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Accelerated pulse oximetry in the neonate: a proposal 新生儿加速脉搏血氧测定:建议
Pub Date : 2020-02-12 DOI: 10.15406/jpnc.2020.10.00407
Julien IE Hoffman
Pulse oximetry is used as a screening test for critical congenital heart disease. Current algorithms involve one or to re-screenings for some patients. That may take 2-8 hours before a diagnosis is made. I propose that after the initial screen, patients who do not pass the test be given a short exposure to high oxygen concentration in order to eliminate lung disease as a cause of the desaturation.
脉搏血氧仪是一种用于筛查严重先天性心脏病的方法。目前的算法包括对一些患者进行一次或多次重新筛查。这可能需要2-8小时才能做出诊断。我建议在初步筛选后,对未通过测试的患者进行短时间的高氧暴露,以消除肺部疾病引起的去饱和。
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引用次数: 0
Primary torsion of epliplon major as a cause of acute abdomen 原发性大上颚扭转是引起急腹症的原因
Pub Date : 2020-01-28 DOI: 10.15406/jpnc.2020.10.00405
It presents the clinical case of a pediatric patient of 9 years old male, of urban origin who underwent surgery for acute abdomen box with preoperative diagnosis of complicated appendicitis, finding the findings transquirúrgicos a primary omental torsion greater, performed a case report and a review of existing literature.
本文报告一名9岁男性城市儿童患者,术前诊断为复杂阑尾炎,行急腹症手术,发现transquirúrgicos原发性大网膜扭转较大,并对现有文献进行了病例报告和复习。
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引用次数: 0
Prevalence of neonatal sepsis and associated factors amongst neonates admitted in arbaminch general hospital, arbaminch, southern Ethiopia, 2019 2019年埃塞俄比亚南部arbaminch arbaminch综合医院新生儿脓毒症患病率及相关因素
Pub Date : 2020-01-03 DOI: 10.15406/jpnc.2020.10.00404
Abdurhaman Mustefa, Amarch Abera, Asegedech Aseffa, Tsigereda Abathun, Nega, Degefa, H. Tadesse, Tomas Yeheyis
Background: There are an estimated 2.9 million deaths worldwide from sepsis every year (44% of them in children under 5 years of age) and one quarter of these are due to neonatal sepsis. According to global burden of neonatal sepsis about 6.9 million neonates were diagnosed with possible serious bacterial infection needing treatment from these 2.9 million cases of neonates needing treatment occur in sub-Saharan Africa. Method: An institution based cross sectional study with retrospective document review was conducted among neonates admitted to neonatal intensive care unit from December 2017 to December 2018 in arbaminch general hospital. Sample size was calculated by using single population proportion sample formula with a final sample size of 351. Data were collected a checklist. Using SPSS version 21 Binary and multiple logistic regressions have been used to observe the association between independent variables and dependent variable. Result: The magnitude of neonatal sepsis was 78.3%. APGAR<6,PROM> 18 hours and duration of labour>12 hours were positively associated with neonatal sepsis where as gestational age > 37 weeks and birth weight >2500 grams were protective factors as evidenced by statistical result of 2.33(0.205-0.33), 1.32(0.71-0.84), 1.20(0.70-0.95), 0.85(0.34-0.815) and 0.12(0.04-030) respectively. Conclusion and recommendation: The finding of this study shows that neonatal sepsis accounts the highest proportion cases amongst neonates admitted in the hospital. Gestational age, birth weight, APGAR score, PROM and duration of labour were found to be determinants of neonatal sepsis. Therefore, service utilization of mothers, early detection of risky situations and appropriate practice of newborn care can halt the problem.
背景:据估计,全世界每年有290万人死于败血症(其中44%为5岁以下儿童),其中四分之一是新生儿败血症。根据全球新生儿败血症负担,约690万新生儿被诊断为可能的严重细菌感染,需要治疗,其中290万例需要治疗的新生儿发生在撒哈拉以南非洲。方法:对2017年12月至2018年12月在阿巴因奇综合医院新生儿重症监护病房住院的新生儿进行回顾性研究。样本量采用单总体比例样本公式计算,最终样本量为351。数据收集清单。使用SPSS version 21二元和多元逻辑回归来观察自变量和因变量之间的关联。结果:新生儿败血症发生率为78.3%。APGAR 18小时、产程>12小时与新生儿脓毒症呈正相关,其中胎龄> 37周、出生体重>2500克是新生儿脓毒症的保护因素,统计结果分别为2.33(0.205 ~ 0.33)、1.32(0.71 ~ 0.84)、1.20(0.70 ~ 0.95)、0.85(0.34 ~ 0.815)、0.12(0.04 ~ 030)。结论和建议:本研究的发现表明,新生儿败血症占入院新生儿的比例最高。发现胎龄、出生体重、APGAR评分、胎膜早破和分娩时间是新生儿脓毒症的决定因素。因此,母亲的服务利用,早期发现危险情况和适当的新生儿护理做法可以制止这一问题。
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引用次数: 16
Evolution of cancer genomics and its clinical implications 癌症基因组学的进化及其临床意义
Pub Date : 2019-12-24 DOI: 10.15406/jpnc.2019.09.00402
M. Tawfique
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引用次数: 0
Unilateral pulmonary agenesis, with esophageal atresia long term results 单侧肺发育不全,长期伴有食管闭锁
Pub Date : 2019-12-14 DOI: 10.15406/jpnc.2020.10.00431
M. Elmetwally, Mohamed H Koura, M. Mahmoud, Madhavan P Nayar, Mohammed Jaffer Sajwani
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引用次数: 1
Non-invasive research in ovarian endometriosis 卵巢子宫内膜异位症的无创研究
Pub Date : 2019-12-03 DOI: 10.15406/jpnc.2019.09.00400
Askerov Aa, Satybaldieva Aj
The article presents the results of a study on noninvasive early diagnosis of the endometriosis ovarian cyst via ultrasound and on-markers CA-125. The effectiveness of using antimulyler hormone in predicting the reserve capacity of the ovary after surgical treatment of endometriosis cyst.
本文报道了超声和CA-125对子宫内膜异位症卵巢囊肿无创早期诊断的研究结果。应用抗米勒激素预测子宫内膜异位症囊肿手术治疗后卵巢储备能力的有效性。
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引用次数: 0
New therapeutic option for junctional ectopic tachycardia in infants following congenital heart surgery: ivabradine, a case report 新生儿先天性心脏手术后结性异位性心动过速的新治疗选择:伊伐布雷定
Pub Date : 2019-11-22 DOI: 10.15406/jpnc.2019.09.00399
Marianne Touma Boulos, S. Abou Jaoudé, Z. Saliba, Samah Fattah, S. Saadé, N. Hanna
Junctional ectopic tachycardia (JET) is the most common tachyarrhythmia that appears mostly during the immediate postoperative period of congenital heart surgery. Patients who develop JET have increased mortality and morbidity. Despite the availability of different antiarrhythmic treatments, management of JET is still challenging. We report a case of reversing of malignant JET following congenital heart surgery with the use of oral Ivabradine, after the failure of all the others treatment options of JET. Ivabradine is a drug used in adult practice to lower heart rate in heart failure and angina. Our case report may provide hope that Ivabradine may be a new therapeutic option for JET in infants following congenital heart surgery.
结缔性异位性心动过速(JET)是先天性心脏手术后最常见的速性心律失常。发生JET的患者死亡率和发病率增加。尽管有不同的抗心律失常治疗方法,但JET的管理仍然具有挑战性。我们报告一例在所有其他JET治疗方案失败后,在先天性心脏手术后使用口服伊伐布雷定逆转恶性JET的病例。伊伐布雷定是一种用于成人实践的药物,用于降低心力衰竭和心绞痛的心率。我们的病例报告可能为伊伐布雷定可能成为先天性心脏手术后婴儿JET的新治疗选择提供了希望。
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引用次数: 1
Subcutaneous fat necrosis in an extremely low birth weight infant 极低出生体重婴儿皮下脂肪坏死
Pub Date : 2019-11-01 DOI: 10.15406/jpnc.2019.09.00397
D. Bharti, I. Patel
We are reporting an infant delivered at 23 weeks of gestation who presented with subcutaneous fat necrosis (SCFN).
我们报告一例妊娠23周分娩的婴儿出现皮下脂肪坏死(SCFN)。
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引用次数: 0
Peritoneal dialysis after pediatric cardiac surgery: benefits and risks 小儿心脏手术后腹膜透析:益处和风险
Pub Date : 2019-10-16 DOI: 10.15406/jpnc.2019.09.00396
S. Saadé, N. Hanna, C. Mourani
Introduction: Neonates and infants having surgical repair for congenital heart disease are at risk of developing acute kidney injury (AKI). Our objectives were to determine surgeries most associated with AKI, to compare effect of peritoneal dialysis (PD) and conventional treatment, and to study the risk factors associated with PD mortality. Materials and methods: Records of Children who underwent cardiac surgery from November 2016 until December 2017 were reviewed. Clinical and biological effects of PD and conventional treatment were compared. In PD group, subgroups of survivors and non-survivors were compared to study risk factors for mortality associated with PD. We compared mortality between early and late PD (more than 24 hours after surgery). Results: 134 children were operated during the study period. 27 (20%) developed AKI and 9 of those (33%) received PD. Arterial switch was most associated with AKI (71.4%). PD had better effect in decreasing creatinine and blood urea nitrogen (BUN) levels after 48 hours treatment than conventional treatment (creatinine: 28.8±14.5 vs 7.5±12.1micromol/L, p=0.003) (BUN: 3.08±2.1 vs 0.91±1.5mmol/L, p=0.017). In PD group, survivors (n=5) had higher mean arterial pressure in the 6 hours prior to PD that non-survivors (n=4) (55.3±9.6 vs 40.0±3.6 mmHg, p=0.019). Survivors had also higher pH 24 hours after PD (7.37±0.03 vs 7.31±0.02, p=0.014), better creatinine variation (-3.6±5.8 vs 29.0±13.0micromol/L, p=0.02), and better diuresis improvement (4.4±3.2 vs 0.23±1.1ml/kg/h, p=0.039). There was no mortality difference between early and late PD. There were no major complications with PD. Conclusion: PD is safe for AKI after heart surgery. It has better outcome on BUN and creatinine levels. PD mortality is higher with low cardiac output, persistence of acidosis and absence of creatinine or diuresis improvement.
新生儿和接受先天性心脏病手术修复的婴儿有发生急性肾损伤(AKI)的风险。我们的目的是确定与AKI最相关的手术,比较腹膜透析(PD)和常规治疗的效果,并研究与PD死亡率相关的危险因素。材料和方法:回顾2016年11月至2017年12月接受心脏手术的儿童的记录。比较PD治疗与常规治疗的临床及生物学效果。在PD组中,将幸存者和非幸存者亚组进行比较,研究PD相关死亡率的危险因素。我们比较了早期和晚期PD(术后24小时以上)的死亡率。结果:研究期间共手术134例。27例(20%)发生AKI,其中9例(33%)接受PD治疗。动脉切换与AKI的相关性最高(71.4%)。PD治疗48h后肌酐和尿素氮(BUN)水平较常规治疗有较好的降低效果(肌酐:28.8±14.5 vs 7.5±12.1 μ mol/L, p=0.003) (BUN: 3.08±2.1 vs 0.91±1.5mmol/L, p=0.017)。PD组幸存者(n=5)在PD前6小时的平均动脉压高于非幸存者(n=4)(55.3±9.6 vs 40.0±3.6 mmHg, p=0.019)。幸存者PD后24小时pH值也较高(7.37±0.03 vs 7.31±0.02,p=0.014),肌酐变化较好(-3.6±5.8 vs 29.0±13.0微mol/L, p=0.02),利尿改善较好(4.4±3.2 vs 0.23±1.1ml/kg/h, p=0.039)。早期和晚期PD患者的死亡率没有差异。PD无重大并发症。结论:PD治疗心脏手术后AKI是安全的。对BUN和肌酐水平有较好的疗效。低心排血量、持续酸中毒和没有肌酐或利尿改善的PD死亡率较高。
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引用次数: 0
Gastric volvolus with wandering spleen and pancreatic torsion in a 5years old girl 1例5岁女童胃扭转伴脾和胰扭转
Pub Date : 2019-10-14 DOI: 10.15406/jpnc.2019.09.00395
D. Codrich, E. Guida, Scarpa Maria Grazia, F. Pederiva, D. Sanabor, J. Schleef
A five years old girl was taken to our emergency department with a history of few hours of acute abdominal pain in the upper quadrants and non biliary vomiting, followed by retching. The patient was afebrile, with a huge distended abdomen, without tenderness. The rest of the physical examination was unremarkable. A nasogastric tube was passed with some difficulty, a venous access was secured and blood tests were taken: WBC were 12.050U/uL, RCP was 8,8mg/L, pancreatic amylase were elevated at 430U/L. Serum electrolytes, liver and renal function, haemostasis were normal. An abdominal ultrasound (US) revealed a spleen localized in the right flank, below the liver and an abdominal computed tomography (CT) scan was performed (Figures 1-2). The exam showed a well vascularised spleen in the right flank below the liver, a dislocation to the right of the pancreatic tail and body and a huge distended stomach with a the nasogastric tube inside. The diagnosis was gastric volvolus associated with wandering spleen and pancreatic torsion. Fluid resuscitation and antibiotic therapy were started. The girl spontaneously lied on the left flank as her preferred decubitus and after a while the spleen was palpated not in the right flank but in mesogastrium. She was taken to the operatory theatre as soon as fluid resuscitation was secured an emergency and an open laparotomy was performed. A gastric mesenteroaxial volvolus was found associated to uncomplete torsion of the spleen and pancreatic tail. There were no legaments of fixation between spleen and stomach, nor between spleen and kidney, nor between spleen and abdominal wall. There were no signs of severe gastric ischemia. The stomach was derotated and the spleen restored to its normal position since the tissue was completely viable. An omental patch associated to splenopexy was performed to keep the spleen in place and a diaphragmatic and anterior gastropexy was performed. The recovery was uneventful, the amylases returned to normal values within two days and the girl was discharged on postoperative day 4th. At 24months the girl is asymptomatic and a follow-up ultrasound revealed a spleen and stomach in its normal position.
一名五岁女童因上腹数小时急性腹痛和非胆汁性呕吐被送往急诊科,随后出现干呕。病人发热,腹部大胀,无压痛。身体检查的其余部分都很普通。艰难地通过鼻胃管,确保静脉通路,并进行血液检查:WBC 12.050U/uL, RCP 8.8 mg/L,胰淀粉酶升高至430U/L。血清电解质、肝肾功能、止血功能正常。腹部超声(US)显示脾脏位于右侧肝脏下方,并进行腹部计算机断层扫描(CT)扫描(图1-2)。检查显示肝脏下方右侧血管通畅的脾脏,胰腺尾部和胰腺体右侧脱位,胃巨大膨胀,内有鼻胃管。诊断为胃扭转伴脾游离及胰扭转。开始液体复苏和抗生素治疗。女孩自发地躺在左侧,作为她的首选卧位,过了一会儿,脾被触诊不在右侧,而在肠系膜。在紧急情况下进行液体复苏并进行开腹手术后,她立即被送往手术室。胃肠系膜轴扭转与脾和胰尾不完全扭转有关。脾胃间、脾肾间、脾腹壁间无固定韧带。未见严重胃缺血的迹象。胃被旋转,脾脏被恢复到正常位置,因为组织是完全有活力的。网膜贴片与脾固定术相结合,以保持脾脏的位置,膈肌和胃前固定术。恢复顺利,淀粉酶在2天内恢复正常,术后第4天出院。24个月时,女婴无症状,后续超声检查显示脾脏和胃处于正常位置。
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引用次数: 0
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Journal of Pediatrics &amp; Neonatal Care
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