Pub Date : 2011-09-01DOI: 10.1097/01.NEP.0000406712.96753.DA
F. Lowry
RenalGuard, a new physiologic therapy that washes contrast through the kidney rapidly, was superior to sodium bicarbonate and Nacetylcysteine (NAC) in preventing contrast-induced acute kidney injury in high-risk patients. These results came from the randomized, multicenter, investigator-driven Renal Insuffi ciency After Contrast Media Administration Trial II (REMEDIAL II), which was conducted in Italy and published online before print by Circulation. “The results of the REMEDIAL II trial support the concept that the most important strategy to prevent contrastinduced acute kidney injury is an optimal increase in the urine fl ow rate without inducing fl uid imbalance,” said lead author Carlo Briguori, MD, PhD, Chief of the Laboratory of Interventional Cardiology at Clinica Mediterranea (Mediterranean Clinic) in Naples, Italy, in an interview. “This effect is reached by the RenalGuard system in almost all patients. By contrast, it is hardly reached by standard hydration.” In REMEDIAL II, which was carried out at four interventional cardiology centers in Italy between January 2009 and December 2010, 294 patients were randomized to receive sodium bicarbonate solution plus NAC at a high dose (the control group), or hydration with saline and NAC at a high dose plus a low dose of furosemide controlled by the RenalGuard system. Two patients, one from each group, did not undergo scheduled treatment, leaving 146 patients in each group for the fi nal analysis.
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Pub Date : 2011-09-01DOI: 10.1097/01.NEP.0000406707.22303.6e
M. Hogan
As Hurricane Irene headed for the East Coast of the United States, the dialysis community was prepared for the worst. These efforts, coupled with changes in storm strength and the weekend timing of landfall, largely had their desired effect, with most units from North Carolina to Maine up, running, and dialyzing patients the day after the storm. “Irene was a large, powerful storm that impacted millions of people along the Eastern Seaboard, many of whom had never experienced the direct effects of a hurricane,” wrote Seth Holloway, MPH, CPH, Emergency Management Specialist for the Kidney Community Emergency Response (KCER) Coalition, in an e-mail message. “The kidney community, through preparation, collaboration, and coordinated response, greatly diminished the storm’s potential impacts to the dialysis and transplant populations, undoubtedly saving many lives.” Marathon and a Sprint The KCER Coalition, which was formed in January 2006, includes representatives of kidney patient and professional organizations, clinicians, dialysis facilities, End-Stage Renal Disease (ESRD) Networks, state emergency and survey representatives, and federal agencies. It facilitates timely and effi cient disaster preparedness, response, and recovery for the kidney community. Hurricane Irene: Coordinated Response Prevents Dialysis Disruption
{"title":"Hurricane Irene: Coordinated Response Prevents Dialysis Disruption","authors":"M. Hogan","doi":"10.1097/01.NEP.0000406707.22303.6e","DOIUrl":"https://doi.org/10.1097/01.NEP.0000406707.22303.6e","url":null,"abstract":"As Hurricane Irene headed for the East Coast of the United States, the dialysis community was prepared for the worst. These efforts, coupled with changes in storm strength and the weekend timing of landfall, largely had their desired effect, with most units from North Carolina to Maine up, running, and dialyzing patients the day after the storm. “Irene was a large, powerful storm that impacted millions of people along the Eastern Seaboard, many of whom had never experienced the direct effects of a hurricane,” wrote Seth Holloway, MPH, CPH, Emergency Management Specialist for the Kidney Community Emergency Response (KCER) Coalition, in an e-mail message. “The kidney community, through preparation, collaboration, and coordinated response, greatly diminished the storm’s potential impacts to the dialysis and transplant populations, undoubtedly saving many lives.” Marathon and a Sprint The KCER Coalition, which was formed in January 2006, includes representatives of kidney patient and professional organizations, clinicians, dialysis facilities, End-Stage Renal Disease (ESRD) Networks, state emergency and survey representatives, and federal agencies. It facilitates timely and effi cient disaster preparedness, response, and recovery for the kidney community. Hurricane Irene: Coordinated Response Prevents Dialysis Disruption","PeriodicalId":380758,"journal":{"name":"Nephrology Times","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127123708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-08-01DOI: 10.1097/01.NEP.0000405323.96362.4F
M. Kamgar, S. Bunnapradist
{"title":"The Mixed Bag of Posttransplant HLA Monitoring","authors":"M. Kamgar, S. Bunnapradist","doi":"10.1097/01.NEP.0000405323.96362.4F","DOIUrl":"https://doi.org/10.1097/01.NEP.0000405323.96362.4F","url":null,"abstract":"","PeriodicalId":380758,"journal":{"name":"Nephrology Times","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127218794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-08-01DOI: 10.1097/01.NEP.0000405322.88739.9C
M. Hogan
{"title":"Nephrology Consultations Come Sooner, but Survival Rates Donʼt Get Much Better","authors":"M. Hogan","doi":"10.1097/01.NEP.0000405322.88739.9C","DOIUrl":"https://doi.org/10.1097/01.NEP.0000405322.88739.9C","url":null,"abstract":"","PeriodicalId":380758,"journal":{"name":"Nephrology Times","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127455536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-08-01DOI: 10.1097/01.NEP.0000405320.11610.BA
F. Lowry
{"title":"In Elective-Start Patients, PD and HD Offer Similar Survival","authors":"F. Lowry","doi":"10.1097/01.NEP.0000405320.11610.BA","DOIUrl":"https://doi.org/10.1097/01.NEP.0000405320.11610.BA","url":null,"abstract":"","PeriodicalId":380758,"journal":{"name":"Nephrology Times","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127902705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-07-01DOI: 10.1097/01.NEP.0000403738.99836.2D
A. Salama
{"title":"B-Cell-Depleting Agents: The Chicken and the Egg","authors":"A. Salama","doi":"10.1097/01.NEP.0000403738.99836.2D","DOIUrl":"https://doi.org/10.1097/01.NEP.0000403738.99836.2D","url":null,"abstract":"","PeriodicalId":380758,"journal":{"name":"Nephrology Times","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131944041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-06-01DOI: 10.1097/01.nep.0000399779.93032.76
M. Hogan
Deceased-donor kidneys from African-Americans with two particular gene variants failed much more quickly than those from African-Americans without the two variants, found a single-center study published in the American Journal of Transplantation (2011;11:1025-1030). These results extend to transplantation the previously reported relationship between the apolipoprotein L1 (APOL1) gene and nondiabetic nephropathy risk in this population. “The APOL1 genetic association with nondiabetic kidney failure in African-Americans is among—if not the—most powerful genetic association in any common disease,” said senior author Barry I. Freedman, MD, Professor and Chief of the Section on Nephrology at Wake Forest School of Medicine, in a phone interview. “It fully explains the excess risk of nondiabetic kidney failure in blacks compared with whites in the United States and accounts for 40 percent or so of all African-Americans on dialysis. That’s very impressive, and there are no other genes in the renal literature of this effect. “If a kidney is donated by an African-American, it does not statistically function for as long as a kidney donated by a white, so one of the questions we had was, could this have anything to do with APOL1?” Finding this relationship between APOL1 risk variants in the donor and graft survival in the recipient could mean big changes for kidney transplantation, but not just yet. “These results have to be For African-American Kidney Donors, Genetic Variants Linked to Graft Survival
发表在《美国移植杂志》(2011;11:1025-1030)上的一项单中心研究发现，患有两种特定基因变异的非裔美国人的死亡肾脏比没有这两种基因变异的非裔美国人的肾脏衰竭得更快。这些结果延伸到移植之前报道的载脂蛋白L1 (APOL1)基因与该人群非糖尿病肾病风险之间的关系。“非裔美国人的APOL1基因与非糖尿病性肾衰竭的关联，如果不是在任何常见疾病中最强大的遗传关联之一，”资深作者、维克森林医学院肾病学教授兼主任Barry I. Freedman医学博士在电话采访中说。这充分解释了美国黑人比白人患非糖尿病性肾衰竭的风险高的原因，在接受透析治疗的所有非洲裔美国人中，黑人占40%左右。这是非常令人印象深刻的，在肾脏文献中没有其他基因有这种效果。“如果一个非裔美国人捐赠的肾脏，从统计上讲，它的功能不如一个白人捐赠的肾脏长，所以我们的问题之一是，这是否与APOL1有关?”发现供体的APOL1风险变异与受体的移植存活之间的关系可能意味着肾移植的重大变化，但目前还不是时候。“对于非裔美国肾脏捐赠者来说，基因变异与移植物存活有关
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