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Therapeutic strategies for pain signaling via endothelin receptor: endothelin A receptor antagonists as novel analgesic adjuncts 通过内皮素受体传导疼痛信号的治疗策略:内皮素A受体拮抗剂作为新型镇痛辅助剂
Pub Date : 2021-09-30 DOI: 10.11154/pain.36.139
Yui Kuroda, Miki Nonaka, K. Yamaguchi, M. Iseki, Y. Uezono
Owing to improvements of medical technology, cancer has become a treatable disease. While the number of cancer survivors is gradually increasing year by year, many patients are suffering from pain as side–effects or after–effects of cancer treatment. Opioids are used as medical narcotics for the treatment of cancer pain. In the United States, opioid prescriptions that prioritize pain relief have led in many cases to opioid addiction and abuse, and many patients have lost their lives due to overdoses of opioid analgesics. There is an urgent need to develop new methods to reduce the use of opioids and novel effective treatments with fewer side–effects to overcome this situation. Endothelin, known as a vasoconstrictor, has been shown to be involved in pain through its specific receptor, the endothelin A receptor. In addition, endothelin A receptor antagonists are also known to potentiate the effects of opioids and relieve opioid tolerance, although the mechanisms are yet to be elucidated. Here, we present a review based on previous reports on the relationship between endothelin–associated pain signaling and opioids. Furthermore, we show that heterodimerized endothelin A and μ–opioid receptors are involved in endothelin A receptor–mediated pain. We also show that a novel endothelin A receptor antagonist with a higher selectivity for the endo thelin A receptor than existing endothelin A receptor antagonists, potentiates opioid effects ; this endothelin A antagonist would potentially be a novel analgesic adjuvant.
由于医疗技术的进步,癌症已成为一种可治疗的疾病。虽然癌症幸存者的数量逐年增加,但许多患者因癌症治疗的副作用或后遗症而遭受痛苦。阿片类药物被用作治疗癌症疼痛的医用麻醉剂。在美国,优先缓解疼痛的阿片类药物处方在许多情况下导致阿片类药物成瘾和滥用,许多患者因过量使用阿片类镇痛药而丧生。目前迫切需要开发减少阿片类药物使用的新方法和副作用更少的新型有效治疗方法来克服这种情况。内皮素是一种血管收缩剂,已被证明通过其特定受体内皮素a受体参与疼痛。此外,内皮素A受体拮抗剂也被认为可以增强阿片样物质的作用并减轻阿片样物质的耐受性,尽管其机制尚未阐明。在此,我们基于先前关于内皮素相关疼痛信号和阿片类药物之间关系的报道进行综述。此外,我们发现异二聚的内皮素A和μ -阿片受体参与内皮素A受体介导的疼痛。我们还发现,一种新型内皮素a受体拮抗剂对内皮素a受体具有比现有内皮素a受体拮抗剂更高的选择性,可增强阿片效应;内皮素A拮抗剂可能是一种新型的镇痛辅助剂。
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引用次数: 0
A study of stroke lesions related to central post–stroke pain 与脑卒中后中枢疼痛相关的脑卒中病变研究
Pub Date : 2021-07-30 DOI: 10.11154/pain.36.81
K. Hosomi, N. Mori, Dong Dong, Chanseok Lim, N. Hattori, Yoshiyuki Watanabe, M. Shibata, S. Oshino, H. Kishima, Y. Saitoh
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引用次数: 0
Novel perceptions toward the pathology and treatment outcomes in lower back pain patients using wearable trackers 对使用可穿戴追踪器的下背部疼痛患者的病理和治疗结果的新认识
Pub Date : 2021-07-30 DOI: 10.11154/pain.36.96
S. Orita, M. Inoue, K. Inage, Yasuhiro Shiga, Y. Eguchi, S. Maki, T. Furuya, S. Ohtori
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引用次数: 0
The epidemiological approach in pain research: the strong and fun points 疼痛研究中的流行病学方法:强而有趣的点
Pub Date : 2021-07-30 DOI: 10.11154/pain.36.88
Keiko Yamada
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引用次数: 0
The epidemiological and clinical features of weather–related pain (TENKITSU) and development of prediction information service for the onset of pain 天气相关性疼痛(TENKITSU)的流行病学和临床特征及发病预测信息服务的发展
Pub Date : 2021-07-30 DOI: 10.11154/pain.36.75
Jun Sato, Ryosuke Ueyama, Kiyoteru Morita, T. Furuya, Yasuko Otsuka, Sayaka Hatakeyama, Mayumi Toda, Naho Toda
Weather changes accompanied by decreases in barometric pressure are suggested to trigger meteoropathy, i.e., weather–related pain. In this paper, the epidemiological and clinical features of weather–related pain ( TENKITSU ) are shown and the mechanism is briefly described. From the weather pain survey 2020, it is estimated that there are at least 10 million people who have weather pain in Japan, but it seems that it is difficult to deal with it in general clinical practice. It is necessary to establish a highly accurate meteoro pathy forecast in order to establish effective preventive treatments. We conducted a large–scale Internet survey and built a predictive model. The survey period was about one year, and 35 surveys were done. We analyzed the correlation between the symptom reports obtained from weather news ( WN ) users ( 157,698 in total ) and the barometric pressure data. The barometric pressure change pattern that contributes to the onset of weather–related pain was indexed. We found that obvious changes in atmospheric pressure, minute changes in atmospheric pressure ( micro– pressure fluctuations ) which occur as a precursor to the collapse of the weather, and diurnal fluctuations in atmospheric pressure ( atmospheric tide ) correlate with worsening of symptoms. Therefore, we weighted the contributions of these three factors, built a model that predicts the risk of developing weather pain up to 6 days ahead every 3 hours, and started using it at WN.
天气变化伴随着大气压的下降被认为会引发流星病,即与天气相关的疼痛。本文介绍了天气相关疼痛(TENKITSU)的流行病学和临床特征,并简要描述了其发病机制。根据2020年天气疼痛调查,据估计,日本至少有1000万人患有天气疼痛,但在一般临床实践中似乎很难应对。为了制定有效的预防措施,有必要建立一个高度准确的气象预报。我们进行了一项大规模的互联网调查,并建立了一个预测模型。调查期约为一年,共进行了35次调查。我们分析了从天气新闻(WN)用户(共157698)获得的症状报告与气压数据之间的相关性。对导致天气相关疼痛发作的大气压变化模式进行了索引。我们发现,大气压力的明显变化、作为天气崩溃前兆的大气压力的微小变化(微压力波动)以及大气压力的昼夜波动(大气潮汐)与症状恶化相关。因此,我们对这三个因素的贡献进行了加权,建立了一个模型,预测每3小时提前6天出现天气疼痛的风险,并开始在WN使用它。
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引用次数: 3
Chronic postsurgical pain after total knee arthroplasty 全膝关节置换术后的慢性术后疼痛
Pub Date : 2021-07-30 DOI: 10.11154/pain.36.102
M. Ikeuchi
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引用次数: 0
Transition from acute pain service to transitional pain service 从急性疼痛服务过渡到过渡性疼痛服务
Pub Date : 2021-07-30 DOI: 10.11154/pain.36.109
K. Yamaguchi, T. Saito, Shie Iida, Chika Kawabe, Hidefumi Tanaka, Tsuyoshi Maeda, M. Iseki
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引用次数: 0
Chronic pain and cortical neural activity 慢性疼痛和皮质神经活动
Pub Date : 2021-04-30 DOI: 10.11154/pain.36.42
M. Hoshiyama
{"title":"Chronic pain and cortical neural activity","authors":"M. Hoshiyama","doi":"10.11154/pain.36.42","DOIUrl":"https://doi.org/10.11154/pain.36.42","url":null,"abstract":"","PeriodicalId":41148,"journal":{"name":"Pain Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42375496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The elucidation of risk factors for acute and chronic postsurgical pain 急性和慢性术后疼痛的危险因素的阐明
Pub Date : 2021-04-30 DOI: 10.11154/pain.36.24
Y. Oono, H. Kohase
{"title":"The elucidation of risk factors for acute and chronic postsurgical pain","authors":"Y. Oono, H. Kohase","doi":"10.11154/pain.36.24","DOIUrl":"https://doi.org/10.11154/pain.36.24","url":null,"abstract":"","PeriodicalId":41148,"journal":{"name":"Pain Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46723760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Association of chronic pain with structural alteration and central sensitization in Japanese patients with knee osteoarthritis 日本膝骨关节炎患者慢性疼痛与结构改变和中枢致敏的关系
Pub Date : 2021-04-30 DOI: 10.11154/pain.36.15
Takafumi Hattori, K. Shimo, Yuto Niwa, Yuji Tokiwa, T. Matsubara
{"title":"Association of chronic pain with structural alteration and central sensitization in Japanese patients with knee osteoarthritis","authors":"Takafumi Hattori, K. Shimo, Yuto Niwa, Yuji Tokiwa, T. Matsubara","doi":"10.11154/pain.36.15","DOIUrl":"https://doi.org/10.11154/pain.36.15","url":null,"abstract":"","PeriodicalId":41148,"journal":{"name":"Pain Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47147547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Pain Research
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