Koichi Osaki, Satoshi Morishige, Takayuki Nakamura, Y. Takagi, Yoshitaka Yamasaki, Shuki Oya, Maki Yamaguchi, Koichi Egashira, Takuro Imai, Takuma Hazama, K. Murotani, K. Aoyama, Fumihiko Mouri, K. Nagafuji
The collection of hematopoietic stem cells mobilized from the bone marrow into the bloodstream of healthy donors has now become a routine procedure throughout the world, with at least comparable or safer toxic profile compared to bone marrow collection. For the mobilization of peripheral blood stem cells(PBSC), administration of granulocyte colonySafety and efficacy of outpatient-based administration of granulocyte colony-stimulating factor in collection of allogeneic peripheral blood stem cells: 10 years of single-center experience in 86 donors
{"title":"Safety and efficacy of outpatient-based administration of granulocyte colony-stimulating factor in collection of allogeneic peripheral blood stem cells: 10 years of single-center experience in 86 donors","authors":"Koichi Osaki, Satoshi Morishige, Takayuki Nakamura, Y. Takagi, Yoshitaka Yamasaki, Shuki Oya, Maki Yamaguchi, Koichi Egashira, Takuro Imai, Takuma Hazama, K. Murotani, K. Aoyama, Fumihiko Mouri, K. Nagafuji","doi":"10.7889/HCT-20-022","DOIUrl":"https://doi.org/10.7889/HCT-20-022","url":null,"abstract":"The collection of hematopoietic stem cells mobilized from the bone marrow into the bloodstream of healthy donors has now become a routine procedure throughout the world, with at least comparable or safer toxic profile compared to bone marrow collection. For the mobilization of peripheral blood stem cells(PBSC), administration of granulocyte colonySafety and efficacy of outpatient-based administration of granulocyte colony-stimulating factor in collection of allogeneic peripheral blood stem cells: 10 years of single-center experience in 86 donors","PeriodicalId":403830,"journal":{"name":"Journal of Hematopoietic Cell Transplantation","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134525789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yumiko Inui, K. Matsui, Hisayuki Matsumoto, T. Nose, Rio Shiraki, Y. Nakamachi, Katsuya Yamamoto, A. Okamura
t(16;21)(p11;q22)is a rare non-random chromosomal abnormality found in approximately 1% of acute myelogenous leukemia(AML)cases. This chromosomal rearrangement results in FUS-ERG fusion transcripts. ERG, located at chromosome 21q22, is a member of the ets oncogene family. Correct ERG gene dosage is critical to maintain hematopoietic stem cell function. FUS, at chromosome 16p11, encodes an RNA-binding protein with extensive amino-acid sequence homology to EWS, which is derived from Ewing sarcoma. The FUS-ERG gene is produced by fusion of the 5’ end of FUS to the 3’ end of ERG. The FUS fusion domain regulates DNA-binding activity of the FUS-ERG chimeric protein, resulting in weaker transcriptional activation than that with normal ERG proteins. Dysregulation of normal ERG transcription by FUS-ERG fusion might contribute to the pathogenesis of AML with t(16;21)(p11;q22). AML with t(16;21)(p11;q22)occurs more often in younger individuals for reasons not fully understood. Buchanan et al. compiled 78 cases and reported that the median age was 25 years. AML with t (16;21)(p11;q22)has Case report
{"title":"HLA-Matched and HLA-Haploidentical Hematopoietic Stem Cell Transplantation for Acute Myelogenous Leukemia with t (16;21) (p11.2;q22)","authors":"Yumiko Inui, K. Matsui, Hisayuki Matsumoto, T. Nose, Rio Shiraki, Y. Nakamachi, Katsuya Yamamoto, A. Okamura","doi":"10.7889/hct-19-017","DOIUrl":"https://doi.org/10.7889/hct-19-017","url":null,"abstract":"t(16;21)(p11;q22)is a rare non-random chromosomal abnormality found in approximately 1% of acute myelogenous leukemia(AML)cases. This chromosomal rearrangement results in FUS-ERG fusion transcripts. ERG, located at chromosome 21q22, is a member of the ets oncogene family. Correct ERG gene dosage is critical to maintain hematopoietic stem cell function. FUS, at chromosome 16p11, encodes an RNA-binding protein with extensive amino-acid sequence homology to EWS, which is derived from Ewing sarcoma. The FUS-ERG gene is produced by fusion of the 5’ end of FUS to the 3’ end of ERG. The FUS fusion domain regulates DNA-binding activity of the FUS-ERG chimeric protein, resulting in weaker transcriptional activation than that with normal ERG proteins. Dysregulation of normal ERG transcription by FUS-ERG fusion might contribute to the pathogenesis of AML with t(16;21)(p11;q22). AML with t(16;21)(p11;q22)occurs more often in younger individuals for reasons not fully understood. Buchanan et al. compiled 78 cases and reported that the median age was 25 years. AML with t (16;21)(p11;q22)has Case report","PeriodicalId":403830,"journal":{"name":"Journal of Hematopoietic Cell Transplantation","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122017580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unmanipulated haploidentical stem cell transplantation using low-dose ATG and steroid for high-risk diseases","authors":"K. Ikegame","doi":"10.7889/hct-20-006","DOIUrl":"https://doi.org/10.7889/hct-20-006","url":null,"abstract":"","PeriodicalId":403830,"journal":{"name":"Journal of Hematopoietic Cell Transplantation","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129924540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michiko Tachibana, S. Tsukamoto, Shio Mitsukawa, Y. Takeda, C. Ohwada, Nagisa Oshima-Hasegawa, M. Takeuchi, N. Mimura, T. Iseki, C. Nakaseko, E. Sakaida
{"title":"Impact of introducing a hematopoietic cell transplant coordinator-led coordination system on the search time for an unrelated donor","authors":"Michiko Tachibana, S. Tsukamoto, Shio Mitsukawa, Y. Takeda, C. Ohwada, Nagisa Oshima-Hasegawa, M. Takeuchi, N. Mimura, T. Iseki, C. Nakaseko, E. Sakaida","doi":"10.7889/HCT-18-019","DOIUrl":"https://doi.org/10.7889/HCT-18-019","url":null,"abstract":"","PeriodicalId":403830,"journal":{"name":"Journal of Hematopoietic Cell Transplantation","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121886449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The role of immunotherapy in patients with adult T-cell leukemia/lymphoma","authors":"Koji Kato","doi":"10.7889/HCT-18-010","DOIUrl":"https://doi.org/10.7889/HCT-18-010","url":null,"abstract":"","PeriodicalId":403830,"journal":{"name":"Journal of Hematopoietic Cell Transplantation","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131632685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rie Ando, Eiki Ogawa, T. Osumi, Maki Taniguchi, Kaoru Yoshida, K. Ohkusu, K. Shoji, I. Miyairi, D. Tomizawa, Kimikazu Matsumoto, Motohiro Kato
{"title":"Successful early detection of pulmonary nocardiosis by bronchoalveolar lavage following allogeneic hematopoietic stem cell transplantation","authors":"Rie Ando, Eiki Ogawa, T. Osumi, Maki Taniguchi, Kaoru Yoshida, K. Ohkusu, K. Shoji, I. Miyairi, D. Tomizawa, Kimikazu Matsumoto, Motohiro Kato","doi":"10.7889/HCT-19-002","DOIUrl":"https://doi.org/10.7889/HCT-19-002","url":null,"abstract":"","PeriodicalId":403830,"journal":{"name":"Journal of Hematopoietic Cell Transplantation","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128415033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nursing care in HSCT elderly patients undergoing","authors":"Asako Sakurai","doi":"10.7889/hct-20-024","DOIUrl":"https://doi.org/10.7889/hct-20-024","url":null,"abstract":"","PeriodicalId":403830,"journal":{"name":"Journal of Hematopoietic Cell Transplantation","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128036906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Yamasaki, J. Aoki, Jinichi Mori, Kaito Harada, M. Sawa, N. Uchida, K. Ohashi, T. Fukuda, S. Koh, H. Kanamori, H. Ogawa, H. Okumura, T. Ichinohe, Y. Kanda, J. Tanaka, Y. Atsuta, M. Yanada, S. Yano
1 Department of Hematology and Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan 2Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan 3Department of Hematology, Jyoban hospital, Iwaki, Japan 4Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan 5Department of Hematology and Oncology, Anjo Kosei Hospital, Anjo, Japan 6 Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan 7Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan 8Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan 9Division of Hematology, Fuchu Hospital, Fuchu, Japan 10Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan 11Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Kobe, Japan 12Department of Internal Medicine, Toyama Prefectural Central Hospital, Toyoma, Japan 13 Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan 14Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan 15Department of Hematology, Tokyo Women’s Medical University, Tokyo, Japan 16 Department of Healthcare Administration, Nagoya University Graduate School of Medicine and Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan 17Department of Hematology and Oncology, Fujita Health University School of Medicine, Toyoake, Japan 18Division of Hematology and Oncology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
{"title":"Effect of allogeneic stem cell transplantation in patients with minimally differentiated acute myeloid leukemia","authors":"S. Yamasaki, J. Aoki, Jinichi Mori, Kaito Harada, M. Sawa, N. Uchida, K. Ohashi, T. Fukuda, S. Koh, H. Kanamori, H. Ogawa, H. Okumura, T. Ichinohe, Y. Kanda, J. Tanaka, Y. Atsuta, M. Yanada, S. Yano","doi":"10.7889/HCT-18-017","DOIUrl":"https://doi.org/10.7889/HCT-18-017","url":null,"abstract":"1 Department of Hematology and Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan 2Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan 3Department of Hematology, Jyoban hospital, Iwaki, Japan 4Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan 5Department of Hematology and Oncology, Anjo Kosei Hospital, Anjo, Japan 6 Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan 7Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan 8Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan 9Division of Hematology, Fuchu Hospital, Fuchu, Japan 10Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan 11Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Kobe, Japan 12Department of Internal Medicine, Toyama Prefectural Central Hospital, Toyoma, Japan 13 Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan 14Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan 15Department of Hematology, Tokyo Women’s Medical University, Tokyo, Japan 16 Department of Healthcare Administration, Nagoya University Graduate School of Medicine and Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan 17Department of Hematology and Oncology, Fujita Health University School of Medicine, Toyoake, Japan 18Division of Hematology and Oncology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan","PeriodicalId":403830,"journal":{"name":"Journal of Hematopoietic Cell Transplantation","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123961819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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