Pub Date : 2015-12-01DOI: 10.1016/J.EGYPRO.2015.11.839
A. Carlucci, F. Carnevale, G. Ciccarella, A. Ficarella, E. Filippo, D. Laforgia, F. Mussardo, L. Strafella
{"title":"Air/methane mixture ignition with Multi-Walled Carbon Nanotubes (MWCNTs) and comparison with spark ignition","authors":"A. Carlucci, F. Carnevale, G. Ciccarella, A. Ficarella, E. Filippo, D. Laforgia, F. Mussardo, L. Strafella","doi":"10.1016/J.EGYPRO.2015.11.839","DOIUrl":"https://doi.org/10.1016/J.EGYPRO.2015.11.839","url":null,"abstract":"","PeriodicalId":413629,"journal":{"name":"2015 1st Workshop on Nanotechnology in Instrumentation and Measurement (NANOFIM)","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132489895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-07-24DOI: 10.1109/NANOFIM.2015.8425352
O. Kanoun, C. Müller, Abderrahmane Benchirouf, Abdulkadir Sanli, Carina Gerlach, A. Bouhamed
Polymer/CNT nanocomposites as piezoresistive films provide an innovative approach for the realization of scalable strain sensors with high sensitivity and low manufacturing costs. These nanocomposites can be realized by thin film deposition or printing techniques on flexible substrates, e.g. foils, mats and textiles, and lead to flexible functional layers. Depending on the sensor geometry the sensing layers allow the strain measurement of integral measurements and local measurement at a certain position. Strain sensors based on carbon nanostructures can overcome several limitations of conventional strain sensors and provide interesting advantages, e.g. high sensitivity, adjustable measurement range and integral measurement on large surfaces. Some of these aspects will be exemplarily discussed for CNT/epoxy and CNT/PEDOT: PSS nanocomposites. Owing to their aforementioned features, CNT based flexible strain sensors are highly attractive for applications in the fields of structural health monitoring (SHM) and wearable devices.
{"title":"Carbon Nanotube Polymer Composites for High Performance Strain Sensors","authors":"O. Kanoun, C. Müller, Abderrahmane Benchirouf, Abdulkadir Sanli, Carina Gerlach, A. Bouhamed","doi":"10.1109/NANOFIM.2015.8425352","DOIUrl":"https://doi.org/10.1109/NANOFIM.2015.8425352","url":null,"abstract":"Polymer/CNT nanocomposites as piezoresistive films provide an innovative approach for the realization of scalable strain sensors with high sensitivity and low manufacturing costs. These nanocomposites can be realized by thin film deposition or printing techniques on flexible substrates, e.g. foils, mats and textiles, and lead to flexible functional layers. Depending on the sensor geometry the sensing layers allow the strain measurement of integral measurements and local measurement at a certain position. Strain sensors based on carbon nanostructures can overcome several limitations of conventional strain sensors and provide interesting advantages, e.g. high sensitivity, adjustable measurement range and integral measurement on large surfaces. Some of these aspects will be exemplarily discussed for CNT/epoxy and CNT/PEDOT: PSS nanocomposites. Owing to their aforementioned features, CNT based flexible strain sensors are highly attractive for applications in the fields of structural health monitoring (SHM) and wearable devices.","PeriodicalId":413629,"journal":{"name":"2015 1st Workshop on Nanotechnology in Instrumentation and Measurement (NANOFIM)","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125163210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-07-24DOI: 10.1109/NANOFIM.2015.8425350
M. Longo, S. Cecchi, S. Selmo, M. Fanciulli, C. Wiemer, J. Battaglia, A. Saci, A. Kusiak
Sb2Te3 is a chalcogenide compound of great interest, due to its applications in the fields of phase change, thermoelectric devices, as well as of topological insulators. In this work, the MOCVD deposition of both Sb2Te3 thin films and nanowires was performed by using the same set of precursors and exploiting the low temperature deposition for thin films and VLS mechanisms for nanowires. A special attention was dedicated to the analysis of the thermal properties, performed by scanning thermal microscopy and modulated photothermal radiometry techniques. The thermal conductivity of the thin layers was compared to that of a nanowire, finding that the values are comparable to those reported for bulk Sb2Te3.
{"title":"MOCVD growth and thermal analysis of Sb2Te3 thin films and nanowires","authors":"M. Longo, S. Cecchi, S. Selmo, M. Fanciulli, C. Wiemer, J. Battaglia, A. Saci, A. Kusiak","doi":"10.1109/NANOFIM.2015.8425350","DOIUrl":"https://doi.org/10.1109/NANOFIM.2015.8425350","url":null,"abstract":"Sb2Te3 is a chalcogenide compound of great interest, due to its applications in the fields of phase change, thermoelectric devices, as well as of topological insulators. In this work, the MOCVD deposition of both Sb2Te3 thin films and nanowires was performed by using the same set of precursors and exploiting the low temperature deposition for thin films and VLS mechanisms for nanowires. A special attention was dedicated to the analysis of the thermal properties, performed by scanning thermal microscopy and modulated photothermal radiometry techniques. The thermal conductivity of the thin layers was compared to that of a nanowire, finding that the values are comparable to those reported for bulk Sb2Te3.","PeriodicalId":413629,"journal":{"name":"2015 1st Workshop on Nanotechnology in Instrumentation and Measurement (NANOFIM)","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130781340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-07-24DOI: 10.1109/NANOFIM.2015.8425337
C. Cozzi, G. Polito, L. Strambini, G. Barillaro
In-vitro culture of liver cells on bio-inspired chips., namely liver-on-chip, to form a 3D hepatic tissue morphologically close to its in-vivo counterpart is rapidly emerging for drug testing applications. This paper reports preliminary results towards fabrication of an in-vitro model of the smallest functional liver unit, which is the hepatic lobule. Simultaneous fabrication of out-of-plane micro-channels interconnected by in-plane nanometric-channels is demonstrated by electrochemical etching of n-type silicon in aqueous (48%) HF: (30%) H2O2=1:1 (by vol.) electrolyte through the synergistic work of back-side illumination, avalanche breakdown, and high oxidizing power chemicals.
{"title":"Towards an in-Vitro Liver Lobule Model","authors":"C. Cozzi, G. Polito, L. Strambini, G. Barillaro","doi":"10.1109/NANOFIM.2015.8425337","DOIUrl":"https://doi.org/10.1109/NANOFIM.2015.8425337","url":null,"abstract":"In-vitro culture of liver cells on bio-inspired chips., namely liver-on-chip, to form a 3D hepatic tissue morphologically close to its in-vivo counterpart is rapidly emerging for drug testing applications. This paper reports preliminary results towards fabrication of an in-vitro model of the smallest functional liver unit, which is the hepatic lobule. Simultaneous fabrication of out-of-plane micro-channels interconnected by in-plane nanometric-channels is demonstrated by electrochemical etching of n-type silicon in aqueous (48%) HF: (30%) H2O2=1:1 (by vol.) electrolyte through the synergistic work of back-side illumination, avalanche breakdown, and high oxidizing power chemicals.","PeriodicalId":413629,"journal":{"name":"2015 1st Workshop on Nanotechnology in Instrumentation and Measurement (NANOFIM)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128602373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-07-24DOI: 10.1109/NANOFIM.2015.8425274
M. Terranova, S. Gay, Mariglen Angjellari, E. Tamburri, S. Orlanducci
This paper designs a robot rapid moving strategy based on curve model. The virtual target points are introduced into the path planning of the robot so that the robot can complete the task smoothly and quickly. We give the method to solve the curve model in detail. At the same time, the design of state feedback from the robot control model based on the turning radius is used to solve the practical error problem. Simulation experiments show that the design of virtual target points can not only make the robot complete the task faster, but also can be applied to multi-robot formation control. The real experiment shows that the curve model can correct the error through the robot state feedback and finally make the robots reach the target point successfully.
{"title":"Exploring CVD techniques for the growth of novel carbon nanostructures","authors":"M. Terranova, S. Gay, Mariglen Angjellari, E. Tamburri, S. Orlanducci","doi":"10.1109/NANOFIM.2015.8425274","DOIUrl":"https://doi.org/10.1109/NANOFIM.2015.8425274","url":null,"abstract":"This paper designs a robot rapid moving strategy based on curve model. The virtual target points are introduced into the path planning of the robot so that the robot can complete the task smoothly and quickly. We give the method to solve the curve model in detail. At the same time, the design of state feedback from the robot control model based on the turning radius is used to solve the practical error problem. Simulation experiments show that the design of virtual target points can not only make the robot complete the task faster, but also can be applied to multi-robot formation control. The real experiment shows that the curve model can correct the error through the robot state feedback and finally make the robots reach the target point successfully.","PeriodicalId":413629,"journal":{"name":"2015 1st Workshop on Nanotechnology in Instrumentation and Measurement (NANOFIM)","volume":"123 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122284549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-07-24DOI: 10.1109/NANOFIM.2015.8425359
P. Dardano, I. Rea, L. de Stefano, A. Caliò, J. Politi
Microneedles have been widely applied in biomedicine as tool both in diagnostics and therapeutics. In fact, microneedles are the perfect and painless interface between the derma and a device. Using microneedles as interface and a porous Silicon membrane as reservoir and optical controller, it is possible to realize a smart device for drug delivery. In this paper, we present the fabrication and the results for a patch device loaded with fluorescein molecules, as proof of concept.
{"title":"Optically Controlled Drug Delivery System based on Porous Silicon and Microneedles patch","authors":"P. Dardano, I. Rea, L. de Stefano, A. Caliò, J. Politi","doi":"10.1109/NANOFIM.2015.8425359","DOIUrl":"https://doi.org/10.1109/NANOFIM.2015.8425359","url":null,"abstract":"Microneedles have been widely applied in biomedicine as tool both in diagnostics and therapeutics. In fact, microneedles are the perfect and painless interface between the derma and a device. Using microneedles as interface and a porous Silicon membrane as reservoir and optical controller, it is possible to realize a smart device for drug delivery. In this paper, we present the fabrication and the results for a patch device loaded with fluorescein molecules, as proof of concept.","PeriodicalId":413629,"journal":{"name":"2015 1st Workshop on Nanotechnology in Instrumentation and Measurement (NANOFIM)","volume":"190 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127376910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-07-24DOI: 10.1109/NANOFIM.2015.8425344
Ilio Miccoli, F. Edler, H. Pfnür, C. Tegenkamp, P. Prete, N. Lovergine
III-V semiconductor compound based nanowires (NWs) are expected to impact the fields of nano-electronic, nano-photonic, and photovoltaic devices. Self-assembly of crystal-phase controlled and high optical quality III-V NWs has been demonstrated. However, important physical and technological issues, such as carrier transport properties and reproducible incorporation of high dopant concentrations in NW materials, remain to be addressed for enabling robust nano-devices fabrication. In this work, we show the use of a multi-probe scanning tunneling microscope for the rapid electrical characterization of free-standing GaAs NWs, without any need for post-growth sample processing and contact fabrication. In particular, 2-probe I-V measurements were performed along the axis of a single 60-nm diameter unpassivated GaAs NW, and its resistance profile determined, obtaining high (in the range of GΩ) resistance values. Due to its reduced radial dimension, the NW is expected to be completely depleted. Analysis of the NW resistance profile reveals instead, that carrier transport is mediated by the NW surface states. Finally, by using the substrate as a reference electrode and placing the other three STM-tips along the NWs, we demonstrate a 4-point probe geometry that can be used for the electrical characterization of highly doped NWs.
{"title":"Surface-mediated electrical transport in single GaAs nanowires","authors":"Ilio Miccoli, F. Edler, H. Pfnür, C. Tegenkamp, P. Prete, N. Lovergine","doi":"10.1109/NANOFIM.2015.8425344","DOIUrl":"https://doi.org/10.1109/NANOFIM.2015.8425344","url":null,"abstract":"III-V semiconductor compound based nanowires (NWs) are expected to impact the fields of nano-electronic, nano-photonic, and photovoltaic devices. Self-assembly of crystal-phase controlled and high optical quality III-V NWs has been demonstrated. However, important physical and technological issues, such as carrier transport properties and reproducible incorporation of high dopant concentrations in NW materials, remain to be addressed for enabling robust nano-devices fabrication. In this work, we show the use of a multi-probe scanning tunneling microscope for the rapid electrical characterization of free-standing GaAs NWs, without any need for post-growth sample processing and contact fabrication. In particular, 2-probe I-V measurements were performed along the axis of a single 60-nm diameter unpassivated GaAs NW, and its resistance profile determined, obtaining high (in the range of GΩ) resistance values. Due to its reduced radial dimension, the NW is expected to be completely depleted. Analysis of the NW resistance profile reveals instead, that carrier transport is mediated by the NW surface states. Finally, by using the substrate as a reference electrode and placing the other three STM-tips along the NWs, we demonstrate a 4-point probe geometry that can be used for the electrical characterization of highly doped NWs.","PeriodicalId":413629,"journal":{"name":"2015 1st Workshop on Nanotechnology in Instrumentation and Measurement (NANOFIM)","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128201106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-07-24DOI: 10.1109/NANOFIM.2015.8425273
M. Di Paola, F. Conversano, E. Sbenaglia, S. Casciaro, A. Quarta, G. Gigli, L. Dini
Among the various nanosized particles developed for innovative biomedical applications, like selective molecular imaging and targeted drug delivery, silica nanoparticles (SiNPs) seem to be particularly attractive since of their low cost, low toxicity, ease of functionalization and acoustic properties. In fact, SiNPs have been demonstrated to effectively enhance ultrasound contrast at clinical diagnostic frequencies and, therefore, they might be potentially employed in non-ionizing echographic molecular imaging. Aim of this work was the development of a silica nanoparticle based system for in vitro molecular imaging of hepatocellular carcinoma, using both ultrasound and laser-scanning confocal microscopy, by exploiting the particular feature of these tumor cells to express on their surface high levels of Glypican-3 protein (GPC-3). At this regard, we have designed and characterized novel GPC-3 ligand peptide-functionalized fluorescent silica nanoparticles and tested them on GPC-3 positive HepG2 cells, a human hepatocarcinoma cell line. Laser scanning confocal microscopy analysis showed that GPC-3-targeted fuorescent SiNP, in the concentration range used for experimental ultrasound detection, did not exert significant cytotoxic effects and were effectively bound and taken up by HepG2 cells. These results suggest that silica nanoparticles might be a very promising contrast agents for non-ionizing ultrasound molecular imaging since of their high biocompatibility, targeting effectiveness and ultrasound enhancement power.
{"title":"Effective Targeting of Hepatocellular Carcinoma through Glypican-3 Ligand Peptide Functionalization of Silica Nanoparticles","authors":"M. Di Paola, F. Conversano, E. Sbenaglia, S. Casciaro, A. Quarta, G. Gigli, L. Dini","doi":"10.1109/NANOFIM.2015.8425273","DOIUrl":"https://doi.org/10.1109/NANOFIM.2015.8425273","url":null,"abstract":"Among the various nanosized particles developed for innovative biomedical applications, like selective molecular imaging and targeted drug delivery, silica nanoparticles (SiNPs) seem to be particularly attractive since of their low cost, low toxicity, ease of functionalization and acoustic properties. In fact, SiNPs have been demonstrated to effectively enhance ultrasound contrast at clinical diagnostic frequencies and, therefore, they might be potentially employed in non-ionizing echographic molecular imaging. Aim of this work was the development of a silica nanoparticle based system for in vitro molecular imaging of hepatocellular carcinoma, using both ultrasound and laser-scanning confocal microscopy, by exploiting the particular feature of these tumor cells to express on their surface high levels of Glypican-3 protein (GPC-3). At this regard, we have designed and characterized novel GPC-3 ligand peptide-functionalized fluorescent silica nanoparticles and tested them on GPC-3 positive HepG2 cells, a human hepatocarcinoma cell line. Laser scanning confocal microscopy analysis showed that GPC-3-targeted fuorescent SiNP, in the concentration range used for experimental ultrasound detection, did not exert significant cytotoxic effects and were effectively bound and taken up by HepG2 cells. These results suggest that silica nanoparticles might be a very promising contrast agents for non-ionizing ultrasound molecular imaging since of their high biocompatibility, targeting effectiveness and ultrasound enhancement power.","PeriodicalId":413629,"journal":{"name":"2015 1st Workshop on Nanotechnology in Instrumentation and Measurement (NANOFIM)","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116653149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-07-24DOI: 10.1109/NANOFIM.2015.8425347
R. Rella, M. G. Manera, A. Colombelli, G. Montagna, C. Fernández, F. Albertini, A. Convertino
Surface Plasmon Resonance (SPR) is known as a leading technology for label-free biosensing. It is based on the optical detection of refractive index changes occurring at a metal/dielectric interface upon a proper choice of the metal layer, its thickness as well as on the excitation light beam. Biological and chemical analysis are achieved by functionalizing the gold surface with surface bioreceptors and measuring the shift of corresponding optical signals when a biomolecular reaction occurs. In order to increase the sensing performances two strategies have been adopted: a proper combination of noble metal and ferromagnetic materials tailored on the nanoscale is used as novel transducer in SPR-based biosensor coupled with an external magnetic field; and a new 3D transductor consisting of silica nanowires decorated by gold nanoparticles have been realized to increase the performance of sensing devices In both case increasing biosensing performance have been demonstrated.
{"title":"Propagating and Localised Plasmonic and Magneto-Plasmonic Transductors for Gas and Biosensing Applications","authors":"R. Rella, M. G. Manera, A. Colombelli, G. Montagna, C. Fernández, F. Albertini, A. Convertino","doi":"10.1109/NANOFIM.2015.8425347","DOIUrl":"https://doi.org/10.1109/NANOFIM.2015.8425347","url":null,"abstract":"Surface Plasmon Resonance (SPR) is known as a leading technology for label-free biosensing. It is based on the optical detection of refractive index changes occurring at a metal/dielectric interface upon a proper choice of the metal layer, its thickness as well as on the excitation light beam. Biological and chemical analysis are achieved by functionalizing the gold surface with surface bioreceptors and measuring the shift of corresponding optical signals when a biomolecular reaction occurs. In order to increase the sensing performances two strategies have been adopted: a proper combination of noble metal and ferromagnetic materials tailored on the nanoscale is used as novel transducer in SPR-based biosensor coupled with an external magnetic field; and a new 3D transductor consisting of silica nanowires decorated by gold nanoparticles have been realized to increase the performance of sensing devices In both case increasing biosensing performance have been demonstrated.","PeriodicalId":413629,"journal":{"name":"2015 1st Workshop on Nanotechnology in Instrumentation and Measurement (NANOFIM)","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132960344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-07-24DOI: 10.1109/NANOFIM.2015.8425325
M. Di Paola, P. Pisani, F. Conversano, E. Sbenaglia, S. Casciaro, S. Leporatti
Halloysite Clay nanotubes (HNTs) are naturally occurring nanomaterials composed of double layered aluminosilicate minerals with a hollow tubular structure. Due to their interesting structural characteristics, chemically active external and internal surfaces, cheap and abundant availability, HNTs have recently become the subject of research attention as a new type of material for various biological applications, including drug and gene delivery vehicles, cancer cells isolation, bone implants, ultrasound contrast agents, cancer and stem cells isolation and cosmetics. Therefore, assessment of HNT biocompatibility has gained importance to demonstrate its suitability for clinical purposes. In this study, HNTs were densely coated with poly(ethylene glycol) (PEG) and MTT measurements were carried out on two different human cancer cell lines, namely HeLa (cervical cancer) cells and HepG2 (hepatocarcinoma) cells, to quantify the biocompatibility of PEG-coated HNTs as a function of nanotube dosage and incubation time. While non-coated nanotubes exhibited significant concentration- and time-dependent toxicity, PEG-coated HNTs resulted fully biocompatible for concentrations up to 0.5 mg/mL and for incubation time up to 72 h, making them suitable candidates for nanomedicine applications.
{"title":"Highly Improved Cytocompatibility of Halloysite Nanotubes through Polymeric Surface Modification","authors":"M. Di Paola, P. Pisani, F. Conversano, E. Sbenaglia, S. Casciaro, S. Leporatti","doi":"10.1109/NANOFIM.2015.8425325","DOIUrl":"https://doi.org/10.1109/NANOFIM.2015.8425325","url":null,"abstract":"Halloysite Clay nanotubes (HNTs) are naturally occurring nanomaterials composed of double layered aluminosilicate minerals with a hollow tubular structure. Due to their interesting structural characteristics, chemically active external and internal surfaces, cheap and abundant availability, HNTs have recently become the subject of research attention as a new type of material for various biological applications, including drug and gene delivery vehicles, cancer cells isolation, bone implants, ultrasound contrast agents, cancer and stem cells isolation and cosmetics. Therefore, assessment of HNT biocompatibility has gained importance to demonstrate its suitability for clinical purposes. In this study, HNTs were densely coated with poly(ethylene glycol) (PEG) and MTT measurements were carried out on two different human cancer cell lines, namely HeLa (cervical cancer) cells and HepG2 (hepatocarcinoma) cells, to quantify the biocompatibility of PEG-coated HNTs as a function of nanotube dosage and incubation time. While non-coated nanotubes exhibited significant concentration- and time-dependent toxicity, PEG-coated HNTs resulted fully biocompatible for concentrations up to 0.5 mg/mL and for incubation time up to 72 h, making them suitable candidates for nanomedicine applications.","PeriodicalId":413629,"journal":{"name":"2015 1st Workshop on Nanotechnology in Instrumentation and Measurement (NANOFIM)","volume":"192 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124269471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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