6%), followed by communication (1.5%), problem-solving (1%), fine motor (0.4%), and personal-social (0.3%), respectively. There were significant statistical differences in personal-social and problem-solving in boys. Among six questions in ASQ, the most common problem was in question 4 (1.4%), which is related to auditory problems. Conclusions: Developmental screening is a basic tool for developmental delay detection. Developmental delay diagnosis and early intervention may be possible through cost-effective screening tools.
{"title":"Prevalence of Developmental Delay in 12-month-old Infants, Urban Health Centers, Shahid Beheshti University of Medical Sciences, Tehran, Iran, 2018 - 2019","authors":"Nasrin Ezatpanah, Masoome Nikoo, S. Arshi, Narges Gholami, L. Gachkar","doi":"10.5812/compreped-126319","DOIUrl":"https://doi.org/10.5812/compreped-126319","url":null,"abstract":"Background: Developmental delay (DD) in children is a crucial issue in pediatric health. The most practical evaluation way for early detection of developmental delay is parent-completed tool by the Ages and Stages Questionnaire (ASQ). Objectives: The aim of this study was to estimate the prevalence of developmental delay in 12-month-old infants. Methods: In this cross-sectional study, 5,025 ASQs of 12-month-old children who presented in urban health centers of Shahid Beheshti University of Medical Sciences from 23 August 2018 to 23 August 2019, were evaluated. Total scores in five main domains and six final questions were extracted. Results: Fifty-one-point-five percent were boys. Also, 243 cases (4.8%) had problem in at least one out of the five domains, 68 cases (1.35%) had DD in two domains, five cases (0.09%) in three domains, four cases (0.07%) in four domains, and two cases (0.03%) had an essential delay in all five domains. Developmental delay was seen more in gross motor (1.6%), followed by communication (1.5%), problem-solving (1%), fine motor (0.4%), and personal-social (0.3%), respectively. There were significant statistical differences in personal-social and problem-solving in boys. Among six questions in ASQ, the most common problem was in question 4 (1.4%), which is related to auditory problems. Conclusions: Developmental screening is a basic tool for developmental delay detection. Developmental delay diagnosis and early intervention may be possible through cost-effective screening tools.","PeriodicalId":37929,"journal":{"name":"Journal of Comprehensive Pediatrics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47618020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-21DOI: 10.5812/compreped-131806
N. Rochmah, Luh Ayu, Asri Wijani, M. Faizi, Yuni Hisbiyah, R. Perwitasari, I. Ketut, A. Utamayasa, N. P. Kusumastuti, I. Irwanto
Background: Children with type-1 diabetes mellitus (T1DM) often experience emotional and behavioral problems such as anxiety and depression. Social restrictions during the COVID-19 pandemic caused social restrictions and limited access to healthcare facilities, which may have worsened the metabolic control. Objectives: This study aimed to analyze the behavioral problems among type 1 diabetes mellitus children with good and poor metabolic control during COVID-19 pandemic. Methods: This cross-sectional study was conducted in January - August 2021 in the Endocrine Outpatient Clinic of General Hospital Dr. Soetomo Surabaya. Type-1-DM children who fulfilled the inclusion criteria were divided into two groups based on metabolic control, including good (HbA1C ≤ 8) and poor (HbA1C > 8). The Pediatric Symptom Checklist-17 (PSC-17) was used as a screening tool with the domain internalizing problems (IP), externalizing problems (EP), and attention problems (AP). The data were analyzed using Pearson or Spearman test with Statistical Product and Service Solution (SPSS) version 18.0. Results: In this study, 27 subjects (17 boys and 10 girls, aged 12.63 ± 3.39 years) were investigated. Of all subjects, only 8 subjects had good metabolic control during the COVID-19 pandemic. Furthermore, 33.3% of the participants had behavioral problems (14.8% IP; 18.5% EP). The frequencies of IP, EP, and AP in the good metabolic control group were 12.5%, 37.5%, and 0%, respectively; while those in the poor metabolic group were 15.8%, 10.5%, and 0%, respectively. There was no significant difference between the good and poor metabolic control groups in terms of behavior problems (P = 1.00, IP; P = 0.14, EP). Conclusions: No significant difference was found between good and poor metabolic control groups (P = 1.00, IP; P = 0.14, EP). However, the frequency of EP was higher in good metabolic control, and the frequency of IP was higher in poor metabolic control.
{"title":"Behavioral Problems among Type 1 Diabetes Mellitus Children with Good and Poor Metabolic Control During COVID-19 Pandemic","authors":"N. Rochmah, Luh Ayu, Asri Wijani, M. Faizi, Yuni Hisbiyah, R. Perwitasari, I. Ketut, A. Utamayasa, N. P. Kusumastuti, I. Irwanto","doi":"10.5812/compreped-131806","DOIUrl":"https://doi.org/10.5812/compreped-131806","url":null,"abstract":"Background: Children with type-1 diabetes mellitus (T1DM) often experience emotional and behavioral problems such as anxiety and depression. Social restrictions during the COVID-19 pandemic caused social restrictions and limited access to healthcare facilities, which may have worsened the metabolic control. Objectives: This study aimed to analyze the behavioral problems among type 1 diabetes mellitus children with good and poor metabolic control during COVID-19 pandemic. Methods: This cross-sectional study was conducted in January - August 2021 in the Endocrine Outpatient Clinic of General Hospital Dr. Soetomo Surabaya. Type-1-DM children who fulfilled the inclusion criteria were divided into two groups based on metabolic control, including good (HbA1C ≤ 8) and poor (HbA1C > 8). The Pediatric Symptom Checklist-17 (PSC-17) was used as a screening tool with the domain internalizing problems (IP), externalizing problems (EP), and attention problems (AP). The data were analyzed using Pearson or Spearman test with Statistical Product and Service Solution (SPSS) version 18.0. Results: In this study, 27 subjects (17 boys and 10 girls, aged 12.63 ± 3.39 years) were investigated. Of all subjects, only 8 subjects had good metabolic control during the COVID-19 pandemic. Furthermore, 33.3% of the participants had behavioral problems (14.8% IP; 18.5% EP). The frequencies of IP, EP, and AP in the good metabolic control group were 12.5%, 37.5%, and 0%, respectively; while those in the poor metabolic group were 15.8%, 10.5%, and 0%, respectively. There was no significant difference between the good and poor metabolic control groups in terms of behavior problems (P = 1.00, IP; P = 0.14, EP). Conclusions: No significant difference was found between good and poor metabolic control groups (P = 1.00, IP; P = 0.14, EP). However, the frequency of EP was higher in good metabolic control, and the frequency of IP was higher in poor metabolic control.","PeriodicalId":37929,"journal":{"name":"Journal of Comprehensive Pediatrics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49593870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-20DOI: 10.5812/compreped-130137
V. Meena, R. Sharma, D. Bagri, Meenakshi Sharma
Background: Viral infections are important etiologies of neonatal sepsis, especially in premature/immune-compromised babies, and are associated with long-term morbidity and mortality. Timely diagnosis of viral infections using newer diagnostic tests in neonates is a necessary prerequisite for reducing the global burdens of neonatal morbidity and mortality. Objectives: This study aimed to assess the patterns of viral infections in newborns over one year. Methods: A total of 660 newborns were included in this hospital-based, cross-sectional, and observational study based on inclusion/exclusion criteria and after obtaining the required clearance from the institutional ethical committee. All newborns admitted in NICUs for suspected clinical sepsis were included except those with congenital malformation, hypoxic-ischemic encephalopathy (HIE), pre-term for care, and negative consent. Results: This study investigated 660 subjects with suspected sepsis, out of which 560 had non-viral sepsis (group one) and 100 had viral sepsis (group two). A significant difference was observed between the two groups in terms of mean hemoglobin level, mean platelet counts, and mean transaminases level. Cytomegaloviruses (CMV), rubella, and herpes simplex virus (HSV) were found in 9.1%, 4.5%, and 3.8% of the subjects, respectively. Conclusions: It was recommended that all neonatologists and pediatricians involved in neonatal care should suspect a viral agent as a possible cause of sepsis and utilize the diagnostic and treatment facilities with antiviral agents whenever and wherever possible.
{"title":"Diagnostic Virology-Based Spectrum of Neonatal Viral Infections at a Tertiary Center: Time to Switch Over","authors":"V. Meena, R. Sharma, D. Bagri, Meenakshi Sharma","doi":"10.5812/compreped-130137","DOIUrl":"https://doi.org/10.5812/compreped-130137","url":null,"abstract":"Background: Viral infections are important etiologies of neonatal sepsis, especially in premature/immune-compromised babies, and are associated with long-term morbidity and mortality. Timely diagnosis of viral infections using newer diagnostic tests in neonates is a necessary prerequisite for reducing the global burdens of neonatal morbidity and mortality. Objectives: This study aimed to assess the patterns of viral infections in newborns over one year. Methods: A total of 660 newborns were included in this hospital-based, cross-sectional, and observational study based on inclusion/exclusion criteria and after obtaining the required clearance from the institutional ethical committee. All newborns admitted in NICUs for suspected clinical sepsis were included except those with congenital malformation, hypoxic-ischemic encephalopathy (HIE), pre-term for care, and negative consent. Results: This study investigated 660 subjects with suspected sepsis, out of which 560 had non-viral sepsis (group one) and 100 had viral sepsis (group two). A significant difference was observed between the two groups in terms of mean hemoglobin level, mean platelet counts, and mean transaminases level. Cytomegaloviruses (CMV), rubella, and herpes simplex virus (HSV) were found in 9.1%, 4.5%, and 3.8% of the subjects, respectively. Conclusions: It was recommended that all neonatologists and pediatricians involved in neonatal care should suspect a viral agent as a possible cause of sepsis and utilize the diagnostic and treatment facilities with antiviral agents whenever and wherever possible.","PeriodicalId":37929,"journal":{"name":"Journal of Comprehensive Pediatrics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48277028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-19DOI: 10.5812/compreped-117406
T. Shahraki, S. Sadeghi-bojd, Saeedeh Yaghoubi, T. Ghaderi
Background: Childhood voiding and defecation dysfunction are common problems in children of all ages worldwide. The prevalence of bowel and bladder dysfunction in children is reported to be approximately 47%. Objectives: Due to the different ethnic and socio-cultural characteristics, this study was conducted to investigate the frequency of voiding and defecation dysfunction in primary school children. In this study, we examined the urinary and defecation problems of patients and their relationship with each other. Methods: This cross-sectional descriptive-analytical study was performed on 400 children aged 7 to 13 years in Zahedan in 2016. Data were collected through a questionnaire. Finally, data were analyzed using SPSS 16 version. Statistical analysis was performed using descriptive and analytical statistics of the chi-square test. P-values less than 0.05 were considered statistically significant. Results: In this study, 400 students with a mean age of 9.96 ± 2.07 were studied, of whom 188 (47.1%) were girls and 212 (52.9%) were boys. The prevalence of urinary incontinence was 56.9%, 63.7% of whom were girls, and 36.3% were boys. The difference in the prevalence of urinary incontinence between girls and boys was large and statistically significant (P = 0.04). The prevalence of fecal incontinence was 61.7% among girls and 62.4% among boys (the total prevalence was 62.4% [239 cases]), but the difference in prevalence between girls and boys was small and statistically insignificant (P = 0.83). Conclusions: The prevalence of defecation dysfunction in school-age children was much higher than in previous studies. This may be due to differences in cultural and geographical environments. Due to the high prevalence of defecation dysfunction in children, it is recommended to have more focus on public education on various types of urinary and fecal dysfunction in urban and rural communities.
{"title":"Frequency of Voiding and Defecation Dysfunction in Primary School Children in Zahedan, Southeast Iran","authors":"T. Shahraki, S. Sadeghi-bojd, Saeedeh Yaghoubi, T. Ghaderi","doi":"10.5812/compreped-117406","DOIUrl":"https://doi.org/10.5812/compreped-117406","url":null,"abstract":"Background: Childhood voiding and defecation dysfunction are common problems in children of all ages worldwide. The prevalence of bowel and bladder dysfunction in children is reported to be approximately 47%. Objectives: Due to the different ethnic and socio-cultural characteristics, this study was conducted to investigate the frequency of voiding and defecation dysfunction in primary school children. In this study, we examined the urinary and defecation problems of patients and their relationship with each other. Methods: This cross-sectional descriptive-analytical study was performed on 400 children aged 7 to 13 years in Zahedan in 2016. Data were collected through a questionnaire. Finally, data were analyzed using SPSS 16 version. Statistical analysis was performed using descriptive and analytical statistics of the chi-square test. P-values less than 0.05 were considered statistically significant. Results: In this study, 400 students with a mean age of 9.96 ± 2.07 were studied, of whom 188 (47.1%) were girls and 212 (52.9%) were boys. The prevalence of urinary incontinence was 56.9%, 63.7% of whom were girls, and 36.3% were boys. The difference in the prevalence of urinary incontinence between girls and boys was large and statistically significant (P = 0.04). The prevalence of fecal incontinence was 61.7% among girls and 62.4% among boys (the total prevalence was 62.4% [239 cases]), but the difference in prevalence between girls and boys was small and statistically insignificant (P = 0.83). Conclusions: The prevalence of defecation dysfunction in school-age children was much higher than in previous studies. This may be due to differences in cultural and geographical environments. Due to the high prevalence of defecation dysfunction in children, it is recommended to have more focus on public education on various types of urinary and fecal dysfunction in urban and rural communities.","PeriodicalId":37929,"journal":{"name":"Journal of Comprehensive Pediatrics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44212382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-12DOI: 10.5812/compreped-129463
J. Narayan, Deepali Bangalia, Laxman Singh Charan, Satyendr Sonkariya, D. Barolia, P. Garg
Background: We measure the umbilical cord thickness of newborn just after delivery with digital Vernier caliper and correlate the association with antenatal maternal risk factors. This helps the pediatricians to predict which newborn need close monitoring. Objectives: The aim of indexed study to evaluate the umbilical cord thickness, maternal antenatal risk factors and determines the association between umbilical cord thickness and antenatal maternal risk factors. Methods: This is a cross sectional prospective study conducted between 2020 and 2021 at Rajkiya Mahila Chikitsalaya, J L N Medical College, Ajmer, India. Total 303 newborn subjected for this study. Out of these 189 newborn enrolled as control group for this study. Enrolment of sample was simple as our convenience during the study period. Results: Mean umbilical cord diameter was found smaller in newborns which associated with antenatal risk factors as compared to controls without antenatal risk factors (cases: 9.89 ± 2.53 mm; controls: 10.56 ± 2.26 mm) and the difference was statistically significant (P = 0.03). Oligohydramnios and meconium-stained liquor were found to be associated with the smaller umbilical cord diameter (P < 0.01). Conclusions: Oligohydramnios and meconium-stained liquor were found to be significantly associated with the thin umbilical cord.
{"title":"Evaluation of Umbilical Cord Thickness and Its Association with Antenatal Maternal Risk Factors: A Cross Sectional Prospective Study","authors":"J. Narayan, Deepali Bangalia, Laxman Singh Charan, Satyendr Sonkariya, D. Barolia, P. Garg","doi":"10.5812/compreped-129463","DOIUrl":"https://doi.org/10.5812/compreped-129463","url":null,"abstract":"Background: We measure the umbilical cord thickness of newborn just after delivery with digital Vernier caliper and correlate the association with antenatal maternal risk factors. This helps the pediatricians to predict which newborn need close monitoring. Objectives: The aim of indexed study to evaluate the umbilical cord thickness, maternal antenatal risk factors and determines the association between umbilical cord thickness and antenatal maternal risk factors. Methods: This is a cross sectional prospective study conducted between 2020 and 2021 at Rajkiya Mahila Chikitsalaya, J L N Medical College, Ajmer, India. Total 303 newborn subjected for this study. Out of these 189 newborn enrolled as control group for this study. Enrolment of sample was simple as our convenience during the study period. Results: Mean umbilical cord diameter was found smaller in newborns which associated with antenatal risk factors as compared to controls without antenatal risk factors (cases: 9.89 ± 2.53 mm; controls: 10.56 ± 2.26 mm) and the difference was statistically significant (P = 0.03). Oligohydramnios and meconium-stained liquor were found to be associated with the smaller umbilical cord diameter (P < 0.01). Conclusions: Oligohydramnios and meconium-stained liquor were found to be significantly associated with the thin umbilical cord.","PeriodicalId":37929,"journal":{"name":"Journal of Comprehensive Pediatrics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45793431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.5812/compreped-130127
A. Hassanzadeh Rad, M. Shahrokhi, Shahin Koohmanaee, Nazanin Medghalchi, Z. Atrkar Roshan, M. Mehrabi, Setila Dalili
Background: Teaching congenital hypothyroidism is a challenging aspect of medical education. Objectives: In this study, the authors implemented storytelling plus simulation (Double-S method) to make a new way of understanding the physiology and pathophysiology of the thyroid gland. Methods: An educational intervention study was conducted on 120 medical students in the third and fourth grades of medicine with little or no clinical experience. Participants were randomly divided into the Double-S and lecture-only groups and underwent the same pre-test and post-test. They attended a 120-minute class by the same pediatric endocrinologist. Results: The intragroup analysis showed no significant difference between the pre-test scores of the two groups (P-value = 0.843), but higher post-test scores were obtained in the Double-S method (7.6 vs. 5.3, respectively, P-value = 0.002). Conclusions: This study showed that teaching heavy physiological and pathophysiological content by unique incorporation of simulation and storytelling can improve learning basic and clinical courses in medical students. As our method had a novelty toward common simulation and storytelling methods, it helped medical students from the base to the bedside.
{"title":"The Novel Method of Teaching Physiology and Pathophysiology of Congenital Hypothyroidism to Medical Students: An Educational Intervention Study","authors":"A. Hassanzadeh Rad, M. Shahrokhi, Shahin Koohmanaee, Nazanin Medghalchi, Z. Atrkar Roshan, M. Mehrabi, Setila Dalili","doi":"10.5812/compreped-130127","DOIUrl":"https://doi.org/10.5812/compreped-130127","url":null,"abstract":"Background: Teaching congenital hypothyroidism is a challenging aspect of medical education. Objectives: In this study, the authors implemented storytelling plus simulation (Double-S method) to make a new way of understanding the physiology and pathophysiology of the thyroid gland. Methods: An educational intervention study was conducted on 120 medical students in the third and fourth grades of medicine with little or no clinical experience. Participants were randomly divided into the Double-S and lecture-only groups and underwent the same pre-test and post-test. They attended a 120-minute class by the same pediatric endocrinologist. Results: The intragroup analysis showed no significant difference between the pre-test scores of the two groups (P-value = 0.843), but higher post-test scores were obtained in the Double-S method (7.6 vs. 5.3, respectively, P-value = 0.002). Conclusions: This study showed that teaching heavy physiological and pathophysiological content by unique incorporation of simulation and storytelling can improve learning basic and clinical courses in medical students. As our method had a novelty toward common simulation and storytelling methods, it helped medical students from the base to the bedside.","PeriodicalId":37929,"journal":{"name":"Journal of Comprehensive Pediatrics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42918571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-16DOI: 10.5812/compreped-129997
Mohammad D. Allugmani, Mazen K. El-Harbi, Mohammad S. Khoshhal, Najia Alrabghy, Sabreen Almutery, Abdulsalam Alawfi, H. Abo-Haded
Introduction: Cornelia de Lange syndrome (CdLS) is a rare non-hereditary syndrome. The key diagnosis is unique facial features, limb anomalies, and growth retardation. Cardiac defects and gastrointestinal and genitourinary anomalies may be associated. Case Presentation: This is a case of neonatal CdLS that we think is interesting due to its association with a novel congenital heart complex. Conclusions: Patients with CdLS have a high incidence of congenital heart disease (CHD), so a cardiologic study of all of these patients is suggested.
简介:Cornelia de Lange综合征(CdLS)是一种罕见的非遗传性综合征。关键的诊断是独特的面部特征、肢体异常和生长迟缓。心脏缺陷和胃肠道及泌尿生殖系统异常可能相关。病例介绍:这是一个新生儿CdLS的病例，我们认为这是一个有趣的病例，因为它与一种新的先天性心脏复合体有关。结论:CdLS患者先天性心脏病(CHD)发病率高，建议对所有这些患者进行心脏学研究。
{"title":"Cornelia de Lange Syndrome: A Case Report with a Novel Congenital Heart Disease Association","authors":"Mohammad D. Allugmani, Mazen K. El-Harbi, Mohammad S. Khoshhal, Najia Alrabghy, Sabreen Almutery, Abdulsalam Alawfi, H. Abo-Haded","doi":"10.5812/compreped-129997","DOIUrl":"https://doi.org/10.5812/compreped-129997","url":null,"abstract":"Introduction: Cornelia de Lange syndrome (CdLS) is a rare non-hereditary syndrome. The key diagnosis is unique facial features, limb anomalies, and growth retardation. Cardiac defects and gastrointestinal and genitourinary anomalies may be associated. Case Presentation: This is a case of neonatal CdLS that we think is interesting due to its association with a novel congenital heart complex. Conclusions: Patients with CdLS have a high incidence of congenital heart disease (CHD), so a cardiologic study of all of these patients is suggested.","PeriodicalId":37929,"journal":{"name":"Journal of Comprehensive Pediatrics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43546002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-16DOI: 10.5812/compreped-129885
Narges Lashkarbolouk, Mahdi Mazandarani, Ali Ahani Azari, Lobat Shahkar, R. Shariatalavi
Introduction: Neuroblastoma (NB) is one of the most common malignant extracranial solid tumors in children, mainly detected in children between the ages of 22 months to five years. It can develop in any location of the sympathetic nervous system. Although it has a broad spectrum of signs and symptoms, it is hard to find cases with major respiratory manifestations. Case Presentation: Our case report presents a 50-day-old male admitted to a local hospital with respiratory distress and cyanosis. Then, he was intubated and transferred to our pediatric center for further evaluation. Our investigation found a mass in the mediastinum with lung involvement. This patient is a rare case of neuroblastoma that occurred earlier in the age of onset with uncommon respiratory manifestation, unresponsive to outpatient treatment. Conclusions: We presented a neuroblastoma case with persistent respiratory manifestations that repeatedly received outpatient treatment for respiratory diseases, but his condition did not improve. Physicians should always suspect this condition in addition to other differential diagnoses, especially in patients unresponsive to outpatient treatment, with abnormal chest X-rays and respiratory symptoms.
{"title":"Neuroblastoma in Early Age with Rare Respiratory Manifestation","authors":"Narges Lashkarbolouk, Mahdi Mazandarani, Ali Ahani Azari, Lobat Shahkar, R. Shariatalavi","doi":"10.5812/compreped-129885","DOIUrl":"https://doi.org/10.5812/compreped-129885","url":null,"abstract":"Introduction: Neuroblastoma (NB) is one of the most common malignant extracranial solid tumors in children, mainly detected in children between the ages of 22 months to five years. It can develop in any location of the sympathetic nervous system. Although it has a broad spectrum of signs and symptoms, it is hard to find cases with major respiratory manifestations. Case Presentation: Our case report presents a 50-day-old male admitted to a local hospital with respiratory distress and cyanosis. Then, he was intubated and transferred to our pediatric center for further evaluation. Our investigation found a mass in the mediastinum with lung involvement. This patient is a rare case of neuroblastoma that occurred earlier in the age of onset with uncommon respiratory manifestation, unresponsive to outpatient treatment. Conclusions: We presented a neuroblastoma case with persistent respiratory manifestations that repeatedly received outpatient treatment for respiratory diseases, but his condition did not improve. Physicians should always suspect this condition in addition to other differential diagnoses, especially in patients unresponsive to outpatient treatment, with abnormal chest X-rays and respiratory symptoms.","PeriodicalId":37929,"journal":{"name":"Journal of Comprehensive Pediatrics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44775460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-16DOI: 10.5812/compreped-130088
Briana Hernandez, S. Manzar
{"title":"Disguised Marijuana Edibles as a Public Health Concern in Pediatrics","authors":"Briana Hernandez, S. Manzar","doi":"10.5812/compreped-130088","DOIUrl":"https://doi.org/10.5812/compreped-130088","url":null,"abstract":"<jats:p />","PeriodicalId":37929,"journal":{"name":"Journal of Comprehensive Pediatrics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48108835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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