{"title":"Narratives of Donors Who Lost Their Siblings in Hematopoietic Stem Cell Transplantation","authors":"Y. Asano, K. Yanagihara","doi":"10.7889/HCT-18-005","DOIUrl":"https://doi.org/10.7889/HCT-18-005","url":null,"abstract":"","PeriodicalId":403830,"journal":{"name":"Journal of Hematopoietic Cell Transplantation","volume":"139 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122534901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Kawano, S. Yoshida, Hidemi Shimonodan, Takuro Kuriyama, N. Ono, D. Himeji, T. Tochigi, Takashi Nakaike, Tomonori Shimokawa, S. Urata, K. Yamashita, Masaki Ito, Hideki Koketsu, Atsushi Toyofuku, T. Muranaka, K. Marutsuka, K. Mashiba, I. Kikuchi, S. Makino, H. Ochiai, K. Shimoda, K. Nagafuji, Y. Mori, T. Miyamoto, K. Akashi
Background: The elucidation of clinical characteristics in deceased patients is essential to improve outcomes of hematopoietic stem cell transplantation（HSCT）for malignancy. Patients and Methods: We retrospectively examined 81 refractory／relapsed hematological malignancy patients treated with allogeneic HSCT（allo-HSCT）（54）and autologous HSCT（auto-HSCT）（27）in our hospital from 2006 to 2016. Results: Consistent with previous Japan Marrow Donor Program annual reports, the overall survival（OS）rate of allo-HSCT and auto-HSCT patients were 59% and 84% at five years, respectively. Among patients receiving allo-HSCT, severe regimen-related toxicity（RRT）（grade ≥ 3）events included cardiomyopathy due to cyclophospha-mide（1）, idiopathic pulmonary syndrome（1）, acute graft-versus-host disease（GVHD）Ⅲ-Ⅳ（3）, acute-exacer-bated chronic GVHD（2）, engraftment failure（2）, human herpesvirus-6 encephalitis（2）, and fungal infection（7）. Moreover, univariate analysis identified disease risk index（DRI）and non-CR status before allo-HSCT as prognostic factors of OS. Among patients receiving auto-HSCT, the severe RRT event was thrombotic microangiopathy （1）. The relapse after auto-HSCT in three patients with malignant lymphoma was a serious concern. Conclusion: Our study revealed critical issues in non-CR patients and those with high／very high DRI before allo-HSCT. Fur -thermore, the occurrence of severe RRT indicated the need for improvements in allo- and auto-HSCT. fusion gene. He achieved complete remission after multi-agent chemotherapy and received an unrelated CBT from a two HLA loci mismatched donor. The patient tested positive for antibodies (IgG) against HHV6 before conditioning for the CBT. The conditioning regimen consisted of total body irradiation (12 Gy) and high-dose cyclophosphamide (60 mg/ kg/day for 2 days). The number of infused nucleated cells in the cord blood was 2.1 × 10 7 /kg body weight. Prophylaxis for graft-versus-host disease (GVHD) consisted of a combination of tacrolimus (0.02 mg/kg/day) and mycophenolate mofetil (30 mg/kg/day). Prophylaxis for herpesvirus infection consisted of oral aciclovir (1,000 mg/day). Grade II acute GVHD of the skin developed on day 12 post-transplantation, and prednisolone (0.5 mg/kg/day) was administered. GVHD responded promptly, and prednisolone was discontinued by We report the case of a 45-year-old male patient who developed human herpesvirus 6 (HHV6)-associated pleurisy after an unrelated cord blood transplantation (CBT) for acute lymphoblastic leukemia. A large amount of pleural effusion accompanied by interstitial pneumonitis was noted on the right side on day 37 post-transplantation. A real-time quantitative PCR (RQ-PCR) assay revealed that the HHV6 viral load was substantially higher in the pleural effusion than in the peripheral blood plasma at the onset of pleurisy, with 2.2 × 10 2 and 7.9 × 10 3 copies of HHV6 DNA/mL in the peripheral blood plasma and the supernatant of the pleural effusion, respectively. More
{"title":"Clinical Features and Treatment Outcomes of Hematopoietic Stem Cell Transplantation During 2006-2016 at a Single Institution in Miyazaki Prefecture","authors":"N. Kawano, S. Yoshida, Hidemi Shimonodan, Takuro Kuriyama, N. Ono, D. Himeji, T. Tochigi, Takashi Nakaike, Tomonori Shimokawa, S. Urata, K. Yamashita, Masaki Ito, Hideki Koketsu, Atsushi Toyofuku, T. Muranaka, K. Marutsuka, K. Mashiba, I. Kikuchi, S. Makino, H. Ochiai, K. Shimoda, K. Nagafuji, Y. Mori, T. Miyamoto, K. Akashi","doi":"10.7889/hct-18-022","DOIUrl":"https://doi.org/10.7889/hct-18-022","url":null,"abstract":"Background: The elucidation of clinical characteristics in deceased patients is essential to improve outcomes of hematopoietic stem cell transplantation（HSCT）for malignancy. Patients and Methods: We retrospectively examined 81 refractory／relapsed hematological malignancy patients treated with allogeneic HSCT（allo-HSCT）（54）and autologous HSCT（auto-HSCT）（27）in our hospital from 2006 to 2016. Results: Consistent with previous Japan Marrow Donor Program annual reports, the overall survival（OS）rate of allo-HSCT and auto-HSCT patients were 59% and 84% at five years, respectively. Among patients receiving allo-HSCT, severe regimen-related toxicity（RRT）（grade ≥ 3）events included cardiomyopathy due to cyclophospha-mide（1）, idiopathic pulmonary syndrome（1）, acute graft-versus-host disease（GVHD）Ⅲ-Ⅳ（3）, acute-exacer-bated chronic GVHD（2）, engraftment failure（2）, human herpesvirus-6 encephalitis（2）, and fungal infection（7）. Moreover, univariate analysis identified disease risk index（DRI）and non-CR status before allo-HSCT as prognostic factors of OS. Among patients receiving auto-HSCT, the severe RRT event was thrombotic microangiopathy （1）. The relapse after auto-HSCT in three patients with malignant lymphoma was a serious concern. Conclusion: Our study revealed critical issues in non-CR patients and those with high／very high DRI before allo-HSCT. Fur -thermore, the occurrence of severe RRT indicated the need for improvements in allo- and auto-HSCT. fusion gene. He achieved complete remission after multi-agent chemotherapy and received an unrelated CBT from a two HLA loci mismatched donor. The patient tested positive for antibodies (IgG) against HHV6 before conditioning for the CBT. The conditioning regimen consisted of total body irradiation (12 Gy) and high-dose cyclophosphamide (60 mg/ kg/day for 2 days). The number of infused nucleated cells in the cord blood was 2.1 × 10 7 /kg body weight. Prophylaxis for graft-versus-host disease (GVHD) consisted of a combination of tacrolimus (0.02 mg/kg/day) and mycophenolate mofetil (30 mg/kg/day). Prophylaxis for herpesvirus infection consisted of oral aciclovir (1,000 mg/day). Grade II acute GVHD of the skin developed on day 12 post-transplantation, and prednisolone (0.5 mg/kg/day) was administered. GVHD responded promptly, and prednisolone was discontinued by We report the case of a 45-year-old male patient who developed human herpesvirus 6 (HHV6)-associated pleurisy after an unrelated cord blood transplantation (CBT) for acute lymphoblastic leukemia. A large amount of pleural effusion accompanied by interstitial pneumonitis was noted on the right side on day 37 post-transplantation. A real-time quantitative PCR (RQ-PCR) assay revealed that the HHV6 viral load was substantially higher in the pleural effusion than in the peripheral blood plasma at the onset of pleurisy, with 2.2 × 10 2 and 7.9 × 10 3 copies of HHV6 DNA/mL in the peripheral blood plasma and the supernatant of the pleural effusion, respectively. More","PeriodicalId":403830,"journal":{"name":"Journal of Hematopoietic Cell Transplantation","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130311555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Hiramatsu, I. Kato, K. Umeda, S. Adachi, J. Takita
{"title":"CAR-T cell therapy for Acute Lymphoblastic Leukemia","authors":"H. Hiramatsu, I. Kato, K. Umeda, S. Adachi, J. Takita","doi":"10.7889/hct-20-004","DOIUrl":"https://doi.org/10.7889/hct-20-004","url":null,"abstract":"","PeriodicalId":403830,"journal":{"name":"Journal of Hematopoietic Cell Transplantation","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133539029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Akira Nishimura, A. Hoshino, Kazuaki Matsumoto, Shintaro Ono, Mari Tanaka, Yasuyoshi Ishiwata, M. Yasuhara, Miho Ashiarai, N. Mitsuiki, K. Higuchi, M. Inoue, T. Miyamura, Y. Hashii, M. Yanagimachi, T. Isoda, M. Kajiwara, M. Takagi, S. Mizutani, H. Kanegane, K. Imai, T. Morio
{"title":"Hematopoietic cell transplantation with reduced intensity conditioning using fludarabine and busulfan for X-linked hyper IgM syndrome","authors":"Akira Nishimura, A. Hoshino, Kazuaki Matsumoto, Shintaro Ono, Mari Tanaka, Yasuyoshi Ishiwata, M. Yasuhara, Miho Ashiarai, N. Mitsuiki, K. Higuchi, M. Inoue, T. Miyamura, Y. Hashii, M. Yanagimachi, T. Isoda, M. Kajiwara, M. Takagi, S. Mizutani, H. Kanegane, K. Imai, T. Morio","doi":"10.7889/HCT-18-009","DOIUrl":"https://doi.org/10.7889/HCT-18-009","url":null,"abstract":"","PeriodicalId":403830,"journal":{"name":"Journal of Hematopoietic Cell Transplantation","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123228630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Adachi, F. Tajima, Yuzuru Hosoda, H. Mochida, S. Sugihara, T. Okamoto, T. Kawatani, J. Suzumiya
Aplastic anemia(AA)is characterized by bone marrow failure and marked decreases of all marrow elements. Hepatitis-associated AA(HAAA)most often affects adolescent and young men who present with severe pancytopenia two to three months after an episode of acute hepatitis. The marrow failure can be precipitous and severe, and is usually fatal if untreated. Furthermore, the hepatitis can be clinically undistinguishable from typical viral hepatitis, but with no specific cause identified. It is well-known that AA is a potentially fatal condition if there is no response to immunotherapy and/or if there is progression to severe pancytopenia. In particular, invasive fungal infections(IFI)are reported to have very poor prognoses. While the role of hematopoietic stem cell transplantation (HSCT)in these AA patients is evolving, even now there are some patients with HSCT-related mortality. However, it is recommended that early allogeneic HSCT(allo-HSCT)should be done in younger severe AA patients with concerns about the risk of severe infections. Patients with AA who lack a matched sibling or unrelated donor and who have a severe Case report
{"title":"Successful treatment of severe aplastic anemia following acute hepatitis with liver fungal abscess by haploidentical peripheral blood stem cell transplantation: a case report","authors":"K. Adachi, F. Tajima, Yuzuru Hosoda, H. Mochida, S. Sugihara, T. Okamoto, T. Kawatani, J. Suzumiya","doi":"10.7889/HCT-18-021","DOIUrl":"https://doi.org/10.7889/HCT-18-021","url":null,"abstract":"Aplastic anemia(AA)is characterized by bone marrow failure and marked decreases of all marrow elements. Hepatitis-associated AA(HAAA)most often affects adolescent and young men who present with severe pancytopenia two to three months after an episode of acute hepatitis. The marrow failure can be precipitous and severe, and is usually fatal if untreated. Furthermore, the hepatitis can be clinically undistinguishable from typical viral hepatitis, but with no specific cause identified. It is well-known that AA is a potentially fatal condition if there is no response to immunotherapy and/or if there is progression to severe pancytopenia. In particular, invasive fungal infections(IFI)are reported to have very poor prognoses. While the role of hematopoietic stem cell transplantation (HSCT)in these AA patients is evolving, even now there are some patients with HSCT-related mortality. However, it is recommended that early allogeneic HSCT(allo-HSCT)should be done in younger severe AA patients with concerns about the risk of severe infections. Patients with AA who lack a matched sibling or unrelated donor and who have a severe Case report","PeriodicalId":403830,"journal":{"name":"Journal of Hematopoietic Cell Transplantation","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133453752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Current status of HLA haplo-identical transplantation using post-transplantation cyclophosphamide","authors":"H. Nakamae","doi":"10.7889/HCT-18-008","DOIUrl":"https://doi.org/10.7889/HCT-18-008","url":null,"abstract":"","PeriodicalId":403830,"journal":{"name":"Journal of Hematopoietic Cell Transplantation","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124592206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ryota Hamada, Michiko Yoshida, Junsuke Miyasaka, Masanobu Murao, M. Nankaku, Jyunya Kanda, T. Kondo, A. Takaori, Susumu Sato, R. Ikeguchi, S. Matsuda
{"title":"The characteristics of changes in skeletal muscle cross-sectional area after allogeneic hematopoietic stem cell transplantation","authors":"Ryota Hamada, Michiko Yoshida, Junsuke Miyasaka, Masanobu Murao, M. Nankaku, Jyunya Kanda, T. Kondo, A. Takaori, Susumu Sato, R. Ikeguchi, S. Matsuda","doi":"10.7889/HCT-18-018","DOIUrl":"https://doi.org/10.7889/HCT-18-018","url":null,"abstract":"","PeriodicalId":403830,"journal":{"name":"Journal of Hematopoietic Cell Transplantation","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127281261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Quality of life after hematopoietic stem cell transplantation in childhood","authors":"Y. Ishida","doi":"10.7889/hct-19-004","DOIUrl":"https://doi.org/10.7889/hct-19-004","url":null,"abstract":"","PeriodicalId":403830,"journal":{"name":"Journal of Hematopoietic Cell Transplantation","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134061873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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