Pub Date : 2022-08-01DOI: 10.21608/puj.2022.153848.1180
Radwa G Diab, Salwa S Younis
Such studies strengthen knowledge of host-parasite interactions in each stage with relevant outcome in identifying novel potential drug targets . While immunomics identify parasite ABSTRACT Over the last two decades, omics studies provide a revolutionary advance of datasets in the field of Medical Parasitology for understanding parasite system biology, host-parasite interactions, and phylogenetic analyses; i.e., genomics, transcriptomes, proteomics, metabolomics. Together with bioinformatics, genome-wide associated studies (GWASs) enabled scientists to identify diagnostic biomarkers, promising drug targets, and potential vaccine candidates for diagnosis, treatment, and protection against several neglected tropical diseases. Omics approaches are either structural (genomics) or functional (post-genomics). To survive, Plasmodium spp. are able to delete certain genes unessential for their survival and growth, enabling them to evade host immune response. In addition, they undergo antigenic variations that lead to gene mutations in enzymes controlling drug uptake. Previously unattainable goals, e.g., host immunoevasion, susceptibility or resistance to infection, drug resistance, novel drugs as well as prevention and control were achieved by omics studies powered by bioinformatics tools. This part of the present review aims to shed light on omics application outcomes regarding Plasmodium
{"title":"Omics: Approaches and applications related to diagnosis, treatment, and control of parasitic diseases. Part I: Plasmodium spp.","authors":"Radwa G Diab, Salwa S Younis","doi":"10.21608/puj.2022.153848.1180","DOIUrl":"https://doi.org/10.21608/puj.2022.153848.1180","url":null,"abstract":"Such studies strengthen knowledge of host-parasite interactions in each stage with relevant outcome in identifying novel potential drug targets . While immunomics identify parasite ABSTRACT Over the last two decades, omics studies provide a revolutionary advance of datasets in the field of Medical Parasitology for understanding parasite system biology, host-parasite interactions, and phylogenetic analyses; i.e., genomics, transcriptomes, proteomics, metabolomics. Together with bioinformatics, genome-wide associated studies (GWASs) enabled scientists to identify diagnostic biomarkers, promising drug targets, and potential vaccine candidates for diagnosis, treatment, and protection against several neglected tropical diseases. Omics approaches are either structural (genomics) or functional (post-genomics). To survive, Plasmodium spp. are able to delete certain genes unessential for their survival and growth, enabling them to evade host immune response. In addition, they undergo antigenic variations that lead to gene mutations in enzymes controlling drug uptake. Previously unattainable goals, e.g., host immunoevasion, susceptibility or resistance to infection, drug resistance, novel drugs as well as prevention and control were achieved by omics studies powered by bioinformatics tools. This part of the present review aims to shed light on omics application outcomes regarding Plasmodium","PeriodicalId":41408,"journal":{"name":"Parasitologists United Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48106066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-16DOI: 10.21608/puj.2022.138041.1166
Maha Alabbassy
{"title":"Assessment of the prophylactic and therapeutic effects of curcumin nanoemulsion in comparison with Spiramycin in mice simulating acute infection with T. gondii (RH strain)","authors":"Maha Alabbassy","doi":"10.21608/puj.2022.138041.1166","DOIUrl":"https://doi.org/10.21608/puj.2022.138041.1166","url":null,"abstract":"","PeriodicalId":41408,"journal":{"name":"Parasitologists United Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47832350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-13DOI: 10.21608/puj.2022.139450.1167
S. Abaza
{"title":"Spotlights on new publications, Drug targets XIX","authors":"S. Abaza","doi":"10.21608/puj.2022.139450.1167","DOIUrl":"https://doi.org/10.21608/puj.2022.139450.1167","url":null,"abstract":"","PeriodicalId":41408,"journal":{"name":"Parasitologists United Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47394944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-27DOI: 10.21608/puj.2022.117557.1148
Fatih Çakır, Alican Bilden, M. Çiçek, N. Ozcan
{"title":"Contested role of procalcitonin and C-reactive protein in the diagnosis of fascioliasis","authors":"Fatih Çakır, Alican Bilden, M. Çiçek, N. Ozcan","doi":"10.21608/puj.2022.117557.1148","DOIUrl":"https://doi.org/10.21608/puj.2022.117557.1148","url":null,"abstract":"","PeriodicalId":41408,"journal":{"name":"Parasitologists United Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41838650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-27DOI: 10.21608/puj.2022.129311.1160
S. Abaza
) and flavine mononucleotide (FMN). Lastly, uracil diphosphate (UDP) is utilized in glucogenesis; a ubiquitous metabolic pathway required for production of glucose from non-carbohydrate carbon substrates
{"title":"Recent advances in identification of potential drug targets and development of novel drugs in parasitic diseases. Part II. Parasite targets","authors":"S. Abaza","doi":"10.21608/puj.2022.129311.1160","DOIUrl":"https://doi.org/10.21608/puj.2022.129311.1160","url":null,"abstract":") and flavine mononucleotide (FMN). Lastly, uracil diphosphate (UDP) is utilized in glucogenesis; a ubiquitous metabolic pathway required for production of glucose from non-carbohydrate carbon substrates","PeriodicalId":41408,"journal":{"name":"Parasitologists United Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41393244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-07DOI: 10.21608/puj.2022.124104.1158
M. Gomaa, Eman Sheta
{"title":"Efficacy of Cuminum cyminum L. Seed Oil on Acute Toxoplasmosis: An Experimental Study on Albino Mice.","authors":"M. Gomaa, Eman Sheta","doi":"10.21608/puj.2022.124104.1158","DOIUrl":"https://doi.org/10.21608/puj.2022.124104.1158","url":null,"abstract":"","PeriodicalId":41408,"journal":{"name":"Parasitologists United Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41733976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-04DOI: 10.21608/puj.2022.120695.1155
H. Shaheen, Alshaimaa Hamed, M. Abdeltawab
{"title":"Investigation of the Relation between the Presence of Cholesterol Cholesterols and the Viability of Hydatid Protoscolices: Is Nitric Oxide Synthase the Possible Answer?","authors":"H. Shaheen, Alshaimaa Hamed, M. Abdeltawab","doi":"10.21608/puj.2022.120695.1155","DOIUrl":"https://doi.org/10.21608/puj.2022.120695.1155","url":null,"abstract":"","PeriodicalId":41408,"journal":{"name":"Parasitologists United Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48869211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-02DOI: 10.21608/puj.2022.121161.1156
S. Morsy
{"title":"Correlation between molecularly detected Entamoeba species and fecal calprotectin level among a cohort of diarrheic patients","authors":"S. Morsy","doi":"10.21608/puj.2022.121161.1156","DOIUrl":"https://doi.org/10.21608/puj.2022.121161.1156","url":null,"abstract":"","PeriodicalId":41408,"journal":{"name":"Parasitologists United Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46332881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/puj.2022.121221.1157
R.Sh. Ibrahimova
dogs and cats with various of helminths and in the formation of The present study investigated the infection of stray dogs and domestic cats with various species of helminths and observed the following: The lifestyle of domestic carnivores (nutrition, behaviors, and individual characteristics) has direct impact on the formation of infective helminthological fauna. The lifestyle of domesticated animals is characterized by features that contrast with other animals: they always preen themselves, dig the ground (soil), domestic cats dig the soil and cover their excretion, they always shake their body, they adhere to the place where they feed, their kindness with humans,
{"title":"Impact of lifestyle on the formation of helminth fauna of domestic carnivores in Azerbaijan","authors":"R.Sh. Ibrahimova","doi":"10.21608/puj.2022.121221.1157","DOIUrl":"https://doi.org/10.21608/puj.2022.121221.1157","url":null,"abstract":"dogs and cats with various of helminths and in the formation of The present study investigated the infection of stray dogs and domestic cats with various species of helminths and observed the following: The lifestyle of domestic carnivores (nutrition, behaviors, and individual characteristics) has direct impact on the formation of infective helminthological fauna. The lifestyle of domesticated animals is characterized by features that contrast with other animals: they always preen themselves, dig the ground (soil), domestic cats dig the soil and cover their excretion, they always shake their body, they adhere to the place where they feed, their kindness with humans,","PeriodicalId":41408,"journal":{"name":"Parasitologists United Journal","volume":"54 3","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41267197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-29DOI: 10.21608/puj.2022.100824.1138
Heba Abdel Menaem, M. Mostafa, R. Sarhan, S. William, A. Abdel Rahman
{"title":"Experimental in vivo assessment of immunomodulatory effect of Kalobin (Pelargonium reinforme/sidoides extract) on schistosomiasis mansoni","authors":"Heba Abdel Menaem, M. Mostafa, R. Sarhan, S. William, A. Abdel Rahman","doi":"10.21608/puj.2022.100824.1138","DOIUrl":"https://doi.org/10.21608/puj.2022.100824.1138","url":null,"abstract":"","PeriodicalId":41408,"journal":{"name":"Parasitologists United Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42131810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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