Pub Date : 2022-11-01DOI: 10.1136/jitc-2022-sitc2022.0113
N. Iwamoto, T. Shimada, T. Moudgil, Ryan Meng, Tanisha Christie, Alexander C. Dowell, R. Leidner, B. Bell, William L. Redmond, E. Tran, Hong-Ming Hu, T. Hilton, B. Piening, Y. Koguchi, B. Fox
Background Discoveries of the last two years have initiated a renaissance in our understanding of the targets T cells recog-nize on cancer cells. Identification of HLA-presented non-can-onical or cryptic peptides that are non-mutated and have high interpatient sharing in AML [PMID: 33740418], coupled with their absence from the thymus, led them to be designated as alternative neoantigens with potential for being universal cancer vaccines [PMID: 33852826]. These cryptic genes, in some cases, appear to play a role in promoting malignancy, further strengthening the rationale for their identification and use as targets for immunotherapy. Our group seeks to identify the Dark Immunopeptidome of HNSCC. Over the last several months we have swithed from exome-capture RNA-Seq, which fails to detect non-canonical gene sequences, to ribo-Seq, which can capture these cryptic transcripts.
{"title":"113 Uncovering the dark immunopeptidome of head and neck squamous cell carcinoma (HNSCC): relevance for universal cancer vaccines, immunological monitoring and TIL therapy","authors":"N. Iwamoto, T. Shimada, T. Moudgil, Ryan Meng, Tanisha Christie, Alexander C. Dowell, R. Leidner, B. Bell, William L. Redmond, E. Tran, Hong-Ming Hu, T. Hilton, B. Piening, Y. Koguchi, B. Fox","doi":"10.1136/jitc-2022-sitc2022.0113","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0113","url":null,"abstract":"Background Discoveries of the last two years have initiated a renaissance in our understanding of the targets T cells recog-nize on cancer cells. Identification of HLA-presented non-can-onical or cryptic peptides that are non-mutated and have high interpatient sharing in AML [PMID: 33740418], coupled with their absence from the thymus, led them to be designated as alternative neoantigens with potential for being universal cancer vaccines [PMID: 33852826]. These cryptic genes, in some cases, appear to play a role in promoting malignancy, further strengthening the rationale for their identification and use as targets for immunotherapy. Our group seeks to identify the Dark Immunopeptidome of HNSCC. Over the last several months we have swithed from exome-capture RNA-Seq, which fails to detect non-canonical gene sequences, to ribo-Seq, which can capture these cryptic transcripts.","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"137 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116605415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.1136/jitc-2022-sitc2022.0799
C. Black, Liya Wang, K. Ramakrishnan, D. Goto
799 Table 1 Real-World Time on Treatment Results http://dx.doi.org/10.1136/jitc-2022-SITC2022.0799 Abstracts A832 J Immunother Cancer 2022;10(Suppl 2):A1–A1603 on Jne 2, 2023 by gest. P rocted by coright. http/jitc.bm jcom / J Im m unther C acer: frst pulished as 10.11jitc-2022-S IT C 20.0799 on 7 N ovem er 222. D ow nladed fom
799表1治疗结果的真实世界时间http://dx.doi.org/10.1136/jitc-2022-SITC2022.0799摘要A832 J Immunother Cancer 2022;10(增刊2):A1-A1603, 2023年6月2日。P由赖特保护。http /宗旨。jj.com / jim m unther C acer:首次发布为10.11 jtc -2022- sit C 20.0799，发布于7月22日。我们从
{"title":"799 Real-world use of pembrolizumab combination regimens in first-line recurrent/metastatic head and neck squamous cell carcinoma","authors":"C. Black, Liya Wang, K. Ramakrishnan, D. Goto","doi":"10.1136/jitc-2022-sitc2022.0799","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0799","url":null,"abstract":"799 Table 1 Real-World Time on Treatment Results http://dx.doi.org/10.1136/jitc-2022-SITC2022.0799 Abstracts A832 J Immunother Cancer 2022;10(Suppl 2):A1–A1603 on Jne 2, 2023 by gest. P rocted by coright. http/jitc.bm jcom / J Im m unther C acer: frst pulished as 10.11jitc-2022-S IT C 20.0799 on 7 N ovem er 222. D ow nladed fom","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"209 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116744588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.1136/jitc-2022-sitc2022.1309
August Culbert, A. Chow, Raad Gharaibah, Naseer Sangwan, M. Dwidar, Rachel C. Newsome, Jin Dai, Siming Ma, Kristianna M Fredenburg, E. Yilmaz, S. Koyfman, Daniel McGrail, J. Ku, C. Jobin, N. Silver
Background Advanced oral cavity squamous cell carcinoma (OSCC) is an aggressive disease, with 5-year overall survival rates below 50%. 1 While smoking and alcohol are the most established risk factors, there is growing evidence implicating the role of the oral microbiome in promoting immunosuppres-sive states in OSCC. 2-6 The objective of this study was to evaluate the taxonomic profile of oral bacteria in advanced OSCC patients and correlate with clinicopathologic features. approved this study of patients diagnosed with treated from Samples were taken from tumor and paired adjacent normal tissues at the time of surgery and snap frozen. Demographics, clinical and pathologic information was collected. DNA from 51 samples was isolated and 16s rRNA gene sequencing was performed after PCR amplification of the V1-V3 regions of the 16s rRNA gene for paired samples. 16S rRNA sequences were processed using DADA2, implemented in QIIME2 package, and taxonomic assignments were made using RDA classifier using the Human Oral Microbiome Data-base V15.22 as the reference database. Sequencing reads proc-essing, denoising, dereplicating, chimeras filtering, and amplicon sequence variants (ASVs) generation was done using DADA2. The association between clinicopathological factors and bacterial profiles was evaluated using R Software.
{"title":"1309 Differential microbial enrichment is associated with oral cancer and perineural invasion","authors":"August Culbert, A. Chow, Raad Gharaibah, Naseer Sangwan, M. Dwidar, Rachel C. Newsome, Jin Dai, Siming Ma, Kristianna M Fredenburg, E. Yilmaz, S. Koyfman, Daniel McGrail, J. Ku, C. Jobin, N. Silver","doi":"10.1136/jitc-2022-sitc2022.1309","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.1309","url":null,"abstract":"Background Advanced oral cavity squamous cell carcinoma (OSCC) is an aggressive disease, with 5-year overall survival rates below 50%. 1 While smoking and alcohol are the most established risk factors, there is growing evidence implicating the role of the oral microbiome in promoting immunosuppres-sive states in OSCC. 2-6 The objective of this study was to evaluate the taxonomic profile of oral bacteria in advanced OSCC patients and correlate with clinicopathologic features. approved this study of patients diagnosed with treated from Samples were taken from tumor and paired adjacent normal tissues at the time of surgery and snap frozen. Demographics, clinical and pathologic information was collected. DNA from 51 samples was isolated and 16s rRNA gene sequencing was performed after PCR amplification of the V1-V3 regions of the 16s rRNA gene for paired samples. 16S rRNA sequences were processed using DADA2, implemented in QIIME2 package, and taxonomic assignments were made using RDA classifier using the Human Oral Microbiome Data-base V15.22 as the reference database. Sequencing reads proc-essing, denoising, dereplicating, chimeras filtering, and amplicon sequence variants (ASVs) generation was done using DADA2. The association between clinicopathological factors and bacterial profiles was evaluated using R Software.","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117019902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.1136/jitc-2022-sitc2022.0081
C. Lefranc, Nicole Meritet, K. Berthelot, O. Flamand, J. Baudhuin, Jack Pollard, L. Canard, A. Biancotto
{"title":"81 T cell stimulation assay and immunoassays comparison for soluble cytokines profiling in drug discovery","authors":"C. Lefranc, Nicole Meritet, K. Berthelot, O. Flamand, J. Baudhuin, Jack Pollard, L. Canard, A. Biancotto","doi":"10.1136/jitc-2022-sitc2022.0081","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0081","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129505308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.1136/jitc-2022-sitc2022.0020
A. Ugolkov, R. Roemeling, Alexander Martin, R. Martell
{"title":"20 Development of VISTA-centric tumor immunophenotyping as a novel approach for identification of potential biomarkers for anti-VISTA therapy","authors":"A. Ugolkov, R. Roemeling, Alexander Martin, R. Martell","doi":"10.1136/jitc-2022-sitc2022.0020","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0020","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129766234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.1136/jitc-2022-sitc2022.0702
J. Iding, Paul VanderLaan, Marcelo Jimenez, J. F. García-Hierro, J. F. Aldeyturriaga, Erik H. F. M. Heijden, C. Ng, R. Lau, Maria Ludeña, Rafael Carías, O. Cedeño, Alicia Moreno-Gonzalez, B. Hatton, W. Krimsky
{"title":"702 Tertiary lymphoid structures (TLS) observed in non-small cell lung cancer (NSCLC) tumors treated with pulsed electric fields","authors":"J. Iding, Paul VanderLaan, Marcelo Jimenez, J. F. García-Hierro, J. F. Aldeyturriaga, Erik H. F. M. Heijden, C. Ng, R. Lau, Maria Ludeña, Rafael Carías, O. Cedeño, Alicia Moreno-Gonzalez, B. Hatton, W. Krimsky","doi":"10.1136/jitc-2022-sitc2022.0702","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0702","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129882443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.1136/jitc-2022-sitc2022.0903
D. Venkatesh, J. Michels, Cailin Lu, S. Budhu, Mariam M. George, O. Ouerfelli, L. Abrahmsén, R. Zappasodi, J. Wolchok, T. Merghoub
{"title":"903 APR-246 induces an increase in tumor immunogenicity in a p53 independent manner","authors":"D. Venkatesh, J. Michels, Cailin Lu, S. Budhu, Mariam M. George, O. Ouerfelli, L. Abrahmsén, R. Zappasodi, J. Wolchok, T. Merghoub","doi":"10.1136/jitc-2022-sitc2022.0903","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0903","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128572150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.1136/jitc-2022-sitc2022.1015
E. Miao, Jennifer Poursine‐Laurent, K. Sheehan, R. Schreiber, W. Yokoyama, S. Piersma
{"title":"1015 Natural killer cells in immunotherapy-induced MHC-I tumor escape","authors":"E. Miao, Jennifer Poursine‐Laurent, K. Sheehan, R. Schreiber, W. Yokoyama, S. Piersma","doi":"10.1136/jitc-2022-sitc2022.1015","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.1015","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"122 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128627437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.1136/jitc-2022-sitc2022.0999
D. Chung, K. Warner, Jehan Vakharia, SeongJun Han, M. Ghaedi, Carlos R. Garcia-Batres, N. Jacquelot, Azin Sayad, Sarah Ferguson, P. Ohashi
{"title":"999 Investigating the immunomodulatory role of innate lymphoid cells in epithelial ovarian carcinoma","authors":"D. Chung, K. Warner, Jehan Vakharia, SeongJun Han, M. Ghaedi, Carlos R. Garcia-Batres, N. Jacquelot, Azin Sayad, Sarah Ferguson, P. Ohashi","doi":"10.1136/jitc-2022-sitc2022.0999","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0999","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128667314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.1136/jitc-2022-sitc2022.0977
Joanina K. Gicobi, Haidong Dong, Cindy Liu
{"title":"977 Highly cytotoxic resilient CD8+T cells avoid exhaustion by lowering ROS through ME1 upregulation","authors":"Joanina K. Gicobi, Haidong Dong, Cindy Liu","doi":"10.1136/jitc-2022-sitc2022.0977","DOIUrl":"https://doi.org/10.1136/jitc-2022-sitc2022.0977","url":null,"abstract":"","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128711854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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