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Treatment of class ii in adulthood by forsus frd device. 成年期使用福苏斯frd装置治疗ii类。
Pub Date : 2017-02-14 eCollection Date: 2016-01-01 DOI: 10.11138/orl/2016.9.1S.103
F DE Nuccio, M M D'Emidio, F DE Nuccio

Objectives: Scientific research data show that the Forsus FRD seems to have a great potential in the correction of Class II in childhood. The conclusions reached by the various Authors seem to support the hypothesis of an exclusively or mainly dentoalveolar correction, as the skeletal correction seems to have no - or little - appreciable results. In the light of such provided by different Authors, the potential of dentoalveolar compensation in adult patients with mild skeletal class II was investigated.

Materials and methods: At the UOC (Complex Operative Unit) of Orthodontics at "G. Eastman" Hospital Rome, 3 cases of skeletal class II mild (ANB <5 °) in adult patients were selected. They were treated with fixed multibracket appliance and Forsus EZ2 module. Cephalometric tracings were compared at the beginning and at the end of the treatment in order to assess the skeletal and dentoalveolar changes.

Results: The occlusal correction was achieved through a dentoalveolar compensation characterized by the flaring of the lower teeth.

Conclusions: Forsus FRD equipment is an excellent compromise for the correction of mild Class II, even during the post development age. The resulting correction is appreciated at dental alveolar level with a mesial movement of the incisors and molars.

目的:科学研究资料显示,Forsus FRD在儿童期II类矫治中具有很大的潜力。不同作者得出的结论似乎支持牙槽齿矫正的假设,因为骨骼矫正似乎没有或很少有明显的结果。根据不同作者提供的这些信息,我们对成人轻度骨骼II类患者牙槽代偿的潜力进行了研究。材料和方法:在罗马“G. Eastman”医院正畸综合手术单元(UOC), 3例骨骼II级轻度(ANB)患者结果:通过以下牙突出为特征的牙槽代偿实现了咬合矫正。结论:福苏斯FRD设备是轻度II级矫治的极好折衷方案,即使在发育后年龄。结果矫正是赞赏在牙槽水平与门牙和磨牙的近中运动。
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引用次数: 0
Clinical and radiographic evaluation of single tantalum dental implants: a prospective pilot clinical study. 单钽牙种植体的临床和放射学评价:一项前瞻性临床试验研究。
Pub Date : 2017-02-14 eCollection Date: 2016-01-01 DOI: 10.11138/orl/2016.9.1S.038
M DE Francesco, E A Gobbato, D Noce, F Cavallari, A Fioretti

Objective: The aim of this prospective pilot clinical case series report was to evaluate, through a clinical and radiographic analysis, the peri-implant bone resorption of the tantalum dental implants (TMT) (Zimmer TMT, Parsippany, NJ, USA) one year after prosthetic rehabilitation.

Methods: Twenty tantalum dental implants were placed in both maxillas and mandibles of 20 patients. Patients were asked to attend a radiographic and clinical follow-up and their previous clinical records and X-rays were assessed. Bone levels were calculated by digitally measuring the distance from the implant shoulder to the first bone-to-implant on periapical radiographs taken at surgery and after 6 and 12 months of functioning. The Pearson correlation analysis was performed to assess it there was a correlation between the measurement of the marginal bone loss (MBL). The Anova Test with a post-hoc analysis using Bonferroni's test was used to compare the three group (0, 6 months and 12 months).

Results: The mean total MBL for the group 0 months was 0.84 mm (SD 0.21), 6 months was 0.87 mm (SD 0.22) and for 12 months was 0.89 mm (SD 0.23). The values of the Pearson's coefficients showed that the data measurement were positively correlated. The Anova test showed a statistically significant difference between the groups.

Conclusion: The statistically significant difference in marginal bone loss can be considered physiological. Within the limits of this study it can be concluded that TMT implants have an excellent bone crest's stability, however, to have most accurate information, will be necessary extend the sample.

目的:本前瞻性临床病例系列报告的目的是通过临床和影像学分析,评估钽牙种植体(Zimmer TMT, Parsippany, NJ, USA)假肢康复一年后种植体周围骨吸收情况。方法:对20例患者在上颌和下颌骨放置20颗钽种植体。患者被要求参加x光摄影和临床随访,并评估他们以前的临床记录和x光片。骨水平通过数字测量从植入体肩关节到第一根骨到植入体的距离,在手术中和功能恢复6个月和12个月后的根尖周x线片上进行计算。采用Pearson相关分析评估边缘骨质流失(MBL)测量之间是否存在相关性。采用方差分析和事后分析,采用Bonferroni检验对三组(0、6个月和12个月)进行比较。结果:0个月组平均总MBL为0.84 mm (SD 0.21), 6个月组为0.87 mm (SD 0.22), 12个月组为0.89 mm (SD 0.23)。Pearson’s系数的值表明数据测量呈正相关。方差分析显示组间差异有统计学意义。结论:边缘骨质流失的差异有统计学意义,可认为是生理性的。在本研究的范围内,可以得出结论,TMT种植体具有优异的骨嵴稳定性,然而,要获得最准确的信息,将需要扩展样本。
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引用次数: 3
In vitro evaluation of prosthodontic impression on natural dentition: a comparison between traditional and digital techniques. 自然牙列修复印模的体外评价:传统技术与数字技术的比较。
Pub Date : 2017-02-14 eCollection Date: 2016-01-01 DOI: 10.11138/orl/2016.9.1S.021
G Malaguti, R Rossi, B Marziali, A Esposito, G Bruno, C Dariol, A DI Fiore

Objectives: The aim of this in vitro study is to evaluate the marginal and internal fit of zirconia core crowns manufactured following different digital and traditional workflows.

Methods: A 6° taper shoulder prepared abutment tooth was used to produce 20 zirconia core crowns using four different scanning techniques: scanned directly with the extraoral lab scanner, scanned with intraoral scanner, dental impressions using individual dental tray and polyether, dental casts from a polyether impressions. Marginal and internal fits were evaluated with digital photography and the silicone replica method.

Results: Medium marginal gaps were 76,00 μm ± 28.9 for extraoral lab scanner, 80.50 μm ± 36,2 for intraoral scanner, 88.10 μm ± 34,8 for dental impression scan and 112,4 μm ± 37,2 for dental cast scan. Medium internal gaps were 23.20 μm ± 10,3 for extraoral lab scanner, 16.20 μm ± 8.3 for intraoral scanner, 27.20 μm ± 16.7 for dental impression scan and 30.20 μm ± 12.7 for dental cast scan.

Conclusion: Internal gap were extensively lower than 70 μm described in literature. Marginal fit was higher than ideal values for all the techniques but within the limit of clinical success. Intraoral scanners obtained the best results for internal gap.

目的:本体外研究的目的是评估不同数字和传统工作流程制造的氧化锆核冠的边缘和内部配合度。方法:采用4种不同的扫描技术:口外实验室扫描仪直接扫描、口内扫描仪扫描、单独牙托印模和聚醚印模印模,以6°锥度肩为基牙制备20个氧化锆核冠。采用数码摄影和硅胶复制法评估边缘和内部配合。结果:口腔外实验室扫描的中等边缘间隙为76000 μm±28.9,口腔内扫描为80.50 μm±36,2,牙印模扫描为88.10 μm±34,8,铸型扫描为1124 μm±37,2。口腔外实验室扫描为23.20 μm±10.3,口内扫描为16.20 μm±8.3,印模扫描为27.20 μm±16.7,铸型扫描为30.20 μm±12.7。结论:文献描述的内间隙广泛小于70 μm。所有技术的边际拟合均高于理想值,但在临床成功的限度内。口腔内扫描对内间隙的检查效果最好。
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引用次数: 22
Oral hygiene in patients with oral cancer undergoing chemotherapy and/or radiotherapy after prosthesis rehabilitation: protocol proposal. 口腔癌患者在修复后接受化疗和/或放疗的口腔卫生:方案建议。
Pub Date : 2017-02-14 eCollection Date: 2016-01-01 DOI: 10.11138/orl/2016.9.1S.090
B Rapone, G M Nardi, D DI Venere, F Pettini, F R Grassi, M Corsalini

Purpose: This study was aimed at assessing the effectiveness and the importance of an oral hygiene (OH) protocol in patients undergoing radiation therapy and chemotherapy after prosthesis rehabilitation, in order to reduce or minimize oral complications.

Materials and methods: This study was carried out at the Department of Dental Science, at the University of Bari-Italy from December 2012 to December 2015 on 34 selected patients with primary oral cancer undergoing chemotherapy and radiotherapy after prosthesis rehabilitation. They were divided into 2 groups according to their age, sex and cancer therapy. Seventeen patients were assigned to the control group and seventeen in the experimental one. In the experimental group (Table 1), patients underwent an oral hygiene protocol whereas in the control group (Table 2) patients received the usual care provided within the clinical setting. All the patients gave written informed consent. It has been asked and obtained the authorisation from the Ethics Committee of the Dental Science and Surgery Department.

Results: Results show that in patients undergoing the oral hygiene protocol, the complications and the risks of infection and permanent dental problems have been minimized. Indeed, of the seventeen patients undergoing the OH protocol, 70% obtained positive results and were satisfied with the program outcome.

Conclusions: The role of the health care providers is essential to educate patients to adhere to the prescribed treatments and reinforce their motivation in oral hygiene. The oral hygiene procedures prevent and ameliorate oral complications due to the radiation therapy and chemotherapy.

目的:本研究旨在评估口腔卫生(OH)方案在假体康复后放疗和化疗患者中的有效性和重要性,以减少或减少口腔并发症。材料与方法:本研究于2012年12月至2015年12月在意大利巴里大学口腔科学系对34例原发性口腔癌患者进行修复康复后化疗和放疗。他们根据年龄、性别和癌症治疗分为两组。对照组17例,实验组17例。在实验组(表1)中,患者接受口腔卫生方案,而在对照组(表2)中,患者接受临床环境中提供的常规护理。所有患者均给予书面知情同意。已经询问并获得了牙科科学与外科伦理委员会的授权。结果:采用口腔卫生方案的患者并发症、感染和永久性牙问题的风险均降至最低。事实上,在接受OH方案的17例患者中,70%的患者获得了阳性结果,并对方案结果感到满意。结论:卫生保健提供者的作用是教育患者坚持规定的治疗,增强他们对口腔卫生的动力。口腔卫生程序预防和改善由于放射治疗和化疗引起的口腔并发症。
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引用次数: 20
Effects of the application of high-pressure oxygen on the treatment of periodontal disease in diabetic patients. 应用高压氧治疗糖尿病患者牙周病的疗效观察。
Pub Date : 2017-01-21 eCollection Date: 2017-10-01 DOI: 10.11138/orl/2017.10.4.412
S Sabatini, M Ricci, V Candotto, D Lauritano, G M Nardi

Purpose: In this study we wanted to observe the improvement in the healing of periodontal tissues in a group of diabetic patients treated with traditional methods compared to another group treated with the addition of oxygen.The potential of oxygen has long been known in the field of plastic surgery, where it is used to treat burns and skin lesions.

Materials and methods: This study consists in a split mouth study which involved 30 patients. We carefully treated them with periodontal therapy using manual and mechanical instrumentation. Then, we applied oxygen in half mouth according to randomization list. Finally we checked up patients after some weeks.

Results: Our results highlight that all areas treated with oxygen application healed more rapidly and better than no treated areas.

Conclusions: All in all, we have demonstrated that oxygen can improve the outcome of non-surgical periodontal treatment in diabetic subjects.

目的:在本研究中,我们想要观察传统方法治疗组与加氧治疗组在牙周组织愈合方面的改善情况。氧气的潜力在整形外科领域早已为人所知,它被用于治疗烧伤和皮肤损伤。材料与方法:本研究采用裂口法,共纳入30例患者。我们用手工和机械仪器对他们进行牙周治疗。然后,根据随机分组表进行半口吸氧。几周后,我们终于对病人进行了检查。结果:我们的研究结果强调,氧敷治疗的所有区域比未治疗的区域愈合更快,更好。结论:总而言之,我们已经证明氧气可以改善糖尿病患者非手术牙周治疗的结果。
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引用次数: 2
Correlation between coronal and apical arch form and degree of divergence: a volumetric computed tomography analysis. 冠状和根尖弓形态与发散程度的相关性:体积计算机断层扫描分析。
Pub Date : 2017-01-21 eCollection Date: 2017-10-01 DOI: 10.11138/orl/2017.10.4.424
L Lombardo, F Veronesi, V Candotto, M Nardone, G Siciliani

Purpose: To determine the existence of any correlation between the degree of divergence and apical and coronal arch form using cone-beam computed tomography (CBCT).

Materials and methods: A total of 176 (88 coronal and 88 apical) CBCT scans pertaining to a sample of 44 subjects (16 males and 28 females), of which 26 were Class I, 14 Class II and 4 Class III, were analysed. A lateral projection of the skull was obtained from each VCT and cephalometric tracing was performed (according to Ricketts) so as to divide the sample into subgroups based on the degree of divergence (11 short-faced, 18 norm-faced and 15 long-faced subjects). Dahlberg's index values were calculated and Student's t-test for paired data was applied.

Results: On the whole, the hyperbolic cosine curve was found to be the most representative of the arch forms considered.

Conclusions: A correlation between degree of divergence and the arch form of the apical and, especially, coronal portions of both the upper and lower jaws was revealed.

目的:利用锥束计算机断层扫描(CBCT)确定分化程度与根冠状弓形态之间是否存在相关性。材料和方法:对44名受试者(16名男性,28名女性)共176张CBCT扫描(88张冠状和88张根尖)进行分析,其中26张为ⅰ类,14张为ⅱ类,4张为ⅲ类。从每个VCT上获得颅骨的侧向投影,并进行头部测量追踪(根据Ricketts),以便根据差异程度将样本分为亚组(11名短脸,18名标准脸和15名长脸受试者)。计算Dahlberg指数值,采用配对数据的Student’st检验。结果:总体而言,双曲余弦曲线是最具代表性的拱型。结论:分化程度与上颌和下颌骨的尖部,特别是冠状部的弓形之间存在相关性。
{"title":"Correlation between coronal and apical arch form and degree of divergence: a volumetric computed tomography analysis.","authors":"L Lombardo,&nbsp;F Veronesi,&nbsp;V Candotto,&nbsp;M Nardone,&nbsp;G Siciliani","doi":"10.11138/orl/2017.10.4.424","DOIUrl":"https://doi.org/10.11138/orl/2017.10.4.424","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the existence of any correlation between the degree of divergence and apical and coronal arch form using cone-beam computed tomography (CBCT).</p><p><strong>Materials and methods: </strong>A total of 176 (88 coronal and 88 apical) CBCT scans pertaining to a sample of 44 subjects (16 males and 28 females), of which 26 were Class I, 14 Class II and 4 Class III, were analysed. A lateral projection of the skull was obtained from each VCT and cephalometric tracing was performed (according to Ricketts) so as to divide the sample into subgroups based on the degree of divergence (11 short-faced, 18 norm-faced and 15 long-faced subjects). Dahlberg's index values were calculated and Student's t-test for paired data was applied.</p><p><strong>Results: </strong>On the whole, the hyperbolic cosine curve was found to be the most representative of the arch forms considered.</p><p><strong>Conclusions: </strong>A correlation between degree of divergence and the arch form of the apical and, especially, coronal portions of both the upper and lower jaws was revealed.</p>","PeriodicalId":38303,"journal":{"name":"ORAL and Implantology","volume":"10 4","pages":"424-438"},"PeriodicalIF":0.0,"publicationDate":"2017-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892657/pdf/424-438.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36031699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stress distribution of various designs of prostheses on short implants or standard implants in posterior maxilla: a three dimensional finite element analysis. 上颌后牙短种植体与标准种植体不同设计的应力分布:三维有限元分析。
Pub Date : 2017-01-21 eCollection Date: 2017-10-01 DOI: 10.11138/orl/2017.10.4.369
K Jomjunyong, P Rungsiyakull, C Rungsiyakull, W Aunmeungtong, M Chantaramungkorn, P Khongkhunthian

Introduction: Although many previous studies have reported on the high success rate of short dental implants, prosthetic design still plays an important role in the long-term implant treatment results. This study aims to evaluate stress distribution characteristics involved with various prosthetic designs on standard implants or short implants in the posterior maxilla.

Materials and methods: Six finite element models were simulated representing the missing first and second maxillary molars. A standard implant (PW+ implant: 5.0×10 mm) and a short implant (PW+ implant: 5.0×6.0 mm) were applied under the various prosthetic conditions. The peri-implant maximum bone stress (V on mises stress) was evaluated when 200 N 30° oblique load was applied. A type III bone was approximated and complete osseous integration was assumed.

Results: Maximum Von mises stress was numerically located at the cortical bone around the implant neck in all models. In every standard implant model shows better stress distribution. Stress values and concentration area decreased in the cortical and cancellous bone when implants were splinted in both the standard and short implant models. With regard to the non-replacing second molar models found that the area of stress at the cortical bone around the first molar implant to be more intensive. Moreover, in the non-replacing second molar models, the stress also spread to the second pre-molar in both the standard and short implant models.

Conclusions: The length of the implant and prosthetics designs both affect the stress value and distribution of stress to the cortical and cancellous bones around the implant.

导读:虽然以往的许多研究报道了短种植体的高成功率,但假体设计仍然对长期种植体治疗效果起着重要作用。本研究旨在评估不同假体设计在标准种植体或短种植体上的应力分布特征。材料与方法:模拟缺失第一、第二上颌磨牙的六个有限元模型。标准种植体(PW+种植体:5.0×10 mm)和短种植体(PW+种植体:5.0×6.0 mm)在各种假体条件下应用。当施加200 N 30°斜载荷时,评估种植体周围最大骨应力(V对mises应力)。接近III型骨,并假设完全骨整合。结果:所有模型的最大Von mises应力均位于种植体颈部周围的皮质骨。各标准种植体模型均表现出较好的应力分布。在标准种植体和短种植体模型中,当种植体被夹板固定时,皮质骨和松质骨的应力值和集中面积都降低。对于非替换的第二磨牙模型,发现第一磨牙种植体周围皮质骨处的应力面积更大。此外,在非替换的第二磨牙模型中,无论是标准种植体模型还是短种植体模型,应力也会扩散到第二前磨牙。结论:种植体长度和假体设计都会影响种植体周围皮质骨和松质骨的应力值和应力分布。
{"title":"Stress distribution of various designs of prostheses on short implants or standard implants in posterior maxilla: a three dimensional finite element analysis.","authors":"K Jomjunyong,&nbsp;P Rungsiyakull,&nbsp;C Rungsiyakull,&nbsp;W Aunmeungtong,&nbsp;M Chantaramungkorn,&nbsp;P Khongkhunthian","doi":"10.11138/orl/2017.10.4.369","DOIUrl":"https://doi.org/10.11138/orl/2017.10.4.369","url":null,"abstract":"<p><strong>Introduction: </strong>Although many previous studies have reported on the high success rate of short dental implants, prosthetic design still plays an important role in the long-term implant treatment results. This study aims to evaluate stress distribution characteristics involved with various prosthetic designs on standard implants or short implants in the posterior maxilla.</p><p><strong>Materials and methods: </strong>Six finite element models were simulated representing the missing first and second maxillary molars. A standard implant (PW+ implant: 5.0×10 mm) and a short implant (PW+ implant: 5.0×6.0 mm) were applied under the various prosthetic conditions. The peri-implant maximum bone stress (V on mises stress) was evaluated when 200 N 30° oblique load was applied. A type III bone was approximated and complete osseous integration was assumed.</p><p><strong>Results: </strong>Maximum Von mises stress was numerically located at the cortical bone around the implant neck in all models. In every standard implant model shows better stress distribution. Stress values and concentration area decreased in the cortical and cancellous bone when implants were splinted in both the standard and short implant models. With regard to the non-replacing second molar models found that the area of stress at the cortical bone around the first molar implant to be more intensive. Moreover, in the non-replacing second molar models, the stress also spread to the second pre-molar in both the standard and short implant models.</p><p><strong>Conclusions: </strong>The length of the implant and prosthetics designs both affect the stress value and distribution of stress to the cortical and cancellous bones around the implant.</p>","PeriodicalId":38303,"journal":{"name":"ORAL and Implantology","volume":"10 4","pages":"369-380"},"PeriodicalIF":0.0,"publicationDate":"2017-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892655/pdf/369-380.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36032277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Identification of oral risk factors for chronic graft versus host disease in haematological patients who underwent allogeneic haematopoietic stem cell transplantation. 接受同种异体造血干细胞移植的血液病患者慢性移植物抗宿主病的口腔危险因素的鉴定
Pub Date : 2017-01-21 eCollection Date: 2017-10-01 DOI: 10.11138/orl/2017.10.4.390
A Picardi, M Miranda, F Liciani, G Paterno, W Arcese, P Bollero

Objective: The aim of this prospective observational study was to identify local risk factors for the development of clinical manifestations of oral chronic Graft versus Host Disease (cGvHD) in a cohort of patients affected by haematological malignant diseases who underwent allogeneic haematopoietic stem cell transplantation (HSCT).

Materials and methods: In the context of an active collaboration between the Rome Transplant Network of the Hematology and the Oral Pathology Division at "Policlinico Tor Vergata", in Rome, 47 haematological patients were included in this trial based on a systematic dental screening and follow-up protocol. The dental checks were planned 1 month before the transplant procedure while the subsequent follow ups were scheduled on day +100, +180, +365 and + 730 after the transplant. The tool used for the dental checks was a detailed report including all the potential oral features responsible of mechanical, chemical or infective injuries, except for the drugs.

Results: Overall, 64% of patients (N=30) did not perform dental hygiene during the screening pre-transplant and 53% (25/47) developed cGvHD with oral involvement. The most part of patients (84%) who experienced oral manifestations of cGvHD during the follow-up period after HSCT did not perform dental hygiene before the transplant procedure. Moreover, the comparison between the "presence" or "absence" of dental hygiene before the allogeneic HSCT showed a statistical significant increasing during the follow-up period in the occurrence of oral lesions due to the cGvHD for patients who lack pre-transplant dental care (p=0.029).On the contrary, the frequency of the other factors such as malocclusions, fractured teeth, incongruous prosthesis, food, smoke, alcol and bad habits, resulted similar between the group with or without typical oral lesions of cGvHD.

Conclusions: The prevention of oral infectious complications provided by primary and secondary dental cares can result in a great benefit for haematological patients who underwent allogeneic HSCT. The combined hematological and dental management represents a clinical need before and after allogeneic HSCT for the removal of inconvenient issues with impact on the short and long-term outcome. Poor dental hygiene seems to be a local risk factor for the development of oral lesions due to cGvHD. However, a larger cohort of patients is necessary to confirm these preliminary data and to evaluate the best preventive and therapeutic oral hygiene protocol in this specific setting.

目的:这项前瞻性观察性研究的目的是在接受同种异体造血干细胞移植(HSCT)的血液恶性疾病患者队列中,确定口腔慢性移植物抗宿主病(cGvHD)临床表现发展的局部危险因素。材料和方法:在罗马血液学移植网络和罗马“polilinico Tor Vergata”口腔病理学部门积极合作的背景下,47名血液学患者被纳入该试验,该试验基于系统的牙科筛查和随访方案。牙科检查计划在移植手术前1个月进行,后续随访安排在移植后第100天、第180天、第365天和第730天进行。用于牙齿检查的工具是一份详细的报告,包括除药物外所有可能导致机械、化学或感染性损伤的口腔特征。结果:总体而言,64%的患者(N=30)在移植前筛查期间没有进行口腔卫生检查,53%(25/47)发生cGvHD并累及口腔。大部分(84%)在移植后随访期间出现cGvHD口腔表现的患者在移植手术前没有进行口腔卫生。此外,对比同种异体造血干细胞移植前“有”或“没有”口腔卫生的患者,移植前缺乏牙科护理的患者在随访期间因cGvHD引起的口腔病变发生率有统计学意义的增加(p=0.029)。而其他因素如牙合错误、断牙、假体不协调、食物、吸烟、饮酒及不良生活习惯的发生频率在有或无典型口腔病变组间相似。结论:通过初级和二级牙科护理预防口腔感染并发症对接受同种异体造血干细胞移植的血液病患者有很大的好处。血液学和牙科联合治疗代表了异体造血干细胞移植前后的临床需要,以消除影响短期和长期结果的不便问题。不良的口腔卫生似乎是导致cGvHD口腔病变发展的局部危险因素。然而,需要更大的患者队列来证实这些初步数据,并评估在这一特定环境下的最佳预防和治疗口腔卫生方案。
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引用次数: 3
Therapeutic efficiency of platelet gel for the treatment of oral ulcers related to chronic graft versus host disease after allogeneic haematopoietic stem cell transplantation. 血小板凝胶治疗同种异体造血干细胞移植后慢性移植物抗宿主病相关口腔溃疡的疗效
Pub Date : 2017-01-21 eCollection Date: 2017-10-01 DOI: 10.11138/orl/2017.10.4.398
A Picardi, A S Ferraro, M Miranda, F Meconi, A Lanti, G Adorno, W Arcese, P Bollero

Background: Platelet (PLT) gel has been successfully used in tissue regeneration of diabetic and surgical wounds through the releasing of growth factors such as basic fibroblast and PLT-derived growth factors. Based on this background, our previous clinical trial have assessed the feasibility and efficacy of PLT gel for the treatment of muco-cutaneous lesions related to graft versus host disease (GvHD) after allogeneic haematopoietic stem cell transplantion (HSCT). The promising results reported in a small series of 6 patients, of whom 1 with oral ulcers, represent the rationale of the present study.

Materials and methods: The aim of this study was to verify the efficacy and safety of PLT gel for treating oral ulcers due to chronic GvHD. Allogeneic hemocomponents were used to obtain PLT gel with an automated system for the on-site preparation and application of patient (autologous) or healthy blood donor (allogeneic)-derived fibrin sealant or PLT-rich fibrin (Vivostat system, Vivostat A/S). Ten patients with multiple oral lesions related to chronic GvHD underwent allogeneic PLT gel as local therapy alone or in combination with systemic therapy in half of the cases.

Results: After the second PLT gel application, all patients resumed the feeding and a significant improvement of the oral pain was observed. After a median of five PLT gel applications (range, 2-15), 7 out of 10 patients showed a complete response. No side effects were documented.

Conclusion: These data confirm that the PLT gel may be used as a safe and effective tool, alone or in combination with systemic therapy, for the treatment of mucosal lesions of mouth related to cGvHD.

背景:血小板(PLT)凝胶通过释放碱性成纤维细胞和PLT衍生的生长因子等生长因子,已成功用于糖尿病和外科伤口的组织再生。基于这一背景,我们之前的临床试验已经评估了PLT凝胶治疗同种异体造血干细胞移植(HSCT)后移植物抗宿主病(GvHD)相关皮肤粘膜病变的可行性和有效性。在6例患者(其中1例患有口腔溃疡)的小系列研究中报告的令人鼓舞的结果代表了本研究的基本原理。材料和方法:本研究的目的是验证PLT凝胶治疗慢性GvHD所致口腔溃疡的有效性和安全性。同种异体血液成分通过自动化系统获得PLT凝胶,用于现场制备和应用患者(自体)或健康供血者(同种异体)来源的纤维蛋白密封剂或富含PLT的纤维蛋白(Vivostat系统,Vivostat A/S)。10例与慢性GvHD相关的多发性口腔病变患者接受了同种异体PLT凝胶作为局部治疗或一半的病例联合全身治疗。结果:第二次应用PLT凝胶后,所有患者均恢复进食,口腔疼痛明显改善。中位数为5次PLT凝胶应用(范围2-15)后,10名患者中有7名显示完全缓解。无副作用记录。结论:这些数据证实,PLT凝胶可作为一种安全有效的工具,单独或联合全身治疗,用于治疗cGvHD相关的口腔黏膜病变。
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引用次数: 9
Bone regeneration in aesthetic areas using titanium micromesh. Three case reports. 使用钛微网在美容部位进行骨再生。三份病例报告。
Pub Date : 2017-01-21 eCollection Date: 2017-10-01 DOI: 10.11138/orl/2017.10.4.488
A Scarano, B Assenza, A DI Cerbo, V Candotto, P Santos DE Oliveira, F Lorusso

Purpose: An adequate bone volume for complete circumferential coverage of the implants is very important for obtaining a long-term success of oral implants. To avoid these problems various membranes and biomaterials were used, but soft tissue pressure could cause a membrane collapse toward the defect. The present work describes a ridge augmentation with titanium mesh shaped by adapting it to a bone defect in aesthetic areas.

Materials and methods: Three patients with alveolar crest defects received three implants (Bone System, Milano, Italy) and the defects were filled with bone chips. The defects were covered with a titanium micromesh above which was positioned a resorbable membrane (Biogide, Geistlich, Wohlhusen, Switzerland).

Results: At the re-entry procedure the titanium micromesh appeared to be surrounded by a dense connective tissue with no clinical signs of inflammation. Clinically in all patients, no residual bone defects were observed, and a significant increase of the alveolar width or height was found.

Conclusions: In conclusion the clinical results of the present study show that most certainly the space for the bone regeneration is one of the most critical factors in the success of the regenerative techniques.

目的:为使口腔种植体获得长期成功,足够的骨量对种植体的周缘进行完全覆盖是非常重要的。为了避免这些问题,人们使用了各种膜和生物材料,但软组织压力可能导致膜向缺损处塌陷。本研究介绍了一种用钛网进行牙脊增量的方法,通过使其适应美学区域的骨缺损来达到增量的目的:三名牙槽嵴缺损患者接受了三颗种植体(Bone System,意大利米兰),缺损处用骨片填充。在缺损处覆盖一层钛微网,微网上方放置一层可吸收膜(Biogide,Geistlich,Wohlhusen,瑞士):结果:再次进入手术室时,钛微网似乎被致密的结缔组织包围,没有炎症的临床表现。从临床上看,所有患者都没有发现残留骨缺损,牙槽宽度和高度都有明显增加:总之,本研究的临床结果表明,骨再生的空间无疑是再生技术成功的最关键因素之一。
{"title":"Bone regeneration in aesthetic areas using titanium micromesh. Three case reports.","authors":"A Scarano, B Assenza, A DI Cerbo, V Candotto, P Santos DE Oliveira, F Lorusso","doi":"10.11138/orl/2017.10.4.488","DOIUrl":"10.11138/orl/2017.10.4.488","url":null,"abstract":"<p><strong>Purpose: </strong>An adequate bone volume for complete circumferential coverage of the implants is very important for obtaining a long-term success of oral implants. To avoid these problems various membranes and biomaterials were used, but soft tissue pressure could cause a membrane collapse toward the defect. The present work describes a ridge augmentation with titanium mesh shaped by adapting it to a bone defect in aesthetic areas.</p><p><strong>Materials and methods: </strong>Three patients with alveolar crest defects received three implants (Bone System, Milano, Italy) and the defects were filled with bone chips. The defects were covered with a titanium micromesh above which was positioned a resorbable membrane (Biogide, Geistlich, Wohlhusen, Switzerland).</p><p><strong>Results: </strong>At the re-entry procedure the titanium micromesh appeared to be surrounded by a dense connective tissue with no clinical signs of inflammation. Clinically in all patients, no residual bone defects were observed, and a significant increase of the alveolar width or height was found.</p><p><strong>Conclusions: </strong>In conclusion the clinical results of the present study show that most certainly the space for the bone regeneration is one of the most critical factors in the success of the regenerative techniques.</p>","PeriodicalId":38303,"journal":{"name":"ORAL and Implantology","volume":"10 4","pages":"488-494"},"PeriodicalIF":0.0,"publicationDate":"2017-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892660/pdf/488-494.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36032126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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ORAL and Implantology
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