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Otology: Foreword. 耳科学:前言。
Q3 Medicine Pub Date : 2024-07-01
Karl T Rew
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引用次数: 0
Otology: Cerumen Impaction and Aural Foreign Bodies. 耳科:耵聍堵塞和耳道异物。
Q3 Medicine Pub Date : 2024-07-01
John Malaty, Michael Tudeen, Maribeth Porter Williams, Frank A Orlando

Cerumen lubricates and protects the external auditory canal, but excess accumulation can lead to ear fullness, itching, otalgia, discharge, hearing loss, and tinnitus. Cerumen should be treated whenever symptoms are present or if it limits diagnosis by preventing a needed otoscopic examination. Clinicians should evaluate for cerumen impaction in those using hearing aids and patients with intellectual disability. Cerumen impaction can be treated with cerumenolytics, ear irrigation, and manual removal with instrumentation. Aural foreign bodies can cause ear fullness, otalgia, discharge, and hearing loss. They are more common in children than adults. The most common type of aural foreign bodies in children is jewelry, followed by paper products, parts of pens or pencils, desk supplies (eg, erasers), BBs or pellets, and earplugs or earphones. In adults, the most common aural foreign bodies are cotton swabs or cotton, followed by hearing aid parts and jewelry or ear accessories. Patients should avoid using cotton tip applicators in the external auditory canal. Alligator forceps, small right angle hooks, and ear irrigation commonly are used to remove aural foreign bodies in an outpatient clinic setting, but the choice depends on the type of foreign body. Soft and irregularly shaped objects can be removed without referral to an otolaryngologist. Patients with hard, spherical, or cylindrical objects should be referred to an otolaryngologist if previous removal attempts have failed or if there is ear trauma to avoid worsening its position in the ear canal.

耵聍能润滑和保护外耳道,但过量积聚会导致耳部胀满、瘙痒、耳痛、流脓、听力下降和耳鸣。只要出现症状,或者耵聍妨碍了所需的耳镜检查,从而限制了诊断,就应该治疗耵聍。临床医生应评估使用助听器的患者和智障患者的耵聍堵塞情况。耵聍堵塞的治疗方法有耵聍溶解剂、耳灌洗和人工用器械清除。耳道异物可导致耳部胀满、耳痛、流脓和听力损失。儿童比成人更常见。儿童最常见的耳道异物是首饰,其次是纸制品、钢笔或铅笔的部件、办公用品(如橡皮擦)、BB 弹或弹丸、耳塞或耳机。在成人中,最常见的耳道异物是棉签或棉花,其次是助听器部件、首饰或耳部配件。患者应避免在外耳道内使用棉签。在门诊环境中,鳄鱼镊、小直角钩和耳灌常用于清除耳道异物,但具体选择哪种方法取决于异物的类型。软异物和形状不规则的异物无需转诊至耳鼻喉科医生即可取出。而对于硬质、球形或圆柱形异物的患者,如果之前的取出尝试失败或有耳部创伤,则应转诊至耳鼻喉科医生,以避免异物在耳道中的位置恶化。
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引用次数: 0
Otology: Vertigo. 耳科:眩晕症。
Q3 Medicine Pub Date : 2024-07-01
Frank A Orlando, John Malaty, Maribeth Porter Williams, Michael Tudeen

Vertigo, an unexpected feeling of self-motion, is no longer characterized simply by symptom quality but by using triggers and timing. Evaluating vertigo by triggers and timing not only distinguishes serious central causes from benign peripheral causes, but also narrows the differential diagnosis by further classifying vertigo as spontaneous episodic vestibular syndrome, triggered episodic vestibular syndrome, or acute vestibular syndrome. A targeted physical examination can then be used to further delineate the cause within each of these three vestibular categories. Neuroimaging and vestibular testing are not routinely recommended. In the management of vertigo, vestibular hypofunction can be treated with vestibular rehabilitation, which can be self-administered or directed by a physical therapist. Pharmacotherapy sometimes is indicated for vertigo based on triggers, timing, and the specific condition, but it is not always beneficial and is used more often for symptom reduction than as a cure. Transtympanic corticosteroid or gentamicin injections are recommended for patients who do not benefit from nonablative therapy. Surgical ablative therapy is reserved for patients who have not benefited from less definitive therapy and have nonusable hearing.

眩晕是一种意想不到的自我运动感,其特征不再是简单的症状质量,而是使用诱因和时间。通过诱发因素和时间来评估眩晕,不仅可以区分严重的中枢性原因和良性的外周性原因,还可以将眩晕进一步分为自发性发作性前庭综合征、诱发性发作性前庭综合征或急性前庭综合征,从而缩小鉴别诊断的范围。然后,可以通过有针对性的体格检查来进一步确定这三类前庭综合征的病因。不建议常规进行神经影像学检查和前庭测试。在眩晕的治疗中,前庭功能减退可以通过前庭康复治疗来解决,康复治疗可以自行进行,也可以由理疗师指导。根据眩晕的诱发因素、时间和具体病情,药物疗法有时也适用于眩晕,但并不总是有益的,而且更多时候是用于减轻症状,而非治疗。对于非烧蚀疗法无效的患者,建议进行颅内皮质类固醇或庆大霉素注射。手术烧蚀疗法适用于无法从不确定性疗法中获益且听力不可用的患者。
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引用次数: 0
Otology: Hearing Loss. 耳科:听力损失。
Q3 Medicine Pub Date : 2024-07-01
Michael Tudeen, Maribeth Porter Williams, Frank A Orlando, John Malaty

Hearing loss is the cause of significant morbidity throughout the United States and the world. Because of numerous factors, such as ongoing noise exposure, poorly controlled chronic disease, and an aging population, the burden of hearing loss is expected to continue to increase. Hearing loss commonly is categorized as conductive, sensorineural, or mixed. The type of hearing loss can be determined through a combination of patient history and physical examination, and then confirmed with audiometry and tympanometry. Advanced imaging is not typically necessary, but it may be helpful in specific instances. The presentation of sudden sensorineural hearing loss should prompt urgent referral to an otolaryngologist and audiologist. Management of this condition is selective but may initially include oral corticosteroids. Management for chronic hearing loss involves the use of hearing aids, which can offer a large benefit to users but historically have been expensive and not covered by many insurance plans. Recent US legislation has made hearing aids more accessible and affordable by allowing direct-to-consumer marketing and offering over-the-counter hearing aids without a clinical evaluation.

在美国和全世界,听力损失都是严重的发病原因。由于持续的噪声暴露、慢性疾病控制不佳和人口老龄化等诸多因素,听力损失的负担预计将继续增加。听力损失通常分为传导性听力损失、感音神经性听力损失或混合性听力损失。听力损失的类型可通过综合患者病史和体格检查来确定,然后再通过听力测定和鼓室测量来确认。通常不需要进行高级成像检查,但在特定情况下可能会有所帮助。突发性感音神经性听力损失应立即转诊至耳鼻喉科医生和听力学家。对这种情况的处理是有选择性的,但最初可能包括口服皮质类固醇。慢性听力损失的治疗包括使用助听器,助听器能给使用者带来很大益处,但历来价格昂贵,许多保险计划都不承保。最近,美国立法允许直接向消费者推销助听器,并提供无需临床评估的非处方助听器,从而使助听器更容易获得,价格也更合理。
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引用次数: 0
Otology: Ear Infections. 耳科:耳部感染
Q3 Medicine Pub Date : 2024-07-01
Maribeth Porter Williams, Michael Tudeen, Frank A Orlando, John Malaty

Acute otitis media (AOM) is a common diagnosis in children who present with symptoms of otalgia, fever, or irritability and is confirmed by a bulging tympanic membrane or otorrhea on physical examination. It often is preceded by a viral infection, but the bacterial pathogens isolated most commonly are Streptococcus pneumonia, Haemophilus influenzae, and Moraxella catarrhalis. Watchful waiting may be appropriate in children 6 months or older with uncomplicated unilateral AOM. When antibiotics are indicated, amoxicillin is the first-line treatment in those without recent treatment with or allergy to this drug. Otitis media with effusion (OME) is fluid in the middle ear without symptoms of AOM and typically resolves within 3 months. Tympanostomy tube placement is the most common ambulatory surgery for children in the United States. It is used to ventilate the middle ear space and may be performed to treat recurrent AOM, persistent AOM, or chronic OME. Acute otitis externa is inflammation of the external ear canal, often due to infection. On examination, the ear canal is red and inflamed, with patients typically experiencing discomfort with manipulation of the affected ear. It is treated with a topical antibiotic with or without topical corticosteroid.

急性中耳炎(AOM)是以耳痛、发热或烦躁不安为主要症状的儿童的常见诊断方法,体格检查时鼓膜隆起或出现耳痛即可确诊。发病前通常有病毒感染,但最常分离出的细菌病原体是肺炎链球菌、流感嗜血杆菌和白喉摩拉菌。对于6个月或以上、无并发症的单侧AOM患儿,可以采取观察等待的方法。如果需要使用抗生素,阿莫西林是近期未接受过治疗或对其过敏的儿童的一线治疗药物。中耳炎伴积液(OME)是指中耳积液而无AOM症状,一般在3个月内消退。鼓室造口术置管术是美国儿童最常见的门诊手术。该手术用于中耳通气,可用于治疗复发性中耳积液、持续性中耳积液或慢性中耳炎。急性外耳道炎是外耳道的炎症,通常由感染引起。检查时,耳道会发红、发炎,患者在操作患耳时通常会感到不适。治疗方法是局部使用抗生素,或不使用局部皮质类固醇。
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引用次数: 0
Common Skin Conditions in Children and Adolescents: Foreword. 儿童和青少年常见皮肤病:前言。
Q3 Medicine Pub Date : 2024-06-01
Ryan D Kauffman
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引用次数: 0
Common Skin Conditions in Children and Adolescents: Atopic and Seborrheic Dermatitis. 儿童和青少年常见皮肤病:特应性皮炎和脂溢性皮炎。
Q3 Medicine Pub Date : 2024-06-01
Mengyi Zha, Richard Usatine

Atopic dermatitis (AD) is a chronic, recurring, inflammatory skin condition. Xerosis, pruritus, and rash make the clinical diagnosis. Adequate skin care and regular emollient use are key in management. Topical corticosteroids are the first-line treatment for AD flare-ups. Wet wrap therapy can improve AD severity and extent. Topical calcineurin inhibitors are second-line treatments. Emollient use, topical corticosteroids and calcineurin inhibitors, and bleach baths can help prevent flare-ups. Patients with refractory AD that might require immunomodulatory treatments, such as dupilumab (Dupixent), Janus kinase inhibitors, or phototherapy, should be referred to a dermatologist. Seborrheic dermatitis (SD) is a common, chronic, relapsing, inflammatory condition that involves sebaceous skin areas. Infection with Malassezia species and the inflammatory response to it are the probable etiologies. The clinical diagnosis is made by the presence of hallmark greasy, yellow scales on the scalp or face. Infantile SD most commonly involves the scalp and forehead and typically is self-limited. In infants, application of emollients followed by hair brushing and shampooing may be effective. In infants and children, if the condition does not improve with this treatment, topical ketoconazole shampoo, gel, or lotion is safe and effective. Refractory cases of SD can be managed with topical corticosteroids and calcineurin inhibitors.

特应性皮炎(AD)是一种慢性、复发性、炎症性皮肤病。干癣、瘙痒和皮疹可作为临床诊断依据。适当的皮肤护理和定期使用润肤剂是治疗的关键。外用皮质类固醇激素是 AD 复发的一线治疗方法。湿敷疗法可改善 AD 的严重程度和范围。外用降钙素抑制剂是二线治疗方法。使用润肤剂、外用皮质类固醇激素、钙调磷酸酶抑制剂和漂白浴有助于预防复发。难治性 AD 患者可能需要接受免疫调节治疗,如杜比鲁单抗(Dupixent)、Janus 激酶抑制剂或光疗,应转诊至皮肤科医生。脂溢性皮炎(SD)是一种常见的慢性、复发性炎症,累及皮脂腺皮肤区域。可能的病因是马拉色菌感染及其炎症反应。临床诊断的依据是头皮或面部出现标志性的油腻性黄色鳞屑。婴儿 SD 最常累及头皮和前额,通常具有自限性。对婴儿来说,使用润肤剂后再梳头和洗发可能会有效。对于婴儿和儿童,如果治疗无效,外用酮康唑洗发水、凝胶或乳液是安全有效的。难治性 SD 病例可使用外用皮质类固醇激素和降钙素抑制剂。
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引用次数: 0
Common Skin Conditions in Children and Adolescents: Nonbacterial Infections. 儿童和青少年常见皮肤病:非细菌感染。
Q3 Medicine Pub Date : 2024-06-01
Mengyi Zha, Richard Usatine

Tinea infections are caused by dermatophytes, except for tinea versicolor, which is caused by yeasts in the Malassezia genus. If available, potassium hydroxide preparation should be performed to confirm diagnosis of tinea capitis or onychomycosis. In some cases, fungal culture, UV light examination, or periodic acid-Schiff stain can be helpful. Topical drugs are effective for tinea corporis, tinea cruris, and tinea pedis. Tinea incognito is an atypical presentation that usually requires systemic treatment. Management of tinea capitis always requires oral drugs. Oral drugs are preferred for onychomycosis treatment but should not be prescribed without confirmation of fungal infection. Localized cases of tinea versicolor can be managed with topical drugs, but oral drugs might be needed for severe, widespread, or recurrent cases. Warts are superficial human papillomavirus infections. Common treatments include irritant, destructive (eg, cryotherapy), immune stimulant (eg, intralesional Candida antigen), and debridement and excision methods. Scabies infestation results in intensely itchy papules, nodules, or vesicles. Mites and burrows on the skin are pathognomonic but difficult to identify. Dermoscopy, particularly with UV light, can make identification easier. Topical permethrin and oral ivermectin are two of the most commonly used treatments. All household and close contacts should be treated regardless of the presence or absence of symptoms.

癣菌感染是由皮癣菌引起的,但花斑癣除外,它是由马拉色菌属的酵母菌引起的。如果有氢氧化钾制剂,应进行氢氧化钾制剂检查,以确诊是头癣或癣菌病。在某些情况下,真菌培养、紫外线检查或周期性酸-希夫染色法也会有所帮助。外用药物对体癣、股癣和足癣有效。隐性癣是一种非典型表现,通常需要系统治疗。治疗头癣总是需要口服药物。口服药物是治疗甲癣的首选,但在未确诊真菌感染前不应处方口服药物。局部的天疱疮可以通过局部用药治疗,但严重、广泛或反复发作的天疱疮可能需要口服药物。尖锐湿疣是表皮人类乳头瘤病毒感染。常见的治疗方法包括刺激性、破坏性(如冷冻疗法)、免疫刺激剂(如腔内念珠菌抗原)以及清创和切除法。疥疮会导致剧烈瘙痒的丘疹、结节或水泡。皮肤上的螨虫和洞穴是病理特征,但很难识别。皮肤镜检查,尤其是紫外线照射下的皮肤镜检查,可以更容易地识别疥疮。外用氯菊酯和口服伊维菌素是两种最常用的治疗方法。无论有无症状,所有家庭和密切接触者都应接受治疗。
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引用次数: 0
Common Skin Conditions in Children and Adolescents: Acne. 儿童和青少年常见皮肤病:痤疮
Q3 Medicine Pub Date : 2024-06-01
Mengyi Zha, Richard Usatine

Acne is a chronic, recurrent inflammatory condition of the pilosebaceous unit. It affects approximately 85% of adolescents and creates significant psychosocial and financial burdens. The pathogenesis involves altered follicular growth and differentiation, microbial colonization with Cutibacterium acnes, increased sebum production influenced by androgen levels, and inflammation. Evidence-based risk factors include family history and body mass index. Diagnosis of acne is clinical, according to patient age and acne morphology and severity. Setting treatment expectations is an important aspect of management. For mild acne, benzoyl peroxide is an effective first-line drug as monotherapy or in combination with a topical retinoid and/or topical antibiotic. Oral tetracyclines are first-line drugs as part of a multipart treatment regimen for moderate to severe acne for patients older than 8 years. Oral isotretinoin is the first-line drug for moderate to severe inflammatory acne. Because of its teratogenic effects, its prescribing is monitored through the iPLEDGE Risk Evaluation and Mitigation Strategy (REMS) program. Prescribing oral or topical antibiotics as monotherapy for acne is not recommended, as this may increase microbial resistance. Combined oral contraceptives and spironolactone are used as adjunctive therapies in female adolescents. Patients with skin of color, pregnant patients, and transgender or gender diverse patients warrant special considerations in acne management.

痤疮是一种慢性、复发性的皮脂腺炎症。大约 85% 的青少年都会受到痤疮的影响,给他们造成巨大的社会心理和经济负担。发病机制包括毛囊生长和分化的改变、痤疮丙酸杆菌的微生物定植、受雄激素水平影响的皮脂分泌增加以及炎症。有证据显示的风险因素包括家族史和体重指数。痤疮的诊断需要根据患者的年龄、痤疮的形态和严重程度进行临床诊断。设定治疗预期是管理的一个重要方面。对于轻度痤疮,过氧化苯甲酰是一种有效的一线药物,可单用或与外用维甲酸和/或外用抗生素联合使用。口服四环素类药物是治疗中度至重度痤疮的一线药物,适用于 8 岁以上的患者。口服异维A酸是治疗中重度炎症性痤疮的一线药物。由于异维A酸有致畸作用,其处方受到 iPLEDGE 风险评估和缓解策略(REMS)计划的监控。不建议将口服或外用抗生素作为治疗痤疮的单一疗法,因为这可能会增加微生物的耐药性。复方口服避孕药和螺内酯可作为女性青少年的辅助疗法。肤色患者、孕妇、变性人或性别不同的患者在治疗痤疮时需要特别注意。
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引用次数: 0
Common Skin Conditions in Children and Adolescents: Bacterial Infections. 儿童和青少年常见皮肤病:细菌感染
Q3 Medicine Pub Date : 2024-06-01
Mengyi Zha, Richard Usatine

Bacterial skin infections represent a significant health care burden. Cellulitis and erysipelas are rapidly spreading, painful, superficial skin infections, usually caused by streptococci or Staphylococcus aureus. Folliculitis is an infection of hair follicles mostly caused by S aureus. Simple folliculitis typically is self-limited. Topical benzoyl peroxide is a first-line nonantibiotic treatment. Mupirocin and clindamycin are topical antibiotic options. For treatment-resistant cases, oral cephalexin or dicloxacillin is an appropriate option. Impetigo is a common, self-limited infection in children. Bullous impetigo is caused by S aureus, and nonbullous impetigo is caused by beta-hemolytic streptococci, S aureus, or both. In most cases, topical mupirocin or retapamulin (Altabax) is effective. Oral antibiotics should be considered for household outbreaks or patients with multiple lesions. Abscesses are red, painful collections of purulence in the dermis and deeper tissues caused by S aureus or polymicrobial infections. Furuncles are abscesses of a hair follicle, whereas carbuncles involve several hair follicles. In recurrent cases of these lesions, culture of the exudate is recommended. Abscess, furuncle, and carbuncle management consists of incision and drainage. Oral antibiotics are not necessary in most cases but should be prescribed for patients with severe immunocompromise or systemic signs of infection. In bacterial skin infections, methicillin-resistant S aureus coverage should be considered for patients with infections that have not improved with treatment.

细菌性皮肤感染给医疗保健带来沉重负担。蜂窝组织炎和红斑狼疮是迅速蔓延、疼痛的表皮感染,通常由链球菌或金黄色葡萄球菌引起。毛囊炎主要是由金黄色葡萄球菌引起的毛囊感染。单纯性毛囊炎通常具有自限性。外用过氧化苯甲酰是一线非抗生素治疗方法。莫匹罗星和克林霉素是外用抗生素的选择。对于耐药病例,可选择口服头孢氨苄或双氯西林。脓疱疮是一种常见的儿童自限性感染。大疱性脓疱疮由金黄色葡萄球菌引起,非大疱性脓疱疮由β-溶血性链球菌、金黄色葡萄球菌或两者同时引起。在大多数情况下,局部使用莫匹罗星或瑞他帕林(Altabax)是有效的。对于家庭爆发或有多个病灶的患者,应考虑口服抗生素。脓肿是由金黄色葡萄球菌或多微生物感染引起的真皮层和深层组织中红色、疼痛的脓性集合体。疖是一个毛囊的脓肿,而痈则涉及多个毛囊。如果这些病变反复发作,建议对渗出物进行培养。脓肿、疖和痈的治疗包括切开和引流。大多数情况下不需要口服抗生素,但对于免疫力严重低下或有全身感染症状的患者,应处方口服抗生素。在细菌性皮肤感染中,如果患者的感染经治疗未见好转,则应考虑使用耐甲氧西林金黄色葡萄球菌。
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引用次数: 0
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