{"title":"Evaluation of the efficacy of different adjuvants in producing murine monoclonal antibodies to the receptor-binding domain of the S-protein of SARS-CoV-2","authors":"T.A. Ivashchenko, Ya.O. Romanenko, M.A. Marin, A.S. Kartseva, M.V. Silkina, N.A. Zeninskaya, I.G. Shemyakin, V.V. Firstova","doi":"10.33029/1816-2134-2023-44-4-481-490","DOIUrl":"https://doi.org/10.33029/1816-2134-2023-44-4-481-490","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135699833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33029/0206-4952-2022-43-1-89-102
I. Nesterova, G. Chudilova, V. N. Chapurina, S. Kovaleva, V. Tarakanov, Yu. V. Teterin, L. Lomtatidze, A.I. Pirogova
{"title":"Differentiation of immunomodulatory effects of arginyl-alpha-aspartyl-lysyl-valyl-tyrosyl-arginine and glucosaminylmuramyldipeptide on effector functions and phenotype of functionally signifi cant subpopulations of neutrophilic granulocytes in an experimental model of viral-bacterial coinfection","authors":"I. Nesterova, G. Chudilova, V. N. Chapurina, S. Kovaleva, V. Tarakanov, Yu. V. Teterin, L. Lomtatidze, A.I. Pirogova","doi":"10.33029/0206-4952-2022-43-1-89-102","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-1-89-102","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69481525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33029/0206-4952-2022-43-2-149-156
V. A. Shmarov, M. Rykova, E. Antropova, O. Kutko, S. Shulgina, K. Orlova, E.A. Zhirova, A. Sadova, D. D. Vlasova, E. A. Lysenko, D. Kudlay, S. Ponomarev
{"title":"Indicators of human cellular immunity in conditions of artificial gravity creation using a short-arm centrifuge","authors":"V. A. Shmarov, M. Rykova, E. Antropova, O. Kutko, S. Shulgina, K. Orlova, E.A. Zhirova, A. Sadova, D. D. Vlasova, E. A. Lysenko, D. Kudlay, S. Ponomarev","doi":"10.33029/0206-4952-2022-43-2-149-156","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-2-149-156","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69481571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33029/0206-4952-2022-43-4-423-439
I. Shilovskiy, E. Barvinskaia, A. A. Nikolskii, A. Nikonova, V. Smirnov, V. Kovchina, L. Vishniakova, K. Yumashev, M.M. Kaganova, T.E. Rusak, A. Mitin, V. Komogorova, M. Litvina, N. Sharova, D. Kudlay, M. Khaitov
{"title":"Mouse model of respiratory syncytial virus infection mimicking acute human pathology","authors":"I. Shilovskiy, E. Barvinskaia, A. A. Nikolskii, A. Nikonova, V. Smirnov, V. Kovchina, L. Vishniakova, K. Yumashev, M.M. Kaganova, T.E. Rusak, A. Mitin, V. Komogorova, M. Litvina, N. Sharova, D. Kudlay, M. Khaitov","doi":"10.33029/0206-4952-2022-43-4-423-439","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-4-423-439","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69481933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33029/0206-4952-2022-43-6-722-736
A. Masyutina, N. Murugina, M. Pashenkov
{"title":"Studying of protein-DNA interactions in the cells of immune system using chromatin immunoprecipitation and chromatin immunocleavage","authors":"A. Masyutina, N. Murugina, M. Pashenkov","doi":"10.33029/0206-4952-2022-43-6-722-736","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-6-722-736","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69482866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33029/0206-4952-2022-43-3-245-254
A. N. Narovlyansky, F. Ershov, A. Sanin, A. Pronin
SARS-CoV-2 is the causative agent of COVID-19 and infects the respiratory tract, blood cells, gastrointestinal tract, kidneys, liver, heart, brain and other organs. The ability of SARS-CoV-2 to escape from immune surveillance leads to deregulation of the immune response, cytokine storm and extensive tissue damage to infected organs. It is assumed that the pathogenesis of the deterioration of the course of COVID-19 is much more complicated and one of the mechanisms for the escape of SARS-Cov-2 from the influence of innate immunity is the inhibition of signaling pathways for the production and action of interferon (IFN). This review summarizes the role of the IFN system in SARS-CoV-2 infection and discusses the sophisticated mechanisms that coronaviruses have developed over the course of evolution to evade immune surveillance and suppress IFN responses. The IFN-related issues of counteraction to SARS-Cov-2 infection and the IFN-dependent adverse course of COVID-19 is also discussed.
{"title":"Interferon system for COVID-19","authors":"A. N. Narovlyansky, F. Ershov, A. Sanin, A. Pronin","doi":"10.33029/0206-4952-2022-43-3-245-254","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-3-245-254","url":null,"abstract":"SARS-CoV-2 is the causative agent of COVID-19 and infects the respiratory tract, blood cells, gastrointestinal tract, kidneys, liver, heart, brain and other organs. The ability of SARS-CoV-2 to escape from immune surveillance leads to deregulation of the immune response, cytokine storm and extensive tissue damage to infected organs. It is assumed that the pathogenesis of the deterioration of the course of COVID-19 is much more complicated and one of the mechanisms for the escape of SARS-Cov-2 from the influence of innate immunity is the inhibition of signaling pathways for the production and action of interferon (IFN). This review summarizes the role of the IFN system in SARS-CoV-2 infection and discusses the sophisticated mechanisms that coronaviruses have developed over the course of evolution to evade immune surveillance and suppress IFN responses. The IFN-related issues of counteraction to SARS-Cov-2 infection and the IFN-dependent adverse course of COVID-19 is also discussed.","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69481713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33029/0206-4952-2022-43-3-255-265
E. Bystritskaya, N. Murashkin, A. I. Materikin, E. Naumova, O. Svitich
{"title":"Genome-wide DNA methylation profi le and expression of TLR2, TLR9, IL4, IL13 genes in pediatric patients with atopic dermatitis","authors":"E. Bystritskaya, N. Murashkin, A. I. Materikin, E. Naumova, O. Svitich","doi":"10.33029/0206-4952-2022-43-3-255-265","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-3-255-265","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69481718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33029/0206-4952-2022-43-1-33-43
S. Ivanova, I. Bulusheva, E. Latysheva, I. A. Manto, A. I. Nikiforova, A. A. Kazakova, T. Latysheva, M. Khaitov, I. Kofiadi
{"title":"New mutations in the BTK gene in Russian patients with X-linked agammaglobulinemia","authors":"S. Ivanova, I. Bulusheva, E. Latysheva, I. A. Manto, A. I. Nikiforova, A. A. Kazakova, T. Latysheva, M. Khaitov, I. Kofiadi","doi":"10.33029/0206-4952-2022-43-1-33-43","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-1-33-43","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69481912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33029/0206-4952-2022-43-4-401-411
V. Tereshchenko, M. Kuznetsova, Y. Shevchenko, M. Fisher, V. Kurilin, A. Alsalloum, Y. Akahori, H. Shiku, S. Sennikov
{"title":"Study of MAGE-A4 specific TCR-like CAR-T lymphocytes in vitro","authors":"V. Tereshchenko, M. Kuznetsova, Y. Shevchenko, M. Fisher, V. Kurilin, A. Alsalloum, Y. Akahori, H. Shiku, S. Sennikov","doi":"10.33029/0206-4952-2022-43-4-401-411","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-4-401-411","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69482383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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