Thyroid Research最新文献

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Meeting Abstracts from the 70^th Annual British Thyroid Association Meeting : London, UK. 20^th May 2022. 第70届英国甲状腺协会年会:伦敦，英国。2022年5月20日。

IF 2.2 Q3 ENDOCRINOLOGY & METABOLISM

Thyroid Research

Pub Date : 2022-07-22 DOI: 10.1186/s13044-022-00129-1

引用次数: 1

Virchow node of an unusual aetiology – the experience of a clinical case 一个不寻常的病因-临床病例的经验

IF 2.2 Q3 ENDOCRINOLOGY & METABOLISM

Thyroid Research

Pub Date : 2022-05-16 DOI: 10.1186/s13044-022-00128-2

M. Borges-Canha, João Sérgio-Neves, Inês Albuquerque, J. Pacheco, M. Silva, A. Oliveira, D. Carvalho

引用次数: 0

Proportion of serum thyroid hormone concentrations within the reference ranges in athyreotic patients on levothyroxine monotherapy: a retrospective study 左甲状腺素单药治疗的运动病患者血清甲状腺激素浓度在参考范围内的比例：一项回顾性研究

IF 2.2 Q3 ENDOCRINOLOGY & METABOLISM

Thyroid Research

Pub Date : 2022-05-10 DOI: 10.1186/s13044-022-00127-3

Mitsuru Ito, Sawako Takahashi, Mikiko Okazaki-Hada, M. Minakata, Kazuyoshi Kohsaka, Tomohiko Nakamura, Toshihiko Kasahara, Takumi Kudo, E. Nishihara, S. Fukata, M. Nishikawa, Takashi Akamiuzu, A. Miyauchi

引用次数: 3

Radioiodine treatment outcome by dosimetric parameters and renal function in hyperthyroidism 甲状腺机能亢进患者放射碘治疗的剂量学参数和肾功能

IF 2.2 Q3 ENDOCRINOLOGY & METABOLISM

Thyroid Research

Pub Date : 2022-04-25 DOI: 10.1186/s13044-022-00126-4

Joachim N. Nilsson, Rebecca Elovsson, D. Thor, J. Calissendorff, O. Ardenfors

引用次数: 1

Evaluation of multinodular goiter and primary hyperparathyroidism leads to a diagnosis of AL amyloidosis 评估多结节性甲状腺肿和原发性甲状旁腺功能亢进可诊断AL淀粉样变性

IF 2.2 Q3 ENDOCRINOLOGY & METABOLISM

Thyroid Research

Pub Date : 2022-04-20 DOI: 10.1186/s13044-022-00125-5

Chandani Patel Chavez, Maria del Mar Morales Hernandez, J. Kresak, W. Woodmansee

引用次数: 1

Postpartum depression in maternal thyroidal changes 产后抑郁症对产妇甲状腺功能的影响

IF 2.2 Q3 ENDOCRINOLOGY & METABOLISM

Thyroid Research

Pub Date : 2022-03-29 DOI: 10.1186/s13044-022-00124-6

Paula Michele da Silva Schmidt, A. Longoni, R. Pinheiro, A. Assis

引用次数: 2

Seasonal variation in calcium treatment after thyroidectomy as surrogate for post-operative hypocalcemia: a retrospective register-based national cohort study 甲状腺切除术后钙治疗替代术后低钙血症的季节性变化：一项基于注册的回顾性全国队列研究

IF 2.2 Q3 ENDOCRINOLOGY & METABOLISM

Thyroid Research

Pub Date : 2022-03-19 DOI: 10.1186/s13044-022-00123-7

Carl Kördel, A. Koman, R. Bränström, Adam Stenman

引用次数: 0

Use of thyroid hormones in hypothyroid and euthyroid patients: a THESIS* survey of Belgian specialists *THESIS: treatment of hypothyroidism in Europe by specialists: an international survey 甲状腺功能减退和甲状腺功能正常患者甲状腺激素的使用：比利时专家的THESIS*调查THESIS:欧洲专家对甲状腺功能减退的治疗：一项国际调查

IF 2.2 Q3 ENDOCRINOLOGY & METABOLISM

Thyroid Research

Pub Date : 2022-03-05 DOI: 10.1186/s13044-022-00121-9

M. Burlacu, R. Attanasio, L. Hegedüs, E. Nagy, E. Papini, P. Perros, K. Sawadogo, M. Bex, B. Corvilain, C. Daumerie, B. Decallonne, D. Gruson, B. Lapauw, Rodrigo Moreno Reyes, P. Petrossians, K. Poppe, A. Van den Bruel, D. Unuane

引用次数: 6

Is Hashimoto thyroiditis associated with increasing risk of thyroid malignancies? A systematic review and meta-analysis. 桥本甲状腺炎与甲状腺恶性肿瘤风险增加有关吗?系统回顾和荟萃分析。

IF 2.2 Q3 ENDOCRINOLOGY & METABOLISM

Thyroid Research

Pub Date : 2021-12-03 DOI: 10.1186/s13044-021-00117-x

Pouya Abbasgholizadeh, Amirreza Naseri, Ehsan Nasiri, Vahideh Sadra

Background and purpose: Hashimoto thyroiditis (HT) is the most common inflammatory autoimmune thyroid disease and also the most common cause of hypothyroidism in developed countries. There is evidence of the role of HT in developing thyroid cancers (TCs). This study investigated the association between HT and different types of TCs.

Methods: Results of a comprehensive search in three major databases, as well as hand searching, were screened in title/abstract and full-text stages and the relevant data were extracted from the studies that met the inclusion criteria. Risk of bias (RoB) was assessed using the Joanna Briggs Institute (JBI) critical appraisal tools and the meta-analysis was conducted with Comprehensive Meta-Analysis software.

Results: Out of 4785 records, 50 studies were included in the systematic review, and 27 of them met the criteria for quantitative synthesis. The results indicated a significant role for HT in developing papillary TC (OR: 1.65; 95% CI: 1.04 to 2.61), medullary TC (OR: 2.70; 95% CI: 1.20 to 6.07) and lymphoma (OR:12.92; 95% CI: 2.15 to 77.63); but not anaplastic TC (OR: 1.92; 95% CI: 0.29 to 1.90) and follicular TC (OR: 0.73; 95% CI: 0.41 to 1.27). Also, this study found a significant association between HT and thyroid malignancies (OR: 1.36; 95% CI: 1.05 to 1.77).

Conclusion: Although we found a significant association between HT and some types of TCs, High RoB studies, high level of heterogeneity, and the limited number of well-designed prospective studies, suggested the need for more studies to reach more reliable evidence.

背景与目的:桥本甲状腺炎(桥本甲状腺炎)是最常见的炎症性自身免疫性甲状腺疾病，也是发达国家甲状腺功能减退症最常见的病因。有证据表明激素在发展甲状腺癌(TCs)中的作用。本研究探讨了HT与不同类型tc之间的关系。方法:在标题/摘要和全文阶段对三大数据库的综合检索结果和人工检索结果进行筛选，并从符合纳入标准的研究中提取相关数据。采用乔安娜布里格斯研究所(JBI)关键评估工具评估偏倚风险(RoB)，采用综合元分析软件进行meta分析。结果:4785篇文献中，有50篇文献被纳入系统评价，其中27篇文献符合定量综合标准。结果表明，HT在乳头状TC的发生中有显著作用(OR: 1.65;95% CI: 1.04 ~ 2.61)，髓质TC (OR: 2.70;95% CI: 1.20 ~ 6.07)和淋巴瘤(OR:12.92;95% CI: 2.15 ~ 77.63);但未见间变性TC (OR: 1.92;95% CI: 0.29 ~ 1.90)和卵泡TC (OR: 0.73;95% CI: 0.41 ~ 1.27)。此外，本研究还发现HT与甲状腺恶性肿瘤之间存在显著关联(OR: 1.36;95% CI: 1.05 ~ 1.77)。结论:尽管我们发现HT与某些类型的tc之间存在显著关联，但高RoB研究、高异质性以及设计良好的前瞻性研究数量有限，表明需要更多的研究来获得更可靠的证据。

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引用次数: 16

Alginate-based 3D cell culture technique to evaluate the half-maximal inhibitory concentration: an in vitro model of anticancer drug study for anaplastic thyroid carcinoma. 基于海藻酸盐的三维细胞培养技术评估半最大抑制浓度:甲状腺间变性癌抗癌药物研究的体外模型。

IF 2.2 Q3 ENDOCRINOLOGY & METABOLISM

Thyroid Research

Pub Date : 2021-12-03 DOI: 10.1186/s13044-021-00118-w

Hilda Samimi, Alireza Naderi Sohi, Shiva Irani, Ehsan Arefian, Mojdeh Mahdiannasser, Parviz Fallah, Vahid Haghpanah

Background: Three-dimensional (3D) cell culture methods are identified for simulating the biological microenvironment and demonstrating more similarity to in vivo circumstances. Anaplastic thyroid carcinoma (ATC) is a lethal endocrine malignancy. Despite different treatment approaches, no improvement in the survival rate of the patients has been shown. In this study, we used the 3D in vitro ATC model to investigate the cytotoxic effect of BI-847325 anticancer drug in two-dimensional (2D)- and 3D- cultured cells.

Methods: Human ATC cell lines, C643 and SW1736, were cultured in one percentage (w/v) sodium alginate. Spheroids were incubated in medium for one week. The reproducibility of the fabrication of alginate beads was evaluated. Encapsulation of the cells in alginate was examined by DAPI (4^',6-diamidino-2-phenylindole) staining. Survival of alginate-encapsulated cells was evaluated by CFSE (5,6-Carboxyfluorescein N-hydroxysuccinimidyl ester) staining. The population doubling times of C643 and SW1736 cell lines cultured in 2D monolayer as well as in 3D system were calculated. The cytotoxic effect of BI-847325 on 2D- and 3D- cultured cell lines was assessed for 24-72 h by MTT [3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide] assay. Finally, the 3D culture results were compared with the 2D culture method.

Results: The half-maximal inhibitory concentration (IC₅₀) values of BI-847325 were higher in 3D culture compared to 2D culture. The cytotoxicity data indicated that 3D in vitro models were more resistant to chemotherapy agents.

Conclusions: The findings of this study are beneficial for developing in vitro ATC 3D models to analyze the efficacy of different chemotherapy drugs and formulations.

背景:三维(3D)细胞培养方法可以模拟生物微环境，并显示出与体内环境更多的相似性。甲状腺间变性癌(ATC)是一种致死性内分泌恶性肿瘤。尽管采用了不同的治疗方法，但没有显示出患者存活率的改善。本研究采用三维体外ATC模型，研究BI-847325抗癌药物对二维(2D)和三维培养细胞的细胞毒作用。方法:用1%海藻酸钠溶液培养人ATC细胞株C643和SW1736。球体在培养基中孵育一周。对制备藻酸盐微球的重现性进行了评价。DAPI(4′，6-二氨基-2-苯基吲哚)染色检测细胞在海藻酸盐中的包封情况。采用CFSE(5,6-羧基荧光素n -羟基琥珀酰亚胺酯)染色评价海藻酸盐包被细胞的存活率。计算C643和SW1736细胞系在二维单层和三维体系中培养的群体倍增率。采用MTT[3-(4,5-二甲基噻唑-2)-2,5-二苯基溴化四唑]测定BI-847325对2D和3D培养细胞系24-72 h的细胞毒作用。最后，将三维培养结果与二维培养方法进行比较。结果:BI-847325在3D培养中的半最大抑制浓度(IC50)值高于2D培养。细胞毒性数据显示3D体外模型对化疗药物的耐药性更强。结论:本研究结果有助于建立体外ATC三维模型，分析不同化疗药物和制剂的疗效。

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引用次数: 5

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