中华眼科杂志最新文献

Objective: To investigate the clinical efficacy of wound exclusion combined with silicone tube bicanalicular intubation for treatment of pigmented nevi of the lacrimal punctum. Methods: A retrospective case series analysis was conducted. Clinical data were collected from patients with pigmented nevi of the lacrimal punctum who underwent wound exclusion combined with silicone tube bicanalicular intubation at the Ophthalmology Center of Zhejiang Provincial People's Hospital from April 2020 to February 2023. During the surgery, a linear silicone tube was annularly placed to support the punctum and lacrimal canaliculus under local anesthesia, followed by the pigmented nevus excision under a surgical microscope. The linear silicone tube was removed at 4 to 6 weeks postoperatively. The duration of surgery and postoperative recovery status were recorded and summarized, including the recurrence of the pigmented nevus, epiphora, shape and position of the punctum, medial canthal morphology, and local scar condition. Results: This study included a total of 15 patients, 5 males and 10 females, with an average age of (47.7±13.5) years (range, 19 to 65 years). Two patients had pigmented nevi of the upper punctum, and 13 had pigmented nevi of the lower punctum. All nevi grew around the punctum and were completely excised during the surgery, which lasted (21.8±2.4) minutes on average. By 2 weeks postoperatively, all wounds healed with conjunctivalization, and new punctum openings formed. By 4 to 6 weeks postoperatively, the eyelid margin morphology was almost normal, when the linear silicone tube was removed. The follow-up ranged from 6 months to 2 years. No recurrence of the pigmented nevus was observed during the follow-up. The puncta were well formed without the symptom of epiphora, the medial canthal morphology was basically symmetrical to the healthy side, and the eyelid margin scars were inconspicuous, with a satisfactory appearance. No complications such as punctal occlusion, trichiasis, entropion, and ectropion occurred. Conclusions: For exophytic pigmented nevi of the punctum that do not deeply involve the lacrimal canaliculus, using the wound exclusion combined with silicone tube bicanalicular intubation during the nevus excision may reduce surgical trauma. This simple and feasible method can achieve good therapeutic effects and cosmetic outcomes.

With the societal aging and the excessive use of video terminals, the prevalence rate of dry eye is increasing, and the causative factors are complex and diverse. Unremitting research and discussions on the diagnosis and treatment of dry eye have been carried out. An expert consensus on this issue was released in 2013. To further standardize and promote the diagnosis and treatment of dry eye, the Cornea Group of Chinese Ophthalmological Society and the Cornea Group of Ophthalmology Branch of Chinese Ophthalmologist Association have recently summarized the latest clinical findings and experience. A new version of the expert consensus has been formed to meet the needs of clinical practice.

The onset of congenital cataract is in the sensitive period of eyeball and visual development, and the pathogenic factors and clinical manifestations are diverse. The age of patients seeking medical treatment can range from the neonatal period to adolescence or even adulthood. However, minors are in continuous growth and development with various characteristics at different periods, which makes the diagnosis and treatment of congenital cataract complicated. In this article, the diagnosis and treatment strategies of congenital cataract are expounded according to the characteristics of the disease in infancy, early childhood, pre-school age and school age. It is pointed out that age is an important factor in the diagnosis and treatment of congenital cataract, which should be considered in related clinical work and scientific research.

Retinoblastoma, one of the most common intraocular malignancies in infants and young children, seriously affects the vision and life. The in-depth study of the origin and pathogenesis of retinoblastoma, which remain controversial, is crucial. This article summarizes the research progress on the cell origin of retinoblastoma and the second hit theory, aiming to provide a theoretical basis for the diagnosis, treatment, and prevention of retinoblastoma.

PM_2.5 is a fine particulate matter with an aerodynamic equivalent diameter of less than or equal to 2.5 μm, and it is the primary pollutant that causes haze. In recent years, numerous research results have shown that PM_2.5 is associated with various ophthalmic diseases and its pathogenic mechanism is complex. It can disrupt the homeostasis of the tear film and the function of the meibomian glands, leading to dry eye; increase the risk of allergic and other types of conjunctivitis; may cause blepharitis; affect the homeostasis of the corneal epithelium and promote the development of keratopathy; the correlation with cataract is controversial; it is related to the risk of glaucoma; it is associated with age-related macular degeneration; it may also indirectly promote diabetic retinopathy. Prevention and control measures include controlling the level of PM_2.5, strengthening publicity and screening, reducing going out and wearing goggles, etc. PM_2.5 is closely related to ophthalmic diseases, but its specific pathogenic mechanism still requires more research to explore.

Lenticule intrastromal keratoplasty (LIKE) was introduced clinically in the 1980s as a refractive surgery. With the advancements of femtosecond laser, LIKE has been significantly revitalized. Currently, femtosecond laser-assisted LIKE has been demonstrated to be a safe and effective surgical procedure to correct hyperopia, but the predictability is still a major limitation. In this article, we review the history, procedures, influencing factors of predictability and challenge of LIKE to provide reference for clinical practice of femtosecond laser-assisted LIKE.

Laser corneal refractive surgery has been carried out in China for three decades. The safety, efficacy, predictability, and long-term stability of the surgery have been well established. In the past 10 years, with the wide use of small incision lenticule extraction (SMILE) and trans-epithelial photorefractive keratectomy (T-PRK), the number of corneal laser surgeries in China has increased significantly. Although severe postoperative complications are rare, there is still the possibility of complications. Once complications occur and are not treated in time and effectively, the visual acuity and visual quality of patients would be affected. Paying attention to preoperative risk factors, standardization of the surgery procedure, and timely diagnosis and treatment of postoperative complications can minimize the negative effects. Therefore, the Cornea Group of Ophthalmology Branch of Chinese Medical Association has organized experts and scholars in this field to establish a consensus on the prevention and treatment of complications in laser corneal refractive surgery, providing guidance for the related clinical work.

Breakthroughs have been achieved recently in the application of artificial intelligence (AI) for the eye disease screening in Chinese primary healthcare institutions, but challenges have also emerged. First, AI software has continuously evolved, expanding the range of eye diseases that can be screened, enhancing diagnostic accuracy, and progressing towards predicting the course of eye diseases. However, inadequate infrastructure such as 5G and a shortage of specialized personnel have hindered the coverage of screenings. Second, while the cost-effectiveness of AI is well-established, new screening models have impacted the equity of screenings. It is essential to tailor AI application models to the specific context of China. Third, AI screening guidelines have been increasingly improved, providing direction for AI development and reference for the promotion and application of AI technologies. Nonetheless, high-quality empirical research is urgently needed to provide scientific evidence for policymaking related to AI in the eye disease screening. Therefore, it is suggested to develop multimodal AI models that integrate basic data such as symptoms and medical history with simple ophthalmic examinations, to accelerate the construction of infrastructure like 5G and focus on cultivating interdisciplinary talents, to explore suitable service systems and models for the large-scale eye disease screening tailored to local conditions, and to conduct long-term, multi-center, empirical studies.

Objective: To comprehend the status and changing trend in the burden of refractive errors in China from 1990 to 2019, and to furnish data-driven support for the formulation of rational strategies in refractive error prevention and control. Methods: Using the Global Burden of Disease Database 2019, data on refractive error prevalence and years lived with disability (YLD) in China from 1990 to 2019 were extracted and their standardized rates were calculated. The trend of refractive error prevalence, age, period, and gender was analyzed using joinpoint regression models. Results: From 1990 to 2019, the number of cases, prevalence rate, and YLD rate of refractive errors in China showed an upward trend, which was consistent with global trends. However, the magnitude of the increase in these parameters was higher than the global average. Conversely, the age-standardized prevalence rate and age-standardized YLD rate demonstrated a declining trend, which was also consistent with global trends, but the reduction rate was less pronounced compared to global levels. Notably, all indicators for females, including prevalence and YLD, exceeded those of males. The prevalence and YLD rates of refractive errors in China increased with age. The older individuals had higher rates compared to younger individuals. In 1990, the highest prevalence and YLD rates were found in the ≥70 years group, while the lowest rates were in the <5 years group. The age group with the most substantial increase in the burden of refractive errors was the 15 to 49 years population, which remained consistent during the three decades. The joinpoint regression analysis results revealed a stage-wise fluctuation in the age-standardized prevalence and YLD rates of refractive errors in China from 1990 to 2019. Specifically, the age-standardized prevalence rate increased by 0.765% from 1990 to 2001, decreased by 0.963% from 2001 to 2014, increased by 4.214% from 2014 to 2017, and decreased by 3.029% from 2017 to 2019. In contrast, the age-standardized YLD rate decreased by 0.113% from 1990 to 1995, increased by 2.252% from 1995 to 2000, decreased by 1.102% from 2000 to 2014, increased by 4.326% from 2014 to 2017, and decreased by 5.090% from 2017 to 2019. Conclusions: The standardized prevalence of refractive errors and the standardized YLD rate in China showed a downward trend, which was less than the global average level, but the disease burden was still heavy. Gender and age emerged as significant influencing factors for the prevalence of refractive errors and YLD. It is imperative to enhance efforts in the prevention and treatment of refractive errors among the middle-aged and elderly population. Attention should also be directed towards the increasing burden in the<50 years population.