C. Iroha, M. Ugwu, I. Iroha, C. Esimone, C. Ejikeugwu
{"title":"Detection and Dissemination of MCR-1 Colistin Resistance Gene in a Hospital Setting in Abakaliki, Nigeria","authors":"C. Iroha, M. Ugwu, I. Iroha, C. Esimone, C. Ejikeugwu","doi":"10.3923/jms.2023.1.6","DOIUrl":"https://doi.org/10.3923/jms.2023.1.6","url":null,"abstract":"","PeriodicalId":39900,"journal":{"name":"Journal of Medical Sciences (Taiwan)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45536852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Obturator hernia (OH) is uncommon. With its low incidence, diagnosis can be difficult with physical exams and laboratory data only. Imaging study with computer tomography significantly improved diagnosis accuracy and lower bowel resection and mortality rate. We present a rare case of a 70-year-old female with OH and managed by laparoscopic nonmesh repair method.
{"title":"Nonmesh laparoscopic repair of incarcerated obturator hernia","authors":"Ching-Ching Chen, Ting-Yuan Feng, Ren-Tzer Wang, Hao-Ming Chang","doi":"10.4103/jmedsci.jmedsci_338_21","DOIUrl":"https://doi.org/10.4103/jmedsci.jmedsci_338_21","url":null,"abstract":"Obturator hernia (OH) is uncommon. With its low incidence, diagnosis can be difficult with physical exams and laboratory data only. Imaging study with computer tomography significantly improved diagnosis accuracy and lower bowel resection and mortality rate. We present a rare case of a 70-year-old female with OH and managed by laparoscopic nonmesh repair method.","PeriodicalId":39900,"journal":{"name":"Journal of Medical Sciences (Taiwan)","volume":"43 1","pages":"47 - 48"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49195831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/jmedsci.jmedsci_335_21
C. Hsiang, Wen‐Yu Lin, C. Lo, C. Liang, Tsung-Kun Lin, Chun-Hsien Hsieh, Jia-En Chen, Wen-Cheng Liu
Background: Coronary artery calcification (CAC) is a well-validated parameter reflecting the extent of subclinical atherosclerosis. Atherosclerosis manifestations are commonly presented in atrial fibrillation (AF) patients. Nevertheless, the long-term cardiovascular risks in AF patients with concomitant CAC are limited. Aim: The aim of this study is to identify the prognostic impact of CAC in patients with AF. Methods: A total of 646 eligible patients who underwent noncontrast coronary computed tomography (nCCT) from January 2012 to December 2018 were evaluated and retrospectively followed up for 2 years. The patients were assessed for cardiovascular outcomes, including nonfatal myocardial infarction, nonfatal stroke, late coronary revascularization, major adverse cardiovascular event (MACE), and total coronary and total composite events, by a multivariable Cox regression hazards model with adjusting for significant confounding factors. Results: AF patients with severe CAC (CAC score [CACS] >400 Agatston units) had significantly higher risks of composite cardiovascular outcomes, including MACEs (adjusted hazard ratio [HR]: 57.18, 95% confidence interval [CI]: 2.28–1434.41, P = 0.014), total coronary events (adjusted HR: 16.48, 95% CI: 1.21–224.15, P = 0.035), and total composite events (adjusted HR: 26.35, 95% CI: 2.45–283.69, P = 0.007), than sinus rhythm patients without CAC. Moreover, severe CAC in AF patients was a significant predictor of total composite events (adjusted HR: 59.1, 95% CI: 2.16–1616.33, P = 0.016). Conclusion: Severe CAC in AF patients may cause significantly higher cardiovascular risks, highlighting the role of nCCT in determining CACs for early risk evaluation to facilitate aggressive risk modification and thereby to prevent subsequent cardiovascular events. Further, large, prospective studies are needed to validate the impact of CAC in patients with AF.
背景:冠状动脉钙化(CAC)是反映亚临床动脉粥样硬化程度的有效参数。动脉粥样硬化是房颤(AF)患者常见的表现。然而，合并CAC的房颤患者的长期心血管风险是有限的。目的:本研究的目的是确定CAC对房颤患者预后的影响。方法:对2012年1月至2018年12月接受非对比冠状动脉计算机断层扫描(nCCT)的646例符合条件的患者进行评估，并进行2年的回顾性随访。通过校正显著混杂因素的多变量Cox回归风险模型，评估患者的心血管结局，包括非致死性心肌梗死、非致死性卒中、晚期冠状动脉血运重建、主要不良心血管事件(MACE)、总冠状动脉和总复合事件。结果:房颤合并严重CAC (CAC评分[CACS] bb0 400 Agatston单位)患者的心血管综合结局风险显著高于无CAC的窦性心律患者，包括mace(校正风险比[HR]: 57.18, 95%可信区间[CI]: 2.28-1434.41, P = 0.014)、总冠状动脉事件(校正风险比:16.48,95% CI: 1.21-224.15, P = 0.035)和总复合事件(校正风险比:26.35,95% CI: 2.45-283.69, P = 0.007)。此外，房颤患者的严重CAC是总复合事件的重要预测因子(校正HR: 59.1, 95% CI: 2.16-1616.33, P = 0.016)。结论:房颤患者的严重CAC可能导致心血管风险显著升高，因此nCCT在确定CAC以进行早期风险评估以促进积极的风险修改从而预防后续心血管事件方面的作用突出。此外，还需要大规模的前瞻性研究来验证CAC对房颤患者的影响。
{"title":"The Prognostic Implication of Coronary Artery Calcification in Patients with Atrial Fibrillation","authors":"C. Hsiang, Wen‐Yu Lin, C. Lo, C. Liang, Tsung-Kun Lin, Chun-Hsien Hsieh, Jia-En Chen, Wen-Cheng Liu","doi":"10.4103/jmedsci.jmedsci_335_21","DOIUrl":"https://doi.org/10.4103/jmedsci.jmedsci_335_21","url":null,"abstract":"Background: Coronary artery calcification (CAC) is a well-validated parameter reflecting the extent of subclinical atherosclerosis. Atherosclerosis manifestations are commonly presented in atrial fibrillation (AF) patients. Nevertheless, the long-term cardiovascular risks in AF patients with concomitant CAC are limited. Aim: The aim of this study is to identify the prognostic impact of CAC in patients with AF. Methods: A total of 646 eligible patients who underwent noncontrast coronary computed tomography (nCCT) from January 2012 to December 2018 were evaluated and retrospectively followed up for 2 years. The patients were assessed for cardiovascular outcomes, including nonfatal myocardial infarction, nonfatal stroke, late coronary revascularization, major adverse cardiovascular event (MACE), and total coronary and total composite events, by a multivariable Cox regression hazards model with adjusting for significant confounding factors. Results: AF patients with severe CAC (CAC score [CACS] >400 Agatston units) had significantly higher risks of composite cardiovascular outcomes, including MACEs (adjusted hazard ratio [HR]: 57.18, 95% confidence interval [CI]: 2.28–1434.41, P = 0.014), total coronary events (adjusted HR: 16.48, 95% CI: 1.21–224.15, P = 0.035), and total composite events (adjusted HR: 26.35, 95% CI: 2.45–283.69, P = 0.007), than sinus rhythm patients without CAC. Moreover, severe CAC in AF patients was a significant predictor of total composite events (adjusted HR: 59.1, 95% CI: 2.16–1616.33, P = 0.016). Conclusion: Severe CAC in AF patients may cause significantly higher cardiovascular risks, highlighting the role of nCCT in determining CACs for early risk evaluation to facilitate aggressive risk modification and thereby to prevent subsequent cardiovascular events. Further, large, prospective studies are needed to validate the impact of CAC in patients with AF.","PeriodicalId":39900,"journal":{"name":"Journal of Medical Sciences (Taiwan)","volume":"43 1","pages":"28 - 36"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45584582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Different preanesthetic evaluation and management cause a major different outcome in an esophageal achalasia patient","authors":"Yu-Chou Chen, Pei-Han Fu, Yao-Tsung Lin, Jen-Yin Chen, Zhi-Fu Wu","doi":"10.4103/jmedsci.jmedsci_73_21","DOIUrl":"https://doi.org/10.4103/jmedsci.jmedsci_73_21","url":null,"abstract":"","PeriodicalId":39900,"journal":{"name":"Journal of Medical Sciences (Taiwan)","volume":"43 1","pages":"49 - 50"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42090279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/jmedsci.jmedsci_75_23
Zhi-Hong Zheng, Wen-Chun Yen
This article provides a narrative review of the risk factors for anterior cruciate ligament reconstruction (ACLR) failures, as well as strategies to prevent such failures. Early timing for ACLR is not a risk factor for arthrofibrosis anymore according to recent studies. Vancomycin-soaked grafts appear to decrease infection rates after ACLR and are cost-effective. Proper tunnel placement is critical for anatomic ACLR to restore knee kinematics and joint stability. The article proposes a reproducible and accurate method for tunnel positioning. Increased sagittal plane tibial slope has been identified as a risk factor for primary ACLR failure. An anterior closing wedge proximal tibial osteotomy is suggested as a viable option for reducing posterior tibial slope. The lateral extra-articular tenodesis procedure in ACLR is effective in restoring both anterior tibial translation and rotatory stability.
{"title":"Risk factors for failures in anterior cruciate ligament reconstruction: A narrative review","authors":"Zhi-Hong Zheng, Wen-Chun Yen","doi":"10.4103/jmedsci.jmedsci_75_23","DOIUrl":"https://doi.org/10.4103/jmedsci.jmedsci_75_23","url":null,"abstract":"This article provides a narrative review of the risk factors for anterior cruciate ligament reconstruction (ACLR) failures, as well as strategies to prevent such failures. Early timing for ACLR is not a risk factor for arthrofibrosis anymore according to recent studies. Vancomycin-soaked grafts appear to decrease infection rates after ACLR and are cost-effective. Proper tunnel placement is critical for anatomic ACLR to restore knee kinematics and joint stability. The article proposes a reproducible and accurate method for tunnel positioning. Increased sagittal plane tibial slope has been identified as a risk factor for primary ACLR failure. An anterior closing wedge proximal tibial osteotomy is suggested as a viable option for reducing posterior tibial slope. The lateral extra-articular tenodesis procedure in ACLR is effective in restoring both anterior tibial translation and rotatory stability.","PeriodicalId":39900,"journal":{"name":"Journal of Medical Sciences (Taiwan)","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135958447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/jmedsci.jmedsci_281_21
Chia-Ying Lai, Yeu-Chin Chen, Tsung-Ying Li
Spontaneous lumbar facet joint bleeding is rarely observed in patients with hemophilia. Since it is categorized as a spinal epidural hematoma, surgery is the main treatment. Conservative treatment was successful in patients with minor or absent neurological deficits. We aimed to present the case of a patient with severe hemophilia who suffered from acute sciatica caused by lumbar facet joint hematoma. Nonsurgical treatment using a multidimensional approach was provided. The hemarthrosis is completely resolved. The patient recovered from clinical neurological symptoms without recurrence throughout the 4-year follow-up period. Spontaneous lumbar facet joint hemarthrosis in patients with severe hemophilia who present with mild neurological symptoms can be conservatively treated if the hemarthrosis is recognized early. Moreover, a multidisciplinary team approach is paramount in achieving good patient outcomes.
{"title":"Conservative management for spontaneous lumbar facet joint hemarthrosis in severe hemophilia a: A rare case report","authors":"Chia-Ying Lai, Yeu-Chin Chen, Tsung-Ying Li","doi":"10.4103/jmedsci.jmedsci_281_21","DOIUrl":"https://doi.org/10.4103/jmedsci.jmedsci_281_21","url":null,"abstract":"Spontaneous lumbar facet joint bleeding is rarely observed in patients with hemophilia. Since it is categorized as a spinal epidural hematoma, surgery is the main treatment. Conservative treatment was successful in patients with minor or absent neurological deficits. We aimed to present the case of a patient with severe hemophilia who suffered from acute sciatica caused by lumbar facet joint hematoma. Nonsurgical treatment using a multidimensional approach was provided. The hemarthrosis is completely resolved. The patient recovered from clinical neurological symptoms without recurrence throughout the 4-year follow-up period. Spontaneous lumbar facet joint hemarthrosis in patients with severe hemophilia who present with mild neurological symptoms can be conservatively treated if the hemarthrosis is recognized early. Moreover, a multidisciplinary team approach is paramount in achieving good patient outcomes.","PeriodicalId":39900,"journal":{"name":"Journal of Medical Sciences (Taiwan)","volume":"43 1","pages":"37 - 39"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46206845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/jmedsci.jmedsci_49_23
Zhi-Hong Zheng, Jui-Yen Weng
{"title":"Refixation of labrum in pincer type of femoroacetabular impingement","authors":"Zhi-Hong Zheng, Jui-Yen Weng","doi":"10.4103/jmedsci.jmedsci_49_23","DOIUrl":"https://doi.org/10.4103/jmedsci.jmedsci_49_23","url":null,"abstract":"","PeriodicalId":39900,"journal":{"name":"Journal of Medical Sciences (Taiwan)","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135319088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/jmedsci.jmedsci_238_22
Tsai-Wang Huang, Fu-Chieh Hsu
Esophageal schwannomas are a subset of rare tumors that are difficult to differentiate from other esophageal tumors preoperatively. On endoscopic ultrasound (EUS), esophageal schwannomas generally appear as well-demarcated masses that are heterogeneous, hypoechoic, or mixed-echogenic in nature. We present a case of esophageal schwannoma with atypical EUS findings. EUS revealed two lobulated tumors that originated from the muscularis propria and characterized by heterogeneous hypoechoic features and poor blood flow signals. Right-sided video-assisted thoracoscopic surgery with esophageal tumor enucleation was performed. Immunostaining finally confirmed the diagnosis of an esophageal schwannoma. Esophageal schwannomas tend to show heterogeneous hypoechoic or mixed-echogenic features, but they rarely present with two lobulated masses.
{"title":"Esophageal schwannoma with unusual endoscopic ultrasound imaging findings","authors":"Tsai-Wang Huang, Fu-Chieh Hsu","doi":"10.4103/jmedsci.jmedsci_238_22","DOIUrl":"https://doi.org/10.4103/jmedsci.jmedsci_238_22","url":null,"abstract":"Esophageal schwannomas are a subset of rare tumors that are difficult to differentiate from other esophageal tumors preoperatively. On endoscopic ultrasound (EUS), esophageal schwannomas generally appear as well-demarcated masses that are heterogeneous, hypoechoic, or mixed-echogenic in nature. We present a case of esophageal schwannoma with atypical EUS findings. EUS revealed two lobulated tumors that originated from the muscularis propria and characterized by heterogeneous hypoechoic features and poor blood flow signals. Right-sided video-assisted thoracoscopic surgery with esophageal tumor enucleation was performed. Immunostaining finally confirmed the diagnosis of an esophageal schwannoma. Esophageal schwannomas tend to show heterogeneous hypoechoic or mixed-echogenic features, but they rarely present with two lobulated masses.","PeriodicalId":39900,"journal":{"name":"Journal of Medical Sciences (Taiwan)","volume":"106 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135319078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/jmedsci.jmedsci_24_23
Zhi-Hong Zheng, Li-Kuei Yang
{"title":"Potential utility of tranexamic acid in combat trauma","authors":"Zhi-Hong Zheng, Li-Kuei Yang","doi":"10.4103/jmedsci.jmedsci_24_23","DOIUrl":"https://doi.org/10.4103/jmedsci.jmedsci_24_23","url":null,"abstract":"","PeriodicalId":39900,"journal":{"name":"Journal of Medical Sciences (Taiwan)","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135958451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/jmedsci.jmedsci_323_21
Victor Arokia Doss, Dharaniyambigai Kuberapandian
Background: Cardiac hypertrophy (CH) is the asymptomatic enlargement of ventricular walls witnessed in diabetes and hypertension, for which early metabolite differences and prediction are less stated previously. Aim: The aim of the study was (i) to understand the metabolic and ventricular events in diabetes and nondiabetes induced CH at the end of 2 weeks and (ii) to identify significant metabolite predictors and pathways that influence the seven metabolic and physiological responders of CH, namely, 3-hydroxybutyrate (3-HB); lactic acid; urea; and electrocardiography (ECG) waves (QRS complex, R amplitude, R-R interval, and heart rate). Methods: Diabetic rat models of CH using streptozotocin (40 mg/kg, i. p., single dose), and nondiabetic models using adrenaline (0.3 mg/kg, i. p, 2 weeks) were developed. Blood glucose levels, ECG, heart weight/body weight ratio, histopathological analysis, and serum metabolite analysis using gas chromatography mass spectrometry were performed at the end of 2 weeks. Strong metabolite predictors and pathways were identified using Pearson's correlation, multiple regression (MRA) and metabolite set enrichment (MSEA) analyses. Results: The prevalence of CH was observed through preliminary screenings at the end of 2 weeks. Galactose, leucine, erythrose, sorbitol, and valine were identified as significant (P < 0.05) predictors in SZ model, whereas isoleucine, galactose, leucine, inositol, and palmitic acid were identified in ADR model. However, galactose metabolism, branched-chain amino acid, and lactose degradation pathways were mapped as the highly influential apparent pathways during early CH remodeling in both the models. Conclusion: This study identified putative initial metabolite shifts, significant predictors pathways that can aid in forecasting, intervention, and prevention of CH.
{"title":"Identification of metabolite shifts and early serum predictors for indicators of remodelling in diabetes and nondiabetic models of cardiac hypertrophy","authors":"Victor Arokia Doss, Dharaniyambigai Kuberapandian","doi":"10.4103/jmedsci.jmedsci_323_21","DOIUrl":"https://doi.org/10.4103/jmedsci.jmedsci_323_21","url":null,"abstract":"Background: Cardiac hypertrophy (CH) is the asymptomatic enlargement of ventricular walls witnessed in diabetes and hypertension, for which early metabolite differences and prediction are less stated previously. Aim: The aim of the study was (i) to understand the metabolic and ventricular events in diabetes and nondiabetes induced CH at the end of 2 weeks and (ii) to identify significant metabolite predictors and pathways that influence the seven metabolic and physiological responders of CH, namely, 3-hydroxybutyrate (3-HB); lactic acid; urea; and electrocardiography (ECG) waves (QRS complex, R amplitude, R-R interval, and heart rate). Methods: Diabetic rat models of CH using streptozotocin (40 mg/kg, i. p., single dose), and nondiabetic models using adrenaline (0.3 mg/kg, i. p, 2 weeks) were developed. Blood glucose levels, ECG, heart weight/body weight ratio, histopathological analysis, and serum metabolite analysis using gas chromatography mass spectrometry were performed at the end of 2 weeks. Strong metabolite predictors and pathways were identified using Pearson's correlation, multiple regression (MRA) and metabolite set enrichment (MSEA) analyses. Results: The prevalence of CH was observed through preliminary screenings at the end of 2 weeks. Galactose, leucine, erythrose, sorbitol, and valine were identified as significant (P < 0.05) predictors in SZ model, whereas isoleucine, galactose, leucine, inositol, and palmitic acid were identified in ADR model. However, galactose metabolism, branched-chain amino acid, and lactose degradation pathways were mapped as the highly influential apparent pathways during early CH remodeling in both the models. Conclusion: This study identified putative initial metabolite shifts, significant predictors pathways that can aid in forecasting, intervention, and prevention of CH.","PeriodicalId":39900,"journal":{"name":"Journal of Medical Sciences (Taiwan)","volume":"43 1","pages":"18 - 27"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47061075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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