Pub Date : 2015-07-24DOI: 10.1109/NANOFIM.2015.8425335
S. Urooj, Snigdha Sharma
In this work, fabrication of Polyaniline (PANI) nanomaterial is performed by employing chemical oxidative technique. Fabrication of the nanomaterial is preceded by analysis of its electrochemical characteristics for distinct applications in numerous power devices. Especial focus is on energy and power saving device i.e. super capacitor. Electrochemical investigation is accomplished with the assistance of CV, EIS, GCD and I-V tests. The electrochemical analysis has assisted to prove it be one of the most promising nanomaterials for power storage devices.
{"title":"Analysis of Electrochemical Characteristics of Fabricated Polyaniline Nanomaterial for Super capacitors and storage Devices","authors":"S. Urooj, Snigdha Sharma","doi":"10.1109/NANOFIM.2015.8425335","DOIUrl":"https://doi.org/10.1109/NANOFIM.2015.8425335","url":null,"abstract":"In this work, fabrication of Polyaniline (PANI) nanomaterial is performed by employing chemical oxidative technique. Fabrication of the nanomaterial is preceded by analysis of its electrochemical characteristics for distinct applications in numerous power devices. Especial focus is on energy and power saving device i.e. super capacitor. Electrochemical investigation is accomplished with the assistance of CV, EIS, GCD and I-V tests. The electrochemical analysis has assisted to prove it be one of the most promising nanomaterials for power storage devices.","PeriodicalId":413629,"journal":{"name":"2015 1st Workshop on Nanotechnology in Instrumentation and Measurement (NANOFIM)","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126311374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-07-01DOI: 10.1109/NANOFIM.2015.8425342
A. Sinibaldi, A. Anopchenko, A. Occhicone, F. Michelotti, N. Danz, P. Munzert, S. Schmieder, F. Sonntag, R. Chandrawati, S. Rana, M. Stevens, L. Napione
We describe the design and fabrication of biochips based on one dimensional photonic crystals supporting Bloch surface waves for label-free optical biosensing. The planar stacks of the biochips are composed of silica, tantala and titania that were deposited using plasma ion assisted evaporation under high vacuum conditions. The biochip surfaces were functionalized by silanization and appropriate fluidic cells were designed to operate in an automated platform. An angularly resolved optical sensing apparatus was assembled to carry out the sensing studies. The angular operation is obtained by a focused laser beam at a fixed wavelength and detection of the angular reflectance spectrum by means of an array detector. Practical application of the sensor was demonstrated by detecting a specific glycoprotein, Angiopoietin 2, that is involved in angiogenesis and inflammation processes. The protocol used for the label-free detection of Angiopoietin 2 is described and the results of an exemplary assay are given, confirming that an efficient detection can be achieved.
{"title":"Label-free detection of angiogenesis biomarkers using Bloch surface waves on one dimensional photonic crystals","authors":"A. Sinibaldi, A. Anopchenko, A. Occhicone, F. Michelotti, N. Danz, P. Munzert, S. Schmieder, F. Sonntag, R. Chandrawati, S. Rana, M. Stevens, L. Napione","doi":"10.1109/NANOFIM.2015.8425342","DOIUrl":"https://doi.org/10.1109/NANOFIM.2015.8425342","url":null,"abstract":"We describe the design and fabrication of biochips based on one dimensional photonic crystals supporting Bloch surface waves for label-free optical biosensing. The planar stacks of the biochips are composed of silica, tantala and titania that were deposited using plasma ion assisted evaporation under high vacuum conditions. The biochip surfaces were functionalized by silanization and appropriate fluidic cells were designed to operate in an automated platform. An angularly resolved optical sensing apparatus was assembled to carry out the sensing studies. The angular operation is obtained by a focused laser beam at a fixed wavelength and detection of the angular reflectance spectrum by means of an array detector. Practical application of the sensor was demonstrated by detecting a specific glycoprotein, Angiopoietin 2, that is involved in angiogenesis and inflammation processes. The protocol used for the label-free detection of Angiopoietin 2 is described and the results of an exemplary assay are given, confirming that an efficient detection can be achieved.","PeriodicalId":413629,"journal":{"name":"2015 1st Workshop on Nanotechnology in Instrumentation and Measurement (NANOFIM)","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122082157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-07-01DOI: 10.1109/NANOFIM.2015.8425357
B. Adinolfi, F. Baldini, A. Giannetti, S. Tombelli, C. Trono, G. Sotgiu, G. Varchi, M. Pellegrino, C. Domenici
The use of antisense oligonucleotide molecular beacons, able to generate a fluorescent signal when they hybridize with their target mRNA, represents an innovative strategy in cancer. This approach is able to conjugate the ability of sensing specific mRNA with the pharmacological silencing activity, preventing the overexpression of proteins associated to cancer development. In this context, this strategy minimizes the non-specific toxicity addressing the therapy mainly towards the tumor cells by using effective delivery systems. The aim of this work was to investigate the ability of polymethylmethacrylate nanoparticles (PMMA-NPs) to act as vehicle of an oligonucleotide molecular beacon (MB) targeting survivin mRNA in A549 human lung adenocarcinoma epithelial cells. Furthermore, this paper focuses the attention on the need for having an appropriate healthy control in in-vitro experiments. In particular, the survivin-MB was firstly characterized in solution in order to verify its functionality and then the PMMA-NPs ability to promote the MB internalization was verified in A549 cells by confocal microscopy. Confluent Human Dermal Fibroblasts from adult (HDFa) were used as healthy control. The results showed that PMMA-NPs promote the survivin-MB cellular up-take and that the use of 10 µg/mL PMMA-NPs as carrier for survivin-MB for 1h 30 min might be a promising strategy to reduce cancer cell proliferation avoiding detectable consequences on the healthy cells.
{"title":"Polymethylmethacrylate Nanoparticles as Vehicle for a Molecular Beacon Specific for Survivin mRNA in A549 Cells","authors":"B. Adinolfi, F. Baldini, A. Giannetti, S. Tombelli, C. Trono, G. Sotgiu, G. Varchi, M. Pellegrino, C. Domenici","doi":"10.1109/NANOFIM.2015.8425357","DOIUrl":"https://doi.org/10.1109/NANOFIM.2015.8425357","url":null,"abstract":"The use of antisense oligonucleotide molecular beacons, able to generate a fluorescent signal when they hybridize with their target mRNA, represents an innovative strategy in cancer. This approach is able to conjugate the ability of sensing specific mRNA with the pharmacological silencing activity, preventing the overexpression of proteins associated to cancer development. In this context, this strategy minimizes the non-specific toxicity addressing the therapy mainly towards the tumor cells by using effective delivery systems. The aim of this work was to investigate the ability of polymethylmethacrylate nanoparticles (PMMA-NPs) to act as vehicle of an oligonucleotide molecular beacon (MB) targeting survivin mRNA in A549 human lung adenocarcinoma epithelial cells. Furthermore, this paper focuses the attention on the need for having an appropriate healthy control in in-vitro experiments. In particular, the survivin-MB was firstly characterized in solution in order to verify its functionality and then the PMMA-NPs ability to promote the MB internalization was verified in A549 cells by confocal microscopy. Confluent Human Dermal Fibroblasts from adult (HDFa) were used as healthy control. The results showed that PMMA-NPs promote the survivin-MB cellular up-take and that the use of 10 µg/mL PMMA-NPs as carrier for survivin-MB for 1h 30 min might be a promising strategy to reduce cancer cell proliferation avoiding detectable consequences on the healthy cells.","PeriodicalId":413629,"journal":{"name":"2015 1st Workshop on Nanotechnology in Instrumentation and Measurement (NANOFIM)","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125600553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-07-01DOI: 10.1109/NANOFIM.2015.8425334
C. Demitri, A. Tarantino, A. Moscatello, V. D. De Benedictis, M. Madaghiele, A. Sannino, A. Maffezzoli
Bioactive food-preserving systems are based on the use of a natural antimicrobial agent loaded in a carrier material, which is able to trigger its release once necessary and to control the rate of release, thereby exerting either lethal or inhibitory effects against food pathogens or spoilage microorganisms. In this study the Schiff base of chitosan was synthesized by the reaction with cinnamaldehyde at different concentrations. Cinnamaldehyde is an aromatic α,ß-unsaturated aldehyde, and the major component in essential oils from some cinnamon species. It has been shown to exert antimicrobial activity against a wide range of microorganisms including bacteria, yeasts, and mould. The formation of the Schiff base is reversible under suitable conditions, and this might allow the release of the active cinnamaldehyde from chitosan, used as the carrier. The reaction kinetics was investigated by means of rheological analyses and infrared spectroscopy was used to assess the efficacy of the functionalization. Cinnamaldehyde-functionalized chitosan films were then prepared and tested antifungal properties in vitro. Moreover, the effect of the addition of expanded graphite sonicated stacks was evaluated in term of mechanical properties.
{"title":"Graphene reinforced Chitosan-Cinnamaldehyde derivatives films: antifungal activity and mechanical properties","authors":"C. Demitri, A. Tarantino, A. Moscatello, V. D. De Benedictis, M. Madaghiele, A. Sannino, A. Maffezzoli","doi":"10.1109/NANOFIM.2015.8425334","DOIUrl":"https://doi.org/10.1109/NANOFIM.2015.8425334","url":null,"abstract":"Bioactive food-preserving systems are based on the use of a natural antimicrobial agent loaded in a carrier material, which is able to trigger its release once necessary and to control the rate of release, thereby exerting either lethal or inhibitory effects against food pathogens or spoilage microorganisms. In this study the Schiff base of chitosan was synthesized by the reaction with cinnamaldehyde at different concentrations. Cinnamaldehyde is an aromatic α,ß-unsaturated aldehyde, and the major component in essential oils from some cinnamon species. It has been shown to exert antimicrobial activity against a wide range of microorganisms including bacteria, yeasts, and mould. The formation of the Schiff base is reversible under suitable conditions, and this might allow the release of the active cinnamaldehyde from chitosan, used as the carrier. The reaction kinetics was investigated by means of rheological analyses and infrared spectroscopy was used to assess the efficacy of the functionalization. Cinnamaldehyde-functionalized chitosan films were then prepared and tested antifungal properties in vitro. Moreover, the effect of the addition of expanded graphite sonicated stacks was evaluated in term of mechanical properties.","PeriodicalId":413629,"journal":{"name":"2015 1st Workshop on Nanotechnology in Instrumentation and Measurement (NANOFIM)","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114688159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-07-01DOI: 10.1109/NANOFIM.2015.8425365
F. Scalera, F. Gervaso, M. Madaghiele, V. D. De Benedictis, C. Demitri
The aim of this study was to investigate the synthesis of chitosan nanoparticles for growth factor delivery in bone tissue engineering. Chitosan nanoparticles were synthesized via a modified precipitation process and their morphology and dimensions characterized by means of scanning electron microscopy (SEM) and dynamic light scattering (DLS), respectively. In particular, both chitosan molecular weight and concentration were varied during the synthesis to assess the effect of those variables on the particle size and morphology. The stability of the nanoparticles in aqueous media was also assessed, by measuring the average increase of the particle size with time. A specific particle formulation was then selected and loaded with a model molecule, i.e. an oligopeptide derived from the bone morphogenetic protein BMP2. The effect of the nanoparticles on the viability of osteoblast-like MG63 cells was finally assessed in a cytotoxicity assay. The encouraging results obtained in this study, although preliminary, suggested the possible use of chitosan nanoparticles for bone tissue engineering.
{"title":"Preliminary assessment of chitosan nanoparticles for growth factor delivery","authors":"F. Scalera, F. Gervaso, M. Madaghiele, V. D. De Benedictis, C. Demitri","doi":"10.1109/NANOFIM.2015.8425365","DOIUrl":"https://doi.org/10.1109/NANOFIM.2015.8425365","url":null,"abstract":"The aim of this study was to investigate the synthesis of chitosan nanoparticles for growth factor delivery in bone tissue engineering. Chitosan nanoparticles were synthesized via a modified precipitation process and their morphology and dimensions characterized by means of scanning electron microscopy (SEM) and dynamic light scattering (DLS), respectively. In particular, both chitosan molecular weight and concentration were varied during the synthesis to assess the effect of those variables on the particle size and morphology. The stability of the nanoparticles in aqueous media was also assessed, by measuring the average increase of the particle size with time. A specific particle formulation was then selected and loaded with a model molecule, i.e. an oligopeptide derived from the bone morphogenetic protein BMP2. The effect of the nanoparticles on the viability of osteoblast-like MG63 cells was finally assessed in a cytotoxicity assay. The encouraging results obtained in this study, although preliminary, suggested the possible use of chitosan nanoparticles for bone tissue engineering.","PeriodicalId":413629,"journal":{"name":"2015 1st Workshop on Nanotechnology in Instrumentation and Measurement (NANOFIM)","volume":"137 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128708727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-07-01DOI: 10.1109/NANOFIM.2015.8425282
R. Franchini, E. Casciaro, F. Conversano, S. Casciaro, A. Lay-Ekuakille
Multimodal contrast agents (CAs) allow the enhancement of medical images acquired through different techniques by employing a single contrast injection, with significant benefits for diagnostic outcome. The present study is focused on the characterization of the magnetic behavior of a novel CA class, consisting of silica (Si) nanoparticles (NPs) covered by either superparamagnetic iron oxide (SPIO) NPs or FePt-IO nanocrystals and designed to be detected through both ultrasound and magnetic resonance imaging (MRI). The use multimodal nanoparticles as negative MRI contrast agents could open up new perspectives for the development of novel tools for nanomedicine, combining different non-ionizing techniques for targeted imaging of specific diseased cells. In this work, we simulated the MRI signal of a blood vessel in presence of the new bimodal CAs and compared it with the response of the superparamagnetic NPs alone. The performed numerical simulations showed that the magnetic response of the novel nanocomposites, in terms of signal magnitude, was similar to that of the conventional superparamagnetic NPs for values of echo time (TE) shorter than 0.4 ms, while for longer TEvalues it was even better, showing a stronger vessel enhancement leading to an easier detection of the smaller vessels. Therefore, the tested bimodal NPs have the potential for an effective employment as MRI CAs.
{"title":"Comparative Assessment of the MRI Enhancement Power of Novel Nanosystems Through Theoretical Simulations","authors":"R. Franchini, E. Casciaro, F. Conversano, S. Casciaro, A. Lay-Ekuakille","doi":"10.1109/NANOFIM.2015.8425282","DOIUrl":"https://doi.org/10.1109/NANOFIM.2015.8425282","url":null,"abstract":"Multimodal contrast agents (CAs) allow the enhancement of medical images acquired through different techniques by employing a single contrast injection, with significant benefits for diagnostic outcome. The present study is focused on the characterization of the magnetic behavior of a novel CA class, consisting of silica (Si) nanoparticles (NPs) covered by either superparamagnetic iron oxide (SPIO) NPs or FePt-IO nanocrystals and designed to be detected through both ultrasound and magnetic resonance imaging (MRI). The use multimodal nanoparticles as negative MRI contrast agents could open up new perspectives for the development of novel tools for nanomedicine, combining different non-ionizing techniques for targeted imaging of specific diseased cells. In this work, we simulated the MRI signal of a blood vessel in presence of the new bimodal CAs and compared it with the response of the superparamagnetic NPs alone. The performed numerical simulations showed that the magnetic response of the novel nanocomposites, in terms of signal magnitude, was similar to that of the conventional superparamagnetic NPs for values of echo time (TE) shorter than 0.4 ms, while for longer TEvalues it was even better, showing a stronger vessel enhancement leading to an easier detection of the smaller vessels. Therefore, the tested bimodal NPs have the potential for an effective employment as MRI CAs.","PeriodicalId":413629,"journal":{"name":"2015 1st Workshop on Nanotechnology in Instrumentation and Measurement (NANOFIM)","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132328748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-07-01DOI: 10.1109/NANOFIM.2015.8425330
S. Casciaro
Over the last decade many research efforts have been devoted to the development of combined diagnostic and therapeutic (theranostic) nanosystems for targeted diagnoses and self-tailored treatments of various diseases, especially in the oncologic field. These nanoplatforms are expected to offer great opportunities in personalized medicine, which represents the next future of patient care. The most promising candidates as targeted theranostic agents are based on specific inorganic nanoparticles (NPs) such as superparamagnetic iron oxide NPs, quantum dots, silica nanospheres, gold nanorods and halloysite nanotubes. The present paper provides an overview of the current state of the art in the development of inorganic NPs that can simultaneously act as both contrast agents for non-ionizing cellular imaging techniques and as therapeutic agents, highlighting their potential strengths and critical aspects in view of an actual clinical translation. The most realistic perspectives of personalized medicine based on nanosized theranostic agents are also outlined, taking into account both the associated challenges and the corresponding opportunities.
{"title":"Inorganic Nanoparticles for Theranostic Applications: State of the Art Review and Main Future Perspectives","authors":"S. Casciaro","doi":"10.1109/NANOFIM.2015.8425330","DOIUrl":"https://doi.org/10.1109/NANOFIM.2015.8425330","url":null,"abstract":"Over the last decade many research efforts have been devoted to the development of combined diagnostic and therapeutic (theranostic) nanosystems for targeted diagnoses and self-tailored treatments of various diseases, especially in the oncologic field. These nanoplatforms are expected to offer great opportunities in personalized medicine, which represents the next future of patient care. The most promising candidates as targeted theranostic agents are based on specific inorganic nanoparticles (NPs) such as superparamagnetic iron oxide NPs, quantum dots, silica nanospheres, gold nanorods and halloysite nanotubes. The present paper provides an overview of the current state of the art in the development of inorganic NPs that can simultaneously act as both contrast agents for non-ionizing cellular imaging techniques and as therapeutic agents, highlighting their potential strengths and critical aspects in view of an actual clinical translation. The most realistic perspectives of personalized medicine based on nanosized theranostic agents are also outlined, taking into account both the associated challenges and the corresponding opportunities.","PeriodicalId":413629,"journal":{"name":"2015 1st Workshop on Nanotechnology in Instrumentation and Measurement (NANOFIM)","volume":"84 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127860728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-07-01DOI: 10.1109/NANOFIM.2015.8425362
E. Alfinito, L. Reggiani
Different scientific disciplines, from biochemistry to electronics, are converging toward the investigation of nanodevices useful for biological, medical and electronic applications. The strategies to attempt this aim are therefore more and more interconnected and innovative so that it is legitimate to announce the born of a new discipline, the proteotronics. Proteotronics has the main objective to propose and develop innovative electronic devices, based on the selective action of specific proteins.
{"title":"Nanodevices Based on Proteins: the Emerging Science of Proteotronics","authors":"E. Alfinito, L. Reggiani","doi":"10.1109/NANOFIM.2015.8425362","DOIUrl":"https://doi.org/10.1109/NANOFIM.2015.8425362","url":null,"abstract":"Different scientific disciplines, from biochemistry to electronics, are converging toward the investigation of nanodevices useful for biological, medical and electronic applications. The strategies to attempt this aim are therefore more and more interconnected and innovative so that it is legitimate to announce the born of a new discipline, the proteotronics. Proteotronics has the main objective to propose and develop innovative electronic devices, based on the selective action of specific proteins.","PeriodicalId":413629,"journal":{"name":"2015 1st Workshop on Nanotechnology in Instrumentation and Measurement (NANOFIM)","volume":"118 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131698998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-07-01DOI: 10.1109/NANOFIM.2015.8425277
C. Dionisi, N. Hanafy, C. Nobile, S. Leporatti, M. L. De Giorgi, R. Rinaldi, S. Casciaro, Y. Lvov
Halloysite is a nanostructured clay mineral with hollow tubular structure, which has recently found an important role as delivery sistem for drugs or other active molecules. One of these is curcumin, main constituent in the rhizome of the plant Curcuma Longa, with a series of useful pharmacological activities, hindered by its poor solubility in water and bioavalaibility. In this study, Halloysite Clay Nanotubes (HNTs) were characterized in terms of both structure and biocompatibily and they were used for curcumin delivery to cancer cells. The performed MTT assay showed that HNTs have a high biocompatibility, also when coated with polymers, while curcumin is highly toxic for cancer cells. The release kinetics of curcumin from HNTs was investigated by the dialysis bag method, showing a slow and constant release of the drug, which can be further controlled by adding layers of polymers to the external surface of the tubes. The Trypan Blue assay showed a cytotoxic effect of loaded HNTs, proportional to the concentration of tubes and the incubation time.
{"title":"Halloysite Clay Nanotubes as Carriers for Curcumin Delivery","authors":"C. Dionisi, N. Hanafy, C. Nobile, S. Leporatti, M. L. De Giorgi, R. Rinaldi, S. Casciaro, Y. Lvov","doi":"10.1109/NANOFIM.2015.8425277","DOIUrl":"https://doi.org/10.1109/NANOFIM.2015.8425277","url":null,"abstract":"Halloysite is a nanostructured clay mineral with hollow tubular structure, which has recently found an important role as delivery sistem for drugs or other active molecules. One of these is curcumin, main constituent in the rhizome of the plant Curcuma Longa, with a series of useful pharmacological activities, hindered by its poor solubility in water and bioavalaibility. In this study, Halloysite Clay Nanotubes (HNTs) were characterized in terms of both structure and biocompatibily and they were used for curcumin delivery to cancer cells. The performed MTT assay showed that HNTs have a high biocompatibility, also when coated with polymers, while curcumin is highly toxic for cancer cells. The release kinetics of curcumin from HNTs was investigated by the dialysis bag method, showing a slow and constant release of the drug, which can be further controlled by adding layers of polymers to the external surface of the tubes. The Trypan Blue assay showed a cytotoxic effect of loaded HNTs, proportional to the concentration of tubes and the incubation time.","PeriodicalId":413629,"journal":{"name":"2015 1st Workshop on Nanotechnology in Instrumentation and Measurement (NANOFIM)","volume":"274 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115667287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-07-01DOI: 10.1109/NANOFIM.2015.8425338
P. Visconti, P. Costantini, G. Colangelo, G. Cavalera
This paper describes a programmable electronic system for controlling the environmental parameters and managing the electrical functions of a civil/industrial thermo-solar plant. The device acquires data from temperature and light sensors, processes these information and commands external equipments (pumps, electric valves and power supplies) with dedicated relay outputs for the optimization of plant performances in order to maximize efficiency and energy saving. Recently several researches, in the field of solar thermal energy production, have demonstrated that nanofluid-based solar collectors present higher conversion efficiency. In this context, the designed control unit can be used to detect physical parameters in order to compare the performances of nanofluid-based solar collector with those of standard one. The electronic experimental setup is capable to monitor, at the same time, the two different types of solar collector in similar environmental conditions and to show on touch screen display the detected performances.
{"title":"Electronic equipment for managing of thermo-solar plant and for performance comparison between standard and nanofluid-based solar collectors","authors":"P. Visconti, P. Costantini, G. Colangelo, G. Cavalera","doi":"10.1109/NANOFIM.2015.8425338","DOIUrl":"https://doi.org/10.1109/NANOFIM.2015.8425338","url":null,"abstract":"This paper describes a programmable electronic system for controlling the environmental parameters and managing the electrical functions of a civil/industrial thermo-solar plant. The device acquires data from temperature and light sensors, processes these information and commands external equipments (pumps, electric valves and power supplies) with dedicated relay outputs for the optimization of plant performances in order to maximize efficiency and energy saving. Recently several researches, in the field of solar thermal energy production, have demonstrated that nanofluid-based solar collectors present higher conversion efficiency. In this context, the designed control unit can be used to detect physical parameters in order to compare the performances of nanofluid-based solar collector with those of standard one. The electronic experimental setup is capable to monitor, at the same time, the two different types of solar collector in similar environmental conditions and to show on touch screen display the detected performances.","PeriodicalId":413629,"journal":{"name":"2015 1st Workshop on Nanotechnology in Instrumentation and Measurement (NANOFIM)","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123585750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：