Pub Date : 2022-11-01DOI: 10.1136/jitc-2022-sitc2022.0236
M. Hossain, Jong Hyeok Kim, Hyun Lee, C. Lim, G. Gong, H. Lee
{"title":"236 Expansion of tumor-infiltrating lymphocytes from head and neck squamous cell carcinoma to assess the successful expansion factors for developing adoptive cell therapy","authors":"M. Hossain, Jong Hyeok Kim, Hyun Lee, C. Lim, G. Gong, H. Lee","doi":"10.1136/jitc-2022-sitc2022.0236","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0236","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125974010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.1136/jitc-2022-sitc2022.0168
Ian Dryg, M. Turner, Ann-Elizabeth Le, Anne Carlisle, Kathleen L. Pfaff, Jason L. Weirather, F. Stephen Hodi, S. Rodig
{"title":"168 Exploring features and parameters for neighborhood analysis in human cancer multiplexed immunofluorescence data","authors":"Ian Dryg, M. Turner, Ann-Elizabeth Le, Anne Carlisle, Kathleen L. Pfaff, Jason L. Weirather, F. Stephen Hodi, S. Rodig","doi":"10.1136/jitc-2022-sitc2022.0168","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0168","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121912384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.1136/jitc-2022-sitc2022.0532
B. Dharmadhikari, D. Thakkar, O. Zharkova, Debleena Ray, Jason Lai, Konrad H. Paszkiewicz, P. Ingram, J. Boyd-Kirkup
{"title":"532 Anti-VISTA antibody HMBD-002 reprograms tumour associated macrophages and promotes cytotoxic T cell response","authors":"B. Dharmadhikari, D. Thakkar, O. Zharkova, Debleena Ray, Jason Lai, Konrad H. Paszkiewicz, P. Ingram, J. Boyd-Kirkup","doi":"10.1136/jitc-2022-sitc2022.0532","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0532","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122244793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.1136/jitc-2022-sitc2022.0749
Nicolas L. Palaskas, Yang Lu, R. Caldwell, Praise Oderinde, G. Pina, Abdelrahman Ali, Khatera Shah, C. Iliescu, S. Yusuf, E. Koutroumpakis, Shaden Khalaf, Ihab Hamzeh, B. Siddiqui, S. Subudhi, A. Deswal
{"title":"749 Use of positron emission tomography for the diagnosis of immune checkpoint inhibitor myocarditis","authors":"Nicolas L. Palaskas, Yang Lu, R. Caldwell, Praise Oderinde, G. Pina, Abdelrahman Ali, Khatera Shah, C. Iliescu, S. Yusuf, E. Koutroumpakis, Shaden Khalaf, Ihab Hamzeh, B. Siddiqui, S. Subudhi, A. Deswal","doi":"10.1136/jitc-2022-sitc2022.0749","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0749","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121769021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.1136/jitc-2022-sitc2022.0464
Megan M Y Hong, R. Figueredo, Saman Maleki
{"title":"464 Anti-CTLA-4 therapy depletes Tregs and expands ICOS+T-cells in neuroblastoma tumors with induced DNA mismatch repair deficiency","authors":"Megan M Y Hong, R. Figueredo, Saman Maleki","doi":"10.1136/jitc-2022-sitc2022.0464","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0464","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115835118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.1136/jitc-2022-sitc2022.0505
Swetha Anandhan, S. Goswami, Shelley M Herbrich, Yu-long Chen, P. Sharma
Background Immune checkpoint therapy (ICT) has revolution-ized cancer treatment, however, has produced around 20% durable clinical response rates. 1 Multiple studies demonstrate myeloid cell abundance and function in the tumor microenvir-onment (TME) correlates with poor outcome in ICT resistant cancers. 2, 3 Despite the wealth of knowledge regarding the biology of these cells, our ability to distinguish immune-sup-pressive versus immune-stimulatory myeloid cells remains a major challenge and, thus, targeting myeloid cells has had lim-ited clinical success. Our objective is to better understand the phenotype of these immunosuppressive myeloid cells to identify potential combination strategies to improve response to ICT. Methods Comparative analyses of intratumoral myeloid cell subsets was performed in orthotopic murine models of ICT sensitive (B16F10 melanoma) and resistant (MT4 pancreatic) tumors at baseline and post ICT treatment (anti-PD-1 and/or anti-CTLA-4 antibodies) using single cell RNA sequencing (scRNAseq). To determine myeloid cell evolution with tumor progression, longitudinal scRNAseq was performed on MT4 tumors.
{"title":"505 High-dimensional analyses of intratumoral myeloid cells highlights presence of distinct myeloid cell phenotypes in immune checkpoint-sensitive and resistant tumors","authors":"Swetha Anandhan, S. Goswami, Shelley M Herbrich, Yu-long Chen, P. Sharma","doi":"10.1136/jitc-2022-sitc2022.0505","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0505","url":null,"abstract":"Background Immune checkpoint therapy (ICT) has revolution-ized cancer treatment, however, has produced around 20% durable clinical response rates. 1 Multiple studies demonstrate myeloid cell abundance and function in the tumor microenvir-onment (TME) correlates with poor outcome in ICT resistant cancers. 2, 3 Despite the wealth of knowledge regarding the biology of these cells, our ability to distinguish immune-sup-pressive versus immune-stimulatory myeloid cells remains a major challenge and, thus, targeting myeloid cells has had lim-ited clinical success. Our objective is to better understand the phenotype of these immunosuppressive myeloid cells to identify potential combination strategies to improve response to ICT. Methods Comparative analyses of intratumoral myeloid cell subsets was performed in orthotopic murine models of ICT sensitive (B16F10 melanoma) and resistant (MT4 pancreatic) tumors at baseline and post ICT treatment (anti-PD-1 and/or anti-CTLA-4 antibodies) using single cell RNA sequencing (scRNAseq). To determine myeloid cell evolution with tumor progression, longitudinal scRNAseq was performed on MT4 tumors.","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131376297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.1136/jitc-2022-sitc2022.1243
M. Smith-Uffen, K. Tselios
{"title":"1243 Immune checkpoint inhibitor-induced polyarthritis: a case series","authors":"M. Smith-Uffen, K. Tselios","doi":"10.1136/jitc-2022-sitc2022.1243","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.1243","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"126 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131920640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.1136/jitc-2022-sitc2022.1248
H. Deng, Jiating Deng, Xinqing Lin, Chengzhi Zhou, Yanbin Zhou
{"title":"1248 Risk factors and a risk-scoring model for severe checkpoint inhibitor-related pneumonitis in lung cancer patients","authors":"H. Deng, Jiating Deng, Xinqing Lin, Chengzhi Zhou, Yanbin Zhou","doi":"10.1136/jitc-2022-sitc2022.1248","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.1248","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132037526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.1136/jitc-2022-sitc2022.0126
Chang-Min Kim, Y. Yu, Jin-Young Park, K. Park
Background Triple-negative breast cancer (TNBC) is the most challenging subtype of breast cancer, and its prognosis is poor compared to the other subtypes. 1 Immune cells have critical role in tumor rejection and prognosis of patient with TNBC. 2 In early TNBC, CD8+ T cells infiltration is positively associ-ated with response to neo-adjuvant chemotherapy and prognosis of patients. 3 Recently, combination of immune checkpoint inhibitor, pembrolizumab, with standard chemotherapy has been approved for the neo-adjuvant setting. 4 However, there are no valid prognostic biomarkers that reflect the CD8+ T cell enriched tumor in patients with early TNBC. To establish an elaborate therapeutic strategy for TNBC, identification of biomarkers that reflecting feature of CD8+ T cell enriched TNBC is needed. RNA conducted the gene expression of sam-ples Single performed signature
{"title":"126 Prognostic gene signature reflecting CD8+ T cell enrichment in early-stage triple-negative breast cancer","authors":"Chang-Min Kim, Y. Yu, Jin-Young Park, K. Park","doi":"10.1136/jitc-2022-sitc2022.0126","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0126","url":null,"abstract":"Background Triple-negative breast cancer (TNBC) is the most challenging subtype of breast cancer, and its prognosis is poor compared to the other subtypes. 1 Immune cells have critical role in tumor rejection and prognosis of patient with TNBC. 2 In early TNBC, CD8+ T cells infiltration is positively associ-ated with response to neo-adjuvant chemotherapy and prognosis of patients. 3 Recently, combination of immune checkpoint inhibitor, pembrolizumab, with standard chemotherapy has been approved for the neo-adjuvant setting. 4 However, there are no valid prognostic biomarkers that reflect the CD8+ T cell enriched tumor in patients with early TNBC. To establish an elaborate therapeutic strategy for TNBC, identification of biomarkers that reflecting feature of CD8+ T cell enriched TNBC is needed. RNA conducted the gene expression of sam-ples Single performed signature","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132067895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.1136/jitc-2022-sitc2022.1200
Stephen Gutowski, Qingtai Su, Austin Burcham, Irina Kalashnikova, Ashley Campbell, Zirong Chen, Bhargavi Allu, Jason B. Miller, T. Zhao
{"title":"1200 A clinically validated pH-sensitive nanomedicine platform for encapsulating therapeutic bispecific T cell engagers for tumor specific delivery and activation","authors":"Stephen Gutowski, Qingtai Su, Austin Burcham, Irina Kalashnikova, Ashley Campbell, Zirong Chen, Bhargavi Allu, Jason B. Miller, T. Zhao","doi":"10.1136/jitc-2022-sitc2022.1200","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.1200","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130167016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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