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The Impact of Delayed Hepatitis C Viral Load Suppression on Patient Risk: Historical Evidence from the Veterans Administration 延迟丙型肝炎病毒载量抑制对患者风险的影响:来自退伍军人管理局的历史证据
Q3 Economics, Econometrics and Finance Pub Date : 2016-12-01 DOI: 10.1515/fhep-2015-0041
T. Matsuda, J. Mccombs, I. Tonnu-Mihara, J. McGinnis, D. Fox
Abstract Background: The high cost of new hepatitis C (HCV) treatments has resulted in “watchful waiting” strategies being developed to safely delay treatment, which will in turn delay viral load suppression (VLS). Objective: To document if delayed VLS adversely impacted patient risk for adverse events and death. Methods: 187,860 patients were selected from the Veterans Administration’s (VA) clinical registry (CCR), a longitudinal compilation of electronic medical records (EMR) data for 1999–2010. Inclusion criteria required at least 6 months of CCR/EMR data prior to their HCV diagnosis and sufficient data post-diagnosis to calculate one or more FIB-4 scores. Primary outcome measures were time-to-death and time-to-a composite of liver-related clinical events. Cox proportional hazards models were estimated separately using three critical FIB-4 levels to define early and late viral response. Results: Achieving an undetectable viral load before the patient’s FIB-4 level exceed pre-specified critical values (1.00, 1.45 and 3.25) effectively reduced the risk of an adverse clinical events by 33–35% and death by 21–26%. However, achieving VLS after FIB-4 exceeds 3.25 significantly reduced the benefit of viral response. Conclusions: Delaying VLS until FIB-4 >3.25 reduces the benefits of VLS in reducing patient risk.
背景:新型丙型肝炎(HCV)治疗的高成本导致“观察等待”策略被开发出来以安全延迟治疗,这反过来又会延迟病毒载量抑制(VLS)。目的:记录延迟的VLS是否对患者不良事件和死亡的风险有不利影响。方法:从退伍军人管理局(VA)临床登记(CCR)中选择187,860例患者,这是1999-2010年电子病历(EMR)数据的纵向汇编。纳入标准需要HCV诊断前至少6个月的CCR/EMR数据和诊断后足够的数据来计算一个或多个FIB-4评分。主要结局指标为死亡时间和肝脏相关临床事件复合时间。Cox比例风险模型分别使用三个关键FIB-4水平来定义早期和晚期病毒反应。结果:在患者FIB-4水平超过预先规定的临界值(1.00、1.45和3.25)之前实现检测不到的病毒载量,可有效降低33-35%的不良临床事件风险和21-26%的死亡风险。然而,在FIB-4超过3.25后达到VLS显著降低了病毒应答的益处。结论:延迟VLS至FIB-4 >3.25会降低VLS在降低患者风险方面的益处。
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引用次数: 11
Quantifying Gains in the War on Cancer Due to Improved Treatment and Earlier Detection 由于治疗的改进和早期检测,量化癌症战争中的收益
Q3 Economics, Econometrics and Finance Pub Date : 2016-06-01 DOI: 10.1515/fhep-2015-0028
S. Seabury, D. Goldman, Charu N. Gupta, Z. Khan, A. Chandra, T. Philipson, D. Lakdawalla
Abstract Introduction: There have been significant improvements in both treatment and screening efforts for many types of cancer over the past decade. However, the effect of these advancements on the survival of cancer patients is unknown, and many question the value of both new treatments and screening efforts. Methods: This study uses a retrospective analysis of SEER Registry data to quantify reductions in mortality rates for cancer patients diagnosed between 1997 and 2007. Using variation in trends in mortality rates by stage of diagnosis across cancer types, we use logistic regression to decompose separate survival gains into those attributable to advances in treatment versus advances in detection. We estimate the gains in survival due to gains in both treatment and detection overall and separately for 15 of the most common cancer types. Results: We estimate that 3-year cancer-related mortality of cancer patients fell 16.7% from 1997 to 2007. Overall, advances in treatment reduced mortality rates by approximately 12.2% while advances in early detection reduced mortality rates by 4.5%. The relative importance of treatment and detection varied across cancer types. Improvements in detection were most important for thyroid, prostate and kidney cancer. Improvements in treatment were most important for non-Hodgkins lymphoma, lung cancer and myeloma. Conclusion: Both improved treatment options and better early detection have led to significant survival gains for cancer patients diagnosed from 1997 to 2007, generating considerable social value over this time period.
摘要:在过去的十年中,许多类型的癌症在治疗和筛查方面都有了显著的进步。然而,这些进步对癌症患者生存的影响尚不清楚,许多人质疑新疗法和筛查工作的价值。方法:本研究采用回顾性分析SEER注册数据,量化1997年至2007年间诊断的癌症患者死亡率的降低。利用不同癌症类型诊断阶段死亡率趋势的变化,我们使用逻辑回归将单独的生存收益分解为可归因于治疗进展与检测进展的收益。我们对15种最常见的癌症类型的总体和单独的治疗和检测的获益进行了估计。结果:我们估计从1997年到2007年,癌症患者的3年癌症相关死亡率下降了16.7%。总体而言,治疗方面的进步使死亡率降低了约12.2%,而早期发现方面的进步使死亡率降低了4.5%。治疗和检测的相对重要性因癌症类型而异。甲状腺癌、前列腺癌和肾癌的检出率提高最为重要。治疗的改善对非霍奇金淋巴瘤、肺癌和骨髓瘤最为重要。结论:从1997年到2007年,改进的治疗方案和更好的早期检测使癌症患者的生存率显著提高,在这段时间内产生了可观的社会价值。
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引用次数: 7
Salience and Health Campaigns 突出和健康运动
Q3 Economics, Econometrics and Finance Pub Date : 2016-06-01 DOI: 10.1515/fhep-2014-0019
Markus Dertwinkel-Kalt
Abstract Motivated by current topics in health economics, we apply the theory of salience to consumer policy. If a government intends to encourage healthier diets without harming consumers by raising taxes, it could initiate information campaigns which focus consumers’ attention either on the healthiness of one item or the unhealthiness of the other item. According to our approach, both campaigns work, but it is more efficient to proclaim the unhealthiness of one product in order to present it as a “ bad.” Our findings imply that comparative advertisement is particularly efficient for entrant firms into established markets.
摘要受当前卫生经济学主题的启发,我们将显著性理论应用于消费者政策。如果政府打算鼓励更健康的饮食而不通过增税来伤害消费者,它可以发起信息宣传活动,将消费者的注意力集中在一种产品的健康或另一种产品的不健康上。根据我们的方法,这两种宣传方式都是有效的,但更有效的方式是宣传一种产品的不健康,从而将其描述为“不好的”。我们的研究结果表明,比较广告对进入成熟市场的新公司特别有效。
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引用次数: 42
Competitive Spillovers and Regulatory Exploitation by Skilled Nursing Facilities 竞争溢出效应和熟练护理机构的监管剥削
Q3 Economics, Econometrics and Finance Pub Date : 2016-06-01 DOI: 10.1515/fhep-2014-0006
J. Bowblis, Christopher S. Brunt, D. Grabowski
Abstract Typically, research on the effect of ownership has considered health care providers in isolation of competitive interaction from other firms. This analysis considers how the selection of Medicare reimbursement codes for skilled nursing facilities varies by ownership and is influenced by the competitive spillovers from market dominance of for-profit institutions. We find evidence that not-for-profits are less likely to code patients into the highest reimbursement categories. Further, as the market becomes dominated by for-profits, both for-profit and not-for-profits increase the share of patients in these high reimbursement categories.
通常,对所有权影响的研究将医疗保健提供者与其他公司的竞争互动隔离开来。本分析考虑了熟练护理机构的医疗保险报销代码的选择如何因所有权而异,并受到营利性机构市场主导地位的竞争溢出效应的影响。我们发现有证据表明,非营利组织不太可能将患者纳入最高报销类别。此外,随着市场被营利机构所主导,营利机构和非营利机构都增加了这些高报销类别的患者份额。
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引用次数: 9
How Effective is Population-Based Cancer Screening? Regression Discontinuity Estimates from the US Guideline Screening Initiation Ages 以人群为基础的癌症筛查有多有效?美国指南筛选起始年龄的回归不连续估计
Q3 Economics, Econometrics and Finance Pub Date : 2016-06-01 DOI: 10.1515/fhep-2014-0014
S. Kadiyala, E. Strumpf
Abstract We estimate the marginal benefits of population-based cancer screening by comparing cancer test and detection rates on either side of US guideline-recommended initiation ages (age 40 for breast cancer and age 50 for colorectal cancer during the study period). Using a regression discontinuity design and self-reported test data from national health surveys, we find test rates for breast and colorectal cancer increase at the guideline age thresholds by 109% and 78%, respectively. Data from cancer registries in twelve US states indicate that cancer detection rates increase at the same thresholds by 50% and 49%, respectively. We estimate significant effects of screening on earlier breast cancer detection (1.2 cases/1000 screened) at age 40 and colorectal cancer detection (1.1 cases/1000 individuals screened) at age 50. Forty-eight and 73% of the increases in breast and colorectal case detection occur among middle-stage cancers (localized and regional) with most of the remainder among early-stage (in-situ). Our analysis suggests that the cost of detecting an asymptomatic case of breast cancer at age 40 via population-based screening is $107,000–134,000 and that the cost of detecting an asymptomatic case of colorectal cancer at age 50 is $473,000–485,000.
我们通过比较美国指南推荐的起始年龄(研究期间乳腺癌为40岁,结直肠癌为50岁)两侧的癌症检测和检出率来估计基于人群的癌症筛查的边际效益。使用回归不连续设计和来自全国健康调查的自我报告测试数据,我们发现乳腺癌和结直肠癌的测试率在指导年龄阈值下分别增加了109%和78%。来自美国12个州癌症登记处的数据表明,在相同的阈值下,癌症检出率分别增加了50%和49%。我们估计筛查对40岁时早期乳腺癌检测(1.2例/1000例筛查)和50岁时结肠直肠癌检测(1.1例/1000例筛查)有显著影响。乳腺癌和结直肠癌病例检出率的增加分别有48%和73%发生在中期癌症(局部和区域),其余大部分发生在早期癌症(原位)。我们的分析表明,通过基于人群的筛查检测40岁无症状乳腺癌病例的成本为107,000-134,000美元,检测50岁无症状结直肠癌病例的成本为473,000-485,000美元。
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引用次数: 14
Returns to Society from Investment in Cancer Research and Development 癌症研发投资回报社会
Q3 Economics, Econometrics and Finance Pub Date : 2016-06-01 DOI: 10.1515/fhep-2014-0022
A. Chandra, J. MacEwan, A. Campinha-Bacote, Z. Khan
Abstract Background: Since the start of the War on Cancer there have been enormous investments in improving oncology treatment. The return to society generated by this investment is unknown. We estimate the returns generated over the previous four decades and extrapolate future returns from current investment in cancer R&D. Methods: Using data on cancer incidence, mortality, and treatment-specific R&D expenditures from 1973 to 2010, we used regression models and two-sided significance tests to relate investment in cancer treatment R&D to cancer mortality, by tumor type. For investment, we used a measure of the knowledge stock generated by cancer treatment R&D expenditures over the previous 25 years to capture the cumulative benefits of past innovations and advances in treatment. Results: Investment of an additional $1 million in cervical, breast, colorectal, and prostate cancer between 1973 and 1990 was associated with a cumulative return of more than $5 million from cancer R&D by 2010. Through 2010, investment in cancer R&D was associated with average benefits in excess of costs in all but two cancers, ovarian and pancreatic. Regarding future returns, we estimated that each additional $1 million invested in cancer treatment research and development in 2010 will produce over $28 million in value over the following 50 years. Conclusions: The return to society from spending on cancer treatment R&D is large, but varies across tumor types.
背景:自从抗癌战争开始以来,人们在改善肿瘤治疗方面投入了大量资金。这种投资给社会带来的回报是未知的。我们估计了过去40年产生的回报,并推断了当前癌症研发投资的未来回报。方法:利用1973年至2010年的癌症发病率、死亡率和治疗特异性研发支出数据,采用回归模型和双侧显著性检验,按肿瘤类型将癌症治疗研发投入与癌症死亡率联系起来。在投资方面,我们对过去25年癌症治疗研发支出产生的知识存量进行了衡量,以捕捉过去治疗创新和进步的累积效益。结果:1973年至1990年间,在宫颈癌、乳腺癌、结肠直肠癌和前列腺癌上额外投资100万美元,到2010年,癌症研发的累计回报超过500万美元。2010年,除了卵巢癌和胰腺癌这两种癌症外,癌症研发投资的平均收益都超过了成本。关于未来的回报,我们估计,2010年在癌症治疗研究和开发上每增加100万美元的投资,将在接下来的50年里产生超过2800万美元的价值。结论:癌症治疗研发投入的社会回报很大,但因肿瘤类型而异。
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引用次数: 4
Demand-Side Factors Associated with the Purchase of Long-Term Care Insurance 与购买长期护理保险相关的需求方因素
Q3 Economics, Econometrics and Finance Pub Date : 2016-06-01 DOI: 10.1515/fhep-2014-0020
M. Unruh, D. Stevenson, R. Frank, Marc Cohen, D. Grabowski
Abstract Demand-side barriers are known to be important toward explaining the limited purchase of private long-term care insurance (LTCI). In this study, we examine several factors associated with the demand for LTCI including the availability of less costly substitutes (e.g., Medicaid, family), consumer information, and risk perception. Using buyer surveys from 2000, 2005, and 2010, our results suggest that, among individuals not eliminated through medical underwriting, consumer risk perception and the presence of lower cost, imperfect substitutes are strongly associated with the limited purchase of LTCI. These factors were also predictive of the generosity of coverage purchased. If policymakers seek to stimulate demand for LTCI, new public policies might include Medicaid reform, integrating LTCI with Medicare Advantage plans, enhanced LTCI offerings through employers, and targeted informational campaigns.
摘要需求侧障碍被认为是解释有限购买私人长期护理保险(LTCI)的重要因素。在本研究中,我们研究了与LTCI需求相关的几个因素,包括成本较低的替代品的可用性(例如,医疗补助,家庭),消费者信息和风险感知。利用2000年、2005年和2010年的购买者调查,我们的结果表明,在未通过医疗保险淘汰的个人中,消费者风险感知和较低成本的存在,不完全替代品与有限购买LTCI密切相关。这些因素也预示着购买保险的慷慨程度。如果政策制定者寻求刺激对LTCI的需求,新的公共政策可能包括医疗补助改革,将LTCI与医疗保险优势计划整合,通过雇主加强LTCI服务,以及有针对性的信息宣传活动。
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引用次数: 4
The Transformation of Medicare, 2015 to 2030 2015年至2030年的医疗改革
Q3 Economics, Econometrics and Finance Pub Date : 2015-12-01 DOI: 10.1515/fhep-2015-0043
H. Aaron, R. Reischauer
Abstract Medicare today is a better program on almost every dimension than it was just after July 30, 1965 when Lyndon Johnson signed public law 89–97. Nonetheless, short-comings, limitations, and inadequacies remain. What should be done to make Medicare a better program? What should Medicare look like in 2030? In this paper we try to answer these questions. Three perspectives are relevant: that of beneficiaries, current and future; that of policymakers and administrators, the program’s stewards; and that of society at large. We posit certain objectives and goals that we believe – and that we think a broad swath of Americans would agree – should be pursued to improve the Medicare program. Those goals include (a) affordability for Medicare beneficiaries, (b) affordability for the working population that is paying and should continue to pay for much of the current cost of the program, (c) reduction in what we regard as needless complexity, and (d) stability and continuity in several different senses. We restrict ourselves to changes that we judge to be affordable and feasible – politically, technically, and administratively – if not today, then over the next decade or two. We believe that changes in Medicare will remain incremental, as they have been for the last 50 years. We shall assume that the ACA takes root and that the exchanges, whether managed by states or by the federal government on behalf of the states, continue to operate. We shall assume that federal and state officials eventually surmount the administrative challenges they still confront. In particular, we assume that the exchanges come to serve a growing share of the American population and that they increasingly exercise the rather considerable regulatory powers over insurance offerings that the ACA grants to them. We divide Medicare reforms into four categories: payment reform, benefit reform, quality reform and management, and the role of private insurance plans (Medicare Advantage [MA]).
今天的医疗保险几乎在各个方面都比1965年7月30日林登·约翰逊签署89-97号公法之后要好。然而,缺点、限制和不足仍然存在。我们应该做些什么来使医疗保险成为一个更好的项目?2030年的医疗保险应该是什么样子?在本文中,我们试图回答这些问题。有三种观点是相关的:当前和未来受益者的观点;政策制定者和管理者,项目的管理者;整个社会也是如此。我们提出了一些目标和目标,我们相信——我们认为广大美国人会同意——我们应该追求这些目标和目标,以改善医疗保险计划。这些目标包括(a)医疗保险受益人的负担能力,(b)正在支付和应该继续支付该计划大部分当前成本的工作人口的负担能力,(c)减少我们认为不必要的复杂性,以及(d)在几个不同意义上的稳定性和连续性。我们把自己限制在我们认为在政治上、技术上和行政上都负担得起和可行的变革上,如果不是今天,那么在未来的十年或二十年里。我们相信,医疗保险的变化将保持渐进,就像过去50年一样。我们假定《平价医疗法案》能够生根发芽,保险交易所,无论是由各州管理还是由代表各州的联邦政府管理,都将继续运作。我们应该假设联邦和州官员最终克服了他们仍然面临的行政挑战。特别是,我们假设交易所为越来越多的美国人口服务,并且他们越来越多地对ACA授予他们的保险产品行使相当大的监管权力。我们将医疗保险改革分为四类:支付改革、福利改革、质量改革和管理,以及私营保险计划的作用(Medicare Advantage [MA])。
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引用次数: 2
Health and Health Care of Medicare Beneficiaries in 2030. 2030年医疗保险受益人的健康和医疗保健。
Q3 Economics, Econometrics and Finance Pub Date : 2015-12-01 Epub Date: 2015-11-28 DOI: 10.1515/fhep-2015-0037
Étienne Gaudette, Bryan Tysinger, Alwyn Cassil, Dana P Goldman

On Medicare's 50th anniversary, we use the Future Elderly Model (FEM) - a microsimulation model of health and economic outcomes for older Americans - to generate a snapshot of changing Medicare demographics and spending between 2010 and 2030. During this period, the baby boomers, who began turning 65 and aging into Medicare in 2011, will drive Medicare demographic changes, swelling the estimated US population aged 65 or older from 39.7 million to 67.0 million. Among the risks for Medicare sustainability, the size of the elderly population in the future likely will have the highest impact on spending but is easiest to forecast. Population health and the proportion of the future elderly with disabilities are more uncertain, though tools such as the FEM can provide reasonable forecasts to guide policymakers. Finally, medical technology breakthroughs and their effect on longevity are most uncertain and perhaps riskiest. Policymakers will need to keep these risks in mind if Medicare is to be sustained for another 50 years. Policymakers may also want to monitor the equity of Medicare financing amid signs that the program's progressivity is declining, resulting in higher-income people benefiting relatively more from Medicare than lower-income people.

在医疗保险50周年之际,我们使用未来老年人模型(FEM)——一个美国老年人健康和经济结果的微观模拟模型——来生成2010年至2030年间医疗保险人口结构和支出变化的快照。在此期间,婴儿潮一代(从2011年开始步入65岁并进入联邦医疗保险年龄)将推动联邦医疗保险人口结构的变化,使美国65岁及以上的人口从3970万增加到6700万。在医疗保险可持续性的风险中,未来老年人口的规模可能会对支出产生最大的影响,但也是最容易预测的。人口健康和未来残疾老年人的比例更加不确定,尽管FEM等工具可以提供合理的预测,以指导决策者。最后,医疗技术的突破及其对寿命的影响是最不确定的,或许也是最危险的。如果联邦医疗保险计划要再维持50年,政策制定者需要牢记这些风险。政策制定者可能还希望监测医疗保险融资的公平性,因为有迹象表明,该计划的累进性正在下降,导致高收入人群从医疗保险中获得的收益相对高于低收入人群。
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引用次数: 40
Revamping Provider Payment in Medicare 改革医疗保险提供商支付
Q3 Economics, Econometrics and Finance Pub Date : 2015-12-01 DOI: 10.1515/fhep-2015-0044
P. Ginsburg, G. Wilensky
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引用次数: 2
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