Pub Date : 2022-01-01DOI: 10.33029/0206-4952-2022-43-1-166-173
A. Yasenyavskaya, A.A. Tsybizova, L. Andreeva, N. Myasoedov, O. Bashkina, M. Samotrueva
{"title":"Effect of glyproline neuropeptides on the level of interleukins and neurotrophic factors under stress","authors":"A. Yasenyavskaya, A.A. Tsybizova, L. Andreeva, N. Myasoedov, O. Bashkina, M. Samotrueva","doi":"10.33029/0206-4952-2022-43-1-166-173","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-1-166-173","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69481856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33029/0206-4952-2022-43-5-515-524
E. Shevela, L. Sakhno, A. Maximova, M. Tikhonova, A. Ostanin, E. Chernykh
{"title":"Expression of Arg1 and MerTK by human macrophages activated by M2-polarizing stimuli and their role in determining low allostimulatory activity","authors":"E. Shevela, L. Sakhno, A. Maximova, M. Tikhonova, A. Ostanin, E. Chernykh","doi":"10.33029/0206-4952-2022-43-5-515-524","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-5-515-524","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69482278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33029/0206-4952-2022-43-5-571-582
O. Kurbacheva, E. Savlevich, V. Egorov, M. E. Dyneva, I. Shilovskiy, V. Kovchina, A. A. Nikolskii, E. Barvinskaia, M.M. Kaganova, E. S. Mitrofanova, E. Savushkina, L. Gaganov, M. Khaitov
{"title":"Expression of the TNFSF13B, APRIL, VEGF, FGF1 и EGF genes in different phenotypes of chronic rhinosinusitis with nasal polyps","authors":"O. Kurbacheva, E. Savlevich, V. Egorov, M. E. Dyneva, I. Shilovskiy, V. Kovchina, A. A. Nikolskii, E. Barvinskaia, M.M. Kaganova, E. S. Mitrofanova, E. Savushkina, L. Gaganov, M. Khaitov","doi":"10.33029/0206-4952-2022-43-5-571-582","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-5-571-582","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69482355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33029/0206-4952-2022-43-6-691-701
E. Ushakova, A. Pichugin, A. Fedorova, E. Lebedeva, R. Ataullakhanov
{"title":"The intensity of antitumor immune responses to immunization with Multivac vaccines against 4T1 carcinoma in BALB/c mice and B16 melanoma in C57BL/6J mice does not depend on the host genotype and the tissue origin of the tumor","authors":"E. Ushakova, A. Pichugin, A. Fedorova, E. Lebedeva, R. Ataullakhanov","doi":"10.33029/0206-4952-2022-43-6-691-701","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-6-691-701","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69482770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33029/0206-4952-2022-43-2-174-187
M. Pervakova, V. Potapenko, O. Tkachenko, E. Volchkova, O. Titova, S. Lapin, E. Surkova, T. Blinova, I. Kholopova, D. A. Kuznetsova, A. Moshnikova, A. Mazing, A. Kulikov, Y. Polushin, A. Afanasyev, I. Shlyk, E. Gavrilova, A. Klimovich, N. Medvedeva, V. Emanuel
Introduction. In severe cases of coronavirus disease 2019 (COVID-19) pulmonary infiltration is accompanied by cytokine storm syndrome (CSS) development. Besides COVID-19, CSS can be triggered by the range of pathologies, which include hemophagocytic lymphohistiocytosis (sHLH) and septic shock (SS). The aim of this study was to compare immunological profiles in fatal cases of COVID-19, sHLH and SS. Material and methods. Serum levels of IL-1β, IL-2, IL-6, IL-8, IL-10, IL-17A, IL-18, IFN-γ, TNF-α, procalcitonin, neopterin, ferritin with percent of glycosylated fraction (% GF) were measured in 37 COVID-19 fatal cases, collected during 2020 year prospectively;and in 39 sHLH and 47 SS fatal cases, collected within 2018–2019 years retrospectively. Comparison groups also included 194 non-fatal COVID-19 cases and 20 healthy donors, collected during 2020 year. Cytokine concentrations, procalcitonin and neopterin were measured by enzyme-linked immunosorbent assay;the ferritin level was determined by the turbidimetry method. The percent of glycosylated ferritin fraction (% GF) was calculated by the modified method of M. Worwood et al. Results. Deceased patients with COVID-19 had higher IL-6, IL-8, IL-10, IL-18, procalcitonin median levels compared to the survived. Meanwhile IL-8, IL-18, IFN-γ, TNFα and ferritin concentrations were significantly lower in deceased COVID-19 patients compared to sHLH and SS. The levels of IL-6 and procalcitonin in fatal COVID-19 were comparable to SS, but significantly higher than in sHLH. Leucocytes were higher in COVID-19 compared to both SS and sHLH. Conclusion. Each fatal condition was accompanied by specific features of the cytokine profile: high IL-6 combined with low IFN-γ, TNFα in COVID-19;high IL-8, IL-6 with low IL-17A, IL-2 in SS;high IL-18, ferritin, IFN-γ with low IL-6, procalcitonin, % GF in sHLH.
{"title":"Cytokine patterns of fatal hyperinflammatory conditions, caused by secondary hemophagocytic lymphohistiocytosis, bacterial sepsis and COVID-19","authors":"M. Pervakova, V. Potapenko, O. Tkachenko, E. Volchkova, O. Titova, S. Lapin, E. Surkova, T. Blinova, I. Kholopova, D. A. Kuznetsova, A. Moshnikova, A. Mazing, A. Kulikov, Y. Polushin, A. Afanasyev, I. Shlyk, E. Gavrilova, A. Klimovich, N. Medvedeva, V. Emanuel","doi":"10.33029/0206-4952-2022-43-2-174-187","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-2-174-187","url":null,"abstract":"Introduction. In severe cases of coronavirus disease 2019 (COVID-19) pulmonary infiltration is accompanied by cytokine storm syndrome (CSS) development. Besides COVID-19, CSS can be triggered by the range of pathologies, which include hemophagocytic lymphohistiocytosis (sHLH) and septic shock (SS). The aim of this study was to compare immunological profiles in fatal cases of COVID-19, sHLH and SS. Material and methods. Serum levels of IL-1β, IL-2, IL-6, IL-8, IL-10, IL-17A, IL-18, IFN-γ, TNF-α, procalcitonin, neopterin, ferritin with percent of glycosylated fraction (% GF) were measured in 37 COVID-19 fatal cases, collected during 2020 year prospectively;and in 39 sHLH and 47 SS fatal cases, collected within 2018–2019 years retrospectively. Comparison groups also included 194 non-fatal COVID-19 cases and 20 healthy donors, collected during 2020 year. Cytokine concentrations, procalcitonin and neopterin were measured by enzyme-linked immunosorbent assay;the ferritin level was determined by the turbidimetry method. The percent of glycosylated ferritin fraction (% GF) was calculated by the modified method of M. Worwood et al. Results. Deceased patients with COVID-19 had higher IL-6, IL-8, IL-10, IL-18, procalcitonin median levels compared to the survived. Meanwhile IL-8, IL-18, IFN-γ, TNFα and ferritin concentrations were significantly lower in deceased COVID-19 patients compared to sHLH and SS. The levels of IL-6 and procalcitonin in fatal COVID-19 were comparable to SS, but significantly higher than in sHLH. Leucocytes were higher in COVID-19 compared to both SS and sHLH. Conclusion. Each fatal condition was accompanied by specific features of the cytokine profile: high IL-6 combined with low IFN-γ, TNFα in COVID-19;high IL-8, IL-6 with low IL-17A, IL-2 in SS;high IL-18, ferritin, IFN-γ with low IL-6, procalcitonin, % GF in sHLH.","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69481585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33029/0206-4952-2021-42-6-78-88
Ye.N. Bogomyagkova, A. Solpov, Y. Vitkovskiy, P. Tereshkov
{"title":"The content of platelet coaggregates with αβ-, γδ-Т-lymphocytes and their some minor subpopulations in the blood of healthy children","authors":"Ye.N. Bogomyagkova, A. Solpov, Y. Vitkovskiy, P. Tereshkov","doi":"10.33029/0206-4952-2021-42-6-78-88","DOIUrl":"https://doi.org/10.33029/0206-4952-2021-42-6-78-88","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69481745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33029/0206-4952-2022-43-5-525-535
Ju.G. Philippova, M. Kuznetsova, Y. Shevchenko, V. Tereshchenko, M. Fisher, V. Kurilin, E. Pashkina, Y. Akahori, H. Shiku, S. Sennikov
{"title":"Phenotype and effector functions of GD2-specific CAR-T lymphocytes in vitro","authors":"Ju.G. Philippova, M. Kuznetsova, Y. Shevchenko, V. Tereshchenko, M. Fisher, V. Kurilin, E. Pashkina, Y. Akahori, H. Shiku, S. Sennikov","doi":"10.33029/0206-4952-2022-43-5-525-535","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-5-525-535","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69482284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33029/0206-4952-2022-43-3-343-351
G. Balasaniants, D. Ruzanov
{"title":"Immunotherapeutic role of interferon-γ at tuberculosis","authors":"G. Balasaniants, D. Ruzanov","doi":"10.33029/0206-4952-2022-43-3-343-351","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-3-343-351","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69482307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33029/0206-4952-2022-43-5-548-557
N. Murugina, V. Murugin, M. Pashenkov
{"title":"Antitumor activity of human macrophages activated by NOD1 and TLR4 receptor agonists in vitro","authors":"N. Murugina, V. Murugin, M. Pashenkov","doi":"10.33029/0206-4952-2022-43-5-548-557","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-5-548-557","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69482341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33029/0206-4952-2022-43-5-558-570
A. Donetskova, M. Nikonova, N. Sharova, V. Komogorova, M. Litvina, E. Grinko, B.V. Kireev, A.D. Donetskov, A. Mitin
{"title":"Differences in immune response of C57BL/6, В10.D2 (R101) and BALB/c mice to EL-4","authors":"A. Donetskova, M. Nikonova, N. Sharova, V. Komogorova, M. Litvina, E. Grinko, B.V. Kireev, A.D. Donetskov, A. Mitin","doi":"10.33029/0206-4952-2022-43-5-558-570","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-5-558-570","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69482345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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