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Hypothermia in Young Infants: Rethinking Definitions and Clinical Implications. 婴儿体温过低:重新思考定义和临床意义。
IF 2.1 Q1 Nursing Pub Date : 2025-10-01 DOI: 10.1542/hpeds.2025-008454
Rebecca Dang, Valerie J Flaherman
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引用次数: 0
Pediatric Inpatient Clinical Team Members Perspectives on a Program to Address Social Needs. 儿科住院患者临床团队成员对解决社会需求计划的看法。
IF 2.1 Q1 Nursing Pub Date : 2025-10-01 DOI: 10.1542/hpeds.2025-008383
Hemen Muleta, Elizabeth Messineo, Miya Lemberg, Amanda Klafter, Samuel Woo, Danielle Fernandes, Tara Buckenmyer, Patricia Hametz, Jessica Haughton, Kevin P Fiori

Objective: Health-related social needs (HRSNs) are associated with pediatric health outcomes. Programs that identify and intervene on unmet HRSNs are growing in pediatric inpatient settings. Research exploring the perspectives of inpatient clinical team members (CTMs) on programs to address unmet HRSNs is currently limited. The objective of this study was to investigate CTM perspectives on a pediatric inpatient HRSN screening, referral, and community health worker (CHW) resource navigation program in an urban tertiary-care pediatric academic hospital.

Methods: Semi-structured interview guides were developed using the Consolidated Framework for Implementation Research. One-on-one interviews were conducted with a purposeful sampling of CTMs. Transcripts were analyzed using a rapid qualitative approach to identify salient themes.

Results: Between August 19 and November 15, 2024, we conducted interviews with 14 CTMs. Analysis identified the following 4 themes: (1) social care is aligned with the goals of inpatient pediatric care; (2) CHWs are a valuable addition to a multidisciplinary inpatient team; (3) there are unique challenges of the inpatient setting, and electronic health record (EHR) integration has the potential to address these challenges; and (4) there is a need for better communication regarding outcomes across all aspects of the intervention to maintain CTM motivation.

Conclusions: Inpatient pediatric CTMs view HRSNs programs as an extension of patient care. CTMs value the role of CHWs as part of the multidisciplinary team to support hospitalized families. Addressing unique inpatient challenges, optimizing EHR integration, and clear communication regarding programmatic impact on families may facilitate program adoption.

目的:与健康相关的社会需求(HRSNs)与儿童健康结局相关。在儿科住院环境中,识别和干预未满足HRSNs的项目正在增加。探索住院临床团队成员(CTMs)对解决未满足的HRSNs项目的观点的研究目前是有限的。本研究的目的是探讨CTM在城市三级护理儿科学术医院儿科住院患者HRSN筛查、转诊和社区卫生工作者(CHW)资源导航计划中的应用。方法:采用实施研究统一框架开发半结构化访谈指南。一对一的访谈是通过有目的的CTMs抽样进行的。使用快速定性方法分析转录本,以确定突出主题。结果:在2024年8月19日至11月15日期间,我们对14名中西医结合患者进行了访谈。分析确定了以下4个主题:(1)社会关怀与儿科住院护理目标一致;(2) chw是多学科住院团队的宝贵补充;(3)住院环境面临着独特的挑战,电子健康记录(EHR)整合有可能解决这些挑战;(4)需要就干预的各个方面的结果进行更好的沟通,以保持CTM的动机。结论:住院儿科CTMs将HRSNs项目视为患者护理的延伸。中医院重视卫生保健员作为支持住院家庭的多学科团队的一部分所发挥的作用。解决独特的住院病人挑战,优化电子病历整合,以及关于项目对家庭影响的明确沟通,可能有助于项目的采用。
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引用次数: 0
Significant Pathology in Young Infants Presenting With Hypothermia: A Multicenter Study. 以低体温表现的婴儿的重要病理:一项多中心研究。
IF 2.1 Q1 Nursing Pub Date : 2025-10-01 DOI: 10.1542/hpeds.2025-008387
Julie K Wood, Annalise Van Meurs, Kathryn Westphal, Vignesh Doraiswamy, Erinn O Schmit, Stephanie Berger, Saylor McCartor, Meredith Mitchell, Clifton Lee, John M Morrison, Monica D Combs, Kira Molas-Torreblanca, Sumeet L Banker, Jennifer Lee, Joni K Evans, Nicholas M Potisek, Elizabeth E Halvorson

Objective: Hypothermia in young infants is often attributed to immature thermoregulation but may be the harbinger of significant pathology. We aimed to determine the prevalence and type of significant pathology in young infants aged 90 days or younger presenting with hypothermia (≤36.0 °C) and explore associations between this outcome and presenting characteristics and evaluation.

Methods: We conducted a multicenter, retrospective cohort study of young infants evaluated in the emergency department (ED) or hospital setting for hypothermia over a 5-year period. Patients aged 90 days or younger with documented or reported hypothermia in the ED or upon admission were included for study. All charts were manually reviewed. Our primary outcome was a diagnosis of significant pathology, infectious or noninfectious, defined as warranting hospitalization for evaluation, care or monitoring. We used a multivariate logistic regression model to test associations with significant pathology.

Results: Among 998 included infants, 32% (n = 318) had significant pathology, 4% with serious bacterial infection or herpes simplex virus (n = 41) and 28% (n = 277) with other diagnoses of significance spanning multiple organ systems and pathologies. Following multivariate logistic regression, presentation at older age (29-60 days [odds ratio {OR}, 6.9; 95% CI, 4.0-11.9] and 61-90 days [OR, 8.1; 95% CI, 3.8-17.0]), ill-appearance (OR, 4.3; 95% CI, 3.0-6.1), repeated temperature instability (OR, 2.0; 95% CI, 1.4-2.8), and abnormal white blood cell count (OR, 2.5; 95% CI, 1.5-4.1) were associated with significant pathology.

Conclusions: Infants presenting with hypothermia often have diagnoses of significance aside from serious or invasive infections. Decision tools for management of hypothermic young infants should account for alternative pathology.

目的:婴儿体温过低通常归因于不成熟的体温调节,但可能是重要病理的先兆。我们的目的是确定90天或以下以低体温(≤36.0°C)为表现的婴儿显著病理的患病率和类型,并探讨这一结果与表现特征和评估之间的关系。方法:我们进行了一项多中心、回顾性队列研究,对5年期间在急诊科(ED)或医院环境中因体温过低而进行评估的婴儿进行了研究。年龄在90天或更小的患者在急诊科或入院时有记录或报告的低温症被纳入研究。所有图表都是手动审查的。我们的主要结局是诊断出明显的病理,传染性或非传染性,定义为需要住院评估、护理或监测。我们使用多变量逻辑回归模型来检验与显著病理的关联。结果:在998例纳入的婴儿中,32% (n = 318)有明显病理,4% (n = 41)有严重细菌感染或单纯疱疹病毒,28% (n = 277)有跨多器官系统和病理的其他重要诊断。经多因素logistic回归分析,老年发病(29-60天[比值比{OR}, 6.9; 95% CI, 4.0-11.9]和61-90天[OR, 8.1; 95% CI, 3.8-17.0])、外观不良(OR, 4.3; 95% CI, 3.0-6.1)、反复体温不稳定(OR, 2.0; 95% CI, 1.4-2.8)和白细胞计数异常(OR, 2.5; 95% CI, 1.5-4.1)与显著病理相关。结论:除了严重或侵袭性感染外,以低体温表现的婴儿通常有重要的诊断。低体温婴儿管理的决策工具应考虑其他病理。
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引用次数: 0
Understanding the Risk of Serious Infections in Young Infants With Hypothermia. 了解低体温婴儿严重感染的风险。
IF 2.1 Q1 Nursing Pub Date : 2025-10-01 DOI: 10.1542/hpeds.2025-008700
Hoi See Tsao, Alexander J Rogers, Sriram Ramgopal
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引用次数: 0
Envisioning Housing Equity: A Framework to Promote Housing Security Among Hospitalized Children. 设想住房公平:促进住院儿童住房保障的框架。
IF 2.1 Q1 Nursing Pub Date : 2025-10-01 DOI: 10.1542/hpeds.2025-008483
Grace Kim, Arvin Garg
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引用次数: 0
All Over the Map: Variation in Inpatient Pediatric Charges. 全地图:儿科住院收费的变化。
IF 2.1 Q1 Nursing Pub Date : 2025-10-01 DOI: 10.1542/hpeds.2025-008456
Amalia Jereczek, Matthew C Scanlon, Emily Reimer, Andrea R Maxwell
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引用次数: 0
Characterizing Pediatric Aspiration Pneumonia: Diagnostic Gaps and Stewardship Opportunities. 儿童吸入性肺炎的特征:诊断差距和管理机会。
IF 2.1 Q1 Nursing Pub Date : 2025-10-01 DOI: 10.1542/hpeds.2025-008436
Kathleen D Snow, Mollie G Wasserman, Kathleen E Walsh, Jonathan M Mansbach

Background and objectives: Aspiration pneumonia is a common cause for hospitalization, especially in children with medical complexity, yet there are no standard definition or clinical practice guidelines for the condition. Our objectives were to assess the validity of the aspiration pneumonia billing code and to describe the demographics, presenting symptoms, diagnostic results, and outcomes of children hospitalized with this condition.

Methods: We performed a retrospective cross-sectional analysis of 200 patients hospitalized with an International Classification of Diseases, tenth revision (ICD-10) diagnosis of aspiration pneumonia from 2016 to 2021. We conducted a standardized medical record review to identify children with a clinician diagnosis of aspiration pneumonia and collected data on patient and hospitalization characteristics across 4 subgroups defined by a combination of clinical and radiographic features.

Results: Among 200 patients identified by ICD-10 code, 138 (69%) also had a clinician diagnosis of aspiration pneumonia. For these 138 patients, the mean age was 8.4 years (SD, 7), and most had an underlying medical complexity. Diagnostic testing, antibiotic selection, and hospitalization outcomes were similar across definition subgroups. Only 18 patients (13%) had aspiration risk factors, fever, and a probable focal opacity on chest imaging at diagnosis.

Conclusions: We observed significant variability in presenting symptoms and diagnostic testing results among patients assigned a clinician diagnosis of aspiration pneumonia. Our study underscores the need for a standardized clinical definition, improved diagnostic criteria, and evidence-based treatment guidelines to optimize clinical care for this patient population.

背景和目的:吸入性肺炎是住院治疗的常见原因,特别是在医疗复杂的儿童中,但目前尚无标准定义或临床实践指南。我们的目的是评估吸入性肺炎账单代码的有效性,并描述因这种情况住院的儿童的人口统计学、表现症状、诊断结果和结局。方法:我们对2016年至2021年200例诊断为吸入性肺炎的国际疾病分类第十版(ICD-10)住院患者进行回顾性横断面分析。我们进行了一项标准化的医疗记录审查,以确定临床医生诊断为吸入性肺炎的儿童,并收集了4个亚组的患者和住院特征数据,这些亚组由临床和放射学特征组合定义。结果:在200例通过ICD-10编码识别的患者中,138例(69%)也有临床诊断为吸入性肺炎。这138例患者的平均年龄为8.4岁(SD, 7),大多数患者有潜在的医疗复杂性。诊断测试、抗生素选择和住院治疗结果在定义亚组中相似。只有18例(13%)患者在诊断时有误吸危险因素、发热和可能的局灶性不透明。结论:我们观察到临床医生诊断为吸入性肺炎的患者在表现症状和诊断测试结果上存在显著差异。我们的研究强调需要一个标准化的临床定义,改进的诊断标准和循证治疗指南来优化对这一患者群体的临床护理。
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引用次数: 0
Using Virtual Reality to Assess Residents' Clinical Assessments During and After COVID-19. 利用虚拟现实技术评估居民在COVID-19期间和之后的临床评估
IF 2.1 Q1 Nursing Pub Date : 2025-10-01 DOI: 10.1542/hpeds.2025-008393
Jacob T Fleck, Courtney A Gilliam, Andrea Meisman, Alison Richert, Mackenzie McGinty, Rashmi Sahay, Bin Zhang, Francis J Real, Matthew W Zackoff

Objective: Pediatric hospitalizations for respiratory illnesses declined during the SARS-CoV-2 (COVID-19) pandemic, reducing clinical exposure for trainees. A study conducted during this time period demonstrated low skills among pediatric interns related to the assessment and management of impending respiratory failure as measured via performance during a screen-based virtual reality (VR) simulation. However, a key limitation in interpreting the results was a lack of performance data from periods of exposure to normal clinical volumes. The objective of this study is to complete a follow-up to the initial study to assess pediatric intern performance in the same VR simulation during time periods in which interns were exposed to normalized clinical volumes.

Participants and methods: This cross-sectional observational study was conducted at a large, free-standing academic children's hospital. Three cohorts of convenience samples of interns completed the VR simulation. Performance was assessed via video review. Statistical differences among groups were examined through Fischer's exact test.

Results: A total of 22, 11, and 24 interns participated in cohorts 1 (January-May 2021), 2 (January-May 2022), and 3 (April-June 2024), respectively. There were no statistical differences among the performances of cohorts 1, 2, or 3 with regards to identification of altered mental status, impending respiratory failure, or a need for escalation of care.

Conclusions: Although there were no statistically significant differences in the recognition of respiratory failure or proposing an escalation of career among the cohorts of interns across periods of variable clinical volumes, these data prompt further investigation to explore when and how residents gain these critical clinical assessment skills and the role of VR for objectively assessing competency.

目的:在SARS-CoV-2 (COVID-19)大流行期间,儿科呼吸系统疾病住院率下降,减少了实习生的临床暴露。在此期间进行的一项研究表明,通过基于屏幕的虚拟现实(VR)模拟中的表现来衡量,儿科实习生在评估和管理即将发生的呼吸衰竭方面的技能较低。然而,解释结果的一个关键限制是缺乏暴露于正常临床容量期间的表现数据。本研究的目的是完成对初始研究的后续研究,以评估儿科实习生在相同的VR模拟中,在实习生暴露于标准化临床容量的时间段内的表现。参与者和方法:本横断面观察性研究在一家大型、独立的学术儿童医院进行。三组方便样本的实习生完成了VR模拟。通过视频评估表现。通过Fischer精确检验检验各组间的统计差异。结果:队列1(2021年1月- 5月)、队列2(2022年1月- 5月)和队列3(2024年4月- 6月)分别有22名、11名和24名实习生参与。在识别精神状态改变、即将发生的呼吸衰竭或需要升级护理方面,队列1、2和3的表现没有统计学差异。结论:尽管在不同临床量的实习队列中,对呼吸衰竭的认识或提出职业升级方面没有统计学上的显著差异,但这些数据提示进一步的调查,以探索住院医生何时以及如何获得这些关键的临床评估技能,以及VR在客观评估能力方面的作用。
{"title":"Using Virtual Reality to Assess Residents' Clinical Assessments During and After COVID-19.","authors":"Jacob T Fleck, Courtney A Gilliam, Andrea Meisman, Alison Richert, Mackenzie McGinty, Rashmi Sahay, Bin Zhang, Francis J Real, Matthew W Zackoff","doi":"10.1542/hpeds.2025-008393","DOIUrl":"10.1542/hpeds.2025-008393","url":null,"abstract":"<p><strong>Objective: </strong>Pediatric hospitalizations for respiratory illnesses declined during the SARS-CoV-2 (COVID-19) pandemic, reducing clinical exposure for trainees. A study conducted during this time period demonstrated low skills among pediatric interns related to the assessment and management of impending respiratory failure as measured via performance during a screen-based virtual reality (VR) simulation. However, a key limitation in interpreting the results was a lack of performance data from periods of exposure to normal clinical volumes. The objective of this study is to complete a follow-up to the initial study to assess pediatric intern performance in the same VR simulation during time periods in which interns were exposed to normalized clinical volumes.</p><p><strong>Participants and methods: </strong>This cross-sectional observational study was conducted at a large, free-standing academic children's hospital. Three cohorts of convenience samples of interns completed the VR simulation. Performance was assessed via video review. Statistical differences among groups were examined through Fischer's exact test.</p><p><strong>Results: </strong>A total of 22, 11, and 24 interns participated in cohorts 1 (January-May 2021), 2 (January-May 2022), and 3 (April-June 2024), respectively. There were no statistical differences among the performances of cohorts 1, 2, or 3 with regards to identification of altered mental status, impending respiratory failure, or a need for escalation of care.</p><p><strong>Conclusions: </strong>Although there were no statistically significant differences in the recognition of respiratory failure or proposing an escalation of career among the cohorts of interns across periods of variable clinical volumes, these data prompt further investigation to explore when and how residents gain these critical clinical assessment skills and the role of VR for objectively assessing competency.</p>","PeriodicalId":38180,"journal":{"name":"Hospital pediatrics","volume":" ","pages":"e505-e508"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Site-Specific Adaptation of an Inpatient Patient Navigator Program at 2 Children's Hospitals. 2家儿童医院住院病人导航员项目的定点适应
IF 2.1 Q1 Nursing Pub Date : 2025-10-01 DOI: 10.1542/hpeds.2024-008181
Dean J Karavite, Brian O Vazquez, Citlali R Gomez Acosta, Nguyen Tran, Diana C Navarrete, Sumia A Abdullahi, Elizabeth Wingfield, Elena C Griego, Aditi Vasan, Chen C Kenyon, Stephanie G Menko, Kristin D Maletsky, Katherine Yun, K Casey Lion

Objective: The Family Bridge Program was developed at a single pediatric hospital to improve outcomes for hospitalized children from families of color, who are low income, or who speak a language other than English. The program uses a family navigator ("Guide") that supports families via 6 service domains: Language Access, Orientation to the Hospital, Communication Preferences and Coaching, Addressing Unmet Social Needs, Supportive Check-Ins, and Discharge Follow-Up. This study describes an analysis to translate the program to a second pediatric hospital.

Methods: We interviewed clinical and hospital staff with experience matching the program domains to identify Guide tasks and factors that could influence task performance between the 2 hospitals. The interview format and analysis were framed by a sociotechnical model to identify task-related factors (persons and roles, resources and tools, community and organizational characteristics…) and to develop adaptation and communication strategies for the Guide.

Results: We interviewed 45 participants (22 at Hospital 1, 23 at Hospital 2), representing 14 clinical and staff roles. Analysis identified 57 tasks for the Guide across the 6 program domains. Multiple sociotechnical factors were identified that could impact task performance between and within both hospitals. Additional analysis identified sociotechnical factors and adaptation strategies for integrating the Guide with the clinical team.

Conclusions: The analysis facilitated a task-based adaptation of the Family Bridge Program to a second hospital by identifying and addressing sociotechnical differences between sites. This approach provides a framework for replicating the program at other hospitals.

目的:家庭桥梁项目是在一家儿科医院开展的,旨在改善来自有色人种家庭、低收入家庭或非英语家庭的住院儿童的预后。该计划使用家庭导航仪(“指南”),通过6个服务领域为家庭提供支持:语言获取、医院指导、沟通偏好和指导、解决未满足的社会需求、支持性登记和出院随访。本研究描述了一个分析,以翻译程序到第二儿科医院。方法:我们对具有与项目领域相匹配经验的临床和医院工作人员进行访谈,以确定指导任务和可能影响两家医院任务绩效的因素。访谈的形式和分析由一个社会技术模型构成,以确定与任务相关的因素(人员和角色、资源和工具、社区和组织特征……),并为指南制定适应和沟通策略。结果:我们采访了45名参与者(22名在医院1,23名在医院2),代表14个临床和工作人员角色。分析确定了《指南》在6个计划领域的57项任务。确定了可能影响两家医院之间和内部任务绩效的多种社会技术因素。额外的分析确定了社会技术因素和适应策略,以便将指南与临床团队相结合。结论:该分析通过识别和解决地点之间的社会技术差异,促进了基于任务的家庭桥梁计划适应第二家医院。这种方法为在其他医院复制该项目提供了一个框架。
{"title":"Site-Specific Adaptation of an Inpatient Patient Navigator Program at 2 Children's Hospitals.","authors":"Dean J Karavite, Brian O Vazquez, Citlali R Gomez Acosta, Nguyen Tran, Diana C Navarrete, Sumia A Abdullahi, Elizabeth Wingfield, Elena C Griego, Aditi Vasan, Chen C Kenyon, Stephanie G Menko, Kristin D Maletsky, Katherine Yun, K Casey Lion","doi":"10.1542/hpeds.2024-008181","DOIUrl":"10.1542/hpeds.2024-008181","url":null,"abstract":"<p><strong>Objective: </strong>The Family Bridge Program was developed at a single pediatric hospital to improve outcomes for hospitalized children from families of color, who are low income, or who speak a language other than English. The program uses a family navigator (\"Guide\") that supports families via 6 service domains: Language Access, Orientation to the Hospital, Communication Preferences and Coaching, Addressing Unmet Social Needs, Supportive Check-Ins, and Discharge Follow-Up. This study describes an analysis to translate the program to a second pediatric hospital.</p><p><strong>Methods: </strong>We interviewed clinical and hospital staff with experience matching the program domains to identify Guide tasks and factors that could influence task performance between the 2 hospitals. The interview format and analysis were framed by a sociotechnical model to identify task-related factors (persons and roles, resources and tools, community and organizational characteristics…) and to develop adaptation and communication strategies for the Guide.</p><p><strong>Results: </strong>We interviewed 45 participants (22 at Hospital 1, 23 at Hospital 2), representing 14 clinical and staff roles. Analysis identified 57 tasks for the Guide across the 6 program domains. Multiple sociotechnical factors were identified that could impact task performance between and within both hospitals. Additional analysis identified sociotechnical factors and adaptation strategies for integrating the Guide with the clinical team.</p><p><strong>Conclusions: </strong>The analysis facilitated a task-based adaptation of the Family Bridge Program to a second hospital by identifying and addressing sociotechnical differences between sites. This approach provides a framework for replicating the program at other hospitals.</p>","PeriodicalId":38180,"journal":{"name":"Hospital pediatrics","volume":" ","pages":"821-830"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implementing a Hearing-Targeted Congenital CMV Screening Program in a Low-Prevalence Region. 在低患病率地区实施以听力为目标的先天性巨细胞病毒筛查计划。
IF 2.1 Q1 Nursing Pub Date : 2025-10-01 DOI: 10.1542/hpeds.2025-008434
Nichole Wang, Adam Frymoyer, Christine Walravens, Cintia Capasso, Arun Gupta, Jessica Hudson, Benjamin A Pinsky, Nivedita S Srinivas

Objective: Congenital cytomegalovirus (cCMV) is the most common nongenetic cause of congenital sensorineural hearing loss. Hearing-targeted screening (HTS) programs have variable adherence and performance in terms of cCMV detection. Our institution implemented a cCMV HTS program in the newborn nursery with the aim of screening all eligible newborns during the birth hospitalization.

Methods: A bundle of interventions, including a nurse-driven HTS algorithm and process for cCMV screening test follow-up, was implemented in December 2018. cCMV screening was performed by saliva polymerase chain reaction (PCR) with confirmatory urine PCR within 21 days of birth. Our primary outcome was the median percentage of eligible newborns each quarter who completed cCMV screening. Secondary outcomes included the number of patients with confirmed cCMV (saliva +, urine +) and a false-positive saliva screen (saliva +, urine -). An annotated run chart was used to measure the impact of the bundle over time.

Results: Between December 2018 and September 2024, 650 newborns referred on hearing screening. cCMV screening increased from 0% to 94% during the first 14 quarters after implementation and increased further to 100% in the remaining 9 quarters. Thirteen newborns tested positive by saliva; all underwent confirmatory urine testing. Only 1 newborn had confirmed cCMV infection and remained asymptomatic with normal hearing. The remaining 12 were false positives.

Conclusion: We achieved high adherence to HTS but identified only 1 newborn with cCMV infection in 6 years. Alternative approaches to cCMV screening should be considered in regions with low cCMV prevalence that balance feasibility and yield.

目的:先天性巨细胞病毒(cCMV)是先天性感音神经性听力损失最常见的非遗传性原因。听力目标筛查(HTS)项目在cCMV检测方面具有不同的依从性和性能。我们的机构在新生儿托儿所实施了cCMV HTS计划,目的是在出生住院期间筛查所有符合条件的新生儿。方法:2018年12月实施了一系列干预措施,包括护士驱动的HTS算法和cCMV筛查试验随访流程。出生21天内采用唾液聚合酶链反应(PCR)和尿样PCR进行cCMV筛查。我们的主要结局是每个季度完成cCMV筛查的合格新生儿的中位数百分比。次要结局包括确诊cCMV(唾液+,尿液+)和唾液筛查假阳性(唾液+,尿液-)的患者数量。使用带注释的运行图来测量包随时间的影响。结果:2018年12月至2024年9月,650名新生儿接受了听力筛查。在实施后的前14个季度,cCMV筛查从0%增加到94%,并在其余9个季度进一步增加到100%。13名新生儿唾液检测呈阳性;所有患者均接受了尿检。仅有1例新生儿确诊cCMV感染,无症状且听力正常。其余12例为假阳性。结论:我们获得了高依从性HTS,但在6年内仅发现1例新生儿cCMV感染。在cCMV患病率较低的地区,应考虑替代cCMV筛查的方法,以平衡可行性和产量。
{"title":"Implementing a Hearing-Targeted Congenital CMV Screening Program in a Low-Prevalence Region.","authors":"Nichole Wang, Adam Frymoyer, Christine Walravens, Cintia Capasso, Arun Gupta, Jessica Hudson, Benjamin A Pinsky, Nivedita S Srinivas","doi":"10.1542/hpeds.2025-008434","DOIUrl":"10.1542/hpeds.2025-008434","url":null,"abstract":"<p><strong>Objective: </strong>Congenital cytomegalovirus (cCMV) is the most common nongenetic cause of congenital sensorineural hearing loss. Hearing-targeted screening (HTS) programs have variable adherence and performance in terms of cCMV detection. Our institution implemented a cCMV HTS program in the newborn nursery with the aim of screening all eligible newborns during the birth hospitalization.</p><p><strong>Methods: </strong>A bundle of interventions, including a nurse-driven HTS algorithm and process for cCMV screening test follow-up, was implemented in December 2018. cCMV screening was performed by saliva polymerase chain reaction (PCR) with confirmatory urine PCR within 21 days of birth. Our primary outcome was the median percentage of eligible newborns each quarter who completed cCMV screening. Secondary outcomes included the number of patients with confirmed cCMV (saliva +, urine +) and a false-positive saliva screen (saliva +, urine -). An annotated run chart was used to measure the impact of the bundle over time.</p><p><strong>Results: </strong>Between December 2018 and September 2024, 650 newborns referred on hearing screening. cCMV screening increased from 0% to 94% during the first 14 quarters after implementation and increased further to 100% in the remaining 9 quarters. Thirteen newborns tested positive by saliva; all underwent confirmatory urine testing. Only 1 newborn had confirmed cCMV infection and remained asymptomatic with normal hearing. The remaining 12 were false positives.</p><p><strong>Conclusion: </strong>We achieved high adherence to HTS but identified only 1 newborn with cCMV infection in 6 years. Alternative approaches to cCMV screening should be considered in regions with low cCMV prevalence that balance feasibility and yield.</p>","PeriodicalId":38180,"journal":{"name":"Hospital pediatrics","volume":" ","pages":"e487-e494"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Hospital pediatrics
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