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Developing the NIS solid density hydrostatic weighing system up to 20 kg 开发NIS固体密度流体静压称重系统,重量可达20公斤
Q3 Engineering Pub Date : 2020-01-01 DOI: 10.1051/ijmqe/2020006
M. Hamdy, M. Bayoumi, A. Abuelezz, A. Eltawil
This paper presents a developed design and construction to improve the performance and increasing the density measuring capability of the previous Hydrostatic Weighing Apparatus (HWA-NIS) at the National Institute of Standards (NIS) up to 20 kg. The previous (HWA-NIS) has been constructed up to 10 kg on 2014. The 2-Positions mass handler in the previous (HWA) was developed with 4-Positions pentagon shape to be able to make handling for individual masses in a group at once, when transferring the traceability from the primary standard “the Silicon Sphere” to the standard masses in the density scale weighing process. The weighing pan in the previous (HWA) was developed with four suspension wires with a diameter of 0.3 mm each, leads to reduce the surface tension affect on the measurement uncertainty by factor four times. The density of the standard masses in the range from 2 kg up to 20 kg were measured with an improved expanded uncertainty from 0.150 kg/m3to 0.078 kg/m3respectively due to reducing the effect of surface tension via the developed design of the weighing pan.
本文介绍了一种改进的设计和结构,以提高美国国家标准局(NIS)以前的液体静压称重仪(HWA-NIS)的性能,并将其密度测量能力提高到20公斤。之前的(HWA-NIS)在2014年建造了10公斤。在之前的(HWA)中,2位质量处理器被开发为4位五边形,以便在密度秤称重过程中将可追溯性从主要标准“硅球”转移到标准质量时,能够一次处理组中的单个质量。前一种称重盘采用4根直径为0.3 mm的悬丝,将表面张力对测量不确定度的影响降低了1 / 4。通过改进称重盘的设计,减少了表面张力的影响,提高了扩展不确定度,测量了2 ~ 20 kg范围内标准质量的密度,分别从0.150 kg/m3到0.078 kg/m3。
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引用次数: 0
Reliability of RT-PCR tests to detect SARS-CoV-2: risk analysis RT-PCR检测SARS-CoV-2的可靠性:风险分析
Q3 Engineering Pub Date : 2020-01-01 DOI: 10.1051/ijmqe/2020009
Clément Bezier, G. Anthoine, A. Charki
The rapid escalation of the number of COVID-19 (Coronavirus Disease 2019) cases has forced countries around the world to implement systems for the widest possible testing of their populations. The World Health Organization (WHO) has in fact urged all countries to carry out as many tests as they can. Clinical laboratories have had to respond urgently to numerous and rising demands for diagnostic tests for SARS-CoV-2. The majority of laboratories have had to implement the RT-PCR (Reverse Transcriptase − Polymerase Chain Reaction) test method without the benefit of adequate experimental feedback. It is hoped that this article will make a useful contribution in the form of a methodology for the risk analysis of SARS-CoV-2 testing by RT-PCR and at the same time result reliability analysis of diagnostic tests, via an approach based on a combination of Fishbone Diagram and FMECA (Failure Mode, Effects, and Criticality Analysis) methods. The risk analysis is based on lessons learned from the actual experience of a real laboratory, which enabled the authors to pinpoint the principal risks that impact the reliability of RT-PCR test results. The probability of obtaining erroneous results (false positives or negatives) is implicit in the criticality assessment obtained via FMECA. In other words, the higher the criticality, the higher the risk of obtaining an erroneous result. These risks must therefore be controlled as a priority. The principal risks are studied for the following process stages: nucleic acid extraction, preparation of the mix and validation of results. For the extraction of nucleic acids, highly critical risks (exceeding the threshold set from experimentation) are the risk of error when depositing samples on the extraction plate and sample non-conformity. For the preparation of the mix the highest risks are a non-homogenous mix and, predominantly, errors when depositing samples on the amplification plate. For the validation of results, criticality can reach the maximum severity rating: here, the risks that require particular attention concern the interpretation of raw test data, poor IQC (Internal Quality Control) management and the manual entry of results and/or file numbers. Recommendations are therefore made with regard to human factor influences, internal contamination within the laboratory, management of reagents, other consumables and critical equipment, and the effect of sample quality. This article demonstrates the necessity to monitor, both internally and externally, the performance of the test process within a clinical laboratory in terms of quality and reliability.
COVID-19(2019冠状病毒病)病例数量的迅速增加迫使世界各国实施对其人口进行尽可能广泛检测的系统。事实上,世界卫生组织(世卫组织)已经敦促所有国家进行尽可能多的检测。临床实验室不得不紧急应对对SARS-CoV-2诊断检测的众多且不断增长的需求。大多数实验室不得不在没有充分实验反馈的情况下实施RT-PCR(逆转录酶-聚合酶链反应)测试方法。希望本文将鱼骨图与FMECA (Failure Mode, Effects, Criticality analysis)方法相结合,为RT-PCR检测SARS-CoV-2的风险分析和诊断检测结果的可靠性分析提供一种方法。风险分析是基于从真实实验室的实际经验中吸取的教训,这使作者能够确定影响RT-PCR检测结果可靠性的主要风险。获得错误结果(假阳性或假阴性)的概率隐含在通过FMECA获得的临界性评估中。换句话说,临界越高,获得错误结果的风险就越高。因此,必须优先控制这些风险。研究了以下工艺阶段的主要风险:核酸提取、混合物制备和结果验证。对于核酸的提取,高度临界风险(超过实验设定的阈值)是指在提取板上存放样品时出现错误的风险和样品不合格的风险。对于混合物的制备,最高的风险是混合物不均匀,主要是在扩增板上沉积样品时出现错误。对于结果的验证,临界性可以达到最高严重等级:在这里,需要特别注意的风险涉及原始测试数据的解释,不良的IQC(内部质量控制)管理以及人工输入结果和/或文件编号。因此,就人为因素影响、实验室内部污染、试剂、其他消耗品和关键设备的管理以及样品质量的影响提出了建议。本文演示了从质量和可靠性方面监控临床实验室测试过程的内部和外部性能的必要性。
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引用次数: 4
Variable data measurement systems analysis: advances in gage bias and linearity referencing and acceptability 可变数据测量系统分析:量规偏差和线性参考及可接受性方面的进展
Q3 Engineering Pub Date : 2020-01-01 DOI: 10.1051/ijmqe/2020010
Mahjoub Abdelgadir, C. Gerling, J. L. Dobson
Measurement systems analysis (MSA) is a set of requirements and procedures adopted by the automotive industry and other disciplines to evaluate the accuracy and precision of measurement systems through assessing and quantifying the random and systematic errors and assigning appropriate dispositions for tolerance and performance acceptance. The methodology of variable data MSA comprises studies of a system's stability, bias, linearity and gage repeatability and reproducibility (GR&R). This paper describes advances in referencing and criteria for estimation of uncertainty errors, dispositions, and acceptability of MSA bias and linearity, proposing an extension to the basic statistical zero null-hypothesis to include overlap between confidence intervals and uncertainty associated with the reference standards used in bias and linearity studies.
测量系统分析(MSA)是汽车工业和其他学科采用的一套要求和程序,通过评估和量化随机和系统误差,并为公差和性能接受度分配适当的配置,来评估测量系统的准确性和精度。可变数据MSA的方法包括研究系统的稳定性、偏置、线性和测量可重复性和再现性(GR&R)。本文描述了MSA偏差和线性的不确定性误差、倾向和可接受性的参考和估计标准的进展,提出了对基本统计零零假设的扩展,以包括与偏差和线性研究中使用的参考标准相关的置信区间和不确定性之间的重叠。
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引用次数: 3
Reliability of real-time RT-PCR tests to detect SARS-Cov-2: A literature review 实时RT-PCR检测SARS-Cov-2的可靠性:文献综述
Q3 Engineering Pub Date : 2020-01-01 DOI: 10.1051/ijmqe/2020014
Clément Bezier, G. Anthoine, A. Charki
In the face of the COVID-19 (Coronavirus Disease 2019) pandemic, the World Health Organization (WHO) has urged countries to test the population more widely. Clinical laboratories have been confronted with a huge demand for testing and have had to make urgent preparations for staff training, to establish new analytical processes, reorganize the workspace, and stock up on specific equipment and diagnostic test kits. The reliability of SARS-Cov-2 test results is of critical importance, given the impact it has on patient care and the management of the health crisis. A review of the literature available for the period leading up to and including June 2020 on the reliability of SARS-Cov-2 (Severe Acute Respiratory Syndrome Coronavirus) detection methods using real-time RT PCR (Reverse Transcription - Polymerase Chain Reaction) brings together the primary factors teams of scientists claim or demonstrate to affect the reliability of results. A description is given of the RT-PCR testing method, followed by a presentation of the characteristics and validation techniques used. A summary of data from the literature on the reliability of tests and commercial kits for SARS-Cov-2 detection, including current uncertainties with regard to the molecular targets selected and genetic diversity of SARS-Cov-2 is provided. The limitations and perspectives are then discussed in detail in the light of the bibliographic data available. Many questions have been asked that still remain unanswered. The lack of knowledge about this novel virus, which appeared at the end of 2019, has a significant impact on the technical capacity to develop reliable, rapid and practical tools for its detection.
面对2019冠状病毒病(COVID-19)大流行,世界卫生组织(世卫组织)敦促各国更广泛地对人口进行检测。临床实验室面临着巨大的检测需求,不得不为人员培训、建立新的分析流程、重组工作空间以及储备特定设备和诊断检测试剂盒做出紧急准备。鉴于SARS-Cov-2检测结果对患者护理和健康危机管理的影响,其可靠性至关重要。对截至2020年6月及包括2020年6月期间关于使用实时RT PCR(逆转录-聚合酶链反应)检测SARS-Cov-2(严重急性呼吸综合征冠状病毒)方法可靠性的现有文献进行了回顾,汇集了科学家团队声称或证明影响结果可靠性的主要因素。描述了RT-PCR检测方法,随后介绍了所使用的特征和验证技术。本文总结了关于SARS-Cov-2检测方法和商用试剂盒可靠性的文献数据,包括目前在SARS-Cov-2分子靶点选择和遗传多样性方面的不确定性。然后根据现有的书目数据详细讨论了局限性和观点。人们提出了许多问题,但仍未得到解答。对2019年底出现的这种新型病毒缺乏了解,对开发可靠、快速和实用的检测工具的技术能力产生了重大影响。
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引用次数: 16
Operation mode of electric business logistics based on the application of two-dimensional code technology 基于二维码技术应用的电商物流运作模式
Q3 Engineering Pub Date : 2020-01-01 DOI: 10.1051/ijmqe/2020001
Jing Rao
In recent years, with the irresistible pace of e-commerce development, e-commerce logistics orders show blowout growth. For the logistics industry, it is both an opportunity and a difficult problem as there are many problems such as low technology content and poor distribution efficiency. Therefore, it is a challenge that needs to be tackled to integrate technology accurately with the operation mode of e-commerce logistics. In order to improve the effect of logistics operation, bring convenience to the management of business logistics, and ultimately realize the maximum profit of logistics enterprises, based on two-dimensional code technology, this study took the specific mode of logistics operation as the research subject, applied the corresponding two-dimensional code generated to three different logistics processes, put forward specific optimization schemes, and carried out the analysis of the application results. The results showed that the intervention of two-dimensional code could protect users' privacy, prevent channel conflict, and realize logistics tracing of product information, thus effectively improve the logistics operation mode.
近年来,随着电子商务的迅猛发展,电子商务物流订单呈现井喷式增长。对于物流业来说,这是一个机遇,也是一个难题,因为物流业存在着许多技术含量低、配送效率低等问题。因此,如何将技术与电子商务物流的运作模式准确地结合起来,是一个需要解决的难题。为了提高物流作业效果,为企业物流管理带来便利,最终实现物流企业利润最大化,本研究基于二维码技术,以物流作业的具体模式为研究对象,将生成的相应二维码应用到三种不同的物流流程中,提出了具体的优化方案。并对应用结果进行了分析。结果表明,二维码的介入可以保护用户隐私,防止渠道冲突,实现产品信息的物流追溯,从而有效改善物流运作模式。
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引用次数: 0
Comparison of straight line curve fit approaches for determining parameter variances and covariances 确定参数方差和协方差的直线曲线拟合方法的比较
Q3 Engineering Pub Date : 2020-01-01 DOI: 10.1051/ijmqe/2020011
V. Ramnath
Pressure balances are known to have a linear straight line equation of the formy = ax + bthat relates the applied pressurexto the effective areay, and recent work has investigated the use of Ordinary Least Squares (OLS), Weighted Least Squares (WLS), and Generalized Least Squares (GLS) regression schemes in order to quantify the expected values of the zero-pressure areaA0 = band distortion coefficientλ = a/bin pressure balance models of the formy = A0(1 + λx). The limitations with conventional OLS, WLS and GLS approaches is that whilst they may be used to quantify the uncertaintiesu(a) andu(b) and the covariancecov(a,b), it is technically challenging to analytically quantify the covariance termcov(A0,λ) without additional Monte Carlo simulations. In this paper, we revisit an earlier Weighted Total Least Squares with Correlation (WTLSC) algorithm to determine the variancesu2(a) andu2(b) along with the covariancecov(a,b), and develop a simple analytical approach to directly infer the corresponding covariancecov(A0,λ) for pressure metrology uncertainty analysis work. Results are compared to OLS, WLS and GLS approaches and indicate that the WTLSC approach may be preferable as it avoids the need for Monte Carlo simulations and additional numerical post-processing to fit and quantify the covariance term, and is thus simpler and more suitable for industrial metrology pressure calibration laboratories. Novel aspects is that a Gnu Octave/Matlab program for easily implementing the WTLSC algorithm to calculate parameter expected values, variances and covariances is also supplied and reported.
压力平衡已知有一个线性的直线方程,形式= ax + b,将施加的压力x与有效面积联系起来,最近的工作研究了使用普通最小二乘法(OLS),加权最小二乘法(WLS)和广义最小二乘法(GLS)回归方案,以量化形式= A0(1 + λx)的零压力区域的期望值aa0 =带失真系数λ = a/bin压力平衡模型。传统的OLS、WLS和GLS方法的局限性在于,虽然它们可以用于量化不确定性u(a)和u(b)以及协方差ecov(a,b),但在没有额外的蒙特卡罗模拟的情况下,分析量化协方差项cov(A0,λ)在技术上具有挑战性。在本文中,我们回顾了早期的加权总最小二乘与相关(WTLSC)算法来确定方差u2(a)和u2(b)以及协方差ecov(a,b),并开发了一种简单的分析方法来直接推断相应的协方差ecov(A0,λ)用于压力计量不确定性分析工作。结果与OLS、WLS和GLS方法进行了比较,表明WTLSC方法可能更可取,因为它避免了蒙特卡罗模拟和额外的数值后处理来拟合和量化协方差项,因此更简单,更适合工业计量压力校准实验室。新颖之处在于,本文还提供并报告了一个Gnu Octave/Matlab程序,用于方便地实现WTLSC算法来计算参数期望值、方差和协方差。
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引用次数: 0
Analysis of approximations of GUM supplement 2 based non-Gaussian PDFs of measurement models with Rosenblatt Gaussian transformation mappings 基于Rosenblatt高斯变换映射的测量模型非高斯pdf的逼近分析
Q3 Engineering Pub Date : 2020-01-01 DOI: 10.1051/ijmqe/2019018
V. Ramnath
In scientific metrology practise the application of Monte Carlo simulations with the aid of the GUM Supplement 2 (GS2) technique for performing multivariate uncertainty analyses is now more prevalent, however a key remaining challenge for metrologists in many laboratories is the implicit assumption of Gaussian characteristics for summarizing and analysing measurement model results. Whilst non-Gaussian probability density functions (PDFs) may result from Monte Carlo simulations when the GS2 is applied for more complex non-linear measurement models, in practice results are typically only reported in terms of multivariate expected and covariance values. Due to this limitation the measurement model PDF summary is implicitly restricted to a multivariate Gaussian PDF in the absence of additional higher order statistics (HOS) information. In this paper an earlier classical theoretical result by Rosenblatt that allows for an arbitrary multivariate joint distribution function to be transformed into an equivalent system of Gaussian distributions with mapped variables is revisited. Numerical simulations are performed in order to analyse and compare the accuracy of the equivalent Gaussian system of mapped random variables for approximating a measurement model’s PDF with that of an exact non-Gaussian PDF that is obtained with a GS2 Monte Carlo statistical simulation. Results obtained from the investigation indicate that a Rosenblatt transformation offers a convenient mechanism to utilize just the joint PDF obtained from the GS2 data in order to both sample points from a non-Gaussian distribution, and also in addition which allows for a simple two-dimensional approach to estimate coupled uncertainties of random variables residing in higher dimensions using conditional densities without the need for determining parametric based copulas.
在科学计量实践中,借助GUM补充2 (GS2)技术进行多变量不确定性分析的蒙特卡罗模拟的应用现在更加普遍,然而,对于许多实验室的计量学家来说,一个关键的挑战是在总结和分析测量模型结果时隐含的高斯特征假设。虽然当GS2应用于更复杂的非线性测量模型时,蒙特卡罗模拟可能会产生非高斯概率密度函数(pdf),但在实践中,结果通常仅以多元期望值和协方差值的形式报告。由于这一限制,在没有额外的高阶统计量(HOS)信息的情况下,测量模型PDF摘要被隐式地限制为多变量高斯PDF。本文回顾了Rosenblatt早期的经典理论结果,该结果允许将任意多元联合分布函数转换为具有映射变量的等效高斯分布系统。为了分析和比较用映射随机变量的等效高斯系统近似测量模型的PDF与用GS2蒙特卡罗统计模拟得到的精确非高斯PDF的精度,进行了数值模拟。研究结果表明,Rosenblatt变换提供了一种方便的机制,可以仅利用从GS2数据获得的联合PDF来获取非高斯分布的两个样本点,并且还允许使用条件密度来估计高维随机变量的耦合不确定性的简单二维方法,而无需确定基于参数的copuls。
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引用次数: 0
Effect of wheat flour with different quality in the process of making flour products 不同品质小麦粉在制粉过程中的影响
Q3 Engineering Pub Date : 2020-01-01 DOI: 10.1051/ijmqe/2020005
A. Zhang
All kinds of flour products which are made of wheat flour have already become the staple food on people's dining table. With the improvement of living standard, the quality requirements for the flour products have gradually improved. In addition to the production technique, the quality of wheat flour as the raw material is also very important for the quality of flour products. This paper briefly introduced wheat flour and two main components that affected its quality: starch and protein. Then, the related quality of starch and protein and the quality of corresponding flour products were tested for five kinds of wheat flour. The experimental results showed that the quality indexes of five kinds of wheat flour were obviously different and representative. The regression analysis on the quality data of wheat flour and flour products showed that the water absorption of flour decreased with the increase of total starch content, dry gluten content and gluten index, the water solubility of flour decreased with the increase of total starch content and gluten index and increased with the increase of ratio of amylose to amylopectin, and the radial expansion rate of the flour products decreased with the increase of wet gluten content. To sum up, the quality of wheat flour will affect the water absorption, water solubility and radial expansion rate of flour products in the production process.
以小麦粉为原料制成的各种面制品,已经成为人们餐桌上的主食。随着生活水平的提高,人们对面制品的质量要求也逐渐提高。除了生产工艺外,作为原料的小麦粉的质量对面粉产品的质量也非常重要。简要介绍了小麦粉及影响其品质的两种主要成分:淀粉和蛋白质。然后,对5种小麦粉进行了淀粉、蛋白质相关质量及相应面制品质量的检测。实验结果表明,5种小麦粉的品质指标有明显的差异和代表性。对小麦粉和面制品的质量数据进行回归分析表明,面粉的吸水率随着总淀粉含量、干面筋含量和面筋指数的增加而降低,面粉的水溶性随着总淀粉含量和面筋指数的增加而降低,随着直链淀粉与支链淀粉比的增加而增加,面制品的径向膨胀率随着湿面筋含量的增加而降低。综上所述,小麦粉的质量会影响面粉产品在生产过程中的吸水率、水溶性和径向膨胀率。
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引用次数: 3
Action recognition and control of mechanical simulated arm: electromyographic signal detection 机械模拟臂的动作识别与控制:肌电信号检测
Q3 Engineering Pub Date : 2020-01-01 DOI: 10.1051/ijmqe/2020008
Genlai Lv
Electromyography (EMG) signal contains a large amount of human motion information, which can be used to classify human actions. In this study, based on the detection of surface electromyography (sEMG) signal, three actions were designed, the sEMG signal was collected by the EMG acquisition system. Four feature values, including root-mean-square value, average absolute value (MAV), wavelength, and Zero crossing point, were extracted from the signal. Then these values were taken as the input of Back-Propagation neural network (BPNN) to recognize different actions, thereby realizing the real-time control of mechanical simulated arm. The experiment found that the training time of the BPNN method designed in this study was short, 11.36 s, and the average recognition accuracy rate reached 92.2%. In the real-time control experiment of mechanical simulated arm, the recognition accuracy of different actions reached more than 90%, and the running time was short. The experimental results verifies the effectiveness of the proposed method and make some contributions to the efficient control of the mechanical simulation arm.
肌电图(Electromyography, EMG)信号包含了大量的人体运动信息,可以用来对人体的动作进行分类。本研究在检测表面肌电信号的基础上,设计了三种动作,肌电信号采集系统对表面肌电信号进行采集。从信号中提取4个特征值,包括均方根值、平均绝对值(MAV)、波长和零点交叉点。然后将这些值作为反向传播神经网络(BPNN)的输入来识别不同的动作,从而实现机械仿真臂的实时控制。实验发现,本研究设计的BPNN方法训练时间较短,为11.36 s,平均识别准确率达到92.2%。在机械仿真臂的实时控制实验中,对不同动作的识别准确率达到90%以上,且运行时间短。实验结果验证了该方法的有效性,为机械仿真臂的高效控制做出了贡献。
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引用次数: 0
Multiparametric quality by design-fuzzy model applied in the development of a biomedical measuring system 多参数质量设计模糊模型在生物医学测量系统开发中的应用
Q3 Engineering Pub Date : 2020-01-01 DOI: 10.1051/ijmqe/2020013
D. R. Tasé Velázquez, E. Costa Monteiro, Daniel Ramos Louzada, C. H. Barbosa
This work presents the adaptation of the Quality by Design (QbD) approach for application in the quality assurance of a biomedical measuring system under development. First attempts in applying QbD to biomedical technologies indicated a significantly higher number of parameters than its traditional application in the pharmaceutical industry. These preliminary studies did not fulfill the QbD stage of Design Space (DS) configuration for biomedical devices, an essential step to identifying the proper operating ranges of parameters and guaranteeing quality features. Therefore, it persisted the challenge of configuring DS for health devices, overcoming dependences in the interaction of multiple process parameters and critical attributes. The present work develops a hybrid QbD-Fuzzy approach for multiparametric DS configuration. The proposed method was applied in the development phase of a low-cost and high-sensitive magnetic measuring system for locating metallic foreign bodies in patients, employing sensors based on the Giant Magnetoimpedance effect. The results provided the acceptable operating ranges of the multiple process parameters to ensure the biomedical equipment's suitability. The proposed strategy contributes to the QbD implementation in biomedical technologies and, therefore, promotes the reliability of diagnostic and therapeutic results in the clinical environment.
本文介绍了设计质量(QbD)方法在生物医学测量系统质量保证中的应用。将QbD应用于生物医学技术的首次尝试表明,其参数数量明显高于其在制药工业中的传统应用。这些初步研究没有完成生物医学设备设计空间(DS)配置的QbD阶段,这是确定适当的操作参数范围和保证质量特征的重要步骤。因此,它坚持了为健康设备配置DS的挑战,克服了多个工艺参数和关键属性相互作用中的依赖性。本工作发展了一种多参数DS组态的混合qbd -模糊方法。该方法已应用于一种基于巨磁阻抗效应的传感器,用于低成本、高灵敏度的患者金属异物定位磁测量系统的开发阶段。研究结果提供了多种工艺参数的可接受操作范围,以保证生物医学设备的适用性。提出的战略有助于生物医学技术的QbD实施,因此,促进临床环境中诊断和治疗结果的可靠性。
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引用次数: 3
期刊
International Journal of Metrology and Quality Engineering
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