Pub Date : 2022-12-31DOI: 10.47363/jdrr/2022(4)166
R. M. Kisindja, P. Tugirimana, Mitangala Ndeba Prudence, K. Bosunga, Jean-Jeannot Juakali Sihalikyolo, Prosper Kalenga Muenze Kayamba, Albert Mwembo Tambwe-A-Nkoy
Objectives: To explore the geographic determinants of gestational diabetes in eastern DRC and to seek confounding factors. Methods: Cross-sectional descriptive study with a multicenter analytical aim conducted in the hot and cold season from April 2019 to February 2021. Included were 392 pregnant women at 24-28 weeks of amenorrhea. Blood glucose, cortisol, SO2, anthropometric measurements, 30 previous day’s temperature, altitude and atmospheric pressure (atm) were examined. The glycaemia ≥92mg/dL was pathological, in which case cortisolaemia was measured after matching with normal glycaemia. Data were analyzed using SPSS version 23 by calculating median, proportion, ANOVA, Pearson's Chi2 or Fisher's exact test, Wilcoxon -Mann–Whitney test. Results: The proportion of 23.8%, 37.4%, 13.8% and 25.0% of 392 pregnant women lived respectively at the altitude of 1400 m, 1500m, 1700m and 2419m. Pathological glycaemia was twice higher at < 1700 m = atm > 82% [32.9% (n = 295)] Vs ≥ 1700 m [15.0% (n = 295)] [OR 2.2 95% CI (1.5- 3.2)] (p<0.001)] and at SO2 > 95% [30.8% (n= 331)] Vs SO2 ≤ 95% [15.3% (n= 144)] [OR 2.0 95% CI (1.3 - 3.1)] (p < 0.001). Cases with pathological glycaemia had elevated cortisol [281.1 nmol/L (87.6)] (n=118) Vs normal glycaemia [261.1 nmol/L (71.1)] (n= 156)] (p= 0.024). Conclusion: The prevalence of pathological glycaemia was higher at <1700 m altitude corresponding to the atm > 82% and when the SO2 was >95%. After adjustment, blood glucose was no longer correlated with temperature.
{"title":"Geographical Determinants of the Prevalence of Gestational Diabetes in North and South Kivu in the Democratic Republic of Congo","authors":"R. M. Kisindja, P. Tugirimana, Mitangala Ndeba Prudence, K. Bosunga, Jean-Jeannot Juakali Sihalikyolo, Prosper Kalenga Muenze Kayamba, Albert Mwembo Tambwe-A-Nkoy","doi":"10.47363/jdrr/2022(4)166","DOIUrl":"https://doi.org/10.47363/jdrr/2022(4)166","url":null,"abstract":"Objectives: To explore the geographic determinants of gestational diabetes in eastern DRC and to seek confounding factors. Methods: Cross-sectional descriptive study with a multicenter analytical aim conducted in the hot and cold season from April 2019 to February 2021. Included were 392 pregnant women at 24-28 weeks of amenorrhea. Blood glucose, cortisol, SO2, anthropometric measurements, 30 previous day’s temperature, altitude and atmospheric pressure (atm) were examined. The glycaemia ≥92mg/dL was pathological, in which case cortisolaemia was measured after matching with normal glycaemia. Data were analyzed using SPSS version 23 by calculating median, proportion, ANOVA, Pearson's Chi2 or Fisher's exact test, Wilcoxon -Mann–Whitney test. Results: The proportion of 23.8%, 37.4%, 13.8% and 25.0% of 392 pregnant women lived respectively at the altitude of 1400 m, 1500m, 1700m and 2419m. Pathological glycaemia was twice higher at < 1700 m = atm > 82% [32.9% (n = 295)] Vs ≥ 1700 m [15.0% (n = 295)] [OR 2.2 95% CI (1.5- 3.2)] (p<0.001)] and at SO2 > 95% [30.8% (n= 331)] Vs SO2 ≤ 95% [15.3% (n= 144)] [OR 2.0 95% CI (1.3 - 3.1)] (p < 0.001). Cases with pathological glycaemia had elevated cortisol [281.1 nmol/L (87.6)] (n=118) Vs normal glycaemia [261.1 nmol/L (71.1)] (n= 156)] (p= 0.024). Conclusion: The prevalence of pathological glycaemia was higher at <1700 m altitude corresponding to the atm > 82% and when the SO2 was >95%. After adjustment, blood glucose was no longer correlated with temperature.","PeriodicalId":398876,"journal":{"name":"Journal of Diabetes Research Reviews & Reports","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128991520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-31DOI: 10.47363/jdrr/2022(4)161
D. S. N. Rao, Kuldeep Gb
Objective: This study aims to evaluate the levels of Serum uric acid (SUA) and microalbuminuria in Healthy, Newly Diagnosed (N.D.) type 2 Diabetics and in N.D. type 2 Diabetics with hypertension. Method: Cross sectional study involving a total of 343 Individuals of Bengaluru, India from January 2018 to November 2019 were considered for the study. Venous blood and 24-hour urine sample were collected from 100 healthy, 170 N.D. type 2 Diabetics, 73 N.D. type 2 Diabetics with hypertension and analyzed for Glycated hemoglobin (HbA1c) SUA and microalbuminuria along with their demographic details. Results: There was significant increase in SUA levels and microalbuminuria in N.D. Type 2 Diabetics with hypertension compared to healthy and N.D.type 2 Diabetics. Conclusion: Hypertensive Diabetics should be monitored periodically for SUA and microalbuminuria to prevent them from developing renal complication.
{"title":"Evaluation of Serum Uric Acid Levels and Microalbuminuria in Newly Diagnosed Type 2 Diabetics with and without Hypertension","authors":"D. S. N. Rao, Kuldeep Gb","doi":"10.47363/jdrr/2022(4)161","DOIUrl":"https://doi.org/10.47363/jdrr/2022(4)161","url":null,"abstract":"Objective: This study aims to evaluate the levels of Serum uric acid (SUA) and microalbuminuria in Healthy, Newly Diagnosed (N.D.) type 2 Diabetics and in N.D. type 2 Diabetics with hypertension. Method: Cross sectional study involving a total of 343 Individuals of Bengaluru, India from January 2018 to November 2019 were considered for the study. Venous blood and 24-hour urine sample were collected from 100 healthy, 170 N.D. type 2 Diabetics, 73 N.D. type 2 Diabetics with hypertension and analyzed for Glycated hemoglobin (HbA1c) SUA and microalbuminuria along with their demographic details. Results: There was significant increase in SUA levels and microalbuminuria in N.D. Type 2 Diabetics with hypertension compared to healthy and N.D.type 2 Diabetics. Conclusion: Hypertensive Diabetics should be monitored periodically for SUA and microalbuminuria to prevent them from developing renal complication.","PeriodicalId":398876,"journal":{"name":"Journal of Diabetes Research Reviews & Reports","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133731598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-31DOI: 10.47363/jdrr/2022(4)160
Chhavi Mehra, A. M. Raymond, S. L
Background: Type 2 diabetes mellitus (T2DM) is not only one of the leading causes of mortality, but its impact on healthcare costs and burden is becoming unsustainable each year. The quality of life and life expectancy are both significantly impacted by this chronic metabolic condition. To help control their blood glucose levels, patients with T2DM adhere to a self-management regimen as instructed by a professional. Various technological options are available now to help self-management. Methods: Here, we present a case of a 64-year-old female with insulin-dependent type 2 diabetes mellitus, multiple co-morbidities, depression, confined to her room, and inability to walk for about a year. After six months of the Sugar fit approach with daily-personalized life coaching, expert medical advice, tech-enabled, AI-driven model, she showed tremendous improvement in every parameter. Results: Before joining sugar fit, the patient was on 44 units of rapid insulin and 18 units of long-acting and oral anti-diabetic medications. The patient’s Hba1c at baseline was 8%; six months later, it is 6.8% with all rapid and long insulin stopped and oral meds essentially the same as before. She has reduced creatinine from 1.88 to 1.37 and triglycerides from 1015 to 448, respectively. Her BP medications have been reduced to 50%. She walks for 2 km every day and is socially active with resolved depression. She has lost 3 kgs of weight and 3 inches of waist circumference. Conclusions: The findings indicate that a tech-enabled, AI-driven model with intensive, personalized coaching, lifestyle modification, and expert physician guidance has shown remarkable results even in this particularly complicated case. The findings indicate that the personalized and individualized frequent lifestyle coaching and expert physician opinion enabled by superior technology and AI-driven Insights resulted in marked improvement of all parameters and significant medication reductions even in Diabetes of long duration with comorbidities
{"title":"Case Study Presenting Remarkable Improvements of all Parameters in a Long-Term T2DM Patient with Multiple Chronic Comorbidities by Sugar fit’s -Tech/Ai-Driven Platform with Daily Personalised Life Coaching and Expert Medical Advice","authors":"Chhavi Mehra, A. M. Raymond, S. L","doi":"10.47363/jdrr/2022(4)160","DOIUrl":"https://doi.org/10.47363/jdrr/2022(4)160","url":null,"abstract":"Background: Type 2 diabetes mellitus (T2DM) is not only one of the leading causes of mortality, but its impact on healthcare costs and burden is becoming unsustainable each year. The quality of life and life expectancy are both significantly impacted by this chronic metabolic condition. To help control their blood glucose levels, patients with T2DM adhere to a self-management regimen as instructed by a professional. Various technological options are available now to help self-management. Methods: Here, we present a case of a 64-year-old female with insulin-dependent type 2 diabetes mellitus, multiple co-morbidities, depression, confined to her room, and inability to walk for about a year. After six months of the Sugar fit approach with daily-personalized life coaching, expert medical advice, tech-enabled, AI-driven model, she showed tremendous improvement in every parameter. Results: Before joining sugar fit, the patient was on 44 units of rapid insulin and 18 units of long-acting and oral anti-diabetic medications. The patient’s Hba1c at baseline was 8%; six months later, it is 6.8% with all rapid and long insulin stopped and oral meds essentially the same as before. She has reduced creatinine from 1.88 to 1.37 and triglycerides from 1015 to 448, respectively. Her BP medications have been reduced to 50%. She walks for 2 km every day and is socially active with resolved depression. She has lost 3 kgs of weight and 3 inches of waist circumference. Conclusions: The findings indicate that a tech-enabled, AI-driven model with intensive, personalized coaching, lifestyle modification, and expert physician guidance has shown remarkable results even in this particularly complicated case. The findings indicate that the personalized and individualized frequent lifestyle coaching and expert physician opinion enabled by superior technology and AI-driven Insights resulted in marked improvement of all parameters and significant medication reductions even in Diabetes of long duration with comorbidities","PeriodicalId":398876,"journal":{"name":"Journal of Diabetes Research Reviews & Reports","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127954639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-31DOI: 10.47363/jdrr/2022(4)163
Jintu Kurian, Hardik Doshi, R. Nanjundaiah
Background: In addition to the surge in the incidence and prevalence of type 2 diabetes mellitus (T2DM), currently more of young and middle aged adults are found at risk for T2DM in developing countries like India. Aim: With this fact in the background, the current study was conducted with an aim to understand the incidence and prevalence of pre-diabetes among adults of Gujarat. Methods: The survey study was conducted in Sourashtra part of Gujarat (N=230 adults; 32.9±9.6 years), India. Based on Capillary fasting blood glucose (CFBG) subjects were grouped into non-diabetes (n=108), pre-diabetes (n=92, 40%) and T2DM (n=30). Demographic data sheet (DDS) was used to assess the origin, socioeconomic status and habit of the respondents and Indian Diabetes Risk Score (IDRS) screening form to detect the risk for T2DM. Results: Close to half of the screened subjects were newly diagnosed with pre-diabetes, among which one-ninth of them were (n=9; 9.8%) identified with high risk for T2DM. Statistical assessment manifested female subjects at higher risk based on low physical activity and higher waist circumference as compared to male. Substantially, risk identification with IDRS was in line with the expedited results of CFBG among pre-diabetes. Conclusion: Incidence of pre-diabetes among adults of Gujarat is found escalating. Matched with the data obtained from DDS, the current study identified diet, physical inactivity and higher waist circumference as most contributing factors increasing incidence of high risk for T2DM among females and more or less the same factors in male as well.
{"title":"Contemporary Evaluation of Incidence of Pre-diabetes and High Risk for Type 2 Diabetes Mellitus among Adults of Gujarat: A Cross-Sectional Study","authors":"Jintu Kurian, Hardik Doshi, R. Nanjundaiah","doi":"10.47363/jdrr/2022(4)163","DOIUrl":"https://doi.org/10.47363/jdrr/2022(4)163","url":null,"abstract":"Background: In addition to the surge in the incidence and prevalence of type 2 diabetes mellitus (T2DM), currently more of young and middle aged adults are found at risk for T2DM in developing countries like India. Aim: With this fact in the background, the current study was conducted with an aim to understand the incidence and prevalence of pre-diabetes among adults of Gujarat. Methods: The survey study was conducted in Sourashtra part of Gujarat (N=230 adults; 32.9±9.6 years), India. Based on Capillary fasting blood glucose (CFBG) subjects were grouped into non-diabetes (n=108), pre-diabetes (n=92, 40%) and T2DM (n=30). Demographic data sheet (DDS) was used to assess the origin, socioeconomic status and habit of the respondents and Indian Diabetes Risk Score (IDRS) screening form to detect the risk for T2DM. Results: Close to half of the screened subjects were newly diagnosed with pre-diabetes, among which one-ninth of them were (n=9; 9.8%) identified with high risk for T2DM. Statistical assessment manifested female subjects at higher risk based on low physical activity and higher waist circumference as compared to male. Substantially, risk identification with IDRS was in line with the expedited results of CFBG among pre-diabetes. Conclusion: Incidence of pre-diabetes among adults of Gujarat is found escalating. Matched with the data obtained from DDS, the current study identified diet, physical inactivity and higher waist circumference as most contributing factors increasing incidence of high risk for T2DM among females and more or less the same factors in male as well.","PeriodicalId":398876,"journal":{"name":"Journal of Diabetes Research Reviews & Reports","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127191018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-31DOI: 10.47363/jdrr/2022(4)167
O. T. Yayintas
Diabetes Mellitus (DM) is the most common chronic endocrine disorder. Although new drugs and administration techniques for diabetes were developed, the nature of complications that occur chronically and reduce patients’ quality of life have not been entirely determined. In our study, 35 male rats were used. A single dose of 40 mg/kg streptozotocin was injected intraperitoneal into 28 rats, and a total of five groups were formed. The diabetes model was performed by applying 40mg/kg STZ and was not established in the subjects in the control and citrate buffer groups with STZ solvent. The quercetin and moss extract were given by gavage for three weeks. The liver and pancreas tissues were examined by histochemical and immunohistochemical methods. Ki-67 (proliferation marker), antinuclear factor kappa (NF-κB), and interleukin 6 (IL-6) immunohistochemically staining revealed significant differences in inflammation and regeneration in the liver and pancreas tissues. In addition, the TUNEL staining method was used to determine apoptosis. Positivity was significant between the treatment and diabetes groups. It was determined that the agents used as treatment changed serum superoxide dismutase (SOD), malondialdehyde (MDA), C-peptide, insulin, and glucose levels.
糖尿病(DM)是最常见的慢性内分泌疾病。虽然针对糖尿病的新药物和管理技术得到了发展，但长期发生并降低患者生活质量的并发症的性质尚未完全确定。在我们的研究中，使用了35只雄性大鼠。将链脲佐菌素单剂量40 mg/kg腹腔注射28只大鼠，共分为5组。糖尿病模型采用40mg/kg STZ，对照组和柠檬酸盐缓冲剂组未建立糖尿病模型。槲皮素和苔藓提取物灌胃3周。采用组织化学和免疫组织化学方法检查肝脏和胰腺组织。Ki-67(增殖标志物)、抗核因子κ b (NF-κB)和白细胞介素6 (IL-6)免疫组化染色显示肝脏和胰腺组织的炎症和再生有显著差异。TUNEL染色法检测细胞凋亡。治疗组和糖尿病组之间呈显著阳性。结果表明，使用的药物可改变血清超氧化物歧化酶(SOD)、丙二醛(MDA)、c肽、胰岛素和葡萄糖水平。
{"title":"Protective Effects of Quercetin/Moss Extract (Homalothecium Sericeum Hedw.) Combination on STZ-Induced Diabetic Rats","authors":"O. T. Yayintas","doi":"10.47363/jdrr/2022(4)167","DOIUrl":"https://doi.org/10.47363/jdrr/2022(4)167","url":null,"abstract":"Diabetes Mellitus (DM) is the most common chronic endocrine disorder. Although new drugs and administration techniques for diabetes were developed, the nature of complications that occur chronically and reduce patients’ quality of life have not been entirely determined. In our study, 35 male rats were used. A single dose of 40 mg/kg streptozotocin was injected intraperitoneal into 28 rats, and a total of five groups were formed. The diabetes model was performed by applying 40mg/kg STZ and was not established in the subjects in the control and citrate buffer groups with STZ solvent. The quercetin and moss extract were given by gavage for three weeks. The liver and pancreas tissues were examined by histochemical and immunohistochemical methods. Ki-67 (proliferation marker), antinuclear factor kappa (NF-κB), and interleukin 6 (IL-6) immunohistochemically staining revealed significant differences in inflammation and regeneration in the liver and pancreas tissues. In addition, the TUNEL staining method was used to determine apoptosis. Positivity was significant between the treatment and diabetes groups. It was determined that the agents used as treatment changed serum superoxide dismutase (SOD), malondialdehyde (MDA), C-peptide, insulin, and glucose levels.","PeriodicalId":398876,"journal":{"name":"Journal of Diabetes Research Reviews & Reports","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124575722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-31DOI: 10.47363/jdrr/2022(4)162
Esther Brigitte Ovaga
Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a cardiomyopathy of genetic origin, caused by abnormalities of desmosomes, characterized on the physiopathological level by a fibro-adipose infiltration replacing the myocardium of the right ventricle and the clinical level by an electrical instability leading to ventricular arrhythmias. ARVC/D peaks in frequency between the ages of 30 and 50. Diagnostic criteria have been established to retain the diagnosis of ARVC/D. Imaging and especially magnetic resonance imaging (MRI) play an important role in this diagnosis. We report the observation of a 48-year-old man, a former smoker, with a family history of the sudden death of a sister during a bicycle race, and who has been complaining for several years of palpitations. Clinical presentation, electrical signs, cardiac ultrasound and imaging findings lead to the diagnosis of ARVC/D. According to this observation, the authors describe the authors review the literature of this rare entity and discuss the different therapeutic approaches.
{"title":"Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia (ARVC/D) in Adults: Case Report with Review of the Literature","authors":"Esther Brigitte Ovaga","doi":"10.47363/jdrr/2022(4)162","DOIUrl":"https://doi.org/10.47363/jdrr/2022(4)162","url":null,"abstract":"Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a cardiomyopathy of genetic origin, caused by abnormalities of desmosomes, characterized on the physiopathological level by a fibro-adipose infiltration replacing the myocardium of the right ventricle and the clinical level by an electrical instability leading to ventricular arrhythmias. ARVC/D peaks in frequency between the ages of 30 and 50. Diagnostic criteria have been established to retain the diagnosis of ARVC/D. Imaging and especially magnetic resonance imaging (MRI) play an important role in this diagnosis. We report the observation of a 48-year-old man, a former smoker, with a family history of the sudden death of a sister during a bicycle race, and who has been complaining for several years of palpitations. Clinical presentation, electrical signs, cardiac ultrasound and imaging findings lead to the diagnosis of ARVC/D. According to this observation, the authors describe the authors review the literature of this rare entity and discuss the different therapeutic approaches.","PeriodicalId":398876,"journal":{"name":"Journal of Diabetes Research Reviews & Reports","volume":"241 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129950934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-31DOI: 10.47363/jdrr/2022(4)164
Valentina Degrave
In 2020 in our country, a new pandemic with high social impact is added to the growing incidence of type 2 diabetes mellitus (DM2): COVID-19. In this context, it is necessary to obtain evidence as to whether the isolation measures to stop the spread of the virus brought about changes in the lifestyle and in the clinical-metabolic parameters of patients with DM2 treated at the Italian Hospital of the Autonomous City of Buenos Aires. Changes in lifestyle were evaluated using a questionnaire designed ad hoc. The clinical-metabolic parameters were obtained from the clinical history of each patient. Descriptive statistics were used for data analysis using IBM SPSS software. The sample consisted of 83 patients, with an average age of 64 ± 8 years and a prevalence of the male gender (69%). 52% perceived that the months of confinement did not affect their diet, indicating that they had continued with the same consumption of fruits, vegetables and snacks, fried or processed (53%, 54% and 45%, respectively). The majority (74%) mentioned doing less physical activity and 65% had presented at least one negative emotion. Body Mass Index (BMI), body weight, and HbA1c were significantly (p<0.05) higher after isolation. In the population studied, ASPO was associated with reduced physical activity, negative emotions, and increased BMI, body weight, and HbA1c.
{"title":"Impact of COVID-19 Confinement on the Lifestyle and Metabolic Control of Adult Patients with Type 2 Diabetes Mellitus in the City of Buenos Aires (Argentina)","authors":"Valentina Degrave","doi":"10.47363/jdrr/2022(4)164","DOIUrl":"https://doi.org/10.47363/jdrr/2022(4)164","url":null,"abstract":"In 2020 in our country, a new pandemic with high social impact is added to the growing incidence of type 2 diabetes mellitus (DM2): COVID-19. In this context, it is necessary to obtain evidence as to whether the isolation measures to stop the spread of the virus brought about changes in the lifestyle and in the clinical-metabolic parameters of patients with DM2 treated at the Italian Hospital of the Autonomous City of Buenos Aires. Changes in lifestyle were evaluated using a questionnaire designed ad hoc. The clinical-metabolic parameters were obtained from the clinical history of each patient. Descriptive statistics were used for data analysis using IBM SPSS software. The sample consisted of 83 patients, with an average age of 64 ± 8 years and a prevalence of the male gender (69%). 52% perceived that the months of confinement did not affect their diet, indicating that they had continued with the same consumption of fruits, vegetables and snacks, fried or processed (53%, 54% and 45%, respectively). The majority (74%) mentioned doing less physical activity and 65% had presented at least one negative emotion. Body Mass Index (BMI), body weight, and HbA1c were significantly (p<0.05) higher after isolation. In the population studied, ASPO was associated with reduced physical activity, negative emotions, and increased BMI, body weight, and HbA1c.","PeriodicalId":398876,"journal":{"name":"Journal of Diabetes Research Reviews & Reports","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125554190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.47363/jdrr/2022(4)159
Aidibi Amena, Al-hajje Ama, Zein Salam, Awada Sanaa, R. Samar, El-Hajj Maya
Objective: Diabetic patients usually have co-morbidities requiring the use of multiple medications, making them more vulnerable in experiencing drug related problems (DRPs) that may affect their quality of life (QOL). The objective of this study was to asses DRP in type 2 diabetes (T2D) patients and factors associated with its occurrence and the DRPs that affect QoL. Methods: A cross-sectional study was conducted among T2D patients who were attending a tertiary care teaching hospital, Lebanon. The identification and assessment of DRPs were based on the Pharmaceutical Care Network Europe tool version 8.03. The QoL was assessed using Health Related Quality of Life Brief Clinical Inventory. Results: The total number of DRP was 313 with a mean of 2.05 ± 1.03 per patient. The most common DRPs encountered were adverse drug event (31.3%), untreated symptoms or indication ( 10.54%), effect of drug treatment not optimal (7.34%) and high drug dose (7.34%). Logistic regression showed that polypharmacy and several comorbidities such as stroke, dyslipidemia, heart failure, coronary artery disease, renal and liver impairment were common factors significantly associated with different types of DRPs (p<0.005). The risk of having problems” No effect of drug treatment”,” Effect of drug treatment not optimal” and “Adverse drug event (possibly) occurring” was significantly increased in patients with abnormal HbA1c. The use of sulfonylurea increases the risk of ” Inappropriate duplication of therapeutic group” (p= 0.047). Following a low sugar diet showed to decrease the probability of having problem” Patient uses/takes more drug than prescribed” by 99.99%. On the other hand, insulin administration showed to increase 7.63 times this probability (p=0.006). The average HRQoL was 40 ± 9.900. Linear regression showed that problems “Untreated indication and “Patient uses unnecessary drug” were associated with poor QoL score. Having a medical insurance was found to be associated with better HRQoL scores. Conclusion: Early identification of DRPs and factors associated with them are essential to pre- vent and resolve them in diabetic patients by engaging clinical pharmacist, which may ultimately improve patient’s QoL
{"title":"Evaluation of Drug Related Problems in Patients with Type 2 Diabetes","authors":"Aidibi Amena, Al-hajje Ama, Zein Salam, Awada Sanaa, R. Samar, El-Hajj Maya","doi":"10.47363/jdrr/2022(4)159","DOIUrl":"https://doi.org/10.47363/jdrr/2022(4)159","url":null,"abstract":"Objective: Diabetic patients usually have co-morbidities requiring the use of multiple medications, making them more vulnerable in experiencing drug related problems (DRPs) that may affect their quality of life (QOL). The objective of this study was to asses DRP in type 2 diabetes (T2D) patients and factors associated with its occurrence and the DRPs that affect QoL. Methods: A cross-sectional study was conducted among T2D patients who were attending a tertiary care teaching hospital, Lebanon. The identification and assessment of DRPs were based on the Pharmaceutical Care Network Europe tool version 8.03. The QoL was assessed using Health Related Quality of Life Brief Clinical Inventory. Results: The total number of DRP was 313 with a mean of 2.05 ± 1.03 per patient. The most common DRPs encountered were adverse drug event (31.3%), untreated symptoms or indication ( 10.54%), effect of drug treatment not optimal (7.34%) and high drug dose (7.34%). Logistic regression showed that polypharmacy and several comorbidities such as stroke, dyslipidemia, heart failure, coronary artery disease, renal and liver impairment were common factors significantly associated with different types of DRPs (p<0.005). The risk of having problems” No effect of drug treatment”,” Effect of drug treatment not optimal” and “Adverse drug event (possibly) occurring” was significantly increased in patients with abnormal HbA1c. The use of sulfonylurea increases the risk of ” Inappropriate duplication of therapeutic group” (p= 0.047). Following a low sugar diet showed to decrease the probability of having problem” Patient uses/takes more drug than prescribed” by 99.99%. On the other hand, insulin administration showed to increase 7.63 times this probability (p=0.006). The average HRQoL was 40 ± 9.900. Linear regression showed that problems “Untreated indication and “Patient uses unnecessary drug” were associated with poor QoL score. Having a medical insurance was found to be associated with better HRQoL scores. Conclusion: Early identification of DRPs and factors associated with them are essential to pre- vent and resolve them in diabetic patients by engaging clinical pharmacist, which may ultimately improve patient’s QoL","PeriodicalId":398876,"journal":{"name":"Journal of Diabetes Research Reviews & Reports","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132040586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.47363/jdrr/2022(4)156
Christian Pérez Calvo, Michel Perez Marrugo, Emerson Javier García Ballesteros, Alejandro Alberto Nuñez Ospino, Luis Saray Ricardo, Gabriel Padilla Vega, Carlos José Brito Jacome, José María Mejía Barrera, Julio Contreras Pasimino, Jhohanna María Parra Pizarro, Felipe Herrera Lozano
Diabetic kidney disease is one of the microvascular complications with the greatest impact on morbidity and mortality in patients with diabetes. Previously thought to be a linear series of events consisting of ultrafiltration, glomerular hypertension, albuminuria, and successive decreases in GFR, it is now known to be affected by multiple metabolic and hemodynamic pathophysiological mechanisms, leading to cell signaling pathways, oxidative stress, dysregulated autophagy, triggering structural damage and functional alterations leading to disease. There are also recognized risk factors for the disease that trigger pathophysiological mechanisms that contribute to its development, such as obesity, smoking, poor metabolic control, arterial hypertension, ethnicity, among others. Although current therapies have not completely halted the development of the disease, current efforts are focused on developing new therapies that can positively influence its onset and progression, with both SGLTi and AR-GLP1 playing a leading role, improving cardiovascular and renal outcomes, independently of their effect on the control of hyperglycemia, which is why they are currently a fundamental pillar of management. Finerenone, a mineralocorticoid receptor antagonist, is another current therapy that has been shown to have an impact on cardiovascular and renal outcomes, playing a complementary role to ACEI and ARB II in the management of albuminuria
{"title":"Diabetic Kidney Disease: State of the Art","authors":"Christian Pérez Calvo, Michel Perez Marrugo, Emerson Javier García Ballesteros, Alejandro Alberto Nuñez Ospino, Luis Saray Ricardo, Gabriel Padilla Vega, Carlos José Brito Jacome, José María Mejía Barrera, Julio Contreras Pasimino, Jhohanna María Parra Pizarro, Felipe Herrera Lozano","doi":"10.47363/jdrr/2022(4)156","DOIUrl":"https://doi.org/10.47363/jdrr/2022(4)156","url":null,"abstract":"Diabetic kidney disease is one of the microvascular complications with the greatest impact on morbidity and mortality in patients with diabetes. Previously thought to be a linear series of events consisting of ultrafiltration, glomerular hypertension, albuminuria, and successive decreases in GFR, it is now known to be affected by multiple metabolic and hemodynamic pathophysiological mechanisms, leading to cell signaling pathways, oxidative stress, dysregulated autophagy, triggering structural damage and functional alterations leading to disease. There are also recognized risk factors for the disease that trigger pathophysiological mechanisms that contribute to its development, such as obesity, smoking, poor metabolic control, arterial hypertension, ethnicity, among others. Although current therapies have not completely halted the development of the disease, current efforts are focused on developing new therapies that can positively influence its onset and progression, with both SGLTi and AR-GLP1 playing a leading role, improving cardiovascular and renal outcomes, independently of their effect on the control of hyperglycemia, which is why they are currently a fundamental pillar of management. Finerenone, a mineralocorticoid receptor antagonist, is another current therapy that has been shown to have an impact on cardiovascular and renal outcomes, playing a complementary role to ACEI and ARB II in the management of albuminuria","PeriodicalId":398876,"journal":{"name":"Journal of Diabetes Research Reviews & Reports","volume":"122 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117322131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.47363/jdrr/2022(4)158
Sanjay P Gandhi, Sanskriti Gandhi
The New Onset Diabetes was very common finding in young obese persons who presented with very high sugars and weight loss as a prominent symptoms
新发糖尿病在年轻肥胖人群中非常常见，他们以高糖和体重减轻为突出症状
{"title":"Use of Glargine u 300 in Insulin Nieve Patients…….. Use of basal Insulin in Young Newly Detected T2DM in OPD during Covid 19 Pandemic","authors":"Sanjay P Gandhi, Sanskriti Gandhi","doi":"10.47363/jdrr/2022(4)158","DOIUrl":"https://doi.org/10.47363/jdrr/2022(4)158","url":null,"abstract":"The New Onset Diabetes was very common finding in young obese persons who presented with very high sugars and weight loss as a prominent symptoms","PeriodicalId":398876,"journal":{"name":"Journal of Diabetes Research Reviews & Reports","volume":"378 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132084272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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