Shruthi S Hegde, K. Jasmine, Vidya Ajila, S. Babu, Supriya Bhat
Introduction: Developmental disturbances of teeth at the stage of morpho-differentiation have been related to abnormalities associated with changes in the tooth shape and size. Dens evaginatus and dens invaginatus are the developmental variations of the human dentition. Dens evaginatus, a rare anomaly characterized by the presence of a tubercle on the occlusal surface of teeth is seen to occur due to abnormal proliferation and folding of the inner enamel epithelium and part of the dental papilla into the stellate reticulum of the enamel organ; whereas, dens invaginatus is seen to occur due to infolding of the enamel and dentine into the pulp cavity and sometimes extending to the root apex. Case report: We report cases with bilateral dens evaginatus in mandibular second premolars and dens invaginatus in maxillary lateral incisor. Conclusion: Such developmental anomalies of teeth deserve clinical importance, as high chances of early pulpal pathosis.
{"title":"Dens evaginatus and dens invaginatus: A report of two cases","authors":"Shruthi S Hegde, K. Jasmine, Vidya Ajila, S. Babu, Supriya Bhat","doi":"10.5937/ASN2082091H","DOIUrl":"https://doi.org/10.5937/ASN2082091H","url":null,"abstract":"Introduction: Developmental disturbances of teeth at the stage of morpho-differentiation have been related to abnormalities associated with changes in the tooth shape and size. Dens evaginatus and dens invaginatus are the developmental variations of the human dentition. Dens evaginatus, a rare anomaly characterized by the presence of a tubercle on the occlusal surface of teeth is seen to occur due to abnormal proliferation and folding of the inner enamel epithelium and part of the dental papilla into the stellate reticulum of the enamel organ; whereas, dens invaginatus is seen to occur due to infolding of the enamel and dentine into the pulp cavity and sometimes extending to the root apex. Case report: We report cases with bilateral dens evaginatus in mandibular second premolars and dens invaginatus in maxillary lateral incisor. Conclusion: Such developmental anomalies of teeth deserve clinical importance, as high chances of early pulpal pathosis.","PeriodicalId":39229,"journal":{"name":"Acta Stomatologica Naissi","volume":"36 1","pages":"2091-2097"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71202062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Stojković, Marija Igić, Olivera Tričković-Janjić, M. Petrović, P. Janošević, M. Jovanovic, Ana Igić
1 UNIVERZITET U NIŠU, MEDICINSKI FAKULTET, KLINIKA ZA STOMATOLOGIJU, PREVENTIVNA I DEČJA STOMATOLOGIJA, NIŠ, SRBIJA 2 UNIVERZITET U NIŠU, MEDICINSKI FAKULTET, ORALNA MEDICINA I PARODNOTOLOGIJA, NIŠ, SRBIJA 3 UNIVERZITET U NIŠU, MEDICINSKI FAKULTET, KLINIKA ZA STOMATOLOGIJU, ORTOPEDIJA VILICA, NIŠ, SRBIJA 4 UNIVERZITET U NIŠU, MEDICINSKI FAKULTET, STOMATOLOŠKA PROTETIKA, NIŠ, SRBIJA 5 UNIVERZITET U NIŠU, MEDICINSKI FAKULTET, STUDENT DOKTORSKIH STUDIJA, NIŠ, SRBIJA
{"title":"Caries risk profile of preschool children in the City of Niš","authors":"B. Stojković, Marija Igić, Olivera Tričković-Janjić, M. Petrović, P. Janošević, M. Jovanovic, Ana Igić","doi":"10.5937/asn2081946s","DOIUrl":"https://doi.org/10.5937/asn2081946s","url":null,"abstract":"1 UNIVERZITET U NIŠU, MEDICINSKI FAKULTET, KLINIKA ZA STOMATOLOGIJU, PREVENTIVNA I DEČJA STOMATOLOGIJA, NIŠ, SRBIJA 2 UNIVERZITET U NIŠU, MEDICINSKI FAKULTET, ORALNA MEDICINA I PARODNOTOLOGIJA, NIŠ, SRBIJA 3 UNIVERZITET U NIŠU, MEDICINSKI FAKULTET, KLINIKA ZA STOMATOLOGIJU, ORTOPEDIJA VILICA, NIŠ, SRBIJA 4 UNIVERZITET U NIŠU, MEDICINSKI FAKULTET, STOMATOLOŠKA PROTETIKA, NIŠ, SRBIJA 5 UNIVERZITET U NIŠU, MEDICINSKI FAKULTET, STUDENT DOKTORSKIH STUDIJA, NIŠ, SRBIJA","PeriodicalId":39229,"journal":{"name":"Acta Stomatologica Naissi","volume":"36 1","pages":"1946-1956"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71201944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marija Bradić-Vasić, A. Pejčić, M. Kostić, I. Minić, R. Obradović, I. Stanković
Introduction: Some of the typical skin diseases, such as Pemphigus vulgaris, Pemphigoid mucosae oris, Erythema exudativum multiforme, Sclerodremia, Dermatitis herpetiformis-Duhring and Lichen planus, can cause swelling and irritation in mucous membranes of the oral cavity. Aim: The aim of the study was to precise diagnosis and treatment of oral Lichen planus manifestations. Methods: Analyzing the literature data and the experience of clinicians, the most common oral lichen planus manifestations were investigated. Results: This disease most commonly occurs in middle-aged patients (30-60 years) and is more common in women than in men. Oral Lichen planus is rarely seen in children. The disease presents in 0.5% to 2% of the population. Clinical history established the relation between oral Lichen planus and oral carcinoma, and therefore this disease should be considered a precancerous lesion. Conclusion: Dermatoses in the mouth are localized most often in the oral mucosa, both at the height of the occlusal line and in the mucous membrane of the retromolar area, but they can also occur in the mucous membranes of the tongue, the floor of the mouth and lips.
{"title":"Lichen planus: Oral manifestations, differential diagnosis and treatment","authors":"Marija Bradić-Vasić, A. Pejčić, M. Kostić, I. Minić, R. Obradović, I. Stanković","doi":"10.5937/asn2081980b","DOIUrl":"https://doi.org/10.5937/asn2081980b","url":null,"abstract":"Introduction: Some of the typical skin diseases, such as Pemphigus vulgaris, Pemphigoid mucosae oris, Erythema exudativum multiforme, Sclerodremia, Dermatitis herpetiformis-Duhring and Lichen planus, can cause swelling and irritation in mucous membranes of the oral cavity. Aim: The aim of the study was to precise diagnosis and treatment of oral Lichen planus manifestations. Methods: Analyzing the literature data and the experience of clinicians, the most common oral lichen planus manifestations were investigated. Results: This disease most commonly occurs in middle-aged patients (30-60 years) and is more common in women than in men. Oral Lichen planus is rarely seen in children. The disease presents in 0.5% to 2% of the population. Clinical history established the relation between oral Lichen planus and oral carcinoma, and therefore this disease should be considered a precancerous lesion. Conclusion: Dermatoses in the mouth are localized most often in the oral mucosa, both at the height of the occlusal line and in the mucous membrane of the retromolar area, but they can also occur in the mucous membranes of the tongue, the floor of the mouth and lips.","PeriodicalId":39229,"journal":{"name":"Acta Stomatologica Naissi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71201995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Pejčić, R. Obradović, Marija Bradić-Vasić, I. Minić, Džemil Kurtagić
Introduction: Recent studies have found that patients with periodontitis have greater risk of incurring fatal cardiovascular disease than patients without periodontitis. Emerging research has identified inflammation caused by periodontitis as significantly increasing the risk for ACS. Aim: The aim of this study was to investigate a periodontal status in the patients with ACS, and to assess the association of different periodontal parameters with ACS. Material and methods: In the first group, patients both with ACS and periodontitis were enrolled as cases. Patients were examined 3 days after ischemia. The second group consisted of patients who had only periodontitis. The control group consisted of healthy individuals. Periodontal parameters were measured and matched on the basis of demographic characteristics and assessed between the groups. The severity of periodontitis in both cases was analyzed. Results: Analysis of the periodontal parameters showed that median scores were higher in patients in the first and the second group compared to the third control group but significantly higher in group with ACS. Levels of inflammatory markers were highest in the first group, compared to the second group and the control group. Periodontal pathogens were more strongly present in patients with ACS than in the group with periodontitis, indicating that it was a serious illness in these patients. Conclusion: This study supports an association between periodontitis and ACS. Severe periodontitis is present in this patients indicating that periodontitis can further act on the development of ACS.
{"title":"Periodontal health and detection of periodontal bacteria in patients with acute coronary syndrome","authors":"A. Pejčić, R. Obradović, Marija Bradić-Vasić, I. Minić, Džemil Kurtagić","doi":"10.5937/ASN2082079P","DOIUrl":"https://doi.org/10.5937/ASN2082079P","url":null,"abstract":"Introduction: Recent studies have found that patients with periodontitis have greater risk of incurring fatal cardiovascular disease than patients without periodontitis. Emerging research has identified inflammation caused by periodontitis as significantly increasing the risk for ACS. Aim: The aim of this study was to investigate a periodontal status in the patients with ACS, and to assess the association of different periodontal parameters with ACS. Material and methods: In the first group, patients both with ACS and periodontitis were enrolled as cases. Patients were examined 3 days after ischemia. The second group consisted of patients who had only periodontitis. The control group consisted of healthy individuals. Periodontal parameters were measured and matched on the basis of demographic characteristics and assessed between the groups. The severity of periodontitis in both cases was analyzed. Results: Analysis of the periodontal parameters showed that median scores were higher in patients in the first and the second group compared to the third control group but significantly higher in group with ACS. Levels of inflammatory markers were highest in the first group, compared to the second group and the control group. Periodontal pathogens were more strongly present in patients with ACS than in the group with periodontitis, indicating that it was a serious illness in these patients. Conclusion: This study supports an association between periodontitis and ACS. Severe periodontitis is present in this patients indicating that periodontitis can further act on the development of ACS.","PeriodicalId":39229,"journal":{"name":"Acta Stomatologica Naissi","volume":"36 1","pages":"2079-2090"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71202055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N Predrag Janošević, Mirjana Janošević Lj., M. T. Perović, B. Stojković, M. Stojanović
Background: Imperfect smile and face profile is one of the main reasons why patients turn to orthodontists. Aim was to investigate if there is a difference in perception of smile and profile esthetics between the examined groups. Subjects and method: In conducted research, smiles of 21 persons (8 male and 13 female), 18 to 30 years old were evaluated by 15 orthodontists, 15 students of dentistry and 15 laypeople. They were to rate esthetics of every smile from 1 to 9 and choose just one main reason that impairs aesthetics. Orthodontists and laypeople should also evaluate male and female normal, bimaxillary prognathic and bimaxillary retrognathic profiles from 1 to 3. The most beautiful profile should be marked with number 3. Results: Although there was no statistically significant difference in the evaluation of smile esthetics among groups, laypeople gave the lowest evaluation. Apart from irregular position of certain teeth, all investigated groups emphasized different factors that impair smile esthetics. Orthodontists and laypeople marked bimaxillary prognathic male and female profile as less beautiful than the others. Conclusion: Because of the differences in perception of the smile aesthetics between orthodontists and laypeople, it is necessary to create a new diagnostic plan of treatment protocols that includes studies investigating laypeople perception of smile and facial esthetics.
{"title":"Assessment of smile esthetics and various types of face profiles","authors":"N Predrag Janošević, Mirjana Janošević Lj., M. T. Perović, B. Stojković, M. Stojanović","doi":"10.5937/asn2081957j","DOIUrl":"https://doi.org/10.5937/asn2081957j","url":null,"abstract":"Background: Imperfect smile and face profile is one of the main reasons why patients turn to orthodontists. Aim was to investigate if there is a difference in perception of smile and profile esthetics between the examined groups. Subjects and method: In conducted research, smiles of 21 persons (8 male and 13 female), 18 to 30 years old were evaluated by 15 orthodontists, 15 students of dentistry and 15 laypeople. They were to rate esthetics of every smile from 1 to 9 and choose just one main reason that impairs aesthetics. Orthodontists and laypeople should also evaluate male and female normal, bimaxillary prognathic and bimaxillary retrognathic profiles from 1 to 3. The most beautiful profile should be marked with number 3. Results: Although there was no statistically significant difference in the evaluation of smile esthetics among groups, laypeople gave the lowest evaluation. Apart from irregular position of certain teeth, all investigated groups emphasized different factors that impair smile esthetics. Orthodontists and laypeople marked bimaxillary prognathic male and female profile as less beautiful than the others. Conclusion: Because of the differences in perception of the smile aesthetics between orthodontists and laypeople, it is necessary to create a new diagnostic plan of treatment protocols that includes studies investigating laypeople perception of smile and facial esthetics.","PeriodicalId":39229,"journal":{"name":"Acta Stomatologica Naissi","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71201955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Uvod: Briga o pacijentima, poznavanje medicinskog prava i usklađenost sa zakonom doprinose efikasnijem rešavanju etičkih dilema, sa kojima se stomatolozi danas često susreću. Pored toga, u određivanju "najboljeg" stomatološkog tretmana, izvesnu ulogu imaju i pacijenti. Cilj istraživanja bilo je ispitivanje stavova stomatologa u Srbiji u vezi etičkih dilema u svakodnevnoj praksi, kako bi se utvrdili faktori koji utiču na njihovo rešavanje. Materijali i metode: Rad je realizovan kao studija preseka. Istraživanje je obuhvatilo 88 ispitanika, 42 apsolventa stomatologije Medicinskog fakulteta u Nišu i Stomatološkog fakulteta u Beogradu i 46 stomatologa iz privatne i državne prakse. Prvi deo upitnika obuhvatio je socio-demografske karakteristike ispitanika, a drugi deo, sačinjen od 7 pitanja zatvorenog tipa, bio je posvećen određenim etičkim dilemama. Statistička analiza urađena je korišćenjem Excel programa iz Microsoft Office programskog paketa i SPSS programa u verziji 18.0. Rezultati: Odgovori studenata i stomatologa na pitanja o pojedinačnim etičkim aspektima nisu se znatno razlikovali, osim u domenu 2. pitanja pod b – da li je oralni hirurg trebalo da izvadi oba zuba na zahtev pacijenta, koji je srčani bolesnik. Pronađena je statistički značajna razlika (χ= 18,834; p < 0,0001) u odgovorima stomatologa u odnosu na odgovore studenata. Zaključak: Znanje većine ispitanika o etičkim principima bilo je zadovoljavajuće. Manji deo ispitanika nije bio dovoljno svestan važnosti primene etičkih principa u stomatološkoj praksi, tako da je potrebno promovisati programe edukacije o lekarskoj etici za stomatologe i studente stomatologije.
包容性：患者的担忧、对医疗法的了解以及与法律的一致性有助于更有效地解决口腔医生今天经常遇到的道德困境。此外，在决定最佳牙科治疗方案时，患者也有一定的作用。本研究的目的是检验塞尔维亚口腔医生对日常实践中道德困境的看法，以确定影响其解决方案的因素。材料和方法：这项工作是作为一项剖面研究来完成的。Istraživanje obuhvatilo 88 ispitanika，42 apsolventa口腔医学博士fakulta u Nišu i Stomatološkog fakultta u Beogradu i 46口腔医学博士。问卷的第一部分包括问卷的社会人口学特征，第二部分由7个封闭的问题提出，专门讨论某些道德困境。使用Microsoft Office软件包中的Excel程序和SPSS 18.0版程序进行统计分析。结果：学生和牙医对个体道德方面的反应没有显著差异，除了领域2。问题B：口腔外科医生是否应心脏病患者的要求拔除两颗牙齿。口腔医生对学生的反应存在统计学显著差异（χ=18.834；p<0.0001）。最后，对大多数伦理原则的了解是令人满意的。大多数受试者没有意识到道德原则在牙科实践中的重要性，因此应该促进牙科道德和口腔医学学生的教育计划。
{"title":"Examining dentists' attitudes about ethical principles in everyday practice","authors":"Katarina Šljivić, Maja Nikolić, N. Krunić","doi":"10.5937/ASN2082067Z","DOIUrl":"https://doi.org/10.5937/ASN2082067Z","url":null,"abstract":"Uvod: Briga o pacijentima, poznavanje medicinskog prava i usklađenost sa zakonom doprinose efikasnijem rešavanju etičkih dilema, sa kojima se stomatolozi danas često susreću. Pored toga, u određivanju \"najboljeg\" stomatološkog tretmana, izvesnu ulogu imaju i pacijenti. Cilj istraživanja bilo je ispitivanje stavova stomatologa u Srbiji u vezi etičkih dilema u svakodnevnoj praksi, kako bi se utvrdili faktori koji utiču na njihovo rešavanje. Materijali i metode: Rad je realizovan kao studija preseka. Istraživanje je obuhvatilo 88 ispitanika, 42 apsolventa stomatologije Medicinskog fakulteta u Nišu i Stomatološkog fakulteta u Beogradu i 46 stomatologa iz privatne i državne prakse. Prvi deo upitnika obuhvatio je socio-demografske karakteristike ispitanika, a drugi deo, sačinjen od 7 pitanja zatvorenog tipa, bio je posvećen određenim etičkim dilemama. Statistička analiza urađena je korišćenjem Excel programa iz Microsoft Office programskog paketa i SPSS programa u verziji 18.0. Rezultati: Odgovori studenata i stomatologa na pitanja o pojedinačnim etičkim aspektima nisu se znatno razlikovali, osim u domenu 2. pitanja pod b – da li je oralni hirurg trebalo da izvadi oba zuba na zahtev pacijenta, koji je srčani bolesnik. Pronađena je statistički značajna razlika (χ= 18,834; p < 0,0001) u odgovorima stomatologa u odnosu na odgovore studenata. Zaključak: Znanje većine ispitanika o etičkim principima bilo je zadovoljavajuće. Manji deo ispitanika nije bio dovoljno svestan važnosti primene etičkih principa u stomatološkoj praksi, tako da je potrebno promovisati programe edukacije o lekarskoj etici za stomatologe i studente stomatologije.","PeriodicalId":39229,"journal":{"name":"Acta Stomatologica Naissi","volume":"36 1","pages":"2067-2078"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71202016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction:The elimination of odontalgia and all other forms of oral pain that occurs on dental tissues during dental interventions is still one of the main goals in the dental profession. Aim: The aim of this paper wasto perform an analysis of the literature data on the use of supplementary intrapulpal anesthesia in clinical dental practice. Material and methods: Literature data on the use of intrapulpal anesthesia, the characteristics of this technique of supplementary anesthesia as well as the results of its application were collected. Various databases were used for this purpose, digital data from Google Scholar, Medline, Science-Direct, as well as traditional libraries with manuscripts in printed form were most often taken. Conclusion: The use of supplementary intrapulpal anesthesia in dental/endodontic practice represents a practical and successful type of local anesthesia, when standard mandibular anesthesia for the lower alveolar nerve does not provide a deep enough periinterventional analgesia for dental procedures.
{"title":"The clinical significance of intrapulpal anesthesia for painless dental procedure","authors":"Nina N. Burić, M. Stojanović, N. Burić","doi":"10.5937/ASN2082117B","DOIUrl":"https://doi.org/10.5937/ASN2082117B","url":null,"abstract":"Introduction:The elimination of odontalgia and all other forms of oral pain that occurs on dental tissues during dental interventions is still one of the main goals in the dental profession. Aim: The aim of this paper wasto perform an analysis of the literature data on the use of supplementary intrapulpal anesthesia in clinical dental practice. Material and methods: Literature data on the use of intrapulpal anesthesia, the characteristics of this technique of supplementary anesthesia as well as the results of its application were collected. Various databases were used for this purpose, digital data from Google Scholar, Medline, Science-Direct, as well as traditional libraries with manuscripts in printed form were most often taken. Conclusion: The use of supplementary intrapulpal anesthesia in dental/endodontic practice represents a practical and successful type of local anesthesia, when standard mandibular anesthesia for the lower alveolar nerve does not provide a deep enough periinterventional analgesia for dental procedures.","PeriodicalId":39229,"journal":{"name":"Acta Stomatologica Naissi","volume":"36 1","pages":"2117-2123"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71202119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Despite substantial advances in the treatment of Hemophilia A with the use of concentrated factor VIII preparations during recent decades, bleeding episodes still occur from time to time. The development of inhibitors significantly reduces the efficacy of traditional replacement therapy, seriously increasing morbidity and mortality in these patients. Emicizumab (HEMLIBRA ®) is a chimeric bispecific humanized antibody that bridges activated FIX and FX and thus restores the function of missing activated FVIII. Aim: The aim of the study was to analyze the literature date of the effect of Emicizumab in the treatment of Hemophilia A. Results: Multicenter randomized studies called HAVEN have shown excellent results of this medication in the treatment of patients with Hemophilia A. FVIII inhibitors do not bind to or neutralize Emicizumab and therefore have no effect on the hemostatic activity of the drug. Emicizumab prophylaxis produced a significant reduction in treated bleedings of 79%, compared to with the group of patients on prophylaxis with bypassing agents, while the rate grew up to even 95% after longer observation. Other studies have also confirmed good treatment results and a favorable safety profile in both adults and children. In the cases of bleeding events or preparation for immediate surgical interventions, it is recommended to user FVII (NovoSeven) ® according to previous guidelines. Conclusion: The results of the prophylactic use of Emicizumabhave so far shown that it may be a revolutionary preparation that can significantly reduce bleeding episodes and improve the quality of life of patients with Hemophilia A. Nevertheless, further testing of this drug is required.
{"title":"Emicizumab in the treatment of hemophilia A","authors":"I. Tijanić, Ivana Golubović, M. Vučić, M. Tijanić","doi":"10.5937/asn2081007t","DOIUrl":"https://doi.org/10.5937/asn2081007t","url":null,"abstract":"Introduction: Despite substantial advances in the treatment of Hemophilia A with the use of concentrated factor VIII preparations during recent decades, bleeding episodes still occur from time to time. The development of inhibitors significantly reduces the efficacy of traditional replacement therapy, seriously increasing morbidity and mortality in these patients. Emicizumab (HEMLIBRA ®) is a chimeric bispecific humanized antibody that bridges activated FIX and FX and thus restores the function of missing activated FVIII. Aim: The aim of the study was to analyze the literature date of the effect of Emicizumab in the treatment of Hemophilia A. Results: Multicenter randomized studies called HAVEN have shown excellent results of this medication in the treatment of patients with Hemophilia A. FVIII inhibitors do not bind to or neutralize Emicizumab and therefore have no effect on the hemostatic activity of the drug. Emicizumab prophylaxis produced a significant reduction in treated bleedings of 79%, compared to with the group of patients on prophylaxis with bypassing agents, while the rate grew up to even 95% after longer observation. Other studies have also confirmed good treatment results and a favorable safety profile in both adults and children. In the cases of bleeding events or preparation for immediate surgical interventions, it is recommended to user FVII (NovoSeven) ® according to previous guidelines. Conclusion: The results of the prophylactic use of Emicizumabhave so far shown that it may be a revolutionary preparation that can significantly reduce bleeding episodes and improve the quality of life of patients with Hemophilia A. Nevertheless, further testing of this drug is required.","PeriodicalId":39229,"journal":{"name":"Acta Stomatologica Naissi","volume":"59 1","pages":"2007-2010"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71201938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: The dental profession is a high-risk profession, considering the aspect of a possible 100% infection from patients who are carriers of bacterial, viral and fungal diseases during dental interventions. Aim: To perform the analysis of all data that explain the possibility of a SARS-CoV-2 virus infection in dental practice. Material and Methods: The literature data on the presence of SARS-CoV-2 virus, and its characteristics and behavior in the external environment and in living tissues was analyzed. Databases from the Medline, Cochrane Library, Science-Direct, EMBASE, and Google scholar libraries were used, as well as other sources of literature information about this virus. Results: SARS-CoV-2 is an RNA virus, which has a submicron size and the ability to survive in various environments. The retention of SARS-CoV-2 virus in air / aerosol lasts an average of 3 hours, while the half-life of this virus is 5 to 6 hours on stainless steel and 6 to 8 hours on plastic. Infected patients with SARS-CoV-2 virus develop COVID-19 disease, which manifests itself through presymptomatic, symptomatic and post-symptomatic periods of the disease. Conclusion: The SARS-CoV-2 virus can be found in aerosols generated by dental equipment, which uses compressed air for its work. Protection of dentists and staff from infection with the virus is possible by wearing an N95 respiratory mask with protection levels 2 and 3, which has a filtration efficiency, i.e. retention of submicron particles with an efficiency of ≥ 98%. Waterproof goggles with a protective visor or a special industrially designed facial visor in the form of a full face mask, which has its own motor for the supply of filtered air to the mask, and which prevents the contamination of the mucous membranes of the eyes, nose and mouth from liquid or solid aerosol in the air, need to be used. Other disposable protective equipment also must be waterproof. Korona virus izaziva prehladu kod ljudi, koja ima uobičajne simptome prehlade gornjih respiratornih puteva; zahvata nosnu šupljinu,a ponekad se širi i na ždrelo, larinks i sinuse 5,6,7 . Sa druge strane, SARS-CoV-2 virus, koji je izazivač masovne/globalne virusne infekcije, ima sličnosti sa druga dva korona virusa -beta korona virusom (SARS-CoV-1) i virusom srednjeistočnog respiratonog sindroma (MERS-CoV).
简介:牙科行业是一个高风险行业，考虑到在牙科干预期间可能100%感染细菌、病毒和真菌疾病携带者。目的:对所有解释牙科诊所中SARS-CoV-2病毒感染可能性的数据进行分析。材料与方法:对SARS-CoV-2病毒的存在及其在外界环境和活体组织中的特征和行为的文献资料进行分析。使用了Medline、Cochrane图书馆、Science-Direct、EMBASE和谷歌学者图书馆的数据库，以及有关该病毒的其他文献信息来源。结果:SARS-CoV-2是一种RNA病毒，具有亚微米大小，能够在各种环境中生存。SARS-CoV-2病毒在空气/气溶胶中的滞留时间平均为3小时，而这种病毒在不锈钢上的半衰期为5至6小时，在塑料上的半衰期为6至8小时。感染SARS-CoV-2病毒的患者可发展为COVID-19疾病，表现为症状前、症状期和症状后。结论:使用压缩空气工作的牙科设备产生的气溶胶中存在SARS-CoV-2病毒。通过佩戴防护等级为2级和3级的N95呼吸口罩，可以保护牙医和工作人员免受病毒感染，该口罩具有过滤效率，即亚微米颗粒的保留效率≥98%。需要使用带防护面罩的防水护目镜或全面罩形式的特殊工业设计的面罩，它有自己的电机用于向面罩供应过滤后的空气，并防止空气中的液体或固体气溶胶污染眼睛，鼻子和嘴巴的粘膜。其他一次性防护用品也必须防水。冠状病毒(冠状病毒);冠状病毒;冠状病毒;Zahvata nosnu šupljinu，一个马尾辫的女孩širi I na ždrelo，链接了I, 5,6,7。病毒株，SARS-CoV-2病毒，流行性腮腺炎病毒/全球感染病毒，甲型h1n1流感病毒-乙型冠状病毒(SARS-CoV-1) -乙型冠状病毒-乙型冠状病毒(MERS-CoV)。
{"title":"Occupational hazard for Dental staff exposed to the SARS-CoV-2 virus during Dental procedures","authors":"Nina N. Burić, Simona Stojanović","doi":"10.5937/asn2081995b","DOIUrl":"https://doi.org/10.5937/asn2081995b","url":null,"abstract":"Introduction: The dental profession is a high-risk profession, considering the aspect of a possible 100% infection from patients who are carriers of bacterial, viral and fungal diseases during dental interventions. Aim: To perform the analysis of all data that explain the possibility of a SARS-CoV-2 virus infection in dental practice. Material and Methods: The literature data on the presence of SARS-CoV-2 virus, and its characteristics and behavior in the external environment and in living tissues was analyzed. Databases from the Medline, Cochrane Library, Science-Direct, EMBASE, and Google scholar libraries were used, as well as other sources of literature information about this virus. Results: SARS-CoV-2 is an RNA virus, which has a submicron size and the ability to survive in various environments. The retention of SARS-CoV-2 virus in air / aerosol lasts an average of 3 hours, while the half-life of this virus is 5 to 6 hours on stainless steel and 6 to 8 hours on plastic. Infected patients with SARS-CoV-2 virus develop COVID-19 disease, which manifests itself through presymptomatic, symptomatic and post-symptomatic periods of the disease. Conclusion: The SARS-CoV-2 virus can be found in aerosols generated by dental equipment, which uses compressed air for its work. Protection of dentists and staff from infection with the virus is possible by wearing an N95 respiratory mask with protection levels 2 and 3, which has a filtration efficiency, i.e. retention of submicron particles with an efficiency of ≥ 98%. Waterproof goggles with a protective visor or a special industrially designed facial visor in the form of a full face mask, which has its own motor for the supply of filtered air to the mask, and which prevents the contamination of the mucous membranes of the eyes, nose and mouth from liquid or solid aerosol in the air, need to be used. Other disposable protective equipment also must be waterproof. Korona virus izaziva prehladu kod ljudi, koja ima uobičajne simptome prehlade gornjih respiratornih puteva; zahvata nosnu šupljinu,a ponekad se širi i na ždrelo, larinks i sinuse 5,6,7 . Sa druge strane, SARS-CoV-2 virus, koji je izazivač masovne/globalne virusne infekcije, ima sličnosti sa druga dva korona virusa -beta korona virusom (SARS-CoV-1) i virusom srednjeistočnog respiratonog sindroma (MERS-CoV).","PeriodicalId":39229,"journal":{"name":"Acta Stomatologica Naissi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71202008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: By examining numerous thermoplastic and flexible materials that would aesthetically and functionally surpass acrylates used for the production of dental prostheses, polyamides were discovered as materials with great potential application in prosthodontics. The aim of this study was to describe polyamide materials used for the production of partial dentures. Material and methods: The main methodological approach of this study was a systematic search of the literature in two electronic databases: Google Scholar and PubMed using predefined keyword combinations. Results: The advantage of polyamide dentures is the comfort and ease of accommodation of the patient, with preserved optimal mechanical and physical properties. The dentures are flexible but rigid enough to be resistant to shock and fractures. Due to their low specific weight, polyamide dentures are light, extremely thin and do not interrupt patient speech. Excellent aesthetics are provided by a high choice of working colors and high translucency of the material, which ensures that the soft tissue that's covered by the denture base or clasp is seen through the prosthesis and gives it a more natural appearance in the patient's mouth. Conslusion: Polyamides, unlike acrylates, do not contain residual monomers, so they have an greater degree of biocompatibility. They can be used for the production of both complete and partial dentures, in combination with a Cr-Co skeleton, or crowns and bridges.
{"title":"Properties and applications of dental polyamides","authors":"N. Gligorijević, M. Igić, M. Kostić, A. Pejčić","doi":"10.5937/ASN2082098G","DOIUrl":"https://doi.org/10.5937/ASN2082098G","url":null,"abstract":"Introduction: By examining numerous thermoplastic and flexible materials that would aesthetically and functionally surpass acrylates used for the production of dental prostheses, polyamides were discovered as materials with great potential application in prosthodontics. The aim of this study was to describe polyamide materials used for the production of partial dentures. Material and methods: The main methodological approach of this study was a systematic search of the literature in two electronic databases: Google Scholar and PubMed using predefined keyword combinations. Results: The advantage of polyamide dentures is the comfort and ease of accommodation of the patient, with preserved optimal mechanical and physical properties. The dentures are flexible but rigid enough to be resistant to shock and fractures. Due to their low specific weight, polyamide dentures are light, extremely thin and do not interrupt patient speech. Excellent aesthetics are provided by a high choice of working colors and high translucency of the material, which ensures that the soft tissue that's covered by the denture base or clasp is seen through the prosthesis and gives it a more natural appearance in the patient's mouth. Conslusion: Polyamides, unlike acrylates, do not contain residual monomers, so they have an greater degree of biocompatibility. They can be used for the production of both complete and partial dentures, in combination with a Cr-Co skeleton, or crowns and bridges.","PeriodicalId":39229,"journal":{"name":"Acta Stomatologica Naissi","volume":"302 1","pages":"2098-2105"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71202070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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