Pub Date : 2018-11-23DOI: 10.2174/1876526201810010046
Prokhorov, D. Kulminskiy, E. Borovkova, A. Karavaev, V. Ponomarenko, A. Kiselev, B. Bezruchko
We develop an autonomous mobile device for continuous monitoring of cardiovascular system functional state, which is based on the assessment of synchronization between the low-frequency oscillations in heart rate and blood flow having a basic frequency close to 0.1 Hz.
{"title":"Mobile Device for Monitoring of Cardiovascular System State Based on Assessment of Synchronization of its Low-Frequency Rhythms","authors":"Prokhorov, D. Kulminskiy, E. Borovkova, A. Karavaev, V. Ponomarenko, A. Kiselev, B. Bezruchko","doi":"10.2174/1876526201810010046","DOIUrl":"https://doi.org/10.2174/1876526201810010046","url":null,"abstract":"We develop an autonomous mobile device for continuous monitoring of cardiovascular system functional state, which is based on the assessment of synchronization between the low-frequency oscillations in heart rate and blood flow having a basic frequency close to 0.1 Hz.","PeriodicalId":38918,"journal":{"name":"Open Hypertension Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44927654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-11-15DOI: 10.2174/1876526201810010076
Elena Olivares-Álvaro, M. B. Ruiz-Roso, M. Klett-Mingo, S. Ballesteros, R. Gredilla, Adrian Galiana-Simal, N. Heras, V. Lahera, B. Martín-Fernández
Aldosterone plays a key role in the development of endothelial dysfunction and hypertension. The regulation of biogenesis and fusion/fission processes of vascular mitochondria has not been examined in aldosterone-induced hypertension. Thereby, we sought to explore in greater depth the role of aldosterone in mitochondrial biogenesis and fusion/fission processes in hypertension and the associated increases in oxidative stress.Male Wistar rats received aldosterone (1mg/Kg/day) + 1% NaCl as drinking water for 3 weeks.Systolic blood pressure was elevated (p<0.05) in aldosterone-treated rats. eNOS and p-eNOSSer1177protein expression was down regulated (p<0.05) and NADPH oxidase subunit p22phox expression was increased (p<0.05) in aldosterone-treated rats. Expression of mitochondrial biogenesis proteins SIRT1, PGC1α, PPARγ, and TFAM decreased (p<0.05) in aldosterone-treated rats. Protein expression of vascular DRP1, OMA1 and S-OPA1 up regulated (p<0.05) in aldosterone-treated rats. MFN1 and L-OPA1 (p<0.05) decreased in aldosterone-treated animals.The results showed that, in aldosterone-treated rats, hypertension is likely associated with increased oxidative stress in the aorta and with changes in the regulation of two key mitochondrial processes such as biogenesis and fusion/fission processes. The overall mitochondrial alterations observed in the study may play a role in aldosterone-derived vascular oxidative stress and hypertension.
{"title":"Regulation of Biogenesis and Fusion/Fission Processes of Vascular Mitochondria In Aldosterone-Induced Hypertension","authors":"Elena Olivares-Álvaro, M. B. Ruiz-Roso, M. Klett-Mingo, S. Ballesteros, R. Gredilla, Adrian Galiana-Simal, N. Heras, V. Lahera, B. Martín-Fernández","doi":"10.2174/1876526201810010076","DOIUrl":"https://doi.org/10.2174/1876526201810010076","url":null,"abstract":"Aldosterone plays a key role in the development of endothelial dysfunction and hypertension. The regulation of biogenesis and fusion/fission processes of vascular mitochondria has not been examined in aldosterone-induced hypertension. Thereby, we sought to explore in greater depth the role of aldosterone in mitochondrial biogenesis and fusion/fission processes in hypertension and the associated increases in oxidative stress.Male Wistar rats received aldosterone (1mg/Kg/day) + 1% NaCl as drinking water for 3 weeks.Systolic blood pressure was elevated (p<0.05) in aldosterone-treated rats. eNOS and p-eNOSSer1177protein expression was down regulated (p<0.05) and NADPH oxidase subunit p22phox expression was increased (p<0.05) in aldosterone-treated rats. Expression of mitochondrial biogenesis proteins SIRT1, PGC1α, PPARγ, and TFAM decreased (p<0.05) in aldosterone-treated rats. Protein expression of vascular DRP1, OMA1 and S-OPA1 up regulated (p<0.05) in aldosterone-treated rats. MFN1 and L-OPA1 (p<0.05) decreased in aldosterone-treated animals.The results showed that, in aldosterone-treated rats, hypertension is likely associated with increased oxidative stress in the aorta and with changes in the regulation of two key mitochondrial processes such as biogenesis and fusion/fission processes. The overall mitochondrial alterations observed in the study may play a role in aldosterone-derived vascular oxidative stress and hypertension.","PeriodicalId":38918,"journal":{"name":"Open Hypertension Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41751241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-23DOI: 10.2174/1876526201810010041
Stelina Alkagiet, K. Tziomalos
Suboptimal adherence to antihypertensive treatment is very common and is associated with poor control of blood pressure and increased risk for cardiovascular events. Therefore, frequent evaluation of compliance is essential in all hypertensive patients. Simplifying treatment regimens, using fixed-dose combinations and long-acting agents improves adherence, facilitates achievement of treatment targets and reduces cardiovascular morbidity and healthcare expenditures. Accordingly, physicians should be educated to implement these changes in hypertensive patients, particularly in those who require multiple antihypertensive agents to achieve blood pressure controls and in those who receive additional medications for comorbidities.
{"title":"Suboptimal Adherence to Antihypertensive Treatment: Causes and Management","authors":"Stelina Alkagiet, K. Tziomalos","doi":"10.2174/1876526201810010041","DOIUrl":"https://doi.org/10.2174/1876526201810010041","url":null,"abstract":"Suboptimal adherence to antihypertensive treatment is very common and is associated with poor control of blood pressure and increased risk for cardiovascular events. Therefore, frequent evaluation of compliance is essential in all hypertensive patients. Simplifying treatment regimens, using fixed-dose combinations and long-acting agents improves adherence, facilitates achievement of treatment targets and reduces cardiovascular morbidity and healthcare expenditures. Accordingly, physicians should be educated to implement these changes in hypertensive patients, particularly in those who require multiple antihypertensive agents to achieve blood pressure controls and in those who receive additional medications for comorbidities.","PeriodicalId":38918,"journal":{"name":"Open Hypertension Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45917670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-17DOI: 10.2174/1876526201810010028
B. Hornstrup, Jeppe B. Rosenbaek, N. Hoffmann-petersen, Pia H. Gjoerup, J. Wessels, T. G. Lauridsen, Erling B. Pedersen, J. Bech
Blunted nocturnal Blood Pressure (BP) decrease is seen in patients with hypertension and obstructive sleep apnoea (OSA). The influence of OSA and renal function on nocturnal BP decrease is not fully clarified.In this case control study of hypertensive patients and healthy controls, we aimed to analyse the relationship between nocturnal BP decrease on one hand and presence of OSA, renal function, plasma levels of syndecan and vasoactive hormones, and urinary sodium excretion on the other.In 75 hypertensive patients and 56 controls, we performed brachial and central 24h ambulatory BP measurement and cardio respiratory monitoring. We measured syndecan, renin, angiotensinII, aldosterone, vasopressin, and brain natriuretic peptide in plasma and 24h urinary excretion of sodium, aquaporin2, and a component of the epithelial sodium channel (u-ENaCγ).Nocturnal BP decrease was lower in patients than controls, brachial (13% versus 17%,p=0.001) and central (8% versus 10%,p=0.019). Moderate-to-severe OSA was present in 13% of patients, 2% of controls (p<0.005). Neither brachial nor central nocturnal BP decrease was associated with OSA, renal function, plasma levels of vasoactive hormones, syndecan-1, or urinary sodium excretion. P-syndecan and u-ENaCɣ were higher in patients than controls.Both brachial and central nocturnal BP decrease was lower in patients than in controls. Neither brachial nor central nocturnal BP decrease was associated with the presence of OSA, renal function, or plasma levels of vasoactive hormones. Increased syndecan in plasma in hypertensive patients suggested damage to the endothelial glycocalyx.
{"title":"Nocturnal Blood Pressure Decrease in Hypertensive Patients and Normotensives- Association with Obstructive Sleep Apnoea and Renal Function","authors":"B. Hornstrup, Jeppe B. Rosenbaek, N. Hoffmann-petersen, Pia H. Gjoerup, J. Wessels, T. G. Lauridsen, Erling B. Pedersen, J. Bech","doi":"10.2174/1876526201810010028","DOIUrl":"https://doi.org/10.2174/1876526201810010028","url":null,"abstract":"Blunted nocturnal Blood Pressure (BP) decrease is seen in patients with hypertension and obstructive sleep apnoea (OSA). The influence of OSA and renal function on nocturnal BP decrease is not fully clarified.In this case control study of hypertensive patients and healthy controls, we aimed to analyse the relationship between nocturnal BP decrease on one hand and presence of OSA, renal function, plasma levels of syndecan and vasoactive hormones, and urinary sodium excretion on the other.In 75 hypertensive patients and 56 controls, we performed brachial and central 24h ambulatory BP measurement and cardio respiratory monitoring. We measured syndecan, renin, angiotensinII, aldosterone, vasopressin, and brain natriuretic peptide in plasma and 24h urinary excretion of sodium, aquaporin2, and a component of the epithelial sodium channel (u-ENaCγ).Nocturnal BP decrease was lower in patients than controls, brachial (13% versus 17%,p=0.001) and central (8% versus 10%,p=0.019). Moderate-to-severe OSA was present in 13% of patients, 2% of controls (p<0.005). Neither brachial nor central nocturnal BP decrease was associated with OSA, renal function, plasma levels of vasoactive hormones, syndecan-1, or urinary sodium excretion. P-syndecan and u-ENaCɣ were higher in patients than controls.Both brachial and central nocturnal BP decrease was lower in patients than in controls. Neither brachial nor central nocturnal BP decrease was associated with the presence of OSA, renal function, or plasma levels of vasoactive hormones. Increased syndecan in plasma in hypertensive patients suggested damage to the endothelial glycocalyx.","PeriodicalId":38918,"journal":{"name":"Open Hypertension Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49327429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-28DOI: 10.2174/1876526201810010015
L. Bawazir, W. Sianipar
The high prevalence of hypertension in developing countries underlines the need for accurate data on the prevalence of adult hypertension, as well as patient characteristics and determinants of blood pressure control. As this information is currently not available, our aim was to collect such data from a population of patients in the Tegal Alur Administrative Village, West Jakarta Indonesia.We conducted a case-control study (n = 152) to identify determinants of hypertension and a cross-sectional study (n = 3842) to determine hypertension prevalence and investigate determinants of blood pressure control in hypertensive adults (≥18 years old).The cross-sectional design involved the diagnosis of hypertension via home visits (active detection) and routine clinical examinations at the Tegal Alur II Community Health Center (passive detection). In the case-control design, the groups were sex-matched.In 2017, the prevalence of hypertension in adults in Tegal Alur was 16.8% (n = 646), and the rate of uncontrolled hypertension was 89% (n = 572). A multivariate analysis showed that the adjusted prevalence ratio for comorbidities was 2.1 (95% confidence interval [CI]: 1.48–3.12;p= 0.005). A body mass index indicative of being overweight (≥23 kg/m2) had an odds ratio of 2.25 (95% CI: 1.14–4.44;p= 0.016).Comorbidities were the strongest predictor of uncontrolled blood pressure in hypertensive adults of Tegal Alur. Being overweight (BMI ≥23 kg/m2) was significantly associated with hypertension.
{"title":"Determinants of Blood Pressure Control and Prevalence of Hypertension in Adults in 2017: A Population-Based Study in West Jakarta","authors":"L. Bawazir, W. Sianipar","doi":"10.2174/1876526201810010015","DOIUrl":"https://doi.org/10.2174/1876526201810010015","url":null,"abstract":"The high prevalence of hypertension in developing countries underlines the need for accurate data on the prevalence of adult hypertension, as well as patient characteristics and determinants of blood pressure control. As this information is currently not available, our aim was to collect such data from a population of patients in the Tegal Alur Administrative Village, West Jakarta Indonesia.We conducted a case-control study (n = 152) to identify determinants of hypertension and a cross-sectional study (n = 3842) to determine hypertension prevalence and investigate determinants of blood pressure control in hypertensive adults (≥18 years old).The cross-sectional design involved the diagnosis of hypertension via home visits (active detection) and routine clinical examinations at the Tegal Alur II Community Health Center (passive detection). In the case-control design, the groups were sex-matched.In 2017, the prevalence of hypertension in adults in Tegal Alur was 16.8% (n = 646), and the rate of uncontrolled hypertension was 89% (n = 572). A multivariate analysis showed that the adjusted prevalence ratio for comorbidities was 2.1 (95% confidence interval [CI]: 1.48–3.12;p= 0.005). A body mass index indicative of being overweight (≥23 kg/m2) had an odds ratio of 2.25 (95% CI: 1.14–4.44;p= 0.016).Comorbidities were the strongest predictor of uncontrolled blood pressure in hypertensive adults of Tegal Alur. Being overweight (BMI ≥23 kg/m2) was significantly associated with hypertension.","PeriodicalId":38918,"journal":{"name":"Open Hypertension Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43126837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-03-30DOI: 10.2174/1876526201810010008
O. Gaisenok, S. Martsevich, M. Leonova
RESEARCH ARTICLE Features of the Lipid Profile in Patients with Arterial Hypertension and Cardiovascular Diseases According to Smoking Status Oleg V. Gaisenok, Sergey Yu. Martsevich and Marina V. Leonova Department of Cardiology, United Hospital with outpatient Department, Moscow, Russia Department of Preventive Pharmacotherapy, National Research Center for Preventive Medicine, Moscow, Russia Department of Clinical Pharmacology, Russian National Research Medical University N.I. Pirogov,Russia
{"title":"Features of the Lipid Profile in Patients with Arterial Hypertension and Cardiovascular Diseases According to Smoking Status","authors":"O. Gaisenok, S. Martsevich, M. Leonova","doi":"10.2174/1876526201810010008","DOIUrl":"https://doi.org/10.2174/1876526201810010008","url":null,"abstract":"RESEARCH ARTICLE Features of the Lipid Profile in Patients with Arterial Hypertension and Cardiovascular Diseases According to Smoking Status Oleg V. Gaisenok, Sergey Yu. Martsevich and Marina V. Leonova Department of Cardiology, United Hospital with outpatient Department, Moscow, Russia Department of Preventive Pharmacotherapy, National Research Center for Preventive Medicine, Moscow, Russia Department of Clinical Pharmacology, Russian National Research Medical University N.I. Pirogov,Russia","PeriodicalId":38918,"journal":{"name":"Open Hypertension Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44051154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-25DOI: 10.2174/1876526201810010001
G. Kisokanth, Ilankoon Imps, K. Arulanandem, Sundaresan Kt, Goonewardena Cse, J. Joseph
Department of Supplementary Health Sciences, Faculty of Health Care Sciences, Eastern University, Chenkaladi, Sri Lanka Department of Allied Health Sciences, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka Department of Primary Health Care, Faculty of Health Care Sciences, Eastern University, Chenkaladi, Sri Lanka Department of Clinical Sciences, Faculty of Health Care Sciences, Eastern University, Chenkaladi, Sri Lanka Department of Community Medicine, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka
{"title":"Perceptions, Attitudes and Self-care Practices on Management of Hypertension Among Hypertensive Patients at Teaching Hospital, Batticaloa District, Sri Lanka","authors":"G. Kisokanth, Ilankoon Imps, K. Arulanandem, Sundaresan Kt, Goonewardena Cse, J. Joseph","doi":"10.2174/1876526201810010001","DOIUrl":"https://doi.org/10.2174/1876526201810010001","url":null,"abstract":"Department of Supplementary Health Sciences, Faculty of Health Care Sciences, Eastern University, Chenkaladi, Sri Lanka Department of Allied Health Sciences, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka Department of Primary Health Care, Faculty of Health Care Sciences, Eastern University, Chenkaladi, Sri Lanka Department of Clinical Sciences, Faculty of Health Care Sciences, Eastern University, Chenkaladi, Sri Lanka Department of Community Medicine, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka","PeriodicalId":38918,"journal":{"name":"Open Hypertension Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47815352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-29DOI: 10.2174/1876526201709010016
V. Khorev, A. Karavaev, E. Lapsheva, T. A. Galushko, M. Prokhorov, A. Kiselev
Department of Dynamic Modeling and Biomedical Engineering, Saratov State University; 83, Astrakhanskaya str., Saratov, 410012, Russia Saratov Branch of the Institute of Radio Engineering and Electronics of Russian Academy of Sciences, 38, Zelyonaya str, Saratov; 410019, Russia Department of New Cardiological Informational Technologies, Research Institute of Cardiology, Saratov State Medical University n.a. V.I. Razumovsky; 112, Bolshaya Kazachya str, Saratov, 410012, Russia Department of Surgical Treatment for Interactive Pathology, Bakulev Scientific Center for Cardiovascular Surgery; 135, Rublevskoe Shosse, Moscow, 121552, Russia
{"title":"Estimation of Delay Times in Coupling Between Autonomic Regulatory Loops of Human Heart Rate and Blood Flow Using Phase Dynamics Analysis","authors":"V. Khorev, A. Karavaev, E. Lapsheva, T. A. Galushko, M. Prokhorov, A. Kiselev","doi":"10.2174/1876526201709010016","DOIUrl":"https://doi.org/10.2174/1876526201709010016","url":null,"abstract":"Department of Dynamic Modeling and Biomedical Engineering, Saratov State University; 83, Astrakhanskaya str., Saratov, 410012, Russia Saratov Branch of the Institute of Radio Engineering and Electronics of Russian Academy of Sciences, 38, Zelyonaya str, Saratov; 410019, Russia Department of New Cardiological Informational Technologies, Research Institute of Cardiology, Saratov State Medical University n.a. V.I. Razumovsky; 112, Bolshaya Kazachya str, Saratov, 410012, Russia Department of Surgical Treatment for Interactive Pathology, Bakulev Scientific Center for Cardiovascular Surgery; 135, Rublevskoe Shosse, Moscow, 121552, Russia","PeriodicalId":38918,"journal":{"name":"Open Hypertension Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44943684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-19DOI: 10.2174/1876526201709010006
O. Posnenkova, S. N. Gerasimov, Y. V. Popova, I. Popov, G. N. Shemetova, V. Gridnev, A. Kiselev
We analyzed the data on 182 patients with essential hypertension (64.6 ± 11.3 yo; 48.5% men), who were treated in polyclinic settings of a rural settlement in the Saratov Region of the Russian Federation. Outpatient medical records were used as a source of clinical data. Repeat patients with hypertension diagnosis specified in their medical records, visiting a therapeutist or cardiologist on two randomly selected workdays, were enrolled in our study. The first appointment took place during 1-31 July, 2015 (n = 88), while the second visit occurred on 131 July, 2016 (n = 94). Eleven district therapeutists, two general practitioners and the only cardiologist of the polyclinic participated in the study. Discriminant function analysis was used to identify factors affecting the achievement of the goal blood pressure in the patients. Basic demographic and anamnesis data, risk factors, medical treatment type and lifestyle modification measures, if any, which exhibited statistical significance in univariate analysis (p<0.05), were selected for multi-factor discriminant analysis.
{"title":"Clinical Factors Affecting the Goal Blood Pressure in Hypertensive Patients of a Rural Polyclinic in Russia","authors":"O. Posnenkova, S. N. Gerasimov, Y. V. Popova, I. Popov, G. N. Shemetova, V. Gridnev, A. Kiselev","doi":"10.2174/1876526201709010006","DOIUrl":"https://doi.org/10.2174/1876526201709010006","url":null,"abstract":"We analyzed the data on 182 patients with essential hypertension (64.6 ± 11.3 yo; 48.5% men), who were treated in polyclinic settings of a rural settlement in the Saratov Region of the Russian Federation. Outpatient medical records were used as a source of clinical data. Repeat patients with hypertension diagnosis specified in their medical records, visiting a therapeutist or cardiologist on two randomly selected workdays, were enrolled in our study. The first appointment took place during 1-31 July, 2015 (n = 88), while the second visit occurred on 131 July, 2016 (n = 94). Eleven district therapeutists, two general practitioners and the only cardiologist of the polyclinic participated in the study. Discriminant function analysis was used to identify factors affecting the achievement of the goal blood pressure in the patients. Basic demographic and anamnesis data, risk factors, medical treatment type and lifestyle modification measures, if any, which exhibited statistical significance in univariate analysis (p<0.05), were selected for multi-factor discriminant analysis.","PeriodicalId":38918,"journal":{"name":"Open Hypertension Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45066206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-28DOI: 10.2174/1876526201709010001
T. Griva, C. Boutari, K. Tziomalos, M. Doumas, A. Karagiannis, V. Athyros
Nonalcoholic fatty liver disease (NAFLD) is diagnosed when there is an accumulation of fat in the liver (>5%) in the absence of alcohol abuse or other chronic liver diseases (CLD) [1]. It is the most frequent cause of elevated liver enzyme levels worldwide [2]. NAFLD can progress to nonalcoholic steatohepatitis (NASH) with liver inflammation, fibrosis, cirrhosis or finally to hepatocellular cancer (HCC). However, cardiovascular disease (CVD) is the most frequent cause of death or disability in NASH patients [3].
{"title":"Arterial Stiffness and Nonalcoholic Fatty Liver Disease: Which is the Chicken and Which is the Egg?","authors":"T. Griva, C. Boutari, K. Tziomalos, M. Doumas, A. Karagiannis, V. Athyros","doi":"10.2174/1876526201709010001","DOIUrl":"https://doi.org/10.2174/1876526201709010001","url":null,"abstract":"Nonalcoholic fatty liver disease (NAFLD) is diagnosed when there is an accumulation of fat in the liver (>5%) in the absence of alcohol abuse or other chronic liver diseases (CLD) [1]. It is the most frequent cause of elevated liver enzyme levels worldwide [2]. NAFLD can progress to nonalcoholic steatohepatitis (NASH) with liver inflammation, fibrosis, cirrhosis or finally to hepatocellular cancer (HCC). However, cardiovascular disease (CVD) is the most frequent cause of death or disability in NASH patients [3].","PeriodicalId":38918,"journal":{"name":"Open Hypertension Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47674187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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