Yui Kuroda, Miki Nonaka, K. Yamaguchi, M. Iseki, Y. Uezono
Owing to improvements of medical technology, cancer has become a treatable disease. While the number of cancer survivors is gradually increasing year by year, many patients are suffering from pain as side–effects or after–effects of cancer treatment. Opioids are used as medical narcotics for the treatment of cancer pain. In the United States, opioid prescriptions that prioritize pain relief have led in many cases to opioid addiction and abuse, and many patients have lost their lives due to overdoses of opioid analgesics. There is an urgent need to develop new methods to reduce the use of opioids and novel effective treatments with fewer side–effects to overcome this situation. Endothelin, known as a vasoconstrictor, has been shown to be involved in pain through its specific receptor, the endothelin A receptor. In addition, endothelin A receptor antagonists are also known to potentiate the effects of opioids and relieve opioid tolerance, although the mechanisms are yet to be elucidated. Here, we present a review based on previous reports on the relationship between endothelin–associated pain signaling and opioids. Furthermore, we show that heterodimerized endothelin A and μ–opioid receptors are involved in endothelin A receptor–mediated pain. We also show that a novel endothelin A receptor antagonist with a higher selectivity for the endo thelin A receptor than existing endothelin A receptor antagonists, potentiates opioid effects ; this endothelin A antagonist would potentially be a novel analgesic adjuvant.
{"title":"Therapeutic strategies for pain signaling via endothelin receptor: endothelin A receptor antagonists as novel analgesic adjuncts","authors":"Yui Kuroda, Miki Nonaka, K. Yamaguchi, M. Iseki, Y. Uezono","doi":"10.11154/pain.36.139","DOIUrl":"https://doi.org/10.11154/pain.36.139","url":null,"abstract":"Owing to improvements of medical technology, cancer has become a treatable disease. While the number of cancer survivors is gradually increasing year by year, many patients are suffering from pain as side–effects or after–effects of cancer treatment. Opioids are used as medical narcotics for the treatment of cancer pain. In the United States, opioid prescriptions that prioritize pain relief have led in many cases to opioid addiction and abuse, and many patients have lost their lives due to overdoses of opioid analgesics. There is an urgent need to develop new methods to reduce the use of opioids and novel effective treatments with fewer side–effects to overcome this situation. Endothelin, known as a vasoconstrictor, has been shown to be involved in pain through its specific receptor, the endothelin A receptor. In addition, endothelin A receptor antagonists are also known to potentiate the effects of opioids and relieve opioid tolerance, although the mechanisms are yet to be elucidated. Here, we present a review based on previous reports on the relationship between endothelin–associated pain signaling and opioids. Furthermore, we show that heterodimerized endothelin A and μ–opioid receptors are involved in endothelin A receptor–mediated pain. We also show that a novel endothelin A receptor antagonist with a higher selectivity for the endo thelin A receptor than existing endothelin A receptor antagonists, potentiates opioid effects ; this endothelin A antagonist would potentially be a novel analgesic adjuvant.","PeriodicalId":41148,"journal":{"name":"Pain Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41300189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Hosomi, N. Mori, Dong Dong, Chanseok Lim, N. Hattori, Yoshiyuki Watanabe, M. Shibata, S. Oshino, H. Kishima, Y. Saitoh
{"title":"A study of stroke lesions related to central post–stroke pain","authors":"K. Hosomi, N. Mori, Dong Dong, Chanseok Lim, N. Hattori, Yoshiyuki Watanabe, M. Shibata, S. Oshino, H. Kishima, Y. Saitoh","doi":"10.11154/pain.36.81","DOIUrl":"https://doi.org/10.11154/pain.36.81","url":null,"abstract":"","PeriodicalId":41148,"journal":{"name":"Pain Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49500566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Orita, M. Inoue, K. Inage, Yasuhiro Shiga, Y. Eguchi, S. Maki, T. Furuya, S. Ohtori
{"title":"Novel perceptions toward the pathology and treatment outcomes in lower back pain patients using wearable trackers","authors":"S. Orita, M. Inoue, K. Inage, Yasuhiro Shiga, Y. Eguchi, S. Maki, T. Furuya, S. Ohtori","doi":"10.11154/pain.36.96","DOIUrl":"https://doi.org/10.11154/pain.36.96","url":null,"abstract":"","PeriodicalId":41148,"journal":{"name":"Pain Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44764478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The epidemiological approach in pain research: the strong and fun points","authors":"Keiko Yamada","doi":"10.11154/pain.36.88","DOIUrl":"https://doi.org/10.11154/pain.36.88","url":null,"abstract":"","PeriodicalId":41148,"journal":{"name":"Pain Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47846200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jun Sato, Ryosuke Ueyama, Kiyoteru Morita, T. Furuya, Yasuko Otsuka, Sayaka Hatakeyama, Mayumi Toda, Naho Toda
Weather changes accompanied by decreases in barometric pressure are suggested to trigger meteoropathy, i.e., weather–related pain. In this paper, the epidemiological and clinical features of weather–related pain ( TENKITSU ) are shown and the mechanism is briefly described. From the weather pain survey 2020, it is estimated that there are at least 10 million people who have weather pain in Japan, but it seems that it is difficult to deal with it in general clinical practice. It is necessary to establish a highly accurate meteoro pathy forecast in order to establish effective preventive treatments. We conducted a large–scale Internet survey and built a predictive model. The survey period was about one year, and 35 surveys were done. We analyzed the correlation between the symptom reports obtained from weather news ( WN ) users ( 157,698 in total ) and the barometric pressure data. The barometric pressure change pattern that contributes to the onset of weather–related pain was indexed. We found that obvious changes in atmospheric pressure, minute changes in atmospheric pressure ( micro– pressure fluctuations ) which occur as a precursor to the collapse of the weather, and diurnal fluctuations in atmospheric pressure ( atmospheric tide ) correlate with worsening of symptoms. Therefore, we weighted the contributions of these three factors, built a model that predicts the risk of developing weather pain up to 6 days ahead every 3 hours, and started using it at WN.
{"title":"The epidemiological and clinical features of weather–related pain (TENKITSU) and development of prediction information service for the onset of pain","authors":"Jun Sato, Ryosuke Ueyama, Kiyoteru Morita, T. Furuya, Yasuko Otsuka, Sayaka Hatakeyama, Mayumi Toda, Naho Toda","doi":"10.11154/pain.36.75","DOIUrl":"https://doi.org/10.11154/pain.36.75","url":null,"abstract":"Weather changes accompanied by decreases in barometric pressure are suggested to trigger meteoropathy, i.e., weather–related pain. In this paper, the epidemiological and clinical features of weather–related pain ( TENKITSU ) are shown and the mechanism is briefly described. From the weather pain survey 2020, it is estimated that there are at least 10 million people who have weather pain in Japan, but it seems that it is difficult to deal with it in general clinical practice. It is necessary to establish a highly accurate meteoro pathy forecast in order to establish effective preventive treatments. We conducted a large–scale Internet survey and built a predictive model. The survey period was about one year, and 35 surveys were done. We analyzed the correlation between the symptom reports obtained from weather news ( WN ) users ( 157,698 in total ) and the barometric pressure data. The barometric pressure change pattern that contributes to the onset of weather–related pain was indexed. We found that obvious changes in atmospheric pressure, minute changes in atmospheric pressure ( micro– pressure fluctuations ) which occur as a precursor to the collapse of the weather, and diurnal fluctuations in atmospheric pressure ( atmospheric tide ) correlate with worsening of symptoms. Therefore, we weighted the contributions of these three factors, built a model that predicts the risk of developing weather pain up to 6 days ahead every 3 hours, and started using it at WN.","PeriodicalId":41148,"journal":{"name":"Pain Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46500499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chronic postsurgical pain after total knee arthroplasty","authors":"M. Ikeuchi","doi":"10.11154/pain.36.102","DOIUrl":"https://doi.org/10.11154/pain.36.102","url":null,"abstract":"","PeriodicalId":41148,"journal":{"name":"Pain Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47937707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Yamaguchi, T. Saito, Shie Iida, Chika Kawabe, Hidefumi Tanaka, Tsuyoshi Maeda, M. Iseki
{"title":"Transition from acute pain service to transitional pain service","authors":"K. Yamaguchi, T. Saito, Shie Iida, Chika Kawabe, Hidefumi Tanaka, Tsuyoshi Maeda, M. Iseki","doi":"10.11154/pain.36.109","DOIUrl":"https://doi.org/10.11154/pain.36.109","url":null,"abstract":"","PeriodicalId":41148,"journal":{"name":"Pain Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45480602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The elucidation of risk factors for acute and chronic postsurgical pain","authors":"Y. Oono, H. Kohase","doi":"10.11154/pain.36.24","DOIUrl":"https://doi.org/10.11154/pain.36.24","url":null,"abstract":"","PeriodicalId":41148,"journal":{"name":"Pain Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46723760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Takafumi Hattori, K. Shimo, Yuto Niwa, Yuji Tokiwa, T. Matsubara
{"title":"Association of chronic pain with structural alteration and central sensitization in Japanese patients with knee osteoarthritis","authors":"Takafumi Hattori, K. Shimo, Yuto Niwa, Yuji Tokiwa, T. Matsubara","doi":"10.11154/pain.36.15","DOIUrl":"https://doi.org/10.11154/pain.36.15","url":null,"abstract":"","PeriodicalId":41148,"journal":{"name":"Pain Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47147547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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