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Yosetsu Gakkai Ronbunshu/Quarterly Journal of the Japan Welding Society最新文献

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Immunohistochemical expression of histone modification pattern in adult glioblastoma. 成人胶质母细胞瘤组蛋白修饰模式的免疫组化表达。
IF 1.3 Q3 Materials Science
Yosetsu Gakkai Ronbunshu/Quarterly Journal of the Japan Welding Society
Pub Date : 2024-01-01 Epub Date: 2022-11-18 DOI: 10.4103/jcrt.jcrt_257_22
B Archana, Lawrence D'Cruze, Sandhya Sundaram, Krishnakumar Ramanathan, Krishnamurthy Ganesh

Background: Despite the growing advances in molecular research and therapeutics, glioblastomas are still considered highly invasive aggressive tumors with a median survival of 15 months. Genetic alterations have been studied in detail; however, additionally, there is now growing evidence on the role of epigenetic alterations in glioblastoma. Recently, histone modification patterns have been found to have a significant part in gene expression and prognosis. However, further research in this field is warranted to establish its role for the betterment of these patients with the deadly disease.

Aims: To determine the immunohistochemical expression of histone modifications like histone-3-lysine-18 acetylation (H3K18Ac) and histone-4-lysine 20 trimethylation (H4K20triMe) in glioblastoma patients.

Materials and methods: This is a retrospective study of 48 glioblastoma patients who underwent surgery. Immunohistochemistry (IHC) for tri-methyl-histone-H4 (Lys20) (H4K20triMe) and acetyl-histone-H3 (Lys18) (H3K18Ac) was performed in paraffin-embedded tissues manually, and the expression was noted. Data on the mitotic index and overall survival was collected and statistically analyzed.

Results: The mean age was 50 years with a M: F ratio of 1.6:1. Out of 48 cases, 60% (28 cases) demonstrated positivity for H3K18Ac and 98% (46 cases) for H4K20triMe. The pattern of expression was nuclear with increased expression adjacent to necrosis and at the invasive front. The overall median Q score for H3K18Ac was 1/12 and for H4K20triMe was 6/12. No significant statistical significance was observed between histone expression, Ki67%, and overall survival.

Conclusion: Histone modification patterns are being explored in detail in an array of tumors. They also have a potential role in glioblastoma for risk stratification and instituting appropriate treatment based on the prognosis. Epigenetic changes like histone modification patterns, in addition to genetics, can pave the way for a better molecular understanding of glioblastomas and provide hope in the future to improve the survival of these patients with deadly diseases.

背景：尽管分子研究和治疗方法不断进步，胶质母细胞瘤仍被认为是侵袭性极强的肿瘤，中位生存期仅为 15 个月。基因改变已被详细研究过，然而，现在有越来越多的证据表明表观遗传改变在胶质母细胞瘤中的作用。最近，人们发现组蛋白修饰模式在基因表达和预后中起着重要作用。目的：确定胶质母细胞瘤患者组蛋白修饰的免疫组化表达，如组蛋白-3-赖氨酸-18乙酰化（H3K18Ac）和组蛋白-4-赖氨酸20三甲基化（H4K20triMe）：这是一项回顾性研究，研究对象为接受手术的48例胶质母细胞瘤患者。人工对石蜡包埋组织进行三甲基组蛋白-H4（Lys20）（H4K20triMe）和乙酰组蛋白-H3（Lys18）（H3K18Ac）的免疫组化（IHC），并记录其表达情况。收集有丝分裂指数和总生存率数据并进行统计分析：平均年龄为 50 岁，男女比例为 1.6:1。在 48 个病例中，60%（28 例）显示 H3K18Ac 阳性，98%（46 例）显示 H4K20triMe 阳性。H3K18Ac和H4K20triMe的表达模式为核型，在坏死附近和侵袭前沿表达增多。H3K18Ac 的总体 Q 评分中位数为 1/12，H4K20triMe 为 6/12。组蛋白表达、Ki67%和总生存率之间没有明显的统计学意义：结论：组蛋白修饰模式正在一系列肿瘤中被详细探索。它们在胶质母细胞瘤中也有潜在的作用，可用于风险分层，并根据预后情况进行适当的治疗。除遗传学外，组蛋白修饰模式等表观遗传学变化可为更好地从分子角度了解胶质母细胞瘤铺平道路，并为改善这些致命疾病患者的生存状况带来希望。
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引用次数: 0
Short time Resistance Spot Welding of 1.2GPa Ultra-High Strength Steel using High Frequency Power Supply 1.2GPa超高强度钢高频电源短时间电阻点焊
Q3 Materials Science
Yosetsu Gakkai Ronbunshu/Quarterly Journal of the Japan Welding Society
Pub Date : 2023-10-30 DOI: 10.2207/qjjws.41.178
Yohsuke Abe, N. Yoshioka, Yoshihito Kinoshita, S. Yamane
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引用次数: 0
The lymph node in IgA vasculitis (Henöch-Schonlein purpura). IgA 血管炎（Henöch-Schonlein 紫癜）的淋巴结。
IF 0.6 Q3 Materials Science
Yosetsu Gakkai Ronbunshu/Quarterly Journal of the Japan Welding Society
Pub Date : 2023-09-01 Epub Date: 2023-05-26 DOI: 10.1007/s12308-023-00546-7
Samuel M Law, Jeffrey J Fadrowski, Ivo M B Francischetti
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引用次数: 0
Strengthening of Al/Cu dissimilar joint due to complicated interface produced by pulsed TIG welding with a constricted nozzle 收缩喷嘴脉冲TIG焊复杂界面对Al/Cu异种接头的强化
Q3 Materials Science
Yosetsu Gakkai Ronbunshu/Quarterly Journal of the Japan Welding Society
Pub Date : 2023-07-27 DOI: 10.2207/qjjws.41.168
Hajime Yamamoto, Yusuke Yanagi, Kazuhiro Ito, Hisaya Komen, Manabu Tanaka, A. Murata
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引用次数: 0
Direct bonding of Ni nanoparticles to a semiconductor Al electrode in air and its form 空气中镍纳米颗粒与半导体铝电极的直接键合及其形态
Q3 Materials Science
Yosetsu Gakkai Ronbunshu/Quarterly Journal of the Japan Welding Society
Pub Date : 2023-07-25 DOI: 10.2207/qjjws.41.159
Yasunori Tanaka, K. Koshiba, T. Iizuka, Mayumi Ito, K. Higashimine, K. Tatsumi
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引用次数: 1
Microstructure of the interface between Aluminum Alloy and Galvannealed Steel Plates Jointed by FSSW Multi-Step Loading Process FSSW多级加载铝合金与镀锌钢板界面的微观组织
Q3 Materials Science
Yosetsu Gakkai Ronbunshu/Quarterly Journal of the Japan Welding Society
Pub Date : 2023-07-21 DOI: 10.2207/qjjws.41.90
Iori Kojima, C. Iwamoto, Yuka Shimizu, T. Matsuda, A. Hirose
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引用次数: 0
Evaluation of Solidification Cracking Susceptibility Factors in Carbon Steel and Availability of Ti Addition Based on Theoretical Analysis 基于理论分析的碳钢凝固开裂敏感性因素评价及Ti添加的有效性
Q3 Materials Science
Yosetsu Gakkai Ronbunshu/Quarterly Journal of the Japan Welding Society
Pub Date : 2023-07-06 DOI: 10.2207/qjjws.41.150
N. Sahara, Shotaro Yamashita, K. Ono, K. Saida
{"title":"Evaluation of Solidification Cracking Susceptibility Factors in Carbon Steel and Availability of Ti Addition Based on Theoretical Analysis","authors":"N. Sahara, Shotaro Yamashita, K. Ono, K. Saida","doi":"10.2207/qjjws.41.150","DOIUrl":"https://doi.org/10.2207/qjjws.41.150","url":null,"abstract":"","PeriodicalId":39980,"journal":{"name":"Yosetsu Gakkai Ronbunshu/Quarterly Journal of the Japan Welding Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43335011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-speed Hot-wire laser Brazing Technology for Steel/Aluminum alloy Dissimilar Joint using Twin Beam Irradiation 双光束辐照钢/铝合金异种接头高速热丝激光钎焊技术
Q3 Materials Science
Yosetsu Gakkai Ronbunshu/Quarterly Journal of the Japan Welding Society
Pub Date : 2023-07-05 DOI: 10.2207/qjjws.41.116
Tamaki Ito, CHOI Jeong-Won, Motomichi Yamamoto, K. Taniguchi, Y. Okita, H. Matsuda
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引用次数: 0
Effects of Annealing on the Interfacial Microstructure and Mechanical Properties of Explosively Welded AZ80 Magnesium Alloy and A6005C Aluminum Alloy 退火对爆炸焊接AZ80镁合金和A6005C铝合金界面组织和力学性能的影响
Q3 Materials Science
Yosetsu Gakkai Ronbunshu/Quarterly Journal of the Japan Welding Society
Pub Date : 2023-07-02 DOI: 10.2207/qjjws.41.107
Mami Mihara-Narita, Konosuke Asai, H. Mori, N. Saito, Y. Chino, H. Sato, Yoshimi Watanabe
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引用次数: 0
Effect of Plate Deformation Around the Nugget during Tensile Test on Tensile Shear Strength of Resistance Spot Welded Lap Joints 试件拉伸变形对电阻点焊搭接接头拉伸剪切强度的影响
Q3 Materials Science
Yosetsu Gakkai Ronbunshu/Quarterly Journal of the Japan Welding Society
Pub Date : 2023-06-15 DOI: 10.2207/qjjws.41.11
T. Kitamura, T. Akiyama, Mitsuhiro Imamura, T. Kawabata, Atsuro Uemura, C. Mihara, Koki Iwatani
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引用次数: 0
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