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手術教育のためのデジタルイラストレーション 手术教育的数字插图
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.7887/jcns.30.65
K. Noda
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引用次数: 0
Non-Sedative Quick-Brain MR Imaging for the Evaluation of Pediatric Patients with Hydrocephalus 非镇静快速脑磁共振成像对儿童脑积水的评价
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.7887/jcns.30.675
Tomomi Kimiwada, M. Kitami, Toshiaki Hayashi, Y. Shimanuki, R. Shirane, T. Tominaga
The potential adverse effects of ionizing radiation exposure during imaging studies are particularly relevant to the pediatric population. To reduce radiation exposure, quick‒brain(or rapid sequence)MR imaging has been used to evaluate cerebral ventricle size in pediatric patients with hydrocephalus in Western countries. The objective of this study was to evaluate the quality of images obtained using non‒ sedative quick‒brain MR imaging and consider its merits and limitations. We retrospectively analyzed a series of quick‒brain MRI studies performed without sedation for pediatric patients with hydrocephalus. A total of 41 quick‒brain MRI examinations were performed without sedation for pediatric patients with hydrocephalus with a median age of 9 months at the time of examination. The duration of each study was less than 30 s. The catheter visualization was good, and the image quality was excellent enough for evaluating the cerebral ventricle size. Non‒sedative quick‒brain MR imaging is reliable for evaluating the ventricle size and ventricular catheter in pediatric patients with hydrocephalus. (Received February 10, 2021;accepted April 27, 2021)
在影像学研究中电离辐射暴露的潜在不良影响与儿科人群特别相关。为了减少辐射暴露,在西方国家,快速脑(或快速序列)磁共振成像已被用于评估脑积水儿童患者的脑室大小。本研究的目的是评估使用非镇静快速脑磁共振成像获得的图像质量,并考虑其优点和局限性。我们回顾性分析了儿童脑积水患者在没有镇静的情况下进行的一系列快速脑MRI研究。对年龄中位数为9个月的儿童脑积水患者进行了41例无镇静的快速脑MRI检查。每次研究持续时间不超过30 s。导管显示良好,图像质量足以评估脑室大小。非镇静快速脑磁共振成像是评估脑积水儿童脑室大小和脑室导管的可靠方法。(2021年2月10日收稿,2021年4月27日收稿)
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引用次数: 0
Theory and Practice of Neurocritical Care for Traumatic Brain Injury 外伤性脑损伤神经危重症护理的理论与实践
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.7887/jcns.30.720
E. Suehiro, M. Kawashima, Michiyasu Suzuki
In each patient with traumatic brain injury, the pathology is different, and cerebral blood flow and metabolism changes over time. In such a situation, attention is being paid to neurocritical care, which pro-vides appropriate treatment under monitoring. The emphasis of neurocritical care is ( 1 ) cerebral perfusion pressure / intracranial pressure management ;( 2 ) infusion / electrolyte management ;( 3 ) respiratory management ;( 4 ) sedation / analgesic management ;( 5 ) body temperature management ; and ( 6 ) diagnostic treatment for convulsions. In recent years, the development of neurocritical care has been remarkable, and many results have been reported. Neurocritical care algorithms using intracranial pressure monitoring or brain tissue oxygen partial pressure monitoring as indicators have been investigated and improved outcomes so that they can be easily practiced in daily medical care. In Japan as well, the spread of neurocritical care that makes full use of monitoring is expected to improve the outcome of severe traumatic brain injury. pressure, brain tissue oxygen partial pressure
在每个外伤性脑损伤患者中,病理是不同的,脑血流量和代谢随时间而变化。在这种情况下,应注意神经危重症护理,在监测下提供适当的治疗。神经危重症护理的重点是(1)脑灌注压/颅内压管理;(2)输液/电解质管理;(3)呼吸管理;(4)镇静/镇痛管理;(5)体温管理;(6)惊厥的诊断治疗。近年来,神经危重症的护理得到了显著的发展,并报道了许多结果。以颅内压监测或脑组织氧分压监测为指标的神经危重症护理算法已经被研究并改善了结果,因此它们可以很容易地在日常医疗护理中实践。在日本也是如此,充分利用监测的神经危重症护理的普及有望改善严重创伤性脑损伤的预后。压力,脑组织氧分压
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引用次数: 0
Acromegaly of the Carney Complex Patient : Case Report 卡尼综合征肢端肥大患者:病例报告
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.7887/jcns.30.741
Y. Sakakibara, Homare Nakamura, Hidetaka Onodera, Kimiyuki Kawaguchi, Y. Aida
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引用次数: 0
Paradigm Shift in the Stroke Medical Care System 脑卒中医疗体系的范式转变
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.7887/JCNS.30.194
S. Miyamoto, Kiyofumi Yamada
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引用次数: 1
まぼろしの名著たち 幻想的名著们
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.7887/jcns.30.48
Toshihiko Wakabayashi
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引用次数: 0
Initial Management of Traumatic Brain Injury : To Reduce Preventable Trauma Death 创伤性脑损伤的初始处理:减少可预防的创伤死亡
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.7887/jcns.30.712
S. Yokobori, Kazuma Sasaki, Ami Shibata, Takahiro Kanaya, Yu Fujiki, M. Yamaguchi, Shin Sato, A. Watanabe, Yutaka Igarashi, Go Suzuki, Junya Kaneko, R. Nakae, Hidetaka Onda, A. Kitahashi, Saori Kudo, Yasuhiro Takayama, Y. Naoe, H. Sato, K. Unemoto, A. Fuse, A. Morita, H. Yokota
Shoji Yokobori, M.D., Ph.D.1)2), Kazuma Sasaki, M.D.1)2), Ami Shibata, M.D. Ph.D.1)2), Takahiro Kanaya, M.D.1)2), Yu Fujiki, M.D. Ph.D.1)2), Masahiro Yamaguchi, M.D., Ph.D.1)2), Shin Sato, M.D.1)2), Akihiro Watanabe, M.D. Ph.D.1)2), Yutaka Igarashi, M.D. Ph.D.1)2), Go Suzuki, M.D. Ph.D.1)2), Junya Kaneko, M.D. Ph.D.1)2), Ryuta Nakae, M.D. Ph.D.1)2), Hidetaka Onda, M.D.1)2), Akiko Kitahashi, M.D.1)2), Saori Kudo, M.D. Ph.D.1)2), Yasuhiro Takayama, M.D.1)2), Yasutaka Naoe, M.D. Ph.D.1)2), Hidetaka Sato, M.D. Ph.D.1)2), Kyoko Unemoto, M.D. Ph.D.1)2), Akira Fuse, M.D. Ph.D.1)2), Akio Morita, M.D. Ph.D.3), and Hiroyuki Yokota, M.D. Ph.D.2)4)
横博里昭二,医学博士,博士1)2),佐佐木和久,医学博士1)1)2 2),柴田Ami,医学博士博士1),金谷隆弘,医学博士2),藤木裕,医学博士(博士1)、山口正宏,医学博士。)2),Ryuta Nakae,M.D.Ph.D.1)2)、Hidetaka Onda,M.D.1)2)和Akiko Kitahashi,M.D.1)2)、工藤纱丽(M.D.Ph.D.1)2),高山康弘(M.D.1
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引用次数: 0
Oculomotor Nerve Palsy caused by the Posterior Communicating Artery with Impending Ruptured Internal Carotid-Posterior Communicating Aneurysm : A Case Report 后交通动脉致动眼神经麻痹伴颈内动脉后交通动脉瘤迫近破裂1例
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.7887/JCNS.30.59
Takumi Kajitani, H. Karibe, A. Narisawa, Hideo Saito, M. Goto, M. Kameyama, T. Tominaga
The sudden onset of oculomotor nerve(OCN)paralysis is a symptom that suggests the impending rupture of a cerebral aneurysm. The mechanism of such OCN paralysis has been proposed as direct compression by an enlarged aneurysm and/or blood leakage from an aneurysm. In this article, we report a rare case of aneurysm enlargement in the posterior communicating(Pcom)artery direction to compress the OCN. A 60‒year‒old woman presented with left OCN paralysis with both ptosis and mydriasis. Although CT did not show any intracranial hemorrhage, CT angiography revealed a left internal carotid‒ Pcom(IC‒PC)aneurysm. We diagnosed it as an impending rupture of the aneurysm that required emergency surgery. Intraoperative findings revealed that the fetal Pcom artery, but not the aneurysm, compressed the OCN. We performed neck clipping and partial wrapping of the aneurysm to change the Pcom artery direction to decompress the OCN. Her symptoms improved after surgery. There was a case report in which the Pcom artery compressed the OCN directly instead of the aneurysm, suggesting that it was caused by an abnormal running of the fetal Pcom artery. In this case, aneurysm clipping reduces the volume of the aneurysm to normalize the Pcom artery direction, resulting in neurovascular decompression of the oculomotor nerve. (Received March 5, 2020;accepted June 24, 2020)
动眼神经(OCN)麻痹的突然发作是提示脑动脉瘤即将破裂的症状。这种OCN瘫痪的机制被认为是由增大的动脉瘤和/或动脉瘤的出血直接压迫。在本文中,我们报告一例罕见的后交通(Pcom)动脉方向的动脉瘤扩大以压迫OCN。一位60岁的女性表现为左眼视神经麻痹,同时伴有上睑下垂和瞳孔肿大。虽然CT未显示颅内出血,但CT血管造影显示左侧颈内动脉- Pcom(IC-PC)动脉瘤。我们诊断为动脉瘤即将破裂,需要紧急手术。术中发现胎儿Pcom动脉压迫OCN,而不是动脉瘤。我们对动脉瘤进行了颈部夹持和部分包裹,以改变Pcom动脉的方向以减压OCN。手术后她的症状有所改善。有一例Pcom动脉直接压迫OCN而不是压迫动脉瘤,提示是胎儿Pcom动脉异常运行所致。在这种情况下,动脉瘤夹闭减少动脉瘤的体积,使Pcom动脉方向正常化,导致动眼神经的神经血管减压。(2020年3月5日收稿,2020年6月24日收稿)
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引用次数: 0
Biology and Treatment of Glioblastoma : Future Direction of Basic Research 胶质母细胞瘤的生物学和治疗:基础研究的未来方向
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.7887/JCNS.30.380
T. Sasayama, Kazuhiro Tanaka
2000年にワインバーグらはがんの特徴的な性質(がん のホールマーク)として,1増殖シグナルの亢進,2血 管新生の亢進,3増殖抑制の解除,4アポトーシスの抑 制,5無制限な複製による不死化,6浸潤や転移の促進 の 6つを提唱した9).その後,がんの研究が進み,7ゲ ノムの不安定性,8エネルギー代謝変化によるがん代 謝,9免疫回避,10がん促進性炎症が加わった10).膠芽 腫は他のがんと同様に上記の性質を合わせ持つが,米国 でのがんゲノムプロジェクトである TCGA(The Cancer Genome Atlas)は 3つの経路の異常を有することを報告 した.つまり,細胞増殖・生存シグナルを司る RTK (receptor tyrosine kinase)経路,アポトーシスを制御し たり,ゲノムの安定化を司る p53経路,細胞周期の調整 を司る Rb(retinoblastoma)経路の 3つの経路の異常で
2000年温伯格等人提出了癌症的特征性的性质(癌症的霍尔标记):1增殖信号的亢进,2血管新生的亢进,3增殖抑制的解除,4凋亡的抑制制,5无限制的复制的不死化,6浸润和转移的促进的6个提倡9).之后,癌症的研究进展,7基因组的不稳定性,8能量代谢变化的癌代谢,9免疫回避,10癌症增加了促进性炎症10)。胶质母细胞瘤和其他癌症一样具有上述性质,但美国的癌症基因组计划TCGA(The Cancer Genome Atlas)报告称,胶质母细胞瘤具有3种异常通路。也就是说,负责细胞增殖和生存信号的RTK (receptor tyrosine kinase)路径,负责控制细胞凋亡和基因组稳定的p53路径,以及负责细胞周期的调整Rb(retinoblastoma)路径的三个异常
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引用次数: 0
Integration of Neuro-regenerative Medicine and Robot Rehabilitation 神经再生医学与机器人康复的融合
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.7887/JCNS.30.128
L. Yuge, T. Mitsuhara, K. Kurisu
われわれは,神経再生に対する細胞治療の臨床応用を 目指して,以前より間葉系幹細胞(mesenchymal stem cells:MSC)の研究を行ってきた2)3)6)8)‒10)15)19).MSCは, 骨髄,脂肪,皮膚,滑膜,筋,臍帯組織など多くの組織 から樹立されており,腫瘍化のリスクがきわめて低く, 患者自身の細胞を起源として自家細胞移植治療が行える ため,MSCを用いた再生医療は移植免疫や倫理面から有 利な側面がある.MSCは,自身が組織細胞に分化するの みならず,種々のサイトカインを分泌する trophic効果が 知られており,組織修復などに相乗的効果が期待されて いる.transforming growth factor(TGF‒α),hepatocyte growth factor(HGF)などの mitogenic proteinを発現し, 線維芽細胞や上皮,内皮細胞の分裂を促す.また vascu-
我们致力于将细胞治疗应用于神经再生的临床,从以前开始将间充质干细胞(mesenchymal stemcells:MSC)的研究2)3)6)8 - 10)15)19 .MSC是从骨髓、脂肪、皮肤、滑膜、肌肉、脐带组织等多种组织中建立的,肿瘤化的风险极低,由于可以以患者自身的细胞为起源进行自体细胞移植治疗,所以采用MSC的再生医疗在移植免疫和伦理方面有好处。MSC不仅自身分化为组织细胞,还会分泌各种细胞因子。已知的trophic效果,有望在组织修复等方面产生协同效果。transforming growth factor(TGF - α),hepatocyte growth表达factor(HGF)等mitogenic protein,促进成纤维细胞、上皮、内皮细胞的分裂。
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引用次数: 0
期刊
Japanese Journal of Neurosurgery
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