Pub Date : 2024-02-29DOI: 10.47363/jdrr/2024(6)178
Bhumi Patel, Amber Healy
Background: Insulin has been the gold standard treatment for T2DM during pregnancy. However, emerging studies indicate that GLP-1 agonists have shown significant improvement in insulin resistance. Despite promising results, research conducted on pregnant animal models has shown fetal developmental defects associated with GLP-1 agonists. There is scarcity of research conducted on the use of GLP-1 agonists in human pregnancies. This case report describes the exposure to dulaglutide (GLP-1 agonist) during first trimester of pregnancy. Case: A 41-year-old female with type 2 diabetes mellitus and polycystic ovarian syndrome had been taking dulaglutide until 15 weeks of gestation. She delivered a healthy baby boy via cesarean delivery at 36 weeks’ gestation. Conclusion: In our case, exposure to dulaglutide during the first trimester showed no significant developmental effects on the baby. However, current research is insufficient to categorize GLP-1 agonists as safe during pregnancy.
{"title":"Positive Pregnancy Outcome following First Trimester Dulaglutide Exposure in a Women with Type 2 Diabetes and PCOS: A Case Report","authors":"Bhumi Patel, Amber Healy","doi":"10.47363/jdrr/2024(6)178","DOIUrl":"https://doi.org/10.47363/jdrr/2024(6)178","url":null,"abstract":"Background: Insulin has been the gold standard treatment for T2DM during pregnancy. However, emerging studies indicate that GLP-1 agonists have shown significant improvement in insulin resistance. Despite promising results, research conducted on pregnant animal models has shown fetal developmental defects associated with GLP-1 agonists. There is scarcity of research conducted on the use of GLP-1 agonists in human pregnancies. This case report describes the exposure to dulaglutide (GLP-1 agonist) during first trimester of pregnancy. Case: A 41-year-old female with type 2 diabetes mellitus and polycystic ovarian syndrome had been taking dulaglutide until 15 weeks of gestation. She delivered a healthy baby boy via cesarean delivery at 36 weeks’ gestation. Conclusion: In our case, exposure to dulaglutide during the first trimester showed no significant developmental effects on the baby. However, current research is insufficient to categorize GLP-1 agonists as safe during pregnancy.","PeriodicalId":398876,"journal":{"name":"Journal of Diabetes Research Reviews & Reports","volume":"156 19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140414841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-29DOI: 10.47363/jdrr/2024(6)174
Alok Modi, Sunil Gupta
{"title":"The Relevance of Primary Care in India","authors":"Alok Modi, Sunil Gupta","doi":"10.47363/jdrr/2024(6)174","DOIUrl":"https://doi.org/10.47363/jdrr/2024(6)174","url":null,"abstract":"","PeriodicalId":398876,"journal":{"name":"Journal of Diabetes Research Reviews & Reports","volume":"25 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140414081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-29DOI: 10.47363/jdrr/2024(6)177
Maniatunufus, Nursiswati
Stroke is the leading cause of disability and the second leading cause of death in the world and the biggest cause of death in Indonesia. Knowledge of stroke risk factors and symptoms can improve stroke prevention measures so as to reduce the risk of disability and death. This study aims to analyze the description of knowledge about risk factors and symptoms of stroke in patients with diabetes mellitus, hypertension, and heart disease. The research was carried out using google scholar search engine and electronic databases, such as Pubmed and Science Direct. The English keywords used are knowledge AND “risk factors” AND “stroke symptoms”. Meanwhile, the Indonesian keywords are: pengetahuan DAN “faktor risiko” DAN “gejala stroke”. The inclusion criteria of the articles collected were articles in English and Indonesian, full text, the Cross-Sectional Study method or descriptive, and publication year between 2012-2022. This research obtained 8 articles which would then be analyzed. All articles analyzed were overseas research reports (two african continent countries and three asia continent countries) and in English. It is shown that knowledge about the risk factors and symptoms of stroke in patients with diabetes mellitus, hypertension, and heart disease is still lacking. There are 2 studies that report 56 and 77% of respondents do not know the risk factors for stroke. Knowledge of stroke symptoms in the form of decreased consciousness was found to be very poor (7.6% of respondents).
{"title":"Risk Factors and Stroke Symptoms Knowledge among Diabetes Mellitus, Hypertension and Heart Disease Patients: Literature Review","authors":"Maniatunufus, Nursiswati","doi":"10.47363/jdrr/2024(6)177","DOIUrl":"https://doi.org/10.47363/jdrr/2024(6)177","url":null,"abstract":"Stroke is the leading cause of disability and the second leading cause of death in the world and the biggest cause of death in Indonesia. Knowledge of stroke risk factors and symptoms can improve stroke prevention measures so as to reduce the risk of disability and death. This study aims to analyze the description of knowledge about risk factors and symptoms of stroke in patients with diabetes mellitus, hypertension, and heart disease. The research was carried out using google scholar search engine and electronic databases, such as Pubmed and Science Direct. The English keywords used are knowledge AND “risk factors” AND “stroke symptoms”. Meanwhile, the Indonesian keywords are: pengetahuan DAN “faktor risiko” DAN “gejala stroke”. The inclusion criteria of the articles collected were articles in English and Indonesian, full text, the Cross-Sectional Study method or descriptive, and publication year between 2012-2022. This research obtained 8 articles which would then be analyzed. All articles analyzed were overseas research reports (two african continent countries and three asia continent countries) and in English. It is shown that knowledge about the risk factors and symptoms of stroke in patients with diabetes mellitus, hypertension, and heart disease is still lacking. There are 2 studies that report 56 and 77% of respondents do not know the risk factors for stroke. Knowledge of stroke symptoms in the form of decreased consciousness was found to be very poor (7.6% of respondents).","PeriodicalId":398876,"journal":{"name":"Journal of Diabetes Research Reviews & Reports","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140415369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-29DOI: 10.47363/jdrr/2024(6)176
Jasmin Ahmad, Akin Elahi
Purpose: To find out the knowledge about diabetic complication of eye & the barriers to uptake of diabetic eye care among Type-1 diabetic patients. Method: This is a hospital based observational case series of 100 cases of Type-1 Diabetes Mellitus (DM1). Demographic data, knowledge about diabetic complication of eye, self reported barriers to uptake diabetes eye health service were collected by face-to-face interview. Interview was done on a formulated questionnaire including pre-existing knowledge about diabetes related ocular problems and factors act as a barrier to receive eye care. All DM1 patients attending in a city diabetic hospital during one year (from October 2017 to September 2018) period were included. Written consent was taken. Patients refuse to give consent & aged more than 30 years were excluded. Results: The mean age of participants was (17.09 ± 3.92) years with range 6 to 23 years and 57% of them were female. About 59 % subjects were students. Around 50% of the respondent had knowledge about the adverse effect of diabetes on eyes, among them only 6% had knowledge about retina problems and 3% knew that blindness may happen. Only 32% of study population gave answer about the reason behind not seeking diabetic eye care and the most common (12%) answer was “not feeling necessity of eye care”. Conclusion: DM1 patients are more prone to systemic and ocular morbidity. The main reasons for not getting eye care services was lacks of awareness. Increase awareness building program can bring them to the eye health service which will very important to reduce diabetic ocular morbidity of young people who have long life in front of them.
{"title":"Pre-Existing Knowledge and Self-Reported Barriers to uptake Eye Care among Type-1 Diabetic Patients attending a City Diabetic Hospital at Southern Bangladesh","authors":"Jasmin Ahmad, Akin Elahi","doi":"10.47363/jdrr/2024(6)176","DOIUrl":"https://doi.org/10.47363/jdrr/2024(6)176","url":null,"abstract":"Purpose: To find out the knowledge about diabetic complication of eye & the barriers to uptake of diabetic eye care among Type-1 diabetic patients. Method: This is a hospital based observational case series of 100 cases of Type-1 Diabetes Mellitus (DM1). Demographic data, knowledge about diabetic complication of eye, self reported barriers to uptake diabetes eye health service were collected by face-to-face interview. Interview was done on a formulated questionnaire including pre-existing knowledge about diabetes related ocular problems and factors act as a barrier to receive eye care. All DM1 patients attending in a city diabetic hospital during one year (from October 2017 to September 2018) period were included. Written consent was taken. Patients refuse to give consent & aged more than 30 years were excluded. Results: The mean age of participants was (17.09 ± 3.92) years with range 6 to 23 years and 57% of them were female. About 59 % subjects were students. Around 50% of the respondent had knowledge about the adverse effect of diabetes on eyes, among them only 6% had knowledge about retina problems and 3% knew that blindness may happen. Only 32% of study population gave answer about the reason behind not seeking diabetic eye care and the most common (12%) answer was “not feeling necessity of eye care”. Conclusion: DM1 patients are more prone to systemic and ocular morbidity. The main reasons for not getting eye care services was lacks of awareness. Increase awareness building program can bring them to the eye health service which will very important to reduce diabetic ocular morbidity of young people who have long life in front of them.","PeriodicalId":398876,"journal":{"name":"Journal of Diabetes Research Reviews & Reports","volume":"2018 47","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140415847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-29DOI: 10.47363/jdrr/2024(6)175
Gary G Adams, Ian Shaw
Background: Women with prior gestational diabetes mellitus (GDM) have a high risk of developing type 2 diabetes mellitus (T2DM) in later life. Lifestyle interventions aimed at postpartum weight loss to reduce T2DM risk have been reported but poor compliance remains a barrier. Objectives: To assess what preventative measures reduce type 2 diabetes prevalence among women with previous gestational diabetes. Method: Search Strategy: Electronic databases CINAHL Web of Science PubMed and EMBASE were searched via the e-library gateway of the University of Nottingham using key words combined in a formal search strategy. Selection Criteria: Randomized Controlled Trials and Cluster Randomized Controlled Trials examining what preventative measures reduce type 2 diabetes prevalence among women with previous gestational diabetes were selected. Results: 14 studies were identified for inclusion in the review after a stringent criterion and their data was extracted using JBI data extraction tool. Three themes were identified across the 14 studies mainly: weight management healthy eating and medication and physical activities. Most interventions had positive outcomes however a few had no significant impact in the prevention of T2DM. Conclusion: The likelihood of developing diabetes is higher for women with a history of GDM, increases with a high BMI, high fasting glucose, impaired glucose tolerance, and elevated fasting glucose. This risk can be greatly reduced by making lifestyle adjustments or taking medication. The main risk factors that increase the risk of T2DM after GDM identified in this review were obesity, poor quality of diet and a sedentary lifestyle.
{"title":"A Systematic Review on Prevention of Type 2 Diabetes Mellitus after Gestational Diabetes Mellitus","authors":"Gary G Adams, Ian Shaw","doi":"10.47363/jdrr/2024(6)175","DOIUrl":"https://doi.org/10.47363/jdrr/2024(6)175","url":null,"abstract":"Background: Women with prior gestational diabetes mellitus (GDM) have a high risk of developing type 2 diabetes mellitus (T2DM) in later life. Lifestyle interventions aimed at postpartum weight loss to reduce T2DM risk have been reported but poor compliance remains a barrier. Objectives: To assess what preventative measures reduce type 2 diabetes prevalence among women with previous gestational diabetes. Method: Search Strategy: Electronic databases CINAHL Web of Science PubMed and EMBASE were searched via the e-library gateway of the University of Nottingham using key words combined in a formal search strategy. Selection Criteria: Randomized Controlled Trials and Cluster Randomized Controlled Trials examining what preventative measures reduce type 2 diabetes prevalence among women with previous gestational diabetes were selected. Results: 14 studies were identified for inclusion in the review after a stringent criterion and their data was extracted using JBI data extraction tool. Three themes were identified across the 14 studies mainly: weight management healthy eating and medication and physical activities. Most interventions had positive outcomes however a few had no significant impact in the prevention of T2DM. Conclusion: The likelihood of developing diabetes is higher for women with a history of GDM, increases with a high BMI, high fasting glucose, impaired glucose tolerance, and elevated fasting glucose. This risk can be greatly reduced by making lifestyle adjustments or taking medication. The main risk factors that increase the risk of T2DM after GDM identified in this review were obesity, poor quality of diet and a sedentary lifestyle.","PeriodicalId":398876,"journal":{"name":"Journal of Diabetes Research Reviews & Reports","volume":"19 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140411069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-31DOI: 10.47363/jdrr/2023(5)172
Álvaro Astasio-Picado
Stroke is a focal or general neurological pathology of sudden onset. This condition is usually of vascular origin. It is considered a medical emergency, which requires rapid action and its evolution and cure is time-dependent, which requires immediate decisions based on evidence. The most widely used treatment is reperfusion by fibrinolysis. Objective: to compare the therapeutic strategies in the management of the stroke care plans of the different autonomies of the Spanish territory.
{"title":"Comparative Study of the Different Therapeutic Strategies of Stroke Patients in the Spanish Health System: About a Bibliographic Narrative Review","authors":"Álvaro Astasio-Picado","doi":"10.47363/jdrr/2023(5)172","DOIUrl":"https://doi.org/10.47363/jdrr/2023(5)172","url":null,"abstract":"Stroke is a focal or general neurological pathology of sudden onset. This condition is usually of vascular origin. It is considered a medical emergency, which requires rapid action and its evolution and cure is time-dependent, which requires immediate decisions based on evidence. The most widely used treatment is reperfusion by fibrinolysis. Objective: to compare the therapeutic strategies in the management of the stroke care plans of the different autonomies of the Spanish territory.","PeriodicalId":398876,"journal":{"name":"Journal of Diabetes Research Reviews & Reports","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125102246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.47363/jdrr/2023(5)170
A. Dikmen, H. Şirin, Merve Atik Sahin, S. Ozkan
Introduction: Awareness-based approaches are proven to reduce disease-related complications, depressive symptoms, anxiety during the disease process, economic losses due to disease, and improve quality of life in diabetes patients. This study aims to present the frequency and awareness of diabetes mellitus in patients who applied to a primary health care institution in the capital city of Turkey. Materials and Methods: This cross-sectional study was conducted in the capital city of Turkey. In statistical analysis; descriptive statistics, Mann Whitney U, Kruskal Wallis and logistic regression analysis methods were employed for the statistical analysis part of this research. Results: 24.4% of the participants had diabetes. Regarding diabetes awareness level, statistically significant differences were found in age, education level, marital status, income, attention to healthy nutrition, BMI and presence of chronic disease. Employment variable has been identified as the factor that affected the diabetes awareness score the most in multiple logistic regression analysis. When only the participants with diabetes were examined in the multiple logistic regression analysis, it was found that the factor affecting the diabetes awareness score the most was diabetes type. Other influencing factors were determined as diet for diabetes and receiving diabetes education, respectively. Conclusion: Despite of many research that were carried out under the roof of diabetes awareness in the world and in Turkey, the desired level of knowledge and awareness is yet to be reached. Further research needs to be conducted in order to reach this goal
{"title":"Frequency and Awareness of Diabetes Mellitus in Participants of Primary Healthcare in the Capital of Turkey","authors":"A. Dikmen, H. Şirin, Merve Atik Sahin, S. Ozkan","doi":"10.47363/jdrr/2023(5)170","DOIUrl":"https://doi.org/10.47363/jdrr/2023(5)170","url":null,"abstract":"Introduction: Awareness-based approaches are proven to reduce disease-related complications, depressive symptoms, anxiety during the disease process, economic losses due to disease, and improve quality of life in diabetes patients. This study aims to present the frequency and awareness of diabetes mellitus in patients who applied to a primary health care institution in the capital city of Turkey. Materials and Methods: This cross-sectional study was conducted in the capital city of Turkey. In statistical analysis; descriptive statistics, Mann Whitney U, Kruskal Wallis and logistic regression analysis methods were employed for the statistical analysis part of this research. Results: 24.4% of the participants had diabetes. Regarding diabetes awareness level, statistically significant differences were found in age, education level, marital status, income, attention to healthy nutrition, BMI and presence of chronic disease. Employment variable has been identified as the factor that affected the diabetes awareness score the most in multiple logistic regression analysis. When only the participants with diabetes were examined in the multiple logistic regression analysis, it was found that the factor affecting the diabetes awareness score the most was diabetes type. Other influencing factors were determined as diet for diabetes and receiving diabetes education, respectively. Conclusion: Despite of many research that were carried out under the roof of diabetes awareness in the world and in Turkey, the desired level of knowledge and awareness is yet to be reached. Further research needs to be conducted in order to reach this goal","PeriodicalId":398876,"journal":{"name":"Journal of Diabetes Research Reviews & Reports","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130846099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-30DOI: 10.47363/jdrr/2023(5)169
Orlando Mejía-Rivera
This text makes a brief historical tour of the knowledge of diabetes mellitus, showing the sequence of ancient discoveries and the effort of several generations of physicians and researchers to better understand a pathology than remains a challenge for contemporary medicine. It also highlights the extraordinary episode of the discovery of insulin by Banting and best, in which some serendipitous facts were exploited by the observant and brilliant mind of Frederich Banting.
{"title":"Brief History of Diabetes Mellitus - From Sushruta to Banting –","authors":"Orlando Mejía-Rivera","doi":"10.47363/jdrr/2023(5)169","DOIUrl":"https://doi.org/10.47363/jdrr/2023(5)169","url":null,"abstract":"This text makes a brief historical tour of the knowledge of diabetes mellitus, showing the sequence of ancient discoveries and the effort of several generations of physicians and researchers to better understand a pathology than remains a challenge for contemporary medicine. It also highlights the extraordinary episode of the discovery of insulin by Banting and best, in which some serendipitous facts were exploited by the observant and brilliant mind of Frederich Banting.","PeriodicalId":398876,"journal":{"name":"Journal of Diabetes Research Reviews & Reports","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128135547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-28DOI: 10.47363/jdrr/2023(5)168
M. Occhipinti, F. Baccetti, S. Bertoli, S. Cosimi, Ilaria Casadidio, Ilaria Cuccuro, A. D. Carlo, G. Gregori, Mary Mori, C. Lencioni, P. Orsini, A. Turco, G. di Cianni
Prevalence of type 2 diabetes represent an epidemic problem especially for aging of population. Median age of people affected is rising and Internation Diabetes federation suggest that 1 patients of 5 has more than 65 years. Same situation affected also Italy where in 2020 about 20% of T2D patients were older than 70 years old. This class of patients present often-severe comorbidity as cardiovascular and kidney impairment and are undergoing complex therapies with multiple daily therapy intakes and difficulties in adherence to prescribed therapy. New developed drug, as GLP1-receptor agonist, like Dulaglutide (DU), may be useful in elderly for drug’s ancillary effects and for demonstrated safety on hypoglycemic events. Nevertheless, majority of knowledge, derived from RCT-study, enrolled patients aged 20-65 years and data in elderly patients are limited. Data from real world experience could be useful to understand safety and efficacy of this drug. We retrospectively analyzed data from 751 T2D patients to evaluate DU after 6, 12 and 18 months, comparing people older and younger than 70 years. The introduction of DU, with a relevant number of insulin and sulphanilureas suspensions, statistically reduced HbA1C and body weight after 6 months while glomerular filtration rate (GFR) remained stable and these results lasted over time. About 23% patients dropped-out (8% for gastrointestinal disturbances). No significative differences in tolerability and efficacy, between the two groups were found. DU is a safe, efficacious and easy to use option even for elderly T2D patients
{"title":"Therapy Simplification with Dulaglutide in Elderly Patients: A Real World Study","authors":"M. Occhipinti, F. Baccetti, S. Bertoli, S. Cosimi, Ilaria Casadidio, Ilaria Cuccuro, A. D. Carlo, G. Gregori, Mary Mori, C. Lencioni, P. Orsini, A. Turco, G. di Cianni","doi":"10.47363/jdrr/2023(5)168","DOIUrl":"https://doi.org/10.47363/jdrr/2023(5)168","url":null,"abstract":"Prevalence of type 2 diabetes represent an epidemic problem especially for aging of population. Median age of people affected is rising and Internation Diabetes federation suggest that 1 patients of 5 has more than 65 years. Same situation affected also Italy where in 2020 about 20% of T2D patients were older than 70 years old. This class of patients present often-severe comorbidity as cardiovascular and kidney impairment and are undergoing complex therapies with multiple daily therapy intakes and difficulties in adherence to prescribed therapy. New developed drug, as GLP1-receptor agonist, like Dulaglutide (DU), may be useful in elderly for drug’s ancillary effects and for demonstrated safety on hypoglycemic events. Nevertheless, majority of knowledge, derived from RCT-study, enrolled patients aged 20-65 years and data in elderly patients are limited. Data from real world experience could be useful to understand safety and efficacy of this drug. We retrospectively analyzed data from 751 T2D patients to evaluate DU after 6, 12 and 18 months, comparing people older and younger than 70 years. The introduction of DU, with a relevant number of insulin and sulphanilureas suspensions, statistically reduced HbA1C and body weight after 6 months while glomerular filtration rate (GFR) remained stable and these results lasted over time. About 23% patients dropped-out (8% for gastrointestinal disturbances). No significative differences in tolerability and efficacy, between the two groups were found. DU is a safe, efficacious and easy to use option even for elderly T2D patients","PeriodicalId":398876,"journal":{"name":"Journal of Diabetes Research Reviews & Reports","volume":"103 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117136374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-31DOI: 10.47363/jdrr/2022(4)165
Gary G Adams, Ian Shaw
ABSTRACT Background: Obesity has been on the rise in developed and developing countries such as Nigeria. Data from the WHO demonstrated the prevalence of obesity increased by 15% between 2002 and 2016 in Nigeria. Here, we examine the rate of obesity in Nigerian adults and the associated cause and impact on the population.
{"title":"Obesity in Nigerian Adults and the Associated Cause and Impact on the Population","authors":"Gary G Adams, Ian Shaw","doi":"10.47363/jdrr/2022(4)165","DOIUrl":"https://doi.org/10.47363/jdrr/2022(4)165","url":null,"abstract":"ABSTRACT Background: Obesity has been on the rise in developed and developing countries such as Nigeria. Data from the WHO demonstrated the prevalence of obesity increased by 15% between 2002 and 2016 in Nigeria. Here, we examine the rate of obesity in Nigerian adults and the associated cause and impact on the population.","PeriodicalId":398876,"journal":{"name":"Journal of Diabetes Research Reviews & Reports","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132744735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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