{"title":"Motivational Interviewing: Preparing People for Change","authors":"S. Dabbo, Nader Dabbo","doi":"10.5015/utmj.v87i2.1178","DOIUrl":"https://doi.org/10.5015/utmj.v87i2.1178","url":null,"abstract":"","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2010-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77285925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dr. Karel terBrugge, MD, FRCPC, is a Professor at the University of Toronto and Chief of Neuroradiology at the Toronto Western Hospital. As an internationally recognized interventional neuroradiologist, he specializes in treatment of brain aneurysms, arterio-venous malformations, and acute stroke.
Dr. Karel terBrugge，医学博士，FRCPC，多伦多大学教授，多伦多西部医院神经放射学主任。作为一名国际公认的介入神经放射学家，他擅长治疗脑动脉瘤、动静脉畸形和急性中风。
{"title":"Interventional Neuroradiology: An Interview with Dr. Karel terBrugge","authors":"C. Woodford","doi":"10.5015/utmj.v87i2.1254","DOIUrl":"https://doi.org/10.5015/utmj.v87i2.1254","url":null,"abstract":"Dr. Karel terBrugge, MD, FRCPC, is a Professor at the University of Toronto and Chief of Neuroradiology at the Toronto Western Hospital. As an internationally recognized interventional neuroradiologist, he specializes in treatment of brain aneurysms, arterio-venous malformations, and acute stroke.","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2010-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79183501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dr. David J. Mikulis is a staff neuroradiologist at Toronto Western Hospital and Senior Scientist at the Toronto Western Research Institute, part of the University Health Network. He met with the UTMJ to discuss his career as a clinician-scientist and his lab's novel method of generating maps of cerebrovascular reactivity.
David J. Mikulis博士是多伦多西部医院的神经放射科医生，也是多伦多西部研究所的高级科学家，该研究所是大学健康网络的一部分。他会见了UTMJ，讨论了他作为临床科学家的职业生涯，以及他的实验室生成脑血管反应性图的新方法。
{"title":"Neuroradiology: An Interview with Dr. David J. Mikulis","authors":"R. Vanner","doi":"10.5015/utmj.v87i2.1255","DOIUrl":"https://doi.org/10.5015/utmj.v87i2.1255","url":null,"abstract":"Dr. David J. Mikulis is a staff neuroradiologist at Toronto Western Hospital and Senior Scientist at the Toronto Western Research Institute, part of the University Health Network. He met with the UTMJ to discuss his career as a clinician-scientist and his lab's novel method of generating maps of cerebrovascular reactivity.","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2010-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72863101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A significant proportion of patients who sufferfrom heart disease have both these predisposing factors andother comorbidities, making their management more difficult.While medical treatment of heart conditions has helped toextend the durability of the native heart, many patients willeventually reach a point where invasive surgical manoeuvreshave to be considered.Fortunately, there is an emerging field in cardiovascular med -icine that can provide a new alternative for these patients: per-cutaneous cardiac therapies. These procedures are minimallyinvasive and are often associated with fewer peri-proceduralcomplications than a coronary-artery bypass graft (CABG), lead -ing to fewer subsequent morbidities.
{"title":"Curing the Heart Under the Wire","authors":"T. Soeyonggo","doi":"10.5015/UTMJ.V87I2.1171","DOIUrl":"https://doi.org/10.5015/UTMJ.V87I2.1171","url":null,"abstract":"A significant proportion of patients who sufferfrom heart disease have both these predisposing factors andother comorbidities, making their management more difficult.While medical treatment of heart conditions has helped toextend the durability of the native heart, many patients willeventually reach a point where invasive surgical manoeuvreshave to be considered.Fortunately, there is an emerging field in cardiovascular med -icine that can provide a new alternative for these patients: per-cutaneous cardiac therapies. These procedures are minimallyinvasive and are often associated with fewer peri-proceduralcomplications than a coronary-artery bypass graft (CABG), lead -ing to fewer subsequent morbidities.","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2010-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75513860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Molecular imaging is a rapidly evolving field that aims to develop novel technologies and methods to image specific biological processes in the living organism at the cellular and molecular level. This review discusses several novel imaging strategies that exploit the unique biological properties of atherosclerosis to detect key aspects of the disease. Among the approaches, targeting macrophage activity, protease activity, apoptosis and angiogenesis for in vivo molecular imaging of atherosclerosis have demonstrated the greatest potential for translation into the clinical setting.
{"title":"Molecular Imaging of Atherosclerosis","authors":"Danny L. Costantini","doi":"10.5015/UTMJ.V87I2.1172","DOIUrl":"https://doi.org/10.5015/UTMJ.V87I2.1172","url":null,"abstract":"Molecular imaging is a rapidly evolving field that aims to develop novel technologies and methods to image specific biological processes in the living organism at the cellular and molecular level. This review discusses several novel imaging strategies that exploit the unique biological properties of atherosclerosis to detect key aspects of the disease. Among the approaches, targeting macrophage activity, protease activity, apoptosis and angiogenesis for in vivo molecular imaging of atherosclerosis have demonstrated the greatest potential for translation into the clinical setting.","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2010-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77253479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Blood coagulation involves the serial activation of plasma serine protease precursors (zymogens) by limited proteolysis, to result in the formation of thrombin. The assembly of the prothrombinase complex is essential for rapid thrombin generation. Thrombin amplifies its own production, by activating platelets and the procofactors VIII and V. Activated factor V is a cofactor protein that accelerates the production of thrombin by prothrombinase, an enzyme complex composed of factor Va, factor Xa, prothrombin, calcium ions, and a negatively charged phospholipid membrane. The activity of prothrombinase is regulated to ensure that adequate, but limited levels of thrombin are generated. In turn, the functions of factor Va are regulated by the balance between factor V activation (by thrombin or factor Xa) and factor Va inactivation (by APC and protein S). This review outlines current knowledge on factor V, including its gene, structure, biosynthesis, and its pro- and anti-coagulant roles in blood coagulation.
{"title":"Review of the Structure and Function of Factor V in Blood Coagulation","authors":"S. Jeimy","doi":"10.5015/UTMJ.V87I2.1170","DOIUrl":"https://doi.org/10.5015/UTMJ.V87I2.1170","url":null,"abstract":"Blood coagulation involves the serial activation of plasma serine protease precursors (zymogens) by limited proteolysis, to result in the formation of thrombin. The assembly of the prothrombinase complex is essential for rapid thrombin generation. Thrombin amplifies its own production, by activating platelets and the procofactors VIII and V. Activated factor V is a cofactor protein that accelerates the production of thrombin by prothrombinase, an enzyme complex composed of factor Va, factor Xa, prothrombin, calcium ions, and a negatively charged phospholipid membrane. The activity of prothrombinase is regulated to ensure that adequate, but limited levels of thrombin are generated. In turn, the functions of factor Va are regulated by the balance between factor V activation (by thrombin or factor Xa) and factor Va inactivation (by APC and protein S). This review outlines current knowledge on factor V, including its gene, structure, biosynthesis, and its pro- and anti-coagulant roles in blood coagulation.","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2010-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83128793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The First of Many Lasts","authors":"C. Law, Ray Guo","doi":"10.5015/UTMJ.V87I1.1216","DOIUrl":"https://doi.org/10.5015/UTMJ.V87I1.1216","url":null,"abstract":"","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2009-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86623097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stem Cells and Regenerative Medicine: An Interview with Dr. William L. Stanford","authors":"C. Woodford, R. Vanner","doi":"10.5015/UTMJ.V87I1.1217","DOIUrl":"https://doi.org/10.5015/UTMJ.V87I1.1217","url":null,"abstract":"","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2009-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90709252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tissue Engineering and Orthopaedics: Stemming the Tide of Chronic Disease","authors":"N. D. Korompay, Ian Mayne","doi":"10.5015/UTMJ.V87I1.1220","DOIUrl":"https://doi.org/10.5015/UTMJ.V87I1.1220","url":null,"abstract":"","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2009-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78997636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tissue Engineering and Regenerative Medicine in the Central Nervous System – Progress and Developments","authors":"B. Ballios","doi":"10.5015/UTMJ.V87I1.1221","DOIUrl":"https://doi.org/10.5015/UTMJ.V87I1.1221","url":null,"abstract":"","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2009-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73260890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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