Pub Date : 2022-12-05DOI: 10.1186/s13044-022-00140-6
Aqeeb Ur Rehman, Muhammad Ehsan, Haseeba Javed, Muhammad Zain Ameer, Aleenah Mohsin, Muhammad Aemaz Ur Rehman, Ahmad Nawaz, Zunaira Amjad, Fatima Ameer
Background: The debate on whether or not there is a difference in the incidence of thyroid cancer between the patients with Solitary thyroid Nodule (STN) and Multinodular Goiter (MNG) has been constantly present for the last few decades. With newer studies yielding mixed results, it was imperative to systematically compile all available literature on the topic.
Methods: PubMed/MEDLINE, Cochrane Central, ScienceDirect, GoogleScholar, International Clinical Trials registry, and reference lists of the included articles were systematically searched for article retrieval. No filter was applied in terms of time, study design, language or country of publication. Rigorous screening as per PRISMA guidelines was undertaken by 2 independent reviewers in order to identify the articles that were most relevant to the topic.
Results: Twenty-two studies spanning from 1992 to 2018 were included in this analysis and encompassed 50,321 patients, 44.2% of which belonged to the STN subgroup and 55.37% to the MNG subgroup. MNG was found to be associated with a significantly lower risk of thyroid cancer (OR = 0.76; 95% CI 0.61-0.96) when compared with STN. Papillary carcinoma was the most frequently occurring carcinoma across both groups, followed by follicular and medullary carcinomas. A subgroup analysis was performed to assess the efficacy of the two most commonly employed diagnostic tools i.e. surgery and fine needle aspiration cytology (FNAC), however it yielded nonsignificant results, indicating a comparable usefulness of the two. Another subgroup analysis run on the basis of the presumed iodine status of the participants also yielded nonsignificant results.
Conclusion: There is a higher incidence of thyroid cancer among patients of STN, however, given the low quality of existing evidence on the topic, it is crucial to conduct larger studies that can establish association with a greater precision.
背景:近几十年来，关于单发甲状腺结节(STN)和多结节性甲状腺肿(MNG)患者甲状腺癌发病率是否存在差异的争论一直存在。由于较新的研究产生了不同的结果，系统地汇编有关该主题的所有可用文献是必要的。方法:系统检索PubMed/MEDLINE、Cochrane Central、ScienceDirect、GoogleScholar、International Clinical Trials registry和纳入文章的参考文献列表，进行文章检索。没有在时间、研究设计、语言或出版国家方面进行筛选。2名独立审稿人根据PRISMA指南进行了严格的筛选，以确定与该主题最相关的文章。结果:该分析纳入了1992年至2018年的22项研究，共纳入50321例患者，其中44.2%属于STN亚组，55.37%属于MNG亚组。发现MNG与甲状腺癌风险显著降低相关(OR = 0.76;95% CI 0.61-0.96)。乳头状癌是两组中最常见的癌症，其次是滤泡癌和髓样癌。进行亚组分析以评估两种最常用的诊断工具(即手术和细针穿刺细胞学(FNAC))的疗效，但结果不显著，表明两者的有用性相当。另一个基于假定的参与者碘状态的亚组分析也产生了不显著的结果。结论:甲状腺癌在STN患者中发病率较高，但鉴于现有证据质量较低，开展更大规模的研究以更精确地建立相关性至关重要。
{"title":"Solitary and multiple thyroid nodules as predictors of malignancy: a systematic review and meta-analysis.","authors":"Aqeeb Ur Rehman, Muhammad Ehsan, Haseeba Javed, Muhammad Zain Ameer, Aleenah Mohsin, Muhammad Aemaz Ur Rehman, Ahmad Nawaz, Zunaira Amjad, Fatima Ameer","doi":"10.1186/s13044-022-00140-6","DOIUrl":"https://doi.org/10.1186/s13044-022-00140-6","url":null,"abstract":"<p><strong>Background: </strong>The debate on whether or not there is a difference in the incidence of thyroid cancer between the patients with Solitary thyroid Nodule (STN) and Multinodular Goiter (MNG) has been constantly present for the last few decades. With newer studies yielding mixed results, it was imperative to systematically compile all available literature on the topic.</p><p><strong>Methods: </strong>PubMed/MEDLINE, Cochrane Central, ScienceDirect, GoogleScholar, International Clinical Trials registry, and reference lists of the included articles were systematically searched for article retrieval. No filter was applied in terms of time, study design, language or country of publication. Rigorous screening as per PRISMA guidelines was undertaken by 2 independent reviewers in order to identify the articles that were most relevant to the topic.</p><p><strong>Results: </strong>Twenty-two studies spanning from 1992 to 2018 were included in this analysis and encompassed 50,321 patients, 44.2% of which belonged to the STN subgroup and 55.37% to the MNG subgroup. MNG was found to be associated with a significantly lower risk of thyroid cancer (OR = 0.76; 95% CI 0.61-0.96) when compared with STN. Papillary carcinoma was the most frequently occurring carcinoma across both groups, followed by follicular and medullary carcinomas. A subgroup analysis was performed to assess the efficacy of the two most commonly employed diagnostic tools i.e. surgery and fine needle aspiration cytology (FNAC), however it yielded nonsignificant results, indicating a comparable usefulness of the two. Another subgroup analysis run on the basis of the presumed iodine status of the participants also yielded nonsignificant results.</p><p><strong>Conclusion: </strong>There is a higher incidence of thyroid cancer among patients of STN, however, given the low quality of existing evidence on the topic, it is crucial to conduct larger studies that can establish association with a greater precision.</p>","PeriodicalId":39048,"journal":{"name":"Thyroid Research","volume":"15 1","pages":"22"},"PeriodicalIF":2.2,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9427926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-15DOI: 10.1186/s13044-022-00135-3
Bashar Bazkke, Joli Osman, Mohammad Shahrour, Mohammad Ziadeh, Aya Haji Mohamad, Mohamed Imad Eddin Mouhandes, Ammar Niazi
Background: Kikuchi-Fujimoto disease (KFD) is a benign, self-limiting disorder characterized by regional lymphadenopathy. Clinical symptoms range from mild fever and tenderness to upper respiratory syndrome. A few cases have been observed during pregnancy or Hashimoto's disease. What we describe here is the first observed case of KFD in a pregnant woman with a history of Hashimoto's thyroiditis.
Case presentation: A 36-year-old woman presented to Aleppo University Hospital during the 13th week of gestation with a painful cervical node on the right side of her neck. The patient's previous medical history confirmed Hashimoto's thyroiditis for several years. After histopathological examinations and radiological investigations, she was diagnosed with Kikuchi-Fujimoto disease and treated with corticosteroids. Although the patient did not adhere to the treatment very well due to her concerns for the fetus, the clinical picture improved after delivery. The patient now is on follow-up and continuing the current treatment with corticosteroids.
Conclusions: Further investigations need to be conducted to understand the possible autoimmune etiology of KFD when it is associated with Hashimoto's thyroiditis disease. It is also necessary to understand the relationship between this disease and pregnancy.
{"title":"A pregnant women with history of hashimoto's thyroiditis diagnosed with Kikuchi-Fujimoto disease: the first case report.","authors":"Bashar Bazkke, Joli Osman, Mohammad Shahrour, Mohammad Ziadeh, Aya Haji Mohamad, Mohamed Imad Eddin Mouhandes, Ammar Niazi","doi":"10.1186/s13044-022-00135-3","DOIUrl":"https://doi.org/10.1186/s13044-022-00135-3","url":null,"abstract":"<p><strong>Background: </strong>Kikuchi-Fujimoto disease (KFD) is a benign, self-limiting disorder characterized by regional lymphadenopathy. Clinical symptoms range from mild fever and tenderness to upper respiratory syndrome. A few cases have been observed during pregnancy or Hashimoto's disease. What we describe here is the first observed case of KFD in a pregnant woman with a history of Hashimoto's thyroiditis.</p><p><strong>Case presentation: </strong>A 36-year-old woman presented to Aleppo University Hospital during the 13<sup>th</sup> week of gestation with a painful cervical node on the right side of her neck. The patient's previous medical history confirmed Hashimoto's thyroiditis for several years. After histopathological examinations and radiological investigations, she was diagnosed with Kikuchi-Fujimoto disease and treated with corticosteroids. Although the patient did not adhere to the treatment very well due to her concerns for the fetus, the clinical picture improved after delivery. The patient now is on follow-up and continuing the current treatment with corticosteroids.</p><p><strong>Conclusions: </strong>Further investigations need to be conducted to understand the possible autoimmune etiology of KFD when it is associated with Hashimoto's thyroiditis disease. It is also necessary to understand the relationship between this disease and pregnancy.</p>","PeriodicalId":39048,"journal":{"name":"Thyroid Research","volume":"15 1","pages":"16"},"PeriodicalIF":2.2,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10874398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-22DOI: 10.1186/s13044-022-00129-1
{"title":"Meeting Abstracts from the 70<sup>th</sup> Annual British Thyroid Association Meeting : London, UK. 20<sup>th</sup> May 2022.","authors":"","doi":"10.1186/s13044-022-00129-1","DOIUrl":"https://doi.org/10.1186/s13044-022-00129-1","url":null,"abstract":"","PeriodicalId":39048,"journal":{"name":"Thyroid Research","volume":"15 Suppl 1","pages":"11"},"PeriodicalIF":2.2,"publicationDate":"2022-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40618365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-16DOI: 10.1186/s13044-022-00128-2
M. Borges-Canha, João Sérgio-Neves, Inês Albuquerque, J. Pacheco, M. Silva, A. Oliveira, D. Carvalho
{"title":"Virchow node of an unusual aetiology – the experience of a clinical case","authors":"M. Borges-Canha, João Sérgio-Neves, Inês Albuquerque, J. Pacheco, M. Silva, A. Oliveira, D. Carvalho","doi":"10.1186/s13044-022-00128-2","DOIUrl":"https://doi.org/10.1186/s13044-022-00128-2","url":null,"abstract":"","PeriodicalId":39048,"journal":{"name":"Thyroid Research","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2022-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48925648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-10DOI: 10.1186/s13044-022-00127-3
Mitsuru Ito, Sawako Takahashi, Mikiko Okazaki-Hada, M. Minakata, Kazuyoshi Kohsaka, Tomohiko Nakamura, Toshihiko Kasahara, Takumi Kudo, E. Nishihara, S. Fukata, M. Nishikawa, Takashi Akamiuzu, A. Miyauchi
{"title":"Proportion of serum thyroid hormone concentrations within the reference ranges in athyreotic patients on levothyroxine monotherapy: a retrospective study","authors":"Mitsuru Ito, Sawako Takahashi, Mikiko Okazaki-Hada, M. Minakata, Kazuyoshi Kohsaka, Tomohiko Nakamura, Toshihiko Kasahara, Takumi Kudo, E. Nishihara, S. Fukata, M. Nishikawa, Takashi Akamiuzu, A. Miyauchi","doi":"10.1186/s13044-022-00127-3","DOIUrl":"https://doi.org/10.1186/s13044-022-00127-3","url":null,"abstract":"","PeriodicalId":39048,"journal":{"name":"Thyroid Research","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2022-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46972958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-25DOI: 10.1186/s13044-022-00126-4
Joachim N. Nilsson, Rebecca Elovsson, D. Thor, J. Calissendorff, O. Ardenfors
{"title":"Radioiodine treatment outcome by dosimetric parameters and renal function in hyperthyroidism","authors":"Joachim N. Nilsson, Rebecca Elovsson, D. Thor, J. Calissendorff, O. Ardenfors","doi":"10.1186/s13044-022-00126-4","DOIUrl":"https://doi.org/10.1186/s13044-022-00126-4","url":null,"abstract":"","PeriodicalId":39048,"journal":{"name":"Thyroid Research","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2022-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49110622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-20DOI: 10.1186/s13044-022-00125-5
Chandani Patel Chavez, Maria del Mar Morales Hernandez, J. Kresak, W. Woodmansee
{"title":"Evaluation of multinodular goiter and primary hyperparathyroidism leads to a diagnosis of AL amyloidosis","authors":"Chandani Patel Chavez, Maria del Mar Morales Hernandez, J. Kresak, W. Woodmansee","doi":"10.1186/s13044-022-00125-5","DOIUrl":"https://doi.org/10.1186/s13044-022-00125-5","url":null,"abstract":"","PeriodicalId":39048,"journal":{"name":"Thyroid Research","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47556504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-29DOI: 10.1186/s13044-022-00124-6
Paula Michele da Silva Schmidt, A. Longoni, R. Pinheiro, A. Assis
{"title":"Postpartum depression in maternal thyroidal changes","authors":"Paula Michele da Silva Schmidt, A. Longoni, R. Pinheiro, A. Assis","doi":"10.1186/s13044-022-00124-6","DOIUrl":"https://doi.org/10.1186/s13044-022-00124-6","url":null,"abstract":"","PeriodicalId":39048,"journal":{"name":"Thyroid Research","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43347106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-19DOI: 10.1186/s13044-022-00123-7
Carl Kördel, A. Koman, R. Bränström, Adam Stenman
{"title":"Seasonal variation in calcium treatment after thyroidectomy as surrogate for post-operative hypocalcemia: a retrospective register-based national cohort study","authors":"Carl Kördel, A. Koman, R. Bränström, Adam Stenman","doi":"10.1186/s13044-022-00123-7","DOIUrl":"https://doi.org/10.1186/s13044-022-00123-7","url":null,"abstract":"","PeriodicalId":39048,"journal":{"name":"Thyroid Research","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2022-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47292810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-05DOI: 10.1186/s13044-022-00121-9
M. Burlacu, R. Attanasio, L. Hegedüs, E. Nagy, E. Papini, P. Perros, K. Sawadogo, M. Bex, B. Corvilain, C. Daumerie, B. Decallonne, D. Gruson, B. Lapauw, Rodrigo Moreno Reyes, P. Petrossians, K. Poppe, A. Van den Bruel, D. Unuane
{"title":"Use of thyroid hormones in hypothyroid and euthyroid patients: a THESIS* survey of Belgian specialists *THESIS: treatment of hypothyroidism in Europe by specialists: an international survey","authors":"M. Burlacu, R. Attanasio, L. Hegedüs, E. Nagy, E. Papini, P. Perros, K. Sawadogo, M. Bex, B. Corvilain, C. Daumerie, B. Decallonne, D. Gruson, B. Lapauw, Rodrigo Moreno Reyes, P. Petrossians, K. Poppe, A. Van den Bruel, D. Unuane","doi":"10.1186/s13044-022-00121-9","DOIUrl":"https://doi.org/10.1186/s13044-022-00121-9","url":null,"abstract":"","PeriodicalId":39048,"journal":{"name":"Thyroid Research","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2022-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49337741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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