Pub Date : 2022-12-19DOI: 10.20473/iabj.v3i2.41526
Ilham Masdar Apriansyah
Examination of semen / ejaculates / sperm is the first screening examination that a subfertile / infertile couple needs to undertake in an attempt to find out the cause of infertility that may come from his side. Besides spermanalysis, it is also necessary to do physical examination, especially about internal and external genital tool because as it is known abnormal result of sperm analysis can be caused by anatomical abnormalities and or testis function. To determine the relationship of testicular volume to semen analysis on male patients in Andrology clinic RSUD Dr. Soetomo Surabaya. The research is a kind of observational analytic research to find out the correlation of testicular volume to semen analysis on male patients in Andrology clinic RSUD Dr. Soetomo Surabaya by using secondary data. Based on the results of statistical tests of 64 samples by using chi square test can be seen that the value of significance or p-value 0.005 <0.05. So it can be concluded that there is a relationship between testicular volume with morphology, motility and sperm concentration. Data were analyzed using chi square test to determine the relationship between testicular volume and semen analysis. Testicular volume is one of the risk factors of decreased semen analysis results
{"title":"Relationship of Testic Volume Towards Semen Analysis in Male Patients in Andrology Poly, RSUD Dr. Soetomo Surabaya","authors":"Ilham Masdar Apriansyah","doi":"10.20473/iabj.v3i2.41526","DOIUrl":"https://doi.org/10.20473/iabj.v3i2.41526","url":null,"abstract":"Examination of semen / ejaculates / sperm is the first screening examination that a subfertile / infertile couple needs to undertake in an attempt to find out the cause of infertility that may come from his side. Besides spermanalysis, it is also necessary to do physical examination, especially about internal and external genital tool because as it is known abnormal result of sperm analysis can be caused by anatomical abnormalities and or testis function. To determine the relationship of testicular volume to semen analysis on male patients in Andrology clinic RSUD Dr. Soetomo Surabaya. The research is a kind of observational analytic research to find out the correlation of testicular volume to semen analysis on male patients in Andrology clinic RSUD Dr. Soetomo Surabaya by using secondary data. Based on the results of statistical tests of 64 samples by using chi square test can be seen that the value of significance or p-value 0.005 <0.05. So it can be concluded that there is a relationship between testicular volume with morphology, motility and sperm concentration. Data were analyzed using chi square test to determine the relationship between testicular volume and semen analysis. Testicular volume is one of the risk factors of decreased semen analysis results","PeriodicalId":385352,"journal":{"name":"Indonesian Andrology and Biomedical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128967563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-19DOI: 10.20473/iabj.v3i2.35866
Vellyana Lie
Introduction Over the past decades, infertility has become a serious health problem worldwide and until nowadays numerous studies have shown it can be a negative prognostic factor for infertility.1 During, natural intercourse, ejaculation of seminal fluid into vagina may deposit spermatozoa, contaminants, and bacteria into the uterus by pelvic or penile thrusting and belling of the glans penis during coitus. In that case, the risk factor of infection in both women and man will happen post natural intercourse. So, the relationship between endometritis and increasing white blood cells level in sperm with infertility such as repeated implantation failure and recurrent miscarriage has recently emerged as an area of inquiry. Aims Aims this study, Correlation of endometritis that found in hysteroscopy examination and increasing white blood cell level in semen in sub fertile couples. Methods This study was conducted from 492 Infertility couple who underwent hysteroscopy from January 2021 to December 2021. The semen analysis was performed at least twice with range two weeks one from the other based on WHO guideline. Hysteroscopy was performed during endometrial proliferation phase. All data analysis performed using IBM SPSS 23. Results The result showed that mean leucocyte level range difference was significant in patient non-endometritis was 0.25 and endometritis patient was 0.66. The leucocyte number had correlation with the result of the pH level and slow progressive motility in semen specimen. Conclusion This research result showed the correlation women with resulted endometritis in hysteroscopy and white blood cell in semen specimen and had correlation with pH level and slow progressive motility in semen specimen. Keywords: White blood cells count in semen, endometritis, subfertil.
{"title":"Correlation of White Blood Cells Level in Semen with Endometritis in Subfertile Couples","authors":"Vellyana Lie","doi":"10.20473/iabj.v3i2.35866","DOIUrl":"https://doi.org/10.20473/iabj.v3i2.35866","url":null,"abstract":"Introduction \u0000 Over the past decades, infertility has become a serious health problem worldwide and until nowadays numerous studies have shown it can be a negative prognostic factor for infertility.1 During, natural intercourse, ejaculation of seminal fluid into vagina may deposit spermatozoa, contaminants, and bacteria into the uterus by pelvic or penile thrusting and belling of the glans penis during coitus. In that case, the risk factor of infection in both women and man will happen post natural intercourse. So, the relationship between endometritis and increasing white blood cells level in sperm with infertility such as repeated implantation failure and recurrent miscarriage has recently emerged as an area of inquiry. \u0000Aims \u0000 Aims this study, Correlation of endometritis that found in hysteroscopy examination and increasing white blood cell level in semen in sub fertile couples. \u0000Methods \u0000 This study was conducted from 492 Infertility couple who underwent hysteroscopy from January 2021 to December 2021. The semen analysis was performed at least twice with range two weeks one from the other based on WHO guideline. Hysteroscopy was performed during endometrial proliferation phase. All data analysis performed using IBM SPSS 23. \u0000Results \u0000 The result showed that mean leucocyte level range difference was significant in patient non-endometritis was 0.25 and endometritis patient was 0.66. The leucocyte number had correlation with the result of the pH level and slow progressive motility in semen specimen. \u0000Conclusion \u0000 This research result showed the correlation women with resulted endometritis in hysteroscopy and white blood cell in semen specimen and had correlation with pH level and slow progressive motility in semen specimen. \u0000Keywords: White blood cells count in semen, endometritis, subfertil.","PeriodicalId":385352,"journal":{"name":"Indonesian Andrology and Biomedical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123206083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-19DOI: 10.20473/iabj.v3i2.40240
Rossy Sintya Marthasari
Background: A good erectile function and normal sexual arousal are indicators of male health. Impaired sexual function due to loss of libido and erectile dysfunction can interfere with quality of life and relationships with partners. Erectile dysfunction can be caused by vasculogenic, endocrinopathy, hormonal imbalance, neurogenic, trauma, iatrogenic and also due to psychological causes. This research to understand and overcome the problems related to sexual function in man with genetic abnormality. Case: A 32-year-old patient came for a sperm analysis examination because he was planning to get married soon. At first, there were no sexual problems complained of but the patient admitted that he was not too much interested in sexual matters since he was young. Nocturnal and morning erection happened rarely. Puberty at 15 years old and currently in a relationship with a woman and planning to get married. At this time libido was good. There was no history of mumps and orchitis. From the physical examination, it was found that the height was 180 cm, weight was 100 kg, and the arm span was 186 cm. waist circumference 104 cm. It means that he was obese. Other physical examinations were within normal limits. Examination of the genitalia showed testicle size of 4 cc right and 4 cc left and soft in consistency. Penis size 8 cm in stretched condition. Sperm analysis showed azoospermia. Cytogenetic examination showed 46XY inv(9)(p11q13) and no Klinefelter syndrome was found. Hormone examination results showed LH 11.92 mIU/ml, FSH 30.29 mIU/ml.He showed hyperprolactinemia 25.89 ng/ml, estradiol 16 pg/ml and total testosterone 2.33 ng/ml. HbA1c 5,9 %. Discussion: The patient was treated with cabergoline 0.25 mg 3 times a week and to overcome hormone imbalance ,we used letrozole 2.5 mg once a day for 2 months.After two months have passed, there is an increase in sexual arousal, morning erections occur at least 4 days a week, erections begin to improve. weight 94 kg, arm span 186 cm. waist circumference 99 cm. Other physical examinations were within normal limits. Examination of the genitalia showed testicle size of 5 cc right and 5 cc left and soft in consistency.Recent investigations showed LH 7.89 mIU/ml, FSH 14.53 mIU/ml, prolactin 15.00 ng/ml, estradiol 10 pg/ml and total testosterone 1.69 ng/ml. Until now, evaluation and treatment is still ongoing. Conclusion: Management of erectile dysfunction can not only be seen from one side but also requires a holistic and multidisciplinary approach. Risk factors that can cause erectile dysfunction problems must be assessed and controlled every single cause. The goal of erectile dysfunction management is not only for sexual satisfaction but also to improve fertility and quality of life.
{"title":"Erectile Dysfunction in Man with Hyperprolactinemia, Obesity and Genetic Abnormality 46XYinv(9)(p11q13)","authors":"Rossy Sintya Marthasari","doi":"10.20473/iabj.v3i2.40240","DOIUrl":"https://doi.org/10.20473/iabj.v3i2.40240","url":null,"abstract":"Background: A good erectile function and normal sexual arousal are indicators of male health. Impaired sexual function due to loss of libido and erectile dysfunction can interfere with quality of life and relationships with partners. Erectile dysfunction can be caused by vasculogenic, endocrinopathy, hormonal imbalance, neurogenic, trauma, iatrogenic and also due to psychological causes. This research to understand and overcome the problems related to sexual function in man with genetic abnormality. \u0000Case: A 32-year-old patient came for a sperm analysis examination because he was planning to get married soon. At first, there were no sexual problems complained of but the patient admitted that he was not too much interested in sexual matters since he was young. Nocturnal and morning erection happened rarely. Puberty at 15 years old and currently in a relationship with a woman and planning to get married. At this time libido was good. There was no history of mumps and orchitis. From the physical examination, it was found that the height was 180 cm, weight was 100 kg, and the arm span was 186 cm. waist circumference 104 cm. It means that he was obese. Other physical examinations were within normal limits. Examination of the genitalia showed testicle size of 4 cc right and 4 cc left and soft in consistency. Penis size 8 cm in stretched condition. Sperm analysis showed azoospermia. Cytogenetic examination showed 46XY inv(9)(p11q13) and no Klinefelter syndrome was found. Hormone examination results showed LH 11.92 mIU/ml, FSH 30.29 mIU/ml.He showed hyperprolactinemia 25.89 ng/ml, estradiol 16 pg/ml and total testosterone 2.33 ng/ml. HbA1c 5,9 %. \u0000Discussion: The patient was treated with cabergoline 0.25 mg 3 times a week and to overcome hormone imbalance ,we used letrozole 2.5 mg once a day for 2 months.After two months have passed, there is an increase in sexual arousal, morning erections occur at least 4 days a week, erections begin to improve. weight 94 kg, arm span 186 cm. waist circumference 99 cm. Other physical examinations were within normal limits. Examination of the genitalia showed testicle size of 5 cc right and 5 cc left and soft in consistency.Recent investigations showed LH 7.89 mIU/ml, FSH 14.53 mIU/ml, prolactin 15.00 ng/ml, estradiol 10 pg/ml and total testosterone 1.69 ng/ml. Until now, evaluation and treatment is still ongoing. \u0000Conclusion: Management of erectile dysfunction can not only be seen from one side but also requires a holistic and multidisciplinary approach. Risk factors that can cause erectile dysfunction problems must be assessed and controlled every single cause. The goal of erectile dysfunction management is not only for sexual satisfaction but also to improve fertility and quality of life.","PeriodicalId":385352,"journal":{"name":"Indonesian Andrology and Biomedical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127669089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-30DOI: 10.20473/iabj.v3i1.35982
R. Ibrahim, Cennikon Pakpahan, Pety Narulita
Background: Around 10 % of infertile men and 1 percent of all males have azoospermia. There are two types of azoospermia, which are obstructive and non-obstructive azoospermia. Non-obstructive azoospermia's main mechanism is because the testes fail to produce the sex hormone and induce spermatogenesis (primary testicular failure). Case: A patient is 28 years old and has a job as a car paint worker. He came with the chief complaint of infertility since two and a half years ago. He and his wife were having intercourse 3-4 times a week. Past medical history is unremarkable. His wife’s medical history is also unremarkable. Physical examination and ultrasound of the testes are normal. The semen analysis in this patient was azoospermia for 2 different times in the span of 2 weeks with no abnormalities in the accessory gland. Hormonal profiles results are testosterone level 2,32 ng/mL and FSH 15,03 mIU/mL, which indicatehypergonadotropic hypogonadism. The patient was suggested to evaluate further (complete hormonal profile, karyotyping analysis, and Y-Chromosome microdeletion) and educate about the possibility to conceive with assisted reproductive technology (ART). Discussion: Hypergonadotropic hypogonadism is a challenging case that needs a complete assessment such as complete hormonal profile, karyotyping analysis, Y-chromosome microdeletion analysis, and also, in this case, the paint thinner exposure in the workplace is needed to be considered. The chance of normal conception is very small, and the assisted reproductive procedure is necessary. Conclusion: Some abnormalities are usually present in the physical examination of azoospermia patients. This case convinces us of the importance of thorough history taking and other investigations. Managing this patient will be challenging, with the goal of the therapy is to achieve spermatogenesis to be able to use the spermatozoa available for ICSI.
{"title":"Non-Obstructive Azoospermia with Hypergonadotropic Hypogonadism without a Significant Abnormalities in the Physical Examination","authors":"R. Ibrahim, Cennikon Pakpahan, Pety Narulita","doi":"10.20473/iabj.v3i1.35982","DOIUrl":"https://doi.org/10.20473/iabj.v3i1.35982","url":null,"abstract":"Background: Around 10 % of infertile men and 1 percent of all males have azoospermia. There are two types of azoospermia, which are obstructive and non-obstructive azoospermia. Non-obstructive azoospermia's main mechanism is because the testes fail to produce the sex hormone and induce spermatogenesis (primary testicular failure). \u0000Case: A patient is 28 years old and has a job as a car paint worker. He came with the chief complaint of infertility since two and a half years ago. He and his wife were having intercourse 3-4 times a week. Past medical history is unremarkable. His wife’s medical history is also unremarkable. Physical examination and ultrasound of the testes are normal. The semen analysis in this patient was azoospermia for 2 different times in the span of 2 weeks with no abnormalities in the accessory gland. Hormonal profiles results are testosterone level 2,32 ng/mL and FSH 15,03 mIU/mL, which indicatehypergonadotropic hypogonadism. The patient was suggested to evaluate further (complete hormonal profile, karyotyping analysis, and Y-Chromosome microdeletion) and educate about the possibility to conceive with assisted reproductive technology (ART). \u0000Discussion: Hypergonadotropic hypogonadism is a challenging case that needs a complete assessment such as complete hormonal profile, karyotyping analysis, Y-chromosome microdeletion analysis, and also, in this case, the paint thinner exposure in the workplace is needed to be considered. The chance of normal conception is very small, and the assisted reproductive procedure is necessary. \u0000Conclusion: Some abnormalities are usually present in the physical examination of azoospermia patients. This case convinces us of the importance of thorough history taking and other investigations. Managing this patient will be challenging, with the goal of the therapy is to achieve spermatogenesis to be able to use the spermatozoa available for ICSI.","PeriodicalId":385352,"journal":{"name":"Indonesian Andrology and Biomedical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122677700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-30DOI: 10.20473/iabj.v3i1.35875
Alycia Madeleine, Yukhi Kurniawan, I Gusti Ngurah Pramesemara
Infertility is the inability of couples who have regular sexual intercourse without using protection to achieve pregnancy within one year. The prevalence of infertility was 21.3% in Indonesia. Intrauterine Insemination (IUI) is an assisted reproductive technology chosen by infertile couples to have children. Various factors influence the success of IUI. One factor that influences the success of IUI is the female partner’s age. To determine the relationship between the age of female partners and the success of IUI. This study is descriptive-analytical research with the Cross-Sectional method using secondary data obtained from medical records of patients who underwent IUI procedures from January to March 2020 at Rumah Sakit Ibu dan Anak Puri Bunda Denpasar. Total research subjects are 31 patients with an average age of 32 years. Positive pregnancies in female partners aged 25-35 years are 8 patients (33,3%) and female partners aged 35-40 are 1 patient (14.3%). Most patients had secondary infertility with a duration of 1-3 years. There is no relation between the increasing age of female partners and the decreasing success of IUI at Rumah Sakit Ibu dan Anak Puri Bunda Denpasar (p=0,329). But female partners aged 25-35 years tended to have a positive pregnancy 2,333 times higher than female partners aged 35-40 years (RR=2,333; CI 95%: 0,349-15,612).
不孕症是指在没有采取保护措施的情况下经常性交的夫妇在一年内无法怀孕。印度尼西亚的不孕症患病率为21.3%。宫内人工授精(IUI)是不育夫妇选择的一种辅助生殖技术。影响人工授精成功的因素有很多。影响人工授精成功的一个因素是女性伴侣的年龄。目的:探讨女性伴侣年龄与人工授精成功率的关系。本研究是一项描述性分析研究，采用横断面方法，使用从2020年1月至3月在Rumah Sakit Ibu dan Anak Puri Bunda Denpasar接受IUI手术的患者的医疗记录中获得的次要数据。研究对象共31例，平均年龄32岁。25-35岁女性伴孕阳性8例(33.3%)，35-40岁女性伴孕阳性1例(14.3%)。大多数患者继发性不孕症持续时间为1-3年。女性伴侣年龄的增加与Rumah Sakit Ibu dan Anak Puri Bunda Denpasar宫内人工授精成功率的降低之间没有关系(p= 0.329)。但25-35岁女性伴侣的阳性妊娠率是35-40岁女性伴侣的2333倍(RR= 2333;Ci 95%: 0,349-15,612)。
{"title":"Relationship Between the Age of Female Partner and the Intrauterine Insemination Success in Rumah Sakit Ibu dan Anak Puri Bunda Denpasar","authors":"Alycia Madeleine, Yukhi Kurniawan, I Gusti Ngurah Pramesemara","doi":"10.20473/iabj.v3i1.35875","DOIUrl":"https://doi.org/10.20473/iabj.v3i1.35875","url":null,"abstract":"Infertility is the inability of couples who have regular sexual intercourse without using protection to achieve pregnancy within one year. The prevalence of infertility was 21.3% in Indonesia. Intrauterine Insemination (IUI) is an assisted reproductive technology chosen by infertile couples to have children. Various factors influence the success of IUI. One factor that influences the success of IUI is the female partner’s age. To determine the relationship between the age of female partners and the success of IUI. This study is descriptive-analytical research with the Cross-Sectional method using secondary data obtained from medical records of patients who underwent IUI procedures from January to March 2020 at Rumah Sakit Ibu dan Anak Puri Bunda Denpasar. Total research subjects are 31 patients with an average age of 32 years. Positive pregnancies in female partners aged 25-35 years are 8 patients (33,3%) and female partners aged 35-40 are 1 patient (14.3%). Most patients had secondary infertility with a duration of 1-3 years. There is no relation between the increasing age of female partners and the decreasing success of IUI at Rumah Sakit Ibu dan Anak Puri Bunda Denpasar (p=0,329). But female partners aged 25-35 years tended to have a positive pregnancy 2,333 times higher than female partners aged 35-40 years (RR=2,333; CI 95%: 0,349-15,612).","PeriodicalId":385352,"journal":{"name":"Indonesian Andrology and Biomedical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129526949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-30DOI: 10.20473/iabj.v3i1.35876
Amelia Heryanto, Gusti Ngurah Pramesemara, Yukhi Kurniawan, G. Widianti
Infertility can occur in men, characterized by the inability to make pregnancy in the partner. The causes of male infertility are multifactorial, one of which is obesity. Obesity parameter by body mass index >25 kg/m2. This study purposes of determining the relationship between obesity with body mass index measurement and male infertility. This type of research is an analytical cross-sectional study. This research was located at the Kasih Ibu General Hospital Denpasar. Purposive sampling was chosen as the sampling technique. The samples were 50 male patients aged 25-45 years who checked themselves at the Kasih Ibu General Hospital Denpasar between January and December 2020. All research data could be seen from the patient's medical records. The Pearson Chi-Square test was used to analyze the data. The results were 26 subjects (52%) with BMI >25 kg/m2 (obese) and 24 subjects (48%) with BMI <25 kg/m2 (non-obese). About 28 subjects (56%) were infertile, and 22 subjects (44%) were fertile. This study found that body mass index was significantly associated with infertility in male patients at Kasih Ibu General Hospital Denpasar. Obese men had a 2,308 higher risk of infertility than men were not obese (p = 0.002, RR = 2.308 (CI95% 1.262-4.220). The study has found that obesity may contribute to the event of male infertility. For further research should use a larger sample size to make it more accurate in population.
{"title":"Relationship Between Body Mass Index and Male Infertility at Kasih Ibu General Hospital Denpasar","authors":"Amelia Heryanto, Gusti Ngurah Pramesemara, Yukhi Kurniawan, G. Widianti","doi":"10.20473/iabj.v3i1.35876","DOIUrl":"https://doi.org/10.20473/iabj.v3i1.35876","url":null,"abstract":"Infertility can occur in men, characterized by the inability to make pregnancy in the partner. The causes of male infertility are multifactorial, one of which is obesity. Obesity parameter by body mass index >25 kg/m2. This study purposes of determining the relationship between obesity with body mass index measurement and male infertility. This type of research is an analytical cross-sectional study. This research was located at the Kasih Ibu General Hospital Denpasar. Purposive sampling was chosen as the sampling technique. The samples were 50 male patients aged 25-45 years who checked themselves at the Kasih Ibu General Hospital Denpasar between January and December 2020. All research data could be seen from the patient's medical records. The Pearson Chi-Square test was used to analyze the data. The results were 26 subjects (52%) with BMI >25 kg/m2 (obese) and 24 subjects (48%) with BMI <25 kg/m2 (non-obese). About 28 subjects (56%) were infertile, and 22 subjects (44%) were fertile. This study found that body mass index was significantly associated with infertility in male patients at Kasih Ibu General Hospital Denpasar. Obese men had a 2,308 higher risk of infertility than men were not obese (p = 0.002, RR = 2.308 (CI95% 1.262-4.220). The study has found that obesity may contribute to the event of male infertility. For further research should use a larger sample size to make it more accurate in population.","PeriodicalId":385352,"journal":{"name":"Indonesian Andrology and Biomedical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114482708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Osteoporosis is a chronic metabolic disorder of the musculoskeletal system associated with reduced bone strength. One of the causes of secondary osteoporosis is diabetes mellitus (DM). The prevalence of both disorders keeps increasing with time. Therefore, this review is conducted to find a possible solution to prevent DM-induced osteoporosis. Diabetes mellitus mainly affects the bone through glucose uptake during the bone remodeling process. Glucose uptake through GLUT 1 is regulated by MST 1, which is an upstream kinase of the Hippo signaling pathway. MST 1 is responsible for regulating cell growth, proliferation, and apoptosis. In the bone remodeling process, MST 1 plays a role by regulating actin ring structures and the integrin signaling pathway. Moreover, DM is also associated with increased oxidative stress. Increased oxidative stress will activate Hippo signaling pathway. This will trigger cellular apoptosis as the Hippo signaling pathway plays a role mainly as a tumor suppressor. Increased cellular apoptosis will cause an imbalance in the bone remodeling process, disrupting bone quality. Inhibition of MST 1 through the Hippo signaling pathway will increase cell growth and reduce cellular apoptosis. Increased cell growth might increase osteogenesis during the bone remodeling process, thus resulting in better bone quality in DM-induced osteoporosis.
{"title":"Effect of MST 1 Inhibition through Hippo Pathway on Diabetes Mellitus (DM) Induced Osteoporosis","authors":"Kintan Adelia Farahannisa, Gadis Meinar Sari, Heri Suroto","doi":"10.20473/iabj.v3i1.35874","DOIUrl":"https://doi.org/10.20473/iabj.v3i1.35874","url":null,"abstract":"Osteoporosis is a chronic metabolic disorder of the musculoskeletal system associated with reduced bone strength. One of the causes of secondary osteoporosis is diabetes mellitus (DM). The prevalence of both disorders keeps increasing with time. Therefore, this review is conducted to find a possible solution to prevent DM-induced osteoporosis. Diabetes mellitus mainly affects the bone through glucose uptake during the bone remodeling process. Glucose uptake through GLUT 1 is regulated by MST 1, which is an upstream kinase of the Hippo signaling pathway. MST 1 is responsible for regulating cell growth, proliferation, and apoptosis. In the bone remodeling process, MST 1 plays a role by regulating actin ring structures and the integrin signaling pathway. Moreover, DM is also associated with increased oxidative stress. Increased oxidative stress will activate Hippo signaling pathway. This will trigger cellular apoptosis as the Hippo signaling pathway plays a role mainly as a tumor suppressor. Increased cellular apoptosis will cause an imbalance in the bone remodeling process, disrupting bone quality. Inhibition of MST 1 through the Hippo signaling pathway will increase cell growth and reduce cellular apoptosis. Increased cell growth might increase osteogenesis during the bone remodeling process, thus resulting in better bone quality in DM-induced osteoporosis.","PeriodicalId":385352,"journal":{"name":"Indonesian Andrology and Biomedical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116591439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-30DOI: 10.20473/iabj.v3i1.35824
Mikhael San Putra Wijanarko, Cathelin Stella, Grevy Yanika
The dissatisfaction of men due to their penile size is found in a number of studies. Concerns can be focused on the penile length or width or even both, whether erect or flaccid. Men who are worried about the penile size also want to increase the size of the penis. Concerns about men’s penile size are also increasing because they think normal penile size is what is shown in pornography. These worries can affect self-esteem, sexual function, and satisfaction, to physical and mental health. Small penis anxiety is an anxiety that arises when a man observes his flaccid penile size and feels concerned that his penile size is less than the normal size. In addition, this concern persists even though it has been refuted by clinical examination. Penile dysmorphic disorder is excessive self-concern, distress, and a preoccupation with trivial or even non-existent deficiencies in penile size and shape that can lead to impaired function. Until now, there have not been effective guidelines for managing patients with complaints of penile size. Some of the treatments that can be conducted are psychosexual counseling, cognitive behavioral therapy, the use of selective serotonin reuptake inhibitors, penile traction devices, and invasive procedures. Various modalities of therapy have been tried to overcome excessive concern about penile size. Yet, so far, no good results have been obtained. Thus, clear and effective guidelines are needed to make treatment can be carried out properly.
{"title":"Men’s Excessive Concern about Penile Size","authors":"Mikhael San Putra Wijanarko, Cathelin Stella, Grevy Yanika","doi":"10.20473/iabj.v3i1.35824","DOIUrl":"https://doi.org/10.20473/iabj.v3i1.35824","url":null,"abstract":"The dissatisfaction of men due to their penile size is found in a number of studies. Concerns can be focused on the penile length or width or even both, whether erect or flaccid. Men who are worried about the penile size also want to increase the size of the penis. Concerns about men’s penile size are also increasing because they think normal penile size is what is shown in pornography. These worries can affect self-esteem, sexual function, and satisfaction, to physical and mental health. Small penis anxiety is an anxiety that arises when a man observes his flaccid penile size and feels concerned that his penile size is less than the normal size. In addition, this concern persists even though it has been refuted by clinical examination. Penile dysmorphic disorder is excessive self-concern, distress, and a preoccupation with trivial or even non-existent deficiencies in penile size and shape that can lead to impaired function. Until now, there have not been effective guidelines for managing patients with complaints of penile size. Some of the treatments that can be conducted are psychosexual counseling, cognitive behavioral therapy, the use of selective serotonin reuptake inhibitors, penile traction devices, and invasive procedures. Various modalities of therapy have been tried to overcome excessive concern about penile size. Yet, so far, no good results have been obtained. Thus, clear and effective guidelines are needed to make treatment can be carried out properly.","PeriodicalId":385352,"journal":{"name":"Indonesian Andrology and Biomedical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124958866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-30DOI: 10.20473/iabj.v3i1.36157
Made sukma Putra, Lilik Djuari, Rina Yudiwati
The incidence of obesity in the world has increased recently and doubled from 1980 to 2014. Obesity can increase the risk of many diseases. Medical students are a vulnerable group affected by obesity because of stressful conditions that can increase the incidence of obesity. This analytical research uses a cross sectional method approach using primary data. The populations in this study were medical students at the Faculty of Medicine, Airlangga University. In this study, 300 samples were taken from first-fifth semester students. The independent variables that will be studied in this study are Gender, physical activity, family obesity history, and consumption of fruit or vegetables. The dependent variable in this study is nutritional status. Based on this study found a significant association between gender, family history of obesity, eating of fruits or vegetables to nutritional status. Still, there is no significant association between physical activity on the nutritional group of medical students. Three variables in this research correlated with the nutritional status of medical education students at the Faculty of Medicine, Airlangga University, Surabaya, which are gender, family obesity history, and consumption of fruit or vegetables. From this research, it was found that the incidence of over-nutrition was still high among medical education students and there was still a lack of awareness among students to exercise and consume fruit or vegetables in their meals.
{"title":"Correlation Between Gender, Physical Activity, Family Obesity History and Consumption of Fruit or Vegetable with Obesity in Medical Students in Surabaya","authors":"Made sukma Putra, Lilik Djuari, Rina Yudiwati","doi":"10.20473/iabj.v3i1.36157","DOIUrl":"https://doi.org/10.20473/iabj.v3i1.36157","url":null,"abstract":"The incidence of obesity in the world has increased recently and doubled from 1980 to 2014. Obesity can increase the risk of many diseases. Medical students are a vulnerable group affected by obesity because of stressful conditions that can increase the incidence of obesity. This analytical research uses a cross sectional method approach using primary data. The populations in this study were medical students at the Faculty of Medicine, Airlangga University. In this study, 300 samples were taken from first-fifth semester students. The independent variables that will be studied in this study are Gender, physical activity, family obesity history, and consumption of fruit or vegetables. The dependent variable in this study is nutritional status. Based on this study found a significant association between gender, family history of obesity, eating of fruits or vegetables to nutritional status. Still, there is no significant association between physical activity on the nutritional group of medical students. Three variables in this research correlated with the nutritional status of medical education students at the Faculty of Medicine, Airlangga University, Surabaya, which are gender, family obesity history, and consumption of fruit or vegetables. From this research, it was found that the incidence of over-nutrition was still high among medical education students and there was still a lack of awareness among students to exercise and consume fruit or vegetables in their meals.","PeriodicalId":385352,"journal":{"name":"Indonesian Andrology and Biomedical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128090447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Indonesia’s Maternal Mortality Rate (MMR) in 2015 was still high around 305 over 100.000 population. South Kalimantan MMR’s in 2018 increase to 108 over 100.000 population. If not handled properly the increasing of MMR, it will not achieve the SDG's by 2030. The high MMR is caused by the large number of pregnancies and deliveries in Indonesia. One of the ways to prevent it, is by reducing the number of pregnancies and one of the most effective way is through the Family Planning (FP) program. Vasectomy is a method of operative contraception in men. Public perception of vasectomy is a complicated operation, so vasectomy is not an option. Aim: Knowing the relations between knowledge and perceptions of eligible men on vasectomy Method: This research is an analytical survey with a cross sectional approach. The number of subjects used as many as 80 respondents who meet the feasibility of being included in this study. The chi-square test with a significance level of p<0.05 was used for statistical analysis. Knowledge is considered good if it has a total score of more than 76 percent, and it is considered poor if it is less than equal to 76 percent. Positive perception if the respondent's mean score is less than the T score, and to be negative perception if the respondent's mean score is more than the T score. Results: A total of 108 respondents were included in this study. There are 89 respondents or 82% who have good knowledge and 19 respondents or 18% who have bad knowledge about vasectomy. Negative perceptions were owned by 81 respondents or 75% while positive perceptions were only found in 27 respondents or 25%. Chi-square analysis showed that there was a significant relation between poor knowledge and negative perceptions with p<0.05. Conclusion: Poor knowledge of vasectomy is associated with negative perceptions. This study shows lack of public knowledge about vasectomy, causing a negative stigma about vasectomy.
{"title":"Relations of Knowledge with Perceptions of Eligible Men About Vasectomy in Angsau Primary Health Care, Tanah Laut, South Kalimantan","authors":"Natasha Bharat Sindunata Sindunata, Laili Wahyuni, Androniko Setiawan","doi":"10.20473/iabj.v2i2.164","DOIUrl":"https://doi.org/10.20473/iabj.v2i2.164","url":null,"abstract":"Background: Indonesia’s Maternal Mortality Rate (MMR) in 2015 was still high around 305 over 100.000 population. South Kalimantan MMR’s in 2018 increase to 108 over 100.000 population. If not handled properly the increasing of MMR, it will not achieve the SDG's by 2030. The high MMR is caused by the large number of pregnancies and deliveries in Indonesia. One of the ways to prevent it, is by reducing the number of pregnancies and one of the most effective way is through the Family Planning (FP) program. Vasectomy is a method of operative contraception in men. Public perception of vasectomy is a complicated operation, so vasectomy is not an option.\u0000Aim: Knowing the relations between knowledge and perceptions of eligible men on vasectomy\u0000Method: This research is an analytical survey with a cross sectional approach. The number of subjects used as many as 80 respondents who meet the feasibility of being included in this study. The chi-square test with a significance level of p<0.05 was used for statistical analysis. Knowledge is considered good if it has a total score of more than 76 percent, and it is considered poor if it is less than equal to 76 percent. Positive perception if the respondent's mean score is less than the T score, and to be negative perception if the respondent's mean score is more than the T score.\u0000Results: A total of 108 respondents were included in this study. There are 89 respondents or 82% who have good knowledge and 19 respondents or 18% who have bad knowledge about vasectomy. Negative perceptions were owned by 81 respondents or 75% while positive perceptions were only found in 27 respondents or 25%. Chi-square analysis showed that there was a significant relation between poor knowledge and negative perceptions with p<0.05.\u0000Conclusion: Poor knowledge of vasectomy is associated with negative perceptions. This study shows lack of public knowledge about vasectomy, causing a negative stigma about vasectomy.","PeriodicalId":385352,"journal":{"name":"Indonesian Andrology and Biomedical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117116730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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