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Time to death and its predictors among early neonatal patients in neonatal intensive care unit of Dessie referral hospital, South Wollo Zone, Northeast Ethiopia 埃塞俄比亚东北部南沃罗区Dessie转诊医院新生儿重症监护室早期新生儿患者的死亡时间及其预测因素
Pub Date : 2022-09-09 DOI: 10.15406/jpnc.2022.12.00471
Yonas Fissha Adem, Yosef Haile, Moges Milashu
Background: Early neonatal death is a serious concern, both in the developing and developed worlds. Early neonatal death remains a health problem and is the biggest component of the neonatal mortality rate. Therefore, substantial reduction in early neonatal mortality is a crucial pre-requisite for achieving further gains in child survival in the country. However, the distribution of deaths in the community within the first week is poorly understood. Therefore, this study was conducted to assess time to death and its predictors among early neonates in the neonatal intensive care unit of Dessie Referral Hospital. Method: A retrospective cohort study was conducted in the early neonatal patient in Dessie referral hospital on the total sample size of 416 selected patients by using a simple random sampling technique. Data were collected by document review. Life table used to estimate the probability of survival, log-rank test to compare survival in two or more groups and the Cox proportional hazard model was used to determine factors associated with time to death of early neonate. The hazard ratio with 95% confidence level was used to declare statistical significant association. Result: A total of 416 early neonates were included in the study. There were 224(53.8%) male neonates. The overall early neonatal mortalities were 47(11.3%), of which 23.41% of them died on the first day of age. early neonatal mortality was associated with neonatal sepsis (AHR=3.349,95% CI,1.842-6.089), low birth weight of neonates (AHR=3.563%,95% CI,1.925-6.595), unable to breastfeeding during delivery (AHR=4.094,95% CI,1.603-10.452), neonatal respiratory distress (AHR=4.018,95% CI,1.733-9.371), perinatal asphyxia (AHR =2.540,95% CI,1.186-5.847). Conclusion: The causes of early neonatal death described in this study were preventable. Managing low birth weight, initiating exclusive breastfeeding, refining quality of service, and confirming the continuity of care are recommended to increase the survival of neonates.
背景:无论是在发展中国家还是发达国家,新生儿早期死亡都是一个令人严重关切的问题。新生儿早期死亡仍然是一个健康问题,是新生儿死亡率的最大组成部分。因此,大幅降低早期新生儿死亡率是该国进一步提高儿童存活率的关键先决条件。然而,人们对第一周内社区内的死亡分布知之甚少。因此,本研究旨在评估Dessie转诊医院新生儿重症监护室早期新生儿的死亡时间及其预测因素。方法:采用简单随机抽样的方法,对Dessie转诊医院的早期新生儿患者进行回顾性队列研究,总样本量为416例。通过文献回顾收集资料。生命表用于估计生存概率,log-rank检验用于比较两组或两组以上的生存,Cox比例风险模型用于确定与早期新生儿死亡时间相关的因素。采用95%置信水平的风险比来宣布统计学上显著的相关性。结果:共纳入416例早期新生儿。男婴224例(53.8%)。新生儿早期总死亡率为47例(11.3%),其中23.41%在出生后第一天死亡。新生儿早期死亡率与新生儿败血症(AHR=3.349,95% CI,1.842-6.089)、新生儿低出生体重(AHR=3.563%,95% CI,1.925-6.595)、分娩时不能母乳喂养(AHR=4.094,95% CI,1.603-10.452)、新生儿呼吸窘迫(AHR=4.018,95% CI,1.733-9.371)、围产期窒息(AHR= 2.540,95% CI,1.186-5.847)相关。结论:本研究描述的早期新生儿死亡原因是可以预防的。建议管理低出生体重,开始纯母乳喂养,提高服务质量,并确认护理的连续性,以提高新生儿的存活率。
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引用次数: 0
Etiology, pathophysiology and management of reye’s syndrome 雷氏综合征的病因、病理生理及治疗
Pub Date : 2022-09-05 DOI: 10.15406/jpnc.2022.12.00469
Gudisa Bereda
Reye’s syndrome is defined as a fatal biphasic disorder that clinically described by preceding viral illness, protracted vomiting from one to two days before the onset of encephalopathy and liver dysfunction. Reye’s syndrome can be characterized as a constellation of delirium, fever, convulsions, vomiting, respiratory collapses, stupor, seizures, or coma typically following an earlier viral illness. Encephalopathy can be frequently progresses rapidly from lethargy to coma within twenty four to forty eight hrs. Both universal mitochondrial injury and triglyceride accumulations are the cornerstone etiology of Reye’s syndrome. Accumulation of high concentration of ammonia leads to encephalopathy and anicteric hepatitis with three times rise in liver enzymes. A frequent pathophysiological mechanism of Reye’s syndrome is induction of the mitochondrial permeability transition. The syndrome is correlated with a high mortality rate and the treatment is symptomatic including intensive care management with correction of metabolic abnormalities especially of hypotension, hypo glycaemia and acidosis, control of convulsions, and monitoring of intracranial hypertension due to cerebral edema. Agents to decrease serum ammonia concentrations are also usually used, the most frequent being are neomycin sulfate or lactulose. Anti-emetic such as ondansetron should be given to inhibit vomiting and potential aspiration.
雷氏综合征是一种致命的双相疾病,临床表现为先前的病毒性疾病、脑病发病前1至2天的持续性呕吐和肝功能障碍。雷氏综合征的特征可表现为谵妄、发热、抽搐、呕吐、呼吸系统衰竭、麻木、癫痫发作或昏迷等一系列症状,通常是早期病毒性疾病后的症状。脑病可在24至48小时内由昏睡迅速发展为昏迷。普遍线粒体损伤和甘油三酯积累是雷氏综合征的基础病因学。高浓度氨的积累导致脑病和无黄疸性肝炎,肝酶升高3倍。雷氏综合征常见的病理生理机制是诱导线粒体通透性转变。该综合征与高死亡率相关,治疗是对症的,包括重症监护管理,纠正代谢异常,特别是低血压、低血糖和酸中毒,控制抽搐,监测脑水肿引起的颅内高压。通常也使用降低血清氨浓度的药物,最常用的是硫酸新霉素或乳果糖。应给予昂丹司琼等止吐药以抑制呕吐和潜在的误吸。
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引用次数: 0
Pattern of admission and outcome of neonates admitted to neonatal intensive care unit of alobaid pediatrics teaching hospital-North Kordofan state, Sudan 苏丹北科尔多凡州alobaid儿科学教学医院新生儿重症监护病房新生儿入院模式和结局
Pub Date : 2022-08-17 DOI: 10.15406/jpnc.2022.12.00467
Abdelhakam GTamomh, Wafa Fadul, Atif Ahmed, Ahmed Ibn Edriss Mohamed
Background: Neonatal morbidity and mortality in our country is high; In order to improve neonatal outcome, it is crucial to identify the areas where health care can be improved. Therefore, studying the pattern of admission and outcome among neonates can be a valuable tool in auditing hospital performance. Materials and Methods: Descriptive cross sectional hospital based study. This study was covered all neonates fulfills case definition; admitted to NICU of Alobaid pediatric teaching hospital during the period from November 2020 to April. Results: the study show the pattern of admission and outcome among neonates with sample size of 750, most of them admitted at the first 24 hours of birth (94%), (70.8%) were term and almost the half of neonates had birth weight less than 2.5 kg (42.1%). The majority of the admitted neonates were delivered via caesarian-section (62.8%). Moreover, the most common cause of admission among them was prematurity and especially RDS (29%), neonatal sepsis (16.5%) and TTN (14%).About tow third of admitted neonates were discharge on good condition (70%) and the overall mortality was 152 neonates (20.4%). Additionally gestational age, maternal complication and antenatal care follow-up were found to be significantly associated with the neonatal outcome. Conclusion: prematurity, RDS and neonatal sepsis were most common cause of admission and death, all these etiologies are preventable up to some extent, and if detected earlier can be effectively treated in order to reduce morbidity and mortality. As (62.8%) of admitted neonates were delivered via caesarian-section, a revisit for the indications of cesarean deliveries may help to improve the neonatal outcome.
背景:我国新生儿发病率和死亡率高;为了改善新生儿的结局,关键是要确定可以改进保健的领域。因此,研究新生儿的入院模式和结局可以成为审计医院绩效的一个有价值的工具。材料与方法:描述性横断面医院研究。这项研究涵盖了所有符合病例定义的新生儿;于2020年11月至4月入住Alobaid儿科教学医院NICU。结果:本研究显示了750例新生儿的入院模式和结局,其中大多数在出生后24小时入院(94%),足月入院(70.8%),几乎一半的新生儿出生体重小于2.5 kg(42.1%)。入院新生儿以剖腹产为主(62.8%)。其中最常见的入院原因是早产,尤其是RDS(29%)、新生儿脓毒症(16.5%)和TTN(14%)。约三分之二的入院新生儿出院时状况良好(70%),总死亡率为152例(20.4%)。此外,发现胎龄、产妇并发症和产前护理随访与新生儿结局显著相关。结论:早产、RDS和新生儿脓毒症是最常见的入院和死亡原因,这些病因在一定程度上是可以预防的,如果及早发现,可以有效治疗,降低发病率和死亡率。由于(62.8%)入院的新生儿通过剖宫产分娩,重新审视剖宫产的指征可能有助于改善新生儿结局。
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引用次数: 0
Midas syndrome (microphthalmia syndrome and linear defects of the skin): case report 米达斯综合征(小眼综合征及皮肤线状缺损)1例
Pub Date : 2022-08-12 DOI: 10.15406/jpnc.2022.12.00466
Patricia Johane Ostia Garza, Moreno Alvarez Lucero Itzel, Reyes Miranda Elga Cristina, Guevara-Yáñez Roberto, Blanco Aguirre María Esther
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引用次数: 0
NSAIDS: Pain killers or kidney killers? 非甾体抗炎药:止痛药还是肾脏杀手?
Pub Date : 2022-08-05 DOI: 10.15406/jpnc.2022.12.00465
S. Gulati, Srishti Gulati, M.A.M. Ahmed, A. Sabhiki
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引用次数: 0
Pediatrics: pharmacokinetics and dose calculation 儿科学:药代动力学和剂量计算
Pub Date : 2022-07-18 DOI: 10.15406/jpnc.2022.12.00463
Gudisa Bereda 
The pediatrics has various pharmacodynamic, physiological and pharmacokinetic properties as well as growth rate in comparison with adults. Gastric pH is neutral at birth but falls to pH 1-3 within twenty four to forty eight hours after birth. At birth, the blood-brain barrier is still not fully mature and medicinal products perhaps obtain access to the central nervous system with sequence toxicity. Plasma protein attaching of compounds is dependent on the amount of present attaching proteins, the number of available binding sites, the affinity constant of the medicine for the protein(s), and the availability of pathophysiological conditions or endogenous compounds that perhaps change the medicine-protein attaching interaction. Total body water, explained as percentage of body weight, reduces with age, from comparatively 80% in newborns to 60% by 1 year of age. Reversibly, body fat accelerates with age, from one percent to two percent in a preterm neonate to ten percent to fifteen percent in a term neonate and 20 to 25% in a 1-year-old. First-pass metabolism of zidovudine was decrease in the first 14 days of life. At birth, renal blood flow is only 5 to 6% of cardiac output, 15 to 25% by one year of age and reaches adult values after two years of age. Children's dosage depends on factors such as their age and weight, their health status, their respiratory system, and the stage of development of their body systems for drugs metabolism (e.g., liver enzymes) and elimination (e.g., kidneys). Young’s rule can be applied quickly approach a situation in which the patients weight is unknown; this rule cannot be used for newborns and consideration must be made for growth variability in growth at any given age. A young’s rule for calculating the dose of medicine correct for a child by adding twelve to the child’s age, dividing the sum by the child’s age, then dividing the adult dose by the figure obtained, as it expressed beneath: (age in years / age (years) + 12)) × adult dose.
与成人相比,儿科具有不同的药效学、生理学和药代动力学特性以及生长速度。胃pH值在出生时为中性,但在出生后24至48小时内降至pH 1-3。出生时,血脑屏障尚未完全成熟,药物可能进入中枢神经系统,具有序列毒性。血浆蛋白对化合物的附着取决于目前附着蛋白的数量、可用结合位点的数量、药物对蛋白质的亲和力常数,以及可能改变药物-蛋白质附着相互作用的病理生理条件或内源性化合物的可用性。身体总水分(以体重百分比来解释)随着年龄的增长而减少,从新生儿的80%下降到1岁时的60%。可逆性地,体脂随着年龄的增长而加速,早产儿的体脂从1%增加到2%,足月新生儿的体脂从10%增加到15%,1岁婴儿的体脂从20%增加到25%。齐多夫定的首过代谢在出生后14天降低。出生时,肾血流量仅为心输出量的5 - 6%,一岁时为15 - 25%,两岁后达到成人水平。儿童的剂量取决于诸如他们的年龄和体重、他们的健康状况、他们的呼吸系统以及他们的身体系统的药物代谢(如肝酶)和消除(如肾脏)的发展阶段等因素。杨氏规则可以快速应用于患者体重未知的情况;这一规则不能用于新生儿,必须考虑到任何年龄的生长变化。一种计算儿童用药剂量的公式,方法是将儿童的年龄加上12,除以儿童的年龄,然后将成人剂量除以所得到的数字,如下所示:(年龄单位:岁/年龄(岁)+ 12)×成人剂量
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引用次数: 1
Sudanese children’s common skin diseases 苏丹儿童常见的皮肤病
Pub Date : 2022-07-11 DOI: 10.15406/jpnc.2022.12.00462
Mohammed Ahmed Ibrahim Ahmed, Sherin Awad Babiker Bala, Fatima Obied Ahmed Adeeel, Nahla Ahmed Mohammed Abdelrahman
Background: Skin diseases are a significant public health concern that affects a considerable percentage of children, causing discomfort and disabilities. Objective: The focus of this research was to determine the most frequent skin diseases among children in the Dermatology Department of the Tropical Disease Teaching Hospital. Methodology: This is a retrospective hospital-based research that took place from January to December 2021 at the Tropical Disease Teaching Hospital. Results: One hundred and eighty patients, ranging in age from one to eighteen years old, were included in this study, with males accounting for 60.7 % of the total (n=68). The overwhelming majority of the patients (90.2%, n=101) were from Khartoum state. In the majority of cases (92.9 % - n=104), the patients' residential situations were a risk factor; there was no crowd in their households, and 83.9 % (94) of the participants had no animals in their homes. In terms of water supply, 85.7 % (96) of the patients used tap water. The majority of patients (90.2 % - n=101) had no seasonality skin condition, and none of the patients have any chronic disorders, according to their clinical data. Skin diseases are prevalent among the patients. Throughout study, contagious skin disease affected more than half of the patients (57.1 %, n =64). Furthermore, fungal infection was found in 62.5 % (40) of patients. The great majority of patients (96.4 %, n=108) responded well to therapy. Conclusion: The sex distribution revealed a significant disparity between males and females, with females outweighing males. The majority of the patients were under the age of five. The preponderance of the incidents was linked to housing situations. There is no seasonal variation in the occurrence of illness. Skin disease was evident in more than half of the individuals. A statistical correlation was revealed between the type of skin condition and a family history of similar condition, as well as the duration of treatment.
背景:皮肤病是一个重大的公共卫生问题,影响到相当大比例的儿童,造成不适和残疾。目的:本研究的重点是确定热带病教学医院皮肤科儿童最常见的皮肤病。方法:这是一项基于医院的回顾性研究,于2021年1月至12月在热带病教学医院进行。结果:本研究纳入180例患者,年龄1 ~ 18岁,男性占60.7% (n=68)。绝大多数患者(90.2%,n=101)来自喀土穆州。在大多数病例中(92.9% - n=104),患者的居住环境是一个危险因素;他们的家庭中没有人群,83.9%(94)的参与者家中没有动物。供水方面,85.7%(96)的患者使用自来水。根据临床资料,大多数患者(90.2% - n=101)无季节性皮肤病,无任何慢性疾病。皮肤病在病人中很普遍。在整个研究过程中,超过一半的患者患有传染性皮肤病(57.1%,n =64)。此外,真菌感染发生率为62.5%(40例)。绝大多数患者(96.4%,n=108)对治疗反应良好。结论:性别分布男女差异明显,女性多于男性。大多数患者年龄在5岁以下。这些事件主要与住房情况有关。疾病的发生没有季节变化。超过一半的人有明显的皮肤病。皮肤状况的类型与类似情况的家族史以及治疗时间之间存在统计学相关性。
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引用次数: 0
Assessing essential new born care practice and associated factors in mothers who gave birth within the last 6 months in east badewacho woreda, hadiyya zone, Ethiopia 评估埃塞俄比亚hadiyya地区东badewacho wooreda过去6个月内分娩的母亲的基本新生儿护理实践和相关因素
Pub Date : 2022-07-01 DOI: 10.15406/jpnc.2022.12.00461
Mengistu Lodebo Funga, M. Thomas
Background: Every year, more than 2.7 million new-borns die before reaching neonatal age in the world, with the majority of these deaths occurring at home. Surprisingly, half of these occur within the first 24 hours of delivery, and 75% occur in the early neonatal period. One low-cost approach to improving new-born baby health outcomes is to promote essential new-born care practices. Objective: Thus, the purpose of this study was to evaluate essential new-born care practices and associated factors among mothers who gave birth within the last 6 months in East Badewacho woreda, Hadiyya zone. Methods: From March 1 to April 30, 2018, a community-based cross-sectional study was designed. The sampled population consisted of 399 mothers who had live births within the previous six months, as determined by a multistage random sampling technique. The data was collected using a semi-structured questionnaire and entered into Epi-data version 3.1 before being exported to SPSS version 21 for analysis. A binary logistic regression analysis with a 95% confidence interval was performed. Results: Less than half of the mothers (34.1 %) practice essential new-born care. The husband's educational status [AOR=0.24, CI (0.089, 0.64)] and [AOR=0.314, CI (0.126, 0.78)], place of delivery [AOR=0.024, CI (0.009, 0.068)] and knowledge of essential new-born care [AOR=2.03, CI (1.223,3.371)] were significant predictors of essential new-born care practice. Conclusion: The study's findings revealed that essential new-born care was not widely practiced in East Badewacho Woreda. As a result, strengthen the link between health centers and health posts in order to increase ANC, institutional delivery, and PNC service utilization.
背景:全世界每年有270多万新生儿在达到新生儿年龄之前死亡,其中大多数死亡发生在家中。令人惊讶的是,其中一半发生在分娩后24小时内,75%发生在新生儿早期。改善新生儿健康结果的一种低成本方法是促进基本的新生儿护理做法。目的:因此,本研究的目的是评估在Hadiyya地区East Badewacho woreda地区过去6个月内分娩的母亲的基本新生儿护理实践及其相关因素。方法:2018年3月1日至4月30日,设计基于社区的横断面研究。通过多阶段随机抽样技术确定的抽样人口包括399名在过去六个月内活产的母亲。使用半结构化问卷收集数据,输入Epi-data 3.1版本,然后导出到SPSS 21版本进行分析。采用二元logistic回归分析,置信区间为95%。结果:只有不到一半(34.1%)的母亲进行了新生儿基本护理。丈夫受教育程度[AOR=0.24, CI(0.089, 0.64)]、[AOR=0.314, CI(0.126, 0.78)]、分娩地点[AOR=0.024, CI(0.009, 0.068)]、新生儿基本护理知识[AOR=2.03, CI(1.223,3.371)]是新生儿基本护理实践的显著预测因子。结论:本研究结果表明,在东巴德瓦乔地区,新生儿基本护理并未得到广泛实施。因此,应加强保健中心和保健站之间的联系,以增加非医疗保健服务、机构服务和非医疗保健服务的利用。
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引用次数: 1
Risk of alcohol consumption during pregnancy on fetus 孕期饮酒对胎儿的影响
Pub Date : 2022-06-15 DOI: 10.15406/jpnc.2022.12.00460
Gudisa Bereda
Miscarriage, premature birth, stillbirth, low birth weight, and a range of lifelong disorders can caused by excessive alcohol consumption during pregnancy is called fetal alcohol spectrum disorders. Alcohol is the most hazardous teratogens which are substances that can detriment an advancing fetus. Every time a pregnant woman has a drink; her unborn child has only, too. Alcohol, like carbon monoxide from cigarettes, passes easily through the placenta from the mother's bloodstream into her baby's blood and puts her fetus at risk of having a fetal alcohol spectrum disorder. Drinking alcohol while pregnant can result in cognitive, social, and motor inadequacies and distinctive lifelong challenges. Usage of alcoholic beverages by pregnant women perhaps results in abortion, fetal mortality and prematurity. The intentions of this review is to teach the women about risk of alcohol consumption during pregnancy on their child and also on themselves and warn them to cease alcohol during pregnancy totally to safe their child from various defects and themselves from unexpected health challenges.
流产、早产、死产、低出生体重和一系列终身疾病可由怀孕期间过量饮酒引起,称为胎儿酒精谱系障碍。酒精是最危险的致畸物,这种物质会损害胎儿的发育。每次孕妇喝酒;她未出生的孩子也有。酒精,就像香烟中的一氧化碳一样,很容易从母亲的血液中通过胎盘进入胎儿的血液,使胎儿有患胎儿酒精谱系障碍的风险。怀孕期间饮酒会导致认知、社交和运动方面的缺陷,并可能带来终生的特殊挑战。孕妇饮用含酒精饮料可能导致流产、胎儿死亡和早产。这篇综述的目的是教育妇女在怀孕期间饮酒对她们的孩子和她们自己的风险,并警告她们在怀孕期间完全停止饮酒,以保护她们的孩子免受各种缺陷,并保护她们自己免受意想不到的健康挑战。
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引用次数: 0
Does pica potentiate autism?: developing a research agenda 异食癖会加剧自闭症吗?:制定研究议程
Pub Date : 2022-05-12 DOI: 10.15406/jpnc.2022.12.00459
Dean Alexander
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引用次数: 0
期刊
Journal of Pediatrics &amp; Neonatal Care
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