Pub Date : 2022-01-01DOI: 10.33029/0206-4952-2022-43-2-137-148
I. Dolgopolov, E. Kochegurova, L. Grivtsova, O. K. Ustinova, M. Rykov
{"title":"Congenital T- and NK-cell immunodeficiency with impaired expression of β-integrin on neutrophils in a patient with a mutation in the KMT2D gene: a description of a clinical case","authors":"I. Dolgopolov, E. Kochegurova, L. Grivtsova, O. K. Ustinova, M. Rykov","doi":"10.33029/0206-4952-2022-43-2-137-148","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-2-137-148","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69481562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33029/0206-4952-2022-43-2-157-165
M. Fisher, V. Kurilin, V. Tereshchenko, A. Bulygin, M. Kuznetsova, E. Ivleva, S. Sennikov
{"title":"Experimental model of antigen-collagen induced arthritis in mice","authors":"M. Fisher, V. Kurilin, V. Tereshchenko, A. Bulygin, M. Kuznetsova, E. Ivleva, S. Sennikov","doi":"10.33029/0206-4952-2022-43-2-157-165","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-2-157-165","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69481578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33029/0206-4952-2022-43-1-103-111
R. Zavodskii, Y. Shevchenko, O.Yu. Koneva, K. Nazarov, M. Kuznetsova, S. Sennikov
Nucleated erythroid cells (NEC) are the precursors of the most massive population of human cells – erythrocytes, for which functions of hemo- and immunoregulation have been shown at various stages of ontogenesis and in various organs and tissues of the human body. NEC perform this function by secreting cytokine proteins, growth factors, enzymes such as arginase-2, ROS, and by surface molecules PD-L1 and PD-L2. Their important regulatory role has been shown for the formation of fetoplacental immunosuppression, immunosuppression during pregnancy, suppression of the response against commensals in the gastrointestinal tract, in the pathogenesis of bacterial and viral infections in adults, in the pathogenesis of tumor growth and autoimmune diseases, as well as participation in the recognition of pathogen-associated molecular patterns using Toll-like receptors in fish and birds. Such qualities, together with their number and width of distribution, represent NEC as active participants in hemo- and immunoregulation, which makes it important to study their regulatory role in health and disease.
{"title":"Immunoregulatory role of nucleated erythroid cells","authors":"R. Zavodskii, Y. Shevchenko, O.Yu. Koneva, K. Nazarov, M. Kuznetsova, S. Sennikov","doi":"10.33029/0206-4952-2022-43-1-103-111","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-1-103-111","url":null,"abstract":"Nucleated erythroid cells (NEC) are the precursors of the most massive population of human cells – erythrocytes, for which functions of hemo- and immunoregulation have been shown at various stages of ontogenesis and in various organs and tissues of the human body. NEC perform this function by secreting cytokine proteins, growth factors, enzymes such as arginase-2, ROS, and by surface molecules PD-L1 and PD-L2. Their important regulatory role has been shown for the formation of fetoplacental immunosuppression, immunosuppression during pregnancy, suppression of the response against commensals in the gastrointestinal tract, in the pathogenesis of bacterial and viral infections in adults, in the pathogenesis of tumor growth and autoimmune diseases, as well as participation in the recognition of pathogen-associated molecular patterns using Toll-like receptors in fish and birds. Such qualities, together with their number and width of distribution, represent NEC as active participants in hemo- and immunoregulation, which makes it important to study their regulatory role in health and disease.","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69481844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33029/0206-4952-2022-43-1-217-223
I. Osmanov, I. M. Khegai, I. Trunina, T. A. Chebotareva, A. Cheburkin, P. Shumilov
{"title":"Immunopathogenesis of COVID-19-related pediatric multisystem inflammatory syndrome","authors":"I. Osmanov, I. M. Khegai, I. Trunina, T. A. Chebotareva, A. Cheburkin, P. Shumilov","doi":"10.33029/0206-4952-2022-43-1-217-223","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-1-217-223","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69481905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33029/0206-4952-2022-43-3-320-332
K. Kozhikhova, S. M. Andreev, D.V. Uspenskaya, A.V. Shatilova, E. Turetskiy, A. Shatilov, A. Lushnikova, L. Vishniakova, I. Shilovskiy, V. Smirnov, D. Kudlay, M. Khaitov
{"title":"Supercationic peptide dendrimers as vectors for nucleic acids delivery to mammalian cells","authors":"K. Kozhikhova, S. M. Andreev, D.V. Uspenskaya, A.V. Shatilova, E. Turetskiy, A. Shatilov, A. Lushnikova, L. Vishniakova, I. Shilovskiy, V. Smirnov, D. Kudlay, M. Khaitov","doi":"10.33029/0206-4952-2022-43-3-320-332","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-3-320-332","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69482115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33029/0206-4952-2022-43-6-746-756
O. Artemyeva, V. Grechenko, T. V. Gromova, L. Gankovskaya
{"title":"Frailty: a controversial role of inflammaging","authors":"O. Artemyeva, V. Grechenko, T. V. Gromova, L. Gankovskaya","doi":"10.33029/0206-4952-2022-43-6-746-756","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-6-746-756","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69482413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33029/0206-4952-2022-43-5-583-592
A. I. Andreev, I. V. Andreev, K.O. Nechay, D. R. Esaulova, O. S. Baklakova, V.I. Vecherko, I. Shilovskiy, I. Kofiadi, G. Gudima, А. Martynov, V. Smirnov, D. Kudlay, M. Khaitov
Pub Date : 2022-01-01DOI: 10.33029/0206-4952-2022-43-4-375-388
R. Ataullakhanov, E. Ushakova, S.A. Al Khudhur, A. Pichugin, E. Lebedeva
{"title":"Reprogramming of myeloid cells of the tumor microenvironment – a new approach in the immunotherapy of malignant neoplasms","authors":"R. Ataullakhanov, E. Ushakova, S.A. Al Khudhur, A. Pichugin, E. Lebedeva","doi":"10.33029/0206-4952-2022-43-4-375-388","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-4-375-388","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69482369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33029/0206-4952-2022-43-4-389-400
E. Ushakova, A. Fedorova, E. Lebedeva, A. Pichugin, R. Ataullakhanov
{"title":"Immunogenicity of a multi-antigen vaccine made from a lysate of tumor malignant cells or from primary solid tumor tissue","authors":"E. Ushakova, A. Fedorova, E. Lebedeva, A. Pichugin, R. Ataullakhanov","doi":"10.33029/0206-4952-2022-43-4-389-400","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-4-389-400","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69482375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33029/0206-4952-2022-43-5-593-605
I. Menshikov, Abdulkadhim Zerjawi, L. Beduleva, K. Fomina, A. Terentiev, N. Abisheva, I. Cherepanov
{"title":"Lipid metabolism in experimental autoimmune atherosclerosis","authors":"I. Menshikov, Abdulkadhim Zerjawi, L. Beduleva, K. Fomina, A. Terentiev, N. Abisheva, I. Cherepanov","doi":"10.33029/0206-4952-2022-43-5-593-605","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-5-593-605","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69482590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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