Pub Date : 2022-03-31DOI: 10.52794/hujpharm.1029943
Oya Unsal Tan, Mustafa Mert Sirim, S. K. Vagolu, Sriram Dharmarajan
{"title":"Design, Synthesis and Antimycobacterial Activity of 2-(Benzimidazol-2-yl)-propanenitrile Analogs","authors":"Oya Unsal Tan, Mustafa Mert Sirim, S. K. Vagolu, Sriram Dharmarajan","doi":"10.52794/hujpharm.1029943","DOIUrl":"https://doi.org/10.52794/hujpharm.1029943","url":null,"abstract":"","PeriodicalId":39138,"journal":{"name":"Hacettepe University Journal of the Faculty of Pharmacy","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80584015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-30DOI: 10.52794/hujpharm.1019625
Yurii Sameliuk, A. Kaplaushenko, Natalia Nedorezaniuk, Liusine Ostretsova, Feodosiia Di̇akova, B. Gutyj
The authors are not native speakers of Turkish The purpose of this literature review was to systematize data from studies of the biological activity of 1,2,4-triazole derivatives with substituents in positions 4 and 5. The authors set the task of forming an idea of current directions in the selection of substitutions for 1,2,4-triazole based on research. As a result of the study, 75 literature sources were analyzed. This made it possible to form a further vector in terms of searching for biologically active structures among 1,2,4-triazole derivatives. The review develops a modern approach to the search for biologically active substances among 1,2,4-triazole derivatives. Systematized data on the nature of substituents in the core of 1,2,4-triazole, which affect a specific type of activity. The search material was selected over the past decade with the highest number of citations at the time of literature analysis.
{"title":"Prospects for the search for new biologically active compounds among the derivatives of the heterocyclic system of 1,2,4-triazole.","authors":"Yurii Sameliuk, A. Kaplaushenko, Natalia Nedorezaniuk, Liusine Ostretsova, Feodosiia Di̇akova, B. Gutyj","doi":"10.52794/hujpharm.1019625","DOIUrl":"https://doi.org/10.52794/hujpharm.1019625","url":null,"abstract":"The authors are not native speakers of Turkish \u0000 \u0000The purpose of this literature review was to systematize data from studies of the biological activity of 1,2,4-triazole derivatives with substituents in positions 4 and 5. The authors set the task of forming an idea of current directions in the selection of substitutions for 1,2,4-triazole based on research. \u0000As a result of the study, 75 literature sources were analyzed. This made it possible to form a further vector in terms of searching for biologically active structures among 1,2,4-triazole derivatives. The review develops a modern approach to the search for biologically active substances among 1,2,4-triazole derivatives. Systematized data on the nature of substituents in the core of 1,2,4-triazole, which affect a specific type of activity. \u0000The search material was selected over the past decade with the highest number of citations at the time of literature analysis.","PeriodicalId":39138,"journal":{"name":"Hacettepe University Journal of the Faculty of Pharmacy","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87946033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-01DOI: 10.52794/hujpharm.1005810
Hülya Tezel, Aylin Balci, Pınar Erkekoğlu
{"title":"Melazma Tedavisinde Güncel Yaklaşımlar Ve Olası Toksik Etkileri","authors":"Hülya Tezel, Aylin Balci, Pınar Erkekoğlu","doi":"10.52794/hujpharm.1005810","DOIUrl":"https://doi.org/10.52794/hujpharm.1005810","url":null,"abstract":"","PeriodicalId":39138,"journal":{"name":"Hacettepe University Journal of the Faculty of Pharmacy","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73165503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-22DOI: 10.52794/hujpharm.1034938
Mehmet Fatih Eki̇ci̇, Alper Akcan, H. Akyildiz, Kemalettin Deni̇z, Recep Saraymen, Yücel Aritaş
{"title":"SIÇANLARDA TIKANMA SARILIĞINDA MELATONİN VE N-ASETİLSİSTEİNİN ETKİLERİ","authors":"Mehmet Fatih Eki̇ci̇, Alper Akcan, H. Akyildiz, Kemalettin Deni̇z, Recep Saraymen, Yücel Aritaş","doi":"10.52794/hujpharm.1034938","DOIUrl":"https://doi.org/10.52794/hujpharm.1034938","url":null,"abstract":"","PeriodicalId":39138,"journal":{"name":"Hacettepe University Journal of the Faculty of Pharmacy","volume":"231 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76108607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-08DOI: 10.52794/hujpharm.1033112
R. Shcherbyna, Yevhen S. Pruhlo, M. Duchenko, Mariia A. Kulagina, V. Kudria, Vashchuk Valentyna
{"title":"Evaluation Of Antioxidant Activity Of 1, 2, 4-Triazole Derivatives With Morpholine Moiety","authors":"R. Shcherbyna, Yevhen S. Pruhlo, M. Duchenko, Mariia A. Kulagina, V. Kudria, Vashchuk Valentyna","doi":"10.52794/hujpharm.1033112","DOIUrl":"https://doi.org/10.52794/hujpharm.1033112","url":null,"abstract":"","PeriodicalId":39138,"journal":{"name":"Hacettepe University Journal of the Faculty of Pharmacy","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90912801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-29DOI: 10.52794/hujpharm.1029049
Noon Kmai̇l, S. Shantier, E. Gadkariem
{"title":"Derivative Spectrophotometric Methods for the Analysis and Stability Studies of Ranolazine in Bulk and Dosage Forms","authors":"Noon Kmai̇l, S. Shantier, E. Gadkariem","doi":"10.52794/hujpharm.1029049","DOIUrl":"https://doi.org/10.52794/hujpharm.1029049","url":null,"abstract":"","PeriodicalId":39138,"journal":{"name":"Hacettepe University Journal of the Faculty of Pharmacy","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79289288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-27DOI: 10.52794/hujpharm.959879
Pelin İrem Sert, Zekiye Tuba TÜYLÜ KÜÇÜKKILINÇ
{"title":"Meme Kanseri Tedavisindeki Güncel Yaklaşımlar","authors":"Pelin İrem Sert, Zekiye Tuba TÜYLÜ KÜÇÜKKILINÇ","doi":"10.52794/hujpharm.959879","DOIUrl":"https://doi.org/10.52794/hujpharm.959879","url":null,"abstract":"","PeriodicalId":39138,"journal":{"name":"Hacettepe University Journal of the Faculty of Pharmacy","volume":"108 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87592564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-27DOI: 10.52794/hujpharm.1017182
A. Shrivastava
{"title":"Characteristics and Analytical Methods of Novel PDE5 Inhibitor Avanafil: An Update","authors":"A. Shrivastava","doi":"10.52794/hujpharm.1017182","DOIUrl":"https://doi.org/10.52794/hujpharm.1017182","url":null,"abstract":"","PeriodicalId":39138,"journal":{"name":"Hacettepe University Journal of the Faculty of Pharmacy","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74580586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-21DOI: 10.52794/hujpharm.1024991
A. Yesildag, İ. Ağirbaş, G. Yılmaz
Non-rational drug use harms both health and the economy. This study aims to evaluate the rational drug use awareness of undergraduate students studying in two faculties where future health professionals are trained. The study was carried out with 449 undergraduate students studying at Karadeniz Technical University (KTU) Faculty of Health Sciences and Faculty of Pharmacy. As a data collection tool, the “Consciousness Scale Towards Rational Drug Use (CRDU) in Adults” was developed by Aktas and Selvi. The descriptive information form consist - ing of 6 questions was used. SPSS 23 program was used for data analysis. Of the 449 students participating in the study, 193 (43%) are pursuing bachelor’s degrees in Nursing, 160 (35.6%) in Pharmacy, and 96 (21.4%) in Health Man - agement. It was determined that the student’s awareness of rational drug usage was x̃=4.19 / s=0.44. It is thought that the students participating in the study had a relatively good level of awareness of the study findings that discussed in the literature. However, in the correct drug awareness dimension, it is seen that there are inadequacies in the fact that the drug recommendations from non-physician health personnel can also be taken into account. It is recommended to carry out studies in which the attitude, awareness or knowledge level of rational drug use is measured through valid and reliable scales.
{"title":"Determination of the Rational Drug Use Awareness of University Students","authors":"A. Yesildag, İ. Ağirbaş, G. Yılmaz","doi":"10.52794/hujpharm.1024991","DOIUrl":"https://doi.org/10.52794/hujpharm.1024991","url":null,"abstract":"Non-rational drug use harms both health and the economy. This study aims to evaluate the rational drug use awareness of undergraduate students studying in two faculties where future health professionals are trained. The study was carried out with 449 undergraduate students studying at Karadeniz Technical University (KTU) Faculty of Health Sciences and Faculty of Pharmacy. As a data collection tool, the “Consciousness Scale Towards Rational Drug Use (CRDU) in Adults” was developed by Aktas and Selvi. The descriptive information form consist - ing of 6 questions was used. SPSS 23 program was used for data analysis. Of the 449 students participating in the study, 193 (43%) are pursuing bachelor’s degrees in Nursing, 160 (35.6%) in Pharmacy, and 96 (21.4%) in Health Man - agement. It was determined that the student’s awareness of rational drug usage was x̃=4.19 / s=0.44. It is thought that the students participating in the study had a relatively good level of awareness of the study findings that discussed in the literature. However, in the correct drug awareness dimension, it is seen that there are inadequacies in the fact that the drug recommendations from non-physician health personnel can also be taken into account. It is recommended to carry out studies in which the attitude, awareness or knowledge level of rational drug use is measured through valid and reliable scales.","PeriodicalId":39138,"journal":{"name":"Hacettepe University Journal of the Faculty of Pharmacy","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86511974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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