Tateki Sumii, Yohei Nakano, Takuma Abe, K. Nakashima, T. Sera, S. Kudo
Nitric oxide (NO) and shear stress modulates hepatocyte functions, including ammonia metabolism. This study investigated the simultaneous effects of NO and shear stress on hepatocyte functions. We developed a cell culture device to simultaneously apply NO and shear stress to hepatocytes, and measured changes in ammonia decomposition by hepatocytes in response to changes in NO concentration and shear stress. NO was supplied directly to cells at a constant rate at 0, 0.5, 5, and 25 ppm, and shear stress was either applied at 0.6 Pa or not (static culture). Ammonia decomposition in static culture was higher under all NO loads compared with 0 ppm NO, and was highest under 0.5 ppm NO and decreased under higher NO loads. In the absence of NO load, ammonia decomposition under shear stress was approximately double that in static culture. Under the simultaneous application of NO and shear stress load, ammonia decomposition under 0.5 ppm NO was approximately twice as high as under 0 ppm NO, but was almost the same under 25 ppm NO as under 0 ppm NO. These results indicate that both NO and shear stress enhance ammonia decomposition although the enhancement depends on the NO concentration in their immediate surroundings.
{"title":"Effects of nitric oxide on ammonia decomposition by hepatocytes under shear stress","authors":"Tateki Sumii, Yohei Nakano, Takuma Abe, K. Nakashima, T. Sera, S. Kudo","doi":"10.17106/JBR.30.19","DOIUrl":"https://doi.org/10.17106/JBR.30.19","url":null,"abstract":"Nitric oxide (NO) and shear stress modulates hepatocyte functions, including ammonia metabolism. This study investigated the simultaneous effects of NO and shear stress on hepatocyte functions. We developed a cell culture device to simultaneously apply NO and shear stress to hepatocytes, and measured changes in ammonia decomposition by hepatocytes in response to changes in NO concentration and shear stress. NO was supplied directly to cells at a constant rate at 0, 0.5, 5, and 25 ppm, and shear stress was either applied at 0.6 Pa or not (static culture). Ammonia decomposition in static culture was higher under all NO loads compared with 0 ppm NO, and was highest under 0.5 ppm NO and decreased under higher NO loads. In the absence of NO load, ammonia decomposition under shear stress was approximately double that in static culture. Under the simultaneous application of NO and shear stress load, ammonia decomposition under 0.5 ppm NO was approximately twice as high as under 0 ppm NO, but was almost the same under 25 ppm NO as under 0 ppm NO. These results indicate that both NO and shear stress enhance ammonia decomposition although the enhancement depends on the NO concentration in their immediate surroundings.","PeriodicalId":39272,"journal":{"name":"Journal of Biorheology","volume":"30 1","pages":"19-26"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.17106/JBR.30.19","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68196268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kinetics of the orientation transition in the triblock copolymer lamellar phase is studied by viscometry. We find that the strain-controlled mechanism dominates the transition kinetics. We propose a possible scenario of the orientation transition from the viewpoint of the dislocation dynamics. We could also evaluate the critical shear rate of the orientation transition by assuming the limiting velocity of the dislocations under shear. evaluated value is in good agreement with the experimental observation. the nucleation of the dislocations might be necessary for the orientation transition.
{"title":"Kinetics of the orientation transition in the lyotropic lamellar phase","authors":"S. Fujii, Yuki Yamamoto","doi":"10.17106/JBR.30.27","DOIUrl":"https://doi.org/10.17106/JBR.30.27","url":null,"abstract":"Kinetics of the orientation transition in the triblock copolymer lamellar phase is studied by viscometry. We find that the strain-controlled mechanism dominates the transition kinetics. We propose a possible scenario of the orientation transition from the viewpoint of the dislocation dynamics. We could also evaluate the critical shear rate of the orientation transition by assuming the limiting velocity of the dislocations under shear. evaluated value is in good agreement with the experimental observation. the nucleation of the dislocations might be necessary for the orientation transition.","PeriodicalId":39272,"journal":{"name":"Journal of Biorheology","volume":"30 1","pages":"27-33"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.17106/JBR.30.27","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68196274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Du, Yang Lu, Lester C. Geonzon, Jingli Xie, S. Matsukawa
The possibility of phase separation in the mixture of iota-carrageenan (IC) and kappa-carrageenan (KC) was elucidated by comparing rheological properties for carrageenan mixtures. In temperature sweeping experiments, lambda-carrageenan (LC) chain slightly lowered the aggregation temperature (Tagg) of IC and KC in the mixture solutions of IC-LC and KC-LC, respectively, by obstructing the aggregation. On the other hand, dextran chain largely lowered the Tagg of IC because of the strong interaction with IC chain, whereas dextran increased Tagg of KC. The IC-KC solutions showed two-step increases at the almost same temperatures with Taggs in single component solutions of IC and KC. This exhibits independent aggregations of IC and KC chains in the mixture and suggesting the phase separation in the IC-KC solution. In the time courses of G', the IC-LC solution showed increases of G' by local aggregation of IC chain and by growing of aggregation of IC chain through the obstructive LC chains. The IC-dextran mixture solution showed a depressed increase of G' caused by a strong interaction between IC and dextran. The time courses of G' for the IC-KC solution showed two-step increases suggesting the induced aggregation of KC chains by the aggregation of IC chains.
{"title":"Rheological properties and interactions between polysaccharides in mixed carrageenan solutions","authors":"L. Du, Yang Lu, Lester C. Geonzon, Jingli Xie, S. Matsukawa","doi":"10.17106/JBR.30.13","DOIUrl":"https://doi.org/10.17106/JBR.30.13","url":null,"abstract":"The possibility of phase separation in the mixture of iota-carrageenan (IC) and kappa-carrageenan (KC) was elucidated by comparing rheological properties for carrageenan mixtures. In temperature sweeping experiments, lambda-carrageenan (LC) chain slightly lowered the aggregation temperature (Tagg) of IC and KC in the mixture solutions of IC-LC and KC-LC, respectively, by obstructing the aggregation. On the other hand, dextran chain largely lowered the Tagg of IC because of the strong interaction with IC chain, whereas dextran increased Tagg of KC. The IC-KC solutions showed two-step increases at the almost same temperatures with Taggs in single component solutions of IC and KC. This exhibits independent aggregations of IC and KC chains in the mixture and suggesting the phase separation in the IC-KC solution. In the time courses of G', the IC-LC solution showed increases of G' by local aggregation of IC chain and by growing of aggregation of IC chain through the obstructive LC chains. The IC-dextran mixture solution showed a depressed increase of G' caused by a strong interaction between IC and dextran. The time courses of G' for the IC-KC solution showed two-step increases suggesting the induced aggregation of KC chains by the aggregation of IC chains.","PeriodicalId":39272,"journal":{"name":"Journal of Biorheology","volume":"30 1","pages":"13-18"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.17106/JBR.30.13","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68196711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In 1944, I graduated from the Department of Physics, the University of Tokyo and entered to the Kobayasi Institute of Physical Research, where Dr. Syoten Oka was a Chief Scientist in the Laboratory of Polymer Physics. I studied the theory of dielectric materials under his guidance. I also belonged to the laboratory of Dr. Heiji Kawai who was known by the basic and applied research on the piezoelectricity of Rochelle Salt crystal. Under his guidance I learned the experimental techniques of vibration, which later led me to the research on the piezoelectricity of polymers. I was a British Council Scholar from August, 1956 to February, 1957. I stayed at the laboratory of Dr. R.W.B. Stephens in the Imperial College of Science and Technology, the University of London, and studied the viscoelasticity of irradiated polyethylene and polyesters under the direction of Dr. A. Charlesby at the Atomic Energy Establishment, Harwell, England. In 1963, I moved to the Institute of Physical and Chemical Research (now RIKEN). I worked there as a Chief Scientist in Polymer Physics Laboratory until 1980. I was an Executive Director of Riken from 1981 to 1984. After retirement, I worked as a Research Advisor at the Tsukuba Institute for Super Materials, ULVAC Japan Ltd from 1987 to 1998. Concurrently, in 1991, I was lucky to come back to the Kobayasi Institute of Physical Research, where I still remained as an Emeritus Scientist. I was a visiting professor at the Physics Department of Gakushuin University from 1961 to 1980. I was lucky to be invited as a visiting professor to various foreign countries. The names to whom I am very grateful are Prof. M.H. Shamos of New York University in 1965, Prof. S. Mascarenhas of the University of Sao Paulo in 1974, Prof. G. M. Sessler of the Technical University of Darmstadt and Prof. K. Dransfeld of the University of Konstanz in 1986 and Prof. G. Arlt of the Technical University of Aachen in 1987 and Prof. D. Liepsch of Eisenhauer Medical Center, Palm Springs in 1988.
1944年，我从东京大学物理系毕业，进入小林物理研究所，在那里的高分子物理实验室担任首席科学家。我在他的指导下学习了介电材料理论。我也属于Kawai平司博士的实验室，他以罗谢尔盐晶体压电性的基础和应用研究而闻名。在他的指导下，我学习了振动的实验技术，并由此开始了聚合物压电性的研究。1956年8月至1957年2月任英国文化协会学者。我待在伦敦大学帝国理工学院R.W.B.斯蒂芬斯博士的实验室里，在英国哈维尔原子能机构A.查尔斯比博士的指导下，研究辐照聚乙烯和聚酯的粘弹性。1963年，我转到物理与化学研究所(现在的理化学研究所)。1980年之前，我一直在那里担任高分子物理实验室的首席科学家。从1981年到1984年，我是Riken的执行董事。退休后，1987年至1998年，我在ULVAC Japan Ltd .筑波超级材料研究所担任研究顾问。同时，在1991年，我很幸运地回到了小林物理研究所，在那里我仍然是名誉科学家。1961年至1980年，我在学习院大学物理系担任客座教授。我很幸运被邀请作为客座教授到不同的国家。我非常感谢的名字是1965年纽约大学的M.H. Shamos教授，1974年圣保罗大学的S. Mascarenhas教授，1986年达姆施塔特工业大学的G. M. Sessler教授和康斯坦茨大学的K. Dransfeld教授，1987年亚琛工业大学的G. Arlt教授和1988年棕榈泉艾森豪医学中心的D. Liepsch教授。
{"title":"Research on bioelectromechanics for 70 years","authors":"E. Fukada","doi":"10.17106/JBR.30.1","DOIUrl":"https://doi.org/10.17106/JBR.30.1","url":null,"abstract":"In 1944, I graduated from the Department of Physics, the University of Tokyo and entered to the Kobayasi Institute of Physical Research, where Dr. Syoten Oka was a Chief Scientist in the Laboratory of Polymer Physics. I studied the theory of dielectric materials under his guidance. I also belonged to the laboratory of Dr. Heiji Kawai who was known by the basic and applied research on the piezoelectricity of Rochelle Salt crystal. Under his guidance I learned the experimental techniques of vibration, which later led me to the research on the piezoelectricity of polymers. I was a British Council Scholar from August, 1956 to February, 1957. I stayed at the laboratory of Dr. R.W.B. Stephens in the Imperial College of Science and Technology, the University of London, and studied the viscoelasticity of irradiated polyethylene and polyesters under the direction of Dr. A. Charlesby at the Atomic Energy Establishment, Harwell, England. In 1963, I moved to the Institute of Physical and Chemical Research (now RIKEN). I worked there as a Chief Scientist in Polymer Physics Laboratory until 1980. I was an Executive Director of Riken from 1981 to 1984. After retirement, I worked as a Research Advisor at the Tsukuba Institute for Super Materials, ULVAC Japan Ltd from 1987 to 1998. Concurrently, in 1991, I was lucky to come back to the Kobayasi Institute of Physical Research, where I still remained as an Emeritus Scientist. I was a visiting professor at the Physics Department of Gakushuin University from 1961 to 1980. I was lucky to be invited as a visiting professor to various foreign countries. The names to whom I am very grateful are Prof. M.H. Shamos of New York University in 1965, Prof. S. Mascarenhas of the University of Sao Paulo in 1974, Prof. G. M. Sessler of the Technical University of Darmstadt and Prof. K. Dransfeld of the University of Konstanz in 1986 and Prof. G. Arlt of the Technical University of Aachen in 1987 and Prof. D. Liepsch of Eisenhauer Medical Center, Palm Springs in 1988.","PeriodicalId":39272,"journal":{"name":"Journal of Biorheology","volume":"30 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.17106/JBR.30.1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68196472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Sakota, Tomotaka Murashige, R. Kosaka, Tatsuki Fujiwara, K. Ouchi, M. Nishida, O. Maruyama
We developed a hyperspectral imaging (HSI) method to image a rotary blood pump rotating at high speed, and we investigated the optical properties of blood associated with the blood clotting. In vitro antithrombogenic testing was conducted. Fresh porcine blood was circulated by a hydrodynamically levitated centrifugal blood pump while light pulsed at the same frequency as the rotational speed illuminated the bottom surface of the pump. Back scattering was captured with an HSI camera, and the spectral image in the wavelength range from 608 to 752 nm was constructed. Back scattering in the area of suspected thrombus formation decreased. the shape of the spectral image was consistent with that of the thrombus formed in the pump. Moreover, the hemoglobin concentration of the thrombus was quantified, and its value was significantly lower than the total hemoglobin concentration. therefore, it is speculated that the decrease in back scattering is caused by a decrease in the number of red blood cells (rBcs) trapped in the thrombus area due to the surrounding blood flow. It was concluded that this optical technique is able to detect blood clotting using the behavior of rBcs as the optical marker for its detection.
{"title":"Noninvasive optical imaging of thrombus formation in mechanical circulatory support devices","authors":"D. Sakota, Tomotaka Murashige, R. Kosaka, Tatsuki Fujiwara, K. Ouchi, M. Nishida, O. Maruyama","doi":"10.17106/JBR.30.6","DOIUrl":"https://doi.org/10.17106/JBR.30.6","url":null,"abstract":"We developed a hyperspectral imaging (HSI) method to image a rotary blood pump rotating at high speed, and we investigated the optical properties of blood associated with the blood clotting. In vitro antithrombogenic testing was conducted. Fresh porcine blood was circulated by a hydrodynamically levitated centrifugal blood pump while light pulsed at the same frequency as the rotational speed illuminated the bottom surface of the pump. Back scattering was captured with an HSI camera, and the spectral image in the wavelength range from 608 to 752 nm was constructed. Back scattering in the area of suspected thrombus formation decreased. the shape of the spectral image was consistent with that of the thrombus formed in the pump. Moreover, the hemoglobin concentration of the thrombus was quantified, and its value was significantly lower than the total hemoglobin concentration. therefore, it is speculated that the decrease in back scattering is caused by a decrease in the number of red blood cells (rBcs) trapped in the thrombus area due to the surrounding blood flow. It was concluded that this optical technique is able to detect blood clotting using the behavior of rBcs as the optical marker for its detection.","PeriodicalId":39272,"journal":{"name":"Journal of Biorheology","volume":"69 1","pages":"6-12"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.17106/JBR.30.6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68196278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The effect of pH on elastic modulus E and turbidity for mixed gels of gelatin and agar was investigated. For (acylated gelatin)/agar mixed gels, the plot of E against the gelatin concentration CG shows a minimum for the gels at pH 10.1 and a maximum for the gels at pH 3.5. A theoretical model for the phase-separated mixed gels was shown to be partly applicable to the data of E as a function of CG. From the pH dependence of turbidity and E for the mixed gels, a correlation between the turbidity and the elastic modulus of the mixed gels was demonstrated.
{"title":"Correlation between rheological properties and turbidity of mixed gels of gelatin and agar","authors":"Y. Maki, Kazushi Toriba, Y. Toyama, T. Dobashi","doi":"10.17106/JBR.29.6","DOIUrl":"https://doi.org/10.17106/JBR.29.6","url":null,"abstract":"The effect of pH on elastic modulus E and turbidity for mixed gels of gelatin and agar was investigated. For (acylated gelatin)/agar mixed gels, the plot of E against the gelatin concentration CG shows a minimum for the gels at pH 10.1 and a maximum for the gels at pH 3.5. A theoretical model for the phase-separated mixed gels was shown to be partly applicable to the data of E as a function of CG. From the pH dependence of turbidity and E for the mixed gels, a correlation between the turbidity and the elastic modulus of the mixed gels was demonstrated.","PeriodicalId":39272,"journal":{"name":"Journal of Biorheology","volume":"102 1","pages":"6-10"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.17106/JBR.29.6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68196384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Takuto Fuse, A. Sapkota, O. Maruyama, R. Kosaka, T. Yamane, M. Takei
Various extracorporeal circulation devices require a real time thrombus detection system. This paper presents a study toward the establishment of real-time thrombus detection by measuring the electrical properties of blood. We conducted experiments on static bovine blood samples and determined the change in relative permittivity of the samples by changing the size and red blood cell (RBC) concentration of the thrombus in each sample. Results show that the relative permittivity increases linearly with increases in the number of RBCs that form the thrombus. Similarly, permittivity also increases linearly with increases in the volume of the blood that forms the thrombus. These results are consistent with the numerical simulations. However, we found the linear relationship to be dependent on the AC frequency of the applied voltage. We compare and explain this dependency on the basis of earlier studies.
{"title":"Analysis of the influence of volume and red blood cell concentration of a thrombus on the permittivity of blood","authors":"Takuto Fuse, A. Sapkota, O. Maruyama, R. Kosaka, T. Yamane, M. Takei","doi":"10.17106/JBR.29.15","DOIUrl":"https://doi.org/10.17106/JBR.29.15","url":null,"abstract":"Various extracorporeal circulation devices require a real time thrombus detection system. This paper presents a study toward the establishment of real-time thrombus detection by measuring the electrical properties of blood. We conducted experiments on static bovine blood samples and determined the change in relative permittivity of the samples by changing the size and red blood cell (RBC) concentration of the thrombus in each sample. Results show that the relative permittivity increases linearly with increases in the number of RBCs that form the thrombus. Similarly, permittivity also increases linearly with increases in the volume of the blood that forms the thrombus. These results are consistent with the numerical simulations. However, we found the linear relationship to be dependent on the AC frequency of the applied voltage. We compare and explain this dependency on the basis of earlier studies.","PeriodicalId":39272,"journal":{"name":"Journal of Biorheology","volume":"29 1","pages":"15-18"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.17106/JBR.29.15","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68195712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amyloid fibrils, formed by protein mis-folding, consist of consecutive hydrogen bonds situated between β-strands. To date, experimental data indicate that amyloid fibrils are structured according to the cross-β structure model, wherein β-strands are oriented perpendicular to the fibril axes. Amyloid fibrils are generally 10 nm in width; however, barnase M1 variants are 20 nm in width. In this study, we performed a comparative analysis of the structural stability of amyloid formation by barnase M1 variants. Based on the results of dynamic light scattering, we propose that the presence or absence of C-terminal amino acids in barnase M1 is dependent on resistance to urea.
{"title":"Evaluation of the structural stability of amyloid fibrils by dynamic light scattering","authors":"Masatoshi Saiki, M. Akimoto","doi":"10.17106/JBR.29.24","DOIUrl":"https://doi.org/10.17106/JBR.29.24","url":null,"abstract":"Amyloid fibrils, formed by protein mis-folding, consist of consecutive hydrogen bonds situated between β-strands. To date, experimental data indicate that amyloid fibrils are structured according to the cross-β structure model, wherein β-strands are oriented perpendicular to the fibril axes. Amyloid fibrils are generally 10 nm in width; however, barnase M1 variants are 20 nm in width. In this study, we performed a comparative analysis of the structural stability of amyloid formation by barnase M1 variants. Based on the results of dynamic light scattering, we propose that the presence or absence of C-terminal amino acids in barnase M1 is dependent on resistance to urea.","PeriodicalId":39272,"journal":{"name":"Journal of Biorheology","volume":"29 1","pages":"24-27"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.17106/JBR.29.24","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68196157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Bito, T. Maeda, Katsuya Hagiwara, S. Yoshida, T. Hasebe, A. Hotta
Attaining high hemocompatibility and promoting endothelialization are two major keys to solve the endoleak problems observed in existing stent-grafts. For the satisfactory long-term use of the stent-grafts, blocking the endoleak symptom is highly essential. This paper deals with the fabricationofelectrospunnanofibersmadeofantithrombogenic poly(2-methacryloyloxyethyl phosphorylcholine) (MPC) containing drug that can sustain the endothelial activityoftheMPCnanofibers.Moreover,thedrugrelease was controlled by micro-patterned diamond-like carbon (DLC) coated on the MPC nanofibers. It was found that MPCnanofibers retainedexcellenthemocompatibilityand that the micro-patterned DLC efficiently controlled the drug-releaserateofMPCfibers.
{"title":"Poly(2-methacryloyloxyethyl phosphorylcholine) (MPC) nanofibers coated with micro-patterned diamond-like carbon (DLC) for the controlled drug release","authors":"K. Bito, T. Maeda, Katsuya Hagiwara, S. Yoshida, T. Hasebe, A. Hotta","doi":"10.17106/JBR.29.51","DOIUrl":"https://doi.org/10.17106/JBR.29.51","url":null,"abstract":"Attaining high hemocompatibility and promoting endothelialization are two major keys to solve the endoleak problems observed in existing stent-grafts. For the satisfactory long-term use of the stent-grafts, blocking the endoleak symptom is highly essential. This paper deals with the fabricationofelectrospunnanofibersmadeofantithrombogenic poly(2-methacryloyloxyethyl phosphorylcholine) (MPC) containing drug that can sustain the endothelial activityoftheMPCnanofibers.Moreover,thedrugrelease was controlled by micro-patterned diamond-like carbon (DLC) coated on the MPC nanofibers. It was found that MPCnanofibers retainedexcellenthemocompatibilityand that the micro-patterned DLC efficiently controlled the drug-releaserateofMPCfibers.","PeriodicalId":39272,"journal":{"name":"Journal of Biorheology","volume":"29 1","pages":"51-55"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.17106/JBR.29.51","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68196330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We study the shear-induced composite onion phase formation behavior of the nonionic surfactant C10E3 lamellar phases containing colloidal particles. Composite lamellar phase gives rise to the onion phase similar to the free-particle system. Depending on the particle size and concentration, the nonlinear rheology and shear modulus are significantly influenced, while the critical shear rate and onion formation kinetics remains unchanged from those of the free-particle system. Modification of the nonlinear rheology indicates that the colloidal particles assist the onion structure formation so that undulation instability is easily induced by anchoring of membranes on surface of particles. The shear modulus of the composite lamellar and onion phases is reasonably explained by considering the line tension of defects and the effect of polyhedral edge of the onion, respectively.
{"title":"Structural rheology of composite onion phase","authors":"S. Fujii","doi":"10.17106/JBR.29.28","DOIUrl":"https://doi.org/10.17106/JBR.29.28","url":null,"abstract":"We study the shear-induced composite onion phase formation behavior of the nonionic surfactant C10E3 lamellar phases containing colloidal particles. Composite lamellar phase gives rise to the onion phase similar to the free-particle system. Depending on the particle size and concentration, the nonlinear rheology and shear modulus are significantly influenced, while the critical shear rate and onion formation kinetics remains unchanged from those of the free-particle system. Modification of the nonlinear rheology indicates that the colloidal particles assist the onion structure formation so that undulation instability is easily induced by anchoring of membranes on surface of particles. The shear modulus of the composite lamellar and onion phases is reasonably explained by considering the line tension of defects and the effect of polyhedral edge of the onion, respectively.","PeriodicalId":39272,"journal":{"name":"Journal of Biorheology","volume":"29 1","pages":"28-35"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.17106/JBR.29.28","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68196223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：