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Blood Pressure Measurement in Clinical Practice Methods and Emerging Options 血压测量在临床实践中的方法和新兴的选择
Q4 Medicine Pub Date : 2019-01-01 DOI: 10.15713/ins.johtn.0161
V. Rao
“Whatever the measurement system is, it needs to be consistent, repeatable, and as unbiased as possible” Pearl Zhu[1] William Harvey discovered circulation in 1628 and century elapsed before Reverend Stephen Hales performed his famous experiment in 1733, demonstrating the rise of blood to height of eight feet, three inches, in glass pipe placed in artery of Horse. It was not until non-invasive occluding arm cuff devised by Scipione Riva Rocci in 1896 that clinical measurement of blood pressure (BP) became reality. He inflated cuff, until it occluded pulse distal to cuff. This application of external counter pressure until the pulse disappeared by palpation corresponds to peak systolic BP (SBP). Quantification of counterpressure was done by connecting the inflatable bag to mercury manometer� In April 1905, Russian surgeon-Nikolai Sergeevich Korotkoff described the measurement of BP by auscultation-peak systolic pressure corresponding to onset of audible sounds by Stethoscope distal to occluding cuff and disappearance of sounds to end-diastolic pressure� Alternative methods of BP measurement, using oscillometry, applanation tonometry, volume clamp method, and analysis of various parameters of arterial pulse wave, have been utilized for noninvasive measurement of arterial BP� The evolution of methods of BP measurement continues and the latest technique of non-invasive measurement of BP using Android smartphone, is commercially available but not yet approved by regulating organizations and professional societies� Direct intra-arterial pressure measurement by cannulation of the vessel is gold standard, but it is not practical for routine clinical measurement of ambulatory patients, as it is invasive and requires technical skill and is associated, although rarely with potential major complications of occlusion of vessels and injury to adjacent structures� Thus, indirect non-invasive measurement of BP is currently clinical standard� Most of these methods base the measurement of pressure, indirectly by applying counter pressure to blood vessels or analyzing various components of pulse wave recorded indirectly by device/sensors applied to blood vessels, transcutaneously� Abstract
“无论测量系统是什么,它都需要是一致的,可重复的,尽可能公正的”珍珠珍珠威廉·哈维在1628年发现了循环,一个世纪之后,牧师斯蒂芬·黑尔斯在1733年进行了他著名的实验,证明了血液在放置在马动脉中的玻璃管中上升到8英尺3英寸的高度。直到1896年Scipione Riva Rocci发明了无创闭塞袖带,临床测量血压(BP)才成为现实。他给袖带充气,直到它阻塞了袖带远端的脉搏。这种应用外部反压直到脉搏通过触诊消失对应于收缩压峰值(SBP)。1905年4月,俄罗斯外科医生nikolai Sergeevich Korotkoff描述了通过听诊测量血压-收缩压峰值对应于听诊器在闭合袖带远端可听到的声音的开始和舒张末期声音的消失-血压测量的替代方法,使用振荡法,压平血压计,容积钳法,血压测量方法不断发展,最新的Android智能手机无创血压测量技术已商品化,但尚未得到监管机构和专业协会的批准。通过血管插管直接测量动脉内压是金标准。但它不适用于门诊患者的常规临床测量,因为它是侵入性的,需要技术技能,并且与血管闭塞和邻近结构损伤的潜在主要并发症相关,尽管很少。因此,间接无创测量血压是目前的临床标准。间接地通过对血管施加反压或分析经皮应用于血管的设备/传感器间接记录的脉搏波的各种成分
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引用次数: 2
Advocating Home Blood Pressure Monitoring in Improving Hypertension Control in the Philippines 在菲律宾提倡家庭血压监测以改善高血压控制
Q4 Medicine Pub Date : 2019-01-01 DOI: 10.15713/ins.johtn.0154
R. Oliva
High blood pressure (BP) is the most common modifiable cardiovascular risk factor worldwide. Guidelines have been formulated all over the world addressing the issue of hypertension; however, the control rates for hypertension remains discouraging, particularly in the Philippines. In the latest National Nutrition and Health Survey, the prevalence of hypertension in the Philippines is 22.3% and is highest in individuals more than 70 years old. The problem with the survey that measurement was based only on single measurements done in doctors’ clinics.[1] The use of conventional measurement of BP done in the office BP monitoring (OBPM) has been the norm in the diagnosis and management, but this method has downsides, particularly of white coat hypertension and masked hypertension, which are quite common for both untreated and treated hypertensives. The reliability of OBPM is questioned with issues such as the unstandardized setting and conditions of clinics, observer bias and errors, and the small number of readings. There is also a discordance in the measurements of OBPM compared to out-of-office BP (OBP) measurements which could have an effect on the “true underlying BP reading” of the individual.[2] Home BP monitoring (HBPM) refers to the measurement of BP at home, ideally by the individual. It is optimal when the patient is seated at rest at around the same time in the morning and evening, usually a period of 1 week.[2,3] The readings are recorded using a validated, automated BP device and are then conveyed to the physician for interpretation. This method is appealing to most patients and can lead to more awareness and control of their hypertension. HBPM allows standardization of conditions, leading to little measurement variability and reproducibility of readings. Home BP (HBP) measurements can easily identify patients with white coat, masked, and sustained hypertension. HBPM is also widely available and can provide day-to-day BP variability values.[3-5] Despite the several advantages of HBP measurements, it has yet to gain popularity in the Philippines due to the cost of the automated BP machines, lack of patient training, and the preferential use of OBP of physicians. Abstract
高血压(BP)是世界上最常见的可改变的心血管危险因素。世界各地都制定了解决高血压问题的指南;然而,高血压控制率仍然令人沮丧,特别是在菲律宾。在最新的全国营养和健康调查中,菲律宾的高血压患病率为22.3%,在70岁以上的人群中最高。这项调查的问题是,测量仅仅基于医生诊所的单一测量。[1]在办公室血压监测(OBPM)中使用传统的血压测量已经成为诊断和管理的标准,但这种方法有缺点,特别是白大衣高血压和隐匿性高血压,这在未经治疗和治疗的高血压患者中都很常见。OBPM的可靠性受到一些问题的质疑,如诊所的不标准化设置和条件,观察者的偏差和错误,以及读数少。与外出血压(OBP)测量值相比,OBPM测量值也存在不一致,这可能对个人的“真实潜在血压读数”产生影响。[2]家庭血压监测(HBPM)是指在家中测量血压,理想情况下由个人进行。患者在早晚大约同一时间坐着休息时最佳,通常为1周。[2,3]使用经过验证的自动BP设备记录读数,然后传送给医生进行解释。这种方法对大多数患者很有吸引力,可以提高他们对高血压的认识和控制。HBPM允许标准化的条件,导致很少的测量变异性和读数的可重复性。家庭血压(HBP)测量可以很容易地识别白大褂、蒙面和持续高血压的患者。HBPM也广泛可用,可以提供日常的血压变异性值。[3-5]尽管HBP测量有几个优点,但由于自动化BP机器的成本,缺乏患者培训以及医生优先使用OBP,它尚未在菲律宾普及。摘要
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引用次数: 0
Therapeutic Principles in Hypertension Management in Patients with Congestive Heart Failure and Coronary Artery Disease 充血性心力衰竭合并冠心病患者高血压的治疗原则
Q4 Medicine Pub Date : 2019-01-01 DOI: 10.15713/ins.johtn.0165
B. Sudhakar
Systemic hypertension (HTN) is the most common identifiable risk factor for the development of cardiovascular diseases (CVD). Epidemiological studies have shown strong association between elevated arterial blood pressure (BP) and the development of coronary artery disease (CAD), stroke cerebrovascular accident, renal failure, aortic dissection, peripheral arterial disease (PAD), and heart failure (HF)�[1] There is enough evidence to suggest that lowering BP has a significant impact on morbidity and mortality.[2] Out of all CV disorders, CAD and HF contribute to the majority of deaths. Thus, prevention, early detection, and control of HTN are of paramount importance. HTN is aptly classified as Stage A HF because of their strong association. Treatment of HTN in patients with HF must take into consideration the type of HF that is present: HF with reduced ejection fraction (HFrEF), in which systolic function is impaired; or HF with preserved ejection fraction (HFpEF), in which diastolic function is impaired but systolic function is preserved� Management guidelines are well established for HFrEF, but less certain for HFpEF� HF patients are nearly evenly divided between those with reduced left ventricular (LV) systolic function and those with preserved LV systolic function. Elderly hypertensives are more prone to HF� Any increase in BP above 120 mmHg systolic or 85 mmHg diastolic is associated with increased risk of developing CAD and eliminating this risk factor is a major concern of primary prevention�[3] Long-standing BP elevations promote endothelial injury, resulting in impaired nitric oxide (vasodilator) release and increased release of inflammatory mediators that promote the development of atherosclerosis and vascular occlusion. Uncontrolled HTN is also responsible for the occurrence of acute coronary events in patients with chronic stable angina�
全身性高血压(HTN)是心血管疾病(CVD)发展的最常见可识别的危险因素。流行病学研究表明,动脉血压(BP)升高与冠状动脉疾病(CAD)、脑卒中脑血管意外、肾功能衰竭、主动脉夹层、外周动脉疾病(PAD)和心力衰竭(HF)的发生有很强的相关性[1],有足够的证据表明,降低血压对发病率和死亡率有显著影响[2]。在所有心血管疾病中,冠心病和心衰是导致死亡的主要原因。因此,HTN的预防、早期发现和控制至关重要。HTN被恰当地归类为A期心衰,因为它们的相关性很强。HF患者的HTN治疗必须考虑到HF的类型:射血分数降低的HF (HFrEF),其中收缩功能受损;或保留射血分数(HFpEF)的HF,其中舒张功能受损但收缩功能保留。HFrEF的管理指南已经建立,但HFpEF的管理指南不太确定,HF患者几乎平均分为左室收缩功能降低的患者和左室收缩功能保留的患者。老年高血压患者更容易发生HF。收缩压高于120 mmHg或舒张压高于85 mmHg与冠心病发生风险增加有关,消除这一风险因素是一级预防的主要关注点。[3]长期血压升高会促进内皮损伤,导致一氧化氮(血管扩张剂)释放受损,炎症介质释放增加,从而促进动脉粥样硬化和血管闭塞的发展。不受控制的HTN也是慢性稳定型心绞痛患者发生急性冠状动脉事件的原因
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引用次数: 0
Resistant Hypertension: Overview 顽固性高血压:概述
Q4 Medicine Pub Date : 2019-01-01 DOI: 10.15713/ins.johtn.0147
K. Krishnakumar
• It is important to obtain accurate BP values before labeling as RH. Standard BP measurement protocols are required to segregate true RH from apparent RH. • To minimize measurement artifacts. • To get a BP value which represents true out-of-office BP. • BP has to be measured accurately in office setting by trained individuals to avoid problem of white-coat effect. • Automated office BP in which a series of BP measurements are made in office usually mimicks daytime recordings.[1] Optimal therapy
•在标记RH之前获得准确的BP值非常重要。需要标准的血压测量方案来区分真实RH和表观RH。•最小化测量工件。•获取一个BP值,该值代表真正的离线BP。•BP必须由经过培训的人员在办公室环境中准确测量,以避免白大褂效应的问题。•自动化办公室血压,在办公室进行一系列血压测量,通常模仿白天的记录。[1]最佳的治疗
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引用次数: 0
The Impact of the 2017 American College of Cardiology/American Heart Association and the 2018 European Society of Cardiology/European Society of Hypertension Guidelines on the Asian Population: Is it Time for Our Own Asian Hypertension Guidelines? 2017年美国心脏病学会/美国心脏协会和2018年欧洲心脏病学会/欧洲高血压学会指南对亚洲人群的影响:是时候制定我们自己的亚洲高血压指南了吗?
Q4 Medicine Pub Date : 2019-01-01 DOI: 10.15713/ins.johtn.0153
Arnold Benjamin C. Mina, Maria Vinny Defensor-Mina, D. Morales
Pioneer Faculty, Department of Internal Medicine, Adventist University of the Philippines-College of Medicine, Silang Cavite, Philippines, Consultant, Department of Medicine, Section of Cardiology, University of Perpetual Help Medical Center Heart and Vascular Institute, Biñan Laguna, Philippines, Department of Internal Medicine, Adventist University of the Philippines–College of Medicine, Silang Cavite, Philippines, Consultant in Rheumatology, University of Perpetual Help Medical Center Heart and Vascular Institute, Biñan Laguna, Philippines, Department of Medicine, Section of Cardiology, Faculty and Consultant, University of the Philippines College of Medicine, Philippine General Hospital, Manila Doctors Hospital, Philippines, Philippine College of Physicians, Philippine Heart Association, Philippine Society of Hypertension, Philippine Lipid and Atherosclerosis Society, Philippines
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引用次数: 0
A Closer Look at the Latest United States and European Pediatric Hypertension Guidelines and its Impact on Local Practice 最新的美国和欧洲儿童高血压指南及其对当地实践的影响
Q4 Medicine Pub Date : 2019-01-01 DOI: 10.15713/ins.johtn.0152
Lourdes Paula R. Resontoc, D. Bonzon
The tracking phenomenon of childhood hypertension (HTN) is widely recognized. Large population-based longitudinal studies showed that a hypertensive child would carry on to become a hypertensive adult.[1] Thus, early recognition and intervention while still at the pediatric age group will prevent these future adults from adding on to the burgeoning population of adult hypertensives at risk for devastating stroke, myocardial infarction, congestive heart failure, arrhythmia, and other cardiovascular events. Over the years, new clinical knowledge, breakthroughs, and scientific evidence have made it difficult for physicians to thresh out crucial medical information necessary for everyday clinical decisions. Hence, clinical guidelines were formulated to assist practitioners in making more consistent and efficient judgments at the bedside and outpatient clinics. Clinical practice guidelines have increasingly become a standard part of clinical practice. These systematically developed recommendations developed into influencing rules of operation at the clinics, hospitals, and even health directives of insurers and government policymakers to standardize practice and improve clinical outcomes. In the Philippines, there is no clinical practice guideline drafted for pediatric HTN. The American Academy of Pediatrics (AAP) and the European Society of HTN (ESH) guidelines have served as the references and the sole basis for the standard of care. From the time, the guideline updates were published Abstract
儿童高血压(HTN)的追踪现象已得到广泛认可。大型人群纵向研究表明,患有高血压的儿童在成年后会继续患有高血压因此,在儿童年龄组进行早期识别和干预,将防止这些未来的成年人加入到迅速增长的成年高血压人群中,面临毁灭性中风、心肌梗死、充血性心力衰竭、心律失常和其他心血管事件的风险。多年来,新的临床知识、突破和科学证据使得医生很难想出日常临床决策所必需的关键医学信息。因此,制定了临床指南,以帮助从业者在床边和门诊诊所做出更一致和有效的判断。临床实践指南日益成为临床实践的标准组成部分。这些系统发展的建议发展成为影响诊所,医院的操作规则,甚至是保险公司和政府决策者的健康指令,以规范实践并改善临床结果。在菲律宾,没有为儿科HTN起草临床实践指南。美国儿科学会(AAP)和欧洲儿科学会(ESH)的指导方针作为参考和护理标准的唯一基础。从那时起,指南更新发表摘要
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引用次数: 0
Hypertension as a Cause of Dementia 高血压是痴呆的一个原因
Q4 Medicine Pub Date : 2019-01-01 DOI: 10.15713/ins.johtn.0162
S. Kaul
Much attention has been paid to kidneys and heart as targets of end-organ damage due to hypertension� However, both large and small artery brain vasculature are probably more vulnerable to this end-organ damage� Many prospective studies have addressed the relationship between high blood pressure (BP) and memory decline. The overall impression does suggest that midlife hypertension has a strong association with late-life dementia of both vascular dementia (VaD) and Alzheimer’s disease (AD) type. The aim of this article is to review the available literature on the subject of hypertension as a cause of dementia�
由于高血压,肾脏和心脏作为终末器官损伤的目标受到了很多关注,然而,大动脉和小动脉的脑血管系统可能更容易受到终末器官损伤,许多前瞻性研究已经解决了高血压(BP)和记忆力下降之间的关系。总体印象确实表明中年高血压与血管性痴呆(VaD)和阿尔茨海默病(AD)型老年痴呆有很强的关联。这篇文章的目的是回顾现有的关于高血压作为痴呆的原因的文献
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引用次数: 0
Treatment of Hypertension in the Different Stages of Chronic Kidney Disease 慢性肾病不同分期高血压的治疗
Q4 Medicine Pub Date : 2019-01-01 DOI: 10.15713/ins.johtn.0158
A. Villanueva, Cheryl E. Flores-Riva, Josephine R. Valdez
Hypertension (HTN) is the chronic elevation of blood pressure (BP) sufficient to increase the risk of HTN-mediated organ damage and other related complications in the general population, particularly in the presence of comorbidities.[1-4] It is the level of BP at which the benefits of lifestyle interventions or medical therapy outweigh the risks of treatment.[5] In 2015, the global prevalence of hypertension (HTN) was estimated to be 1.13 billion.[6] There is around 30–45% of adults worldwide diagnosed with HTN. Majority of those diagnosed with elevated BP are males. This is consistent across different countries regardless of socioeconomic status.[7] The aging population, sedentary lifestyles, and obesity contribute to the rise of HTN cases globally, with an estimated increase in disease prevalence to close to 1.5 billion by 2025.[8]
高血压(HTN)是指血压(BP)的慢性升高,足以增加普通人群中HTN介导的器官损伤和其他相关并发症的风险,特别是在存在合并症的情况下。[1-4]在血压水平上,生活方式干预或药物治疗的益处大于治疗的风险。[5]2015年,全球高血压患病率(HTN)估计为11.3亿。[6]全世界约有30-45%的成年人被诊断患有HTN。大多数被诊断为血压升高的患者是男性。无论社会经济地位如何,这在不同的国家都是一致的。[7]人口老龄化、久坐不动的生活方式和肥胖导致全球HTN病例的增加,预计到2025年疾病患病率将增加近15亿。[8]
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引用次数: 0
Characteristics of Syrian and Lebanese Diabetes and Hypertension Patients in Lebanon 叙利亚和黎巴嫩糖尿病和高血压患者的特点
Q4 Medicine Pub Date : 2018-12-24 DOI: 10.2174/1876526201810010060
S. Doocy, E. Lyles, Zeina Fahed, Abdalla Mkanna, K. Kontunen, G. Burnham
Given the protracted nature of the crisis in Syria, the large caseload of Syrian refugee patients with non-communicable diseases, and the high costs of providing non-communicable disease care, implications for Lebanon’s health system are vast.To provide a profile of the health status of diabetes and hypertension patients enrolled in a longitudinal cohort study in Lebanon.A longitudinal cohort study was implemented from January 2015 through August 2016 to evaluate the effectiveness of treatment guidelines and an mHealth application on the quality of care and health outcomes for patients in primary health care facilities in Lebanon offering low-cost services serving both Syrian refugees and Lebanese host communities. This paper presents baseline characteristics of enrolled patients, providing an overall health status profile.Among participants, 11.5% of patients with hypertension and 9.7% of patients with diabetes were previously undiagnosed. Quality of care, measured as the proportion of patients with biometrics reported and whose condition is controlled, is less than ideal and varied by geographic location. Controlled blood pressure measurements were observed in 64.2% of patients with hypertension; HbA1C values indicated diabetes control in 43.5% of the patients.Differences in diagnostic history and disease control between Syrian and Lebanese patients and across geographic regions were observed, which could be applied to inform strategies aimed at improving diagnosis and quality of care for hypertension and diabetes in primary care settings in Lebanon.
鉴于叙利亚危机的长期性、叙利亚难民非传染性疾病患者的大量病例以及提供非传染性疾病护理的高昂费用,对黎巴嫩卫生系统的影响是巨大的。目的:提供黎巴嫩一项纵向队列研究中糖尿病和高血压患者的健康状况概况。2015年1月至2016年8月实施了一项纵向队列研究,以评估治疗指南和移动健康应用程序对黎巴嫩初级卫生保健设施患者的护理质量和健康结果的有效性,这些设施为叙利亚难民和黎巴嫩收容社区提供低成本服务。本文介绍了入组患者的基线特征,提供了整体健康状况概况。在参与者中,11.5%的高血压患者和9.7%的糖尿病患者以前未被诊断。以报告的具有生物特征且病情得到控制的患者比例来衡量的护理质量并不理想,而且因地理位置而异。64.2%的高血压患者有控制血压测量;HbA1C值表明43.5%的患者糖尿病得到控制。观察到叙利亚和黎巴嫩患者之间以及不同地理区域在诊断史和疾病控制方面的差异,这些差异可用于为旨在改善黎巴嫩初级保健机构对高血压和糖尿病的诊断和护理质量的战略提供信息。
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引用次数: 7
Treatment Assessment Among Hypertensive Patients of a Rural Polyclinic in Russia: The Results of Structured Questionnaire 俄罗斯农村综合医院高血压患者治疗评价:结构化问卷调查结果
Q4 Medicine Pub Date : 2018-11-30 DOI: 10.2174/1876526201810010052
O. Posnenkova, S. N. Gerasimov, Y. V. Popova, V. Gridnev, A. Kiselev
Information on treatment obtained from hypertensive patients could add the data of medical records and reveal the problems addressed to hypertensives’ attitudes and behavior. To evaluate patients’ knowledge on hypertension and treatment behavior at a rural polyclinic with the help of structured questionnaire. We interviewed 83 patients with essential hypertension (64.6±9.6 yo; 30% - men) who referred to a polyclinic of a rural settlement in the Saratov region of the Russia. Consecutive patients with hypertension diagnosis specified in their medical records, visiting a therapeutist or cardiologist on one randomly selected workday, were enrolled in our study. The appointment took place during 1-31 July 2015. Eleven district therapeutists, two general practitioners and the only cardiologist of the polyclinic participated in the study. Structured questionnaire for patients with elevated Blood Pressure (BP) proposed by S.N. Gerasimov et al. (2015) was used for interviewing. The questionnaire included 16 questions addressed to the following issues: Awareness of hypertension and risk factors, BP self-monitoring, non-pharmacological and pharmacological treatment, adherence to antihypertensive therapy, referrals to medical care. Ninety percent of respondents have known previously about BP elevation. Ninety four percent of patients had a tonometer at home. Eighty four percent of hypertensives measured their BP no rare than once a week, and fifty four percent did it every day. Eighty eight percent of study participants took antihypertensive drugs regularly. Only 36% of patients could be classified as adherent to therapy according to the Morisky-Green scale. Ninety two percent of respondents received one or more advices on lifestyle modification. Eighty two percent underwent diet counseling. Two-third of participants were advised to reduce their weight. About half of hypertensives were asked by the doctor to increase their physical activity. One-third of patients received smoking cessation advice, and the same part of enrollees received advice on alcohol consumption. The majority of patients (62.7%) were interested in organization of special follow-up program. With the help of structured questionnaire we revealed high frequency of BP self-measurement among visitors of rural polyclinic in Saratov region whereas the adherence to antihypertensive medication was low. We observed good level of knowledge on non-pharmacologic treatment interventions and revealed patients’ interest in special follow-up program. Such program should be addressed to the increase of patients’ adherence to treatment.
从高血压患者那里获得的治疗信息可以添加医疗记录的数据,并揭示高血压患者的态度和行为问题。采用结构化问卷对某农村综合医院患者的高血压知识和治疗行为进行评价。我们采访了83名原发性高血压患者(64.6±9.6 yo;30%为男性),他们转诊到俄罗斯萨拉托夫地区一个农村定居点的综合诊所。连续有病历中明确诊断为高血压的患者,在一个随机选择的工作日拜访了治疗师或心脏病专家,参与了我们的研究。任命于2015年7月1日至31日进行。11名地区治疗师、两名全科医生和综合诊所唯一的心脏病专家参与了这项研究。S.N.Gerasimov等人(2015)提出的针对血压升高患者的结构化问卷用于访谈。该问卷包括16个问题,涉及以下问题:对高血压和危险因素的认识、血压自我监测、非药物和药理学治疗、坚持降压治疗、转诊到医疗保健。90%的受访者以前都知道BP的提升。94%的患者家里有眼压计。84%的高血压患者每周至少测量一次血压,54%的高血压患者每天都这样做。88%的研究参与者定期服用抗高血压药物。根据Morisky Green量表,只有36%的患者可以被归类为坚持治疗。92%的受访者收到了一条或多条关于改变生活方式的建议。82%的人接受了饮食咨询。三分之二的参与者被建议减轻体重。医生要求大约一半的高血压患者增加体力活动。三分之一的患者接受了戒烟建议,同样一部分参与者接受了饮酒建议。大多数患者(62.7%)对组织特殊的随访计划感兴趣。在结构化问卷的帮助下,我们发现萨拉托夫地区农村综合诊所的来访者自我测量血压的频率很高,而对降压药物的依从性很低。我们观察到非药物治疗干预的知识水平很高,并揭示了患者对特殊随访计划的兴趣。此类方案应针对增加患者对治疗的依从性。
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引用次数: 0
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Open Hypertension Journal
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