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Myeloid/lymphoid neoplasm with ZMYM2::FGFR1 rearrangement: A complex trilineage phenotypic and clonal evolution with associated genomic alterations 髓系/淋巴肿瘤伴ZMYM2: FGFR1重排:复杂的三代表型和克隆进化与相关的基因组改变
Q4 Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.lrr.2023.100370
Dong Chen , Guang Liu , Michael R. Lewis , Xia Li , Matthew Ulrickson , Rajneesh Nath , Weina Chen

We report a case of myeloid/lymphoid neoplasm with ZMYM2::FGFR1 rearrangement (MLNZMYM2::FGFR1) exhibiting a complex disease evolution. This neoplasm initially presented as T-lymphoblastic lymphoma (T-LBL) in lymph node and myeloproliferative neoplasm (MPN) with eosinophilia in bone marrow, then transitioned to systemic mastocytosis (SM) likely accompanied by additional JAK3 and other mutations and finally transformed to acute myeloid leukemia (AML) accompanied by additional/secondary genetic abnormality (gain of chromosome 21, der(13)t(8;13), and RUNX1 mutation). To our knowledge, this is the first case of MLNZMYM2::FGFR1 with a complex trilineage/phenotypic [T-cell (T-LBL), mast cell (SM), and myeloid (MPN and AML)] lineage evolution.

我们报告一例髓系/淋巴肿瘤伴ZMYM2::FGFR1重排(MLNZMYM2::FGFR1),表现出复杂的疾病演变。该肿瘤最初表现为淋巴结t淋巴母细胞淋巴瘤(t - lbl)和骨髓嗜酸性粒细胞增多的骨髓增生性肿瘤(MPN),然后转变为系统性肥大细胞增多症(SM),可能伴有额外的JAK3和其他突变,最后转化为急性髓性白血病(AML),伴有额外的/继发性遗传异常(21号染色体获得,der(13)t(8;13)和RUNX1突变)。据我们所知,这是MLNZMYM2::FGFR1具有复杂的三系/表型[t细胞(T-LBL),肥大细胞(SM)和髓细胞(MPN和AML)]谱系进化的第一例。
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引用次数: 0
Location, location, location: A mini-review of CEBPA variants in patients with acute myeloid leukemia 位置,位置,位置:急性髓性白血病患者CEBPA变异的小型回顾
Q4 Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.lrr.2023.100386
Muhammad Salman Faisal , Pamela J. Sung

CEBPA variants are frequently recurring in acute myeloid leukemia (AML). The prognostic significance of CEBPA mutations has recently undergone a major shift in the 5th edition of WHO classification of hematological neoplasms and ELN 2022 classification. Whereas prior iterations did not specify the type of CEBPA mutation, the updated schema specify that only mutations localized to the C-terminal basic zipper (bZIP) domain are considered prognostically favorable. This change is based primarily on three recently published large datasets evaluating the prognostic significance of mutation location in CEBPA mutant AML. Here, we review the evolution of the prognostic classification of CEBPA variants.

CEBPA变异在急性髓性白血病(AML)中经常复发。最近,在第5版WHO血液学肿瘤分类和ELN 2022分类中,CEBPA突变的预后意义发生了重大转变。先前的迭代没有指定CEBPA突变的类型,而更新的模式指定只有定位于c端基本拉链(bZIP)结构域的突变才被认为是预后有利的。这一变化主要基于最近发表的三个大型数据集,这些数据集评估了突变位置在CEBPA突变型AML中的预后意义。在这里,我们回顾了CEBPA变异预后分类的演变。
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引用次数: 0
Corrigendum to Acute pancreatitis following L-asparaginase in acute lymphoblastic leukemia 急性淋巴细胞白血病中l -天冬酰胺酶引起的急性胰腺炎的勘误表
Q4 Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.lrr.2023.100375
Aziza Elouali , Soulaimane M'harzi , Karim Lahrache , Ayad Ghanam , Abdeladim Babakhouya , Maria Rkain , Noufissa Benajiba
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引用次数: 0
Newly onset cytopenias not always indicate a relapsing AML after allogeneic HSCT, a case of non-destructive post transplant lymphoproliferative disorder 新发作的细胞减少并不总是表明同种异体造血干细胞移植后复发的AML,这是一种非破坏性移植后淋巴细胞增生性疾病
Q4 Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.lrr.2023.100369
Süreyya Yiğit Kaya , Abdullah Emre Askin , Sebnem Bektas , Aslı Çakır , Ömür Gökmen Sevindik

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains an effective option for the treatment of intermediate and high-risk Acute myeloid leukemia (AML). Post-transplant lymphoproliferative disorder (PTLD) is related to the intensity of post-transplant immunosuppression. Although Epstein-Barr virus (EBV) seropositivity and reactivation can be a major risk factor for PTLD. A few PTLDs could be EBV negative. There are a very limited number of PTLD cases following HSCT in patients with AML. We present a differential diagnosis of cytopenias after allo-HSCT. This is the first report of an AML patient developing bone marrow EBV-negative PTLD relatively late in their post-transplant course.

同种异体造血干细胞移植(allo-HSCT)仍然是治疗中高风险急性髓性白血病(AML)的有效选择。移植后淋巴细胞增生性疾病(PTLD)与移植后免疫抑制的强度有关。尽管eb病毒(EBV)血清阳性和再激活可能是PTLD的主要危险因素。一些PTLDs可能是EBV阴性。AML患者在HSCT后出现PTLD的病例非常有限。我们提出同种异体造血干细胞移植后细胞减少的鉴别诊断。这是首例AML患者在移植后较晚阶段发生骨髓ebv阴性PTLD的报道。
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引用次数: 0
Aggressive chronic lymphocytic leukemia masked by extensive marrow fibrosis 侵袭性慢性淋巴细胞白血病被广泛的骨髓纤维化所掩盖
Q4 Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.lrr.2023.100390
Hareem Farooq , Ke Li , Talha Badar

Chronic lymphocytic leukemia (CLL) is one of the most common B-cell leukemias, occurring because of abnormal proliferation of non-functional B-lymphocytes. Progressive disease is commonly complicated by anemia, thrombocytopenia, infections as well as secondary malignancies. Bone marrow fibrosis is infrequently co-occurred along with CLL. Although multiple explanations have been proposed for this association, the etiology remains unclear in most cases. Bone marrow fibrosis occurring as a complication of CLL itself, however, is a rare entity. We present an uncommon case of a patient initially diagnosed with primary myelofibrosis but later revealed to have aggressive CLL leading to bone marrow fibrosis upon re-evaluation. Treatment for CLL resolved the bone marrow fibrosis completely, confirming our suspicion of fibrosis being secondary to CLL. This sheds light on the importance of understanding the etiology of bone marrow fibrosis in patients with CLL owing to its therapeutic implications. The utility of bone marrow biopsy in not only helping understand the etiology of the fibrosis but also providing prognostic information merits reconsideration of performing it in all cases of CLL.

慢性淋巴细胞白血病(CLL)是最常见的b细胞白血病之一,是由于无功能b淋巴细胞异常增殖而发生的。进行性疾病通常并发贫血、血小板减少症、感染以及继发性恶性肿瘤。骨髓纤维化很少与慢性淋巴细胞白血病同时发生。尽管对这种关联提出了多种解释,但在大多数情况下,病因尚不清楚。然而,骨髓纤维化作为CLL本身的并发症是一种罕见的实体。我们提出一个罕见的病例,患者最初诊断为原发性骨髓纤维化,但后来发现侵袭性CLL导致骨髓纤维化的重新评估。CLL的治疗完全消除了骨髓纤维化,证实了我们对CLL继发纤维化的怀疑。这揭示了理解CLL患者骨髓纤维化病因的重要性,因为它具有治疗意义。骨髓活检不仅有助于了解纤维化的病因,而且还提供预后信息,值得重新考虑在所有CLL病例中进行骨髓活检。
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引用次数: 0
Membranous nephropathy in chronic lymphocytic leukemia responsive to ibrutinib: A case report 慢性淋巴细胞白血病膜性肾病对伊鲁替尼反应:1例报告
Q4 Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.lrr.2023.100377
Anna-Eve Turcotte , William F. Glass , Jamie S. Lin , Jan A. Burger

Membranous nephropathy (MN) is an uncommon renal presentation in patients with chronic lymphocytic leukemia (CLL), and as such, there is no standard therapy for these patients. A few cases of MN in CLL have been described with varying success in MN treatment involving alkylating agents and fludarabine. Here we report the first case of MN in a patient with CLL treated with ibrutinib with complete renal response. This presentation underlines the importance of recognizing rare glomerular diseases that may occur with CLL and offers a new therapeutic avenue to the treatment of CLL-associated MN.

膜性肾病(MN)是慢性淋巴细胞白血病(CLL)患者中一种罕见的肾脏表现,因此,对于这些患者没有标准的治疗方法。一些CLL中MN的病例已被描述为在使用烷基化剂和氟达拉滨治疗MN方面取得了不同程度的成功。在这里,我们报告了第一例用依鲁替尼治疗的CLL患者肾反应完全的MN。本报告强调了认识到CLL可能发生的罕见肾小球疾病的重要性,并为CLL相关MN的治疗提供了新的治疗途径。
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引用次数: 0
A rare case of aCML associated with CNS involvement and with aggressive clinical course 罕见的aCML伴中枢神经系统受累及侵袭性临床病程
Q4 Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.lrr.2023.100361
Dorela Lame, Michelangelo Pianelli, Erika Morsia, Alberto Carturan, Gaia Goteri, Stefania Mancini, Attilio Olivieri, Antonella Poloni

The presence of neutrophilic leukocytosis may underlie a wide variety of diseases. Some rare causes of neutrophilia might be chronic neutrophilic leukemia (CNL) and myelodysplastic/myeloproliferative neoplasm with neutrophilia (MDS with neutrophilia). Here we report a case of a 78-year-old woman who came to our ER due to severe leukocytosis and anemia on a routine check-up. The patient was asymptomatic and the last exams available showed a mild leukopenia and thrombocytopenia. The abdominal echography showed mild splenomegaly The patient underwent bone marrow (BM) examinations. One week later, the patient presented mental deterioration. The patient underwent a cranial CT and RMN that showed multiple lesions of 11 mm in the brain parenchyma, cerebellum and encephalic trunk. Another week later, the clinical presentations worsened: she was in a comatous state and feverish 40 °C unresponsive to steroid therapy. Autopsy showed a leukemic and hemorrhage infiltration in multiple organs and in the BM a cellularity of 100% represented by myeloid elements with a slowdown maturation with blasts 5%. According to WHO 2016 this case can be reported as an aCML, an MDS/MPN overlap syndrome that is difficult to differentiate from a CNL.

中性粒细胞增多症的存在可能是多种疾病的基础。一些罕见的中性粒细胞增多的原因可能是慢性中性粒细胞白血病(CNL)和骨髓增生异常/骨髓增生性肿瘤伴中性粒细胞增多(MDS伴中性粒细胞增多)。我们在此报告一位78岁的妇女,在常规检查中因严重的白细胞增多和贫血而来到我们的急诊室。患者无症状,最后一次检查显示轻度白细胞减少和血小板减少。腹部超声显示轻度脾肿大,患者行骨髓检查。一周后,病人出现精神恶化。患者行颅脑CT及RMN检查,发现脑实质、小脑及脑干多发11 mm病灶。一周后,临床表现恶化:患者处于昏迷状态,发烧40°C,对类固醇治疗无反应。尸检显示多个器官有白血病和出血浸润,骨髓细胞100%为髓细胞,成熟缓慢,母细胞5%。根据WHO 2016,该病例可报告为aCML,这是一种MDS/MPN重叠综合征,难以与CNL区分。
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引用次数: 1
A case series of therapy-related leukemias: A deadly ricochet 一系列与治疗相关的白血病病例:致命的反弹
Q4 Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.lrr.2023.100382
Ronit Juthani , Ashish Ranjan Singh , Debdatta Basu

Therapy-related leukemias(t-leukemia) are late complications arising from chemotherapy and radiotherapy. t-leukemia have a poor prognosis and are more difficult to treat compared to de novo leukemias. The authors present three cases of t-leukemia seen in our hospital in a three year period and discuss new updates concerning the treatment of t-leukemia.

治疗相关性白血病(t-白血病)是由化疗和放疗引起的晚期并发症。t-白血病预后差,与新发白血病相比更难治疗。作者报告了三年来在我院所见的三例t-白血病病例,并讨论了有关t-白血病治疗的最新进展。
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引用次数: 0
Allogeneic stem cell transplant for multiple myeloma & myelofibrosis with split-dose busulfan, fludarabine & cyclophosphamide 同种异体干细胞移植治疗多发性骨髓瘤和骨髓纤维化,分剂量布磺胺、氟达拉滨和环磷酰胺
Q4 Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.lrr.2023.100388
Andrew D. Trunk, Sagar S. Patel, Josef T. Prchal, Douglas W. Sborov, Axel R. Zander, Catherine J. Lee

Allogeneic stem cell transplant can have high morbidity and mortality in patients with myelofibrosis (MF) and multiple myeloma (MM). This phase 2 study used a novel myeloablative regimen of split-dose busulfan, fludarabine, and then post-transplant cyclophosphamide. Four patients with MF and 2 with MM were enrolled. At 1 year, non-relapse mortality was 33.3%, and overall survival was 50%. Incidence of acute and chronic GVHD was 33.3% and 16.7%, respectively. Those surviving beyond 1 year (MF = 1, MM = 2) had durable remissions with a median follow-up of 42 months. This small study demonstrates relative safety & favorable key outcomes using this novel approach.

同种异体干细胞移植在骨髓纤维化(MF)和多发性骨髓瘤(MM)患者中具有很高的发病率和死亡率。这项2期研究使用了一种新的骨髓清除方案,即分剂量的布硫凡、氟达拉滨和移植后的环磷酰胺。4名MF患者和2名MM患者入组。1年无复发死亡率为33.3%,总生存率为50%。急性和慢性GVHD的发生率分别为33.3%和16.7%。存活超过1年(MF = 1, MM = 2)的患者持续缓解,中位随访时间为42个月。这项小型研究证明了相对安全性。使用这种新方法的有利关键结果。
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引用次数: 0
Contribution of rare and common coding variants to haematological malignancies in the UK biobank 在英国生物库中,罕见和常见的编码变异对血液系统恶性肿瘤的贡献
Q4 Medicine Pub Date : 2023-01-01 DOI: 10.1016/j.lrr.2023.100362
Bengt Zöller , Eric Manderstedt , Christina Lind-Halldén , Christer Halldén
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引用次数: 0
期刊
Leukemia Research Reports
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