Parasitologists United Journal最新文献

{"title":"Investigating the effect of the nitric oxide donor L-arginine on albendazole efficacy in Trichinella spiralis-induced myositis and myocarditis in mice","authors":"M. Abdeltawab, I. Abdel-Shafi, B. Aboulhoda, Hanaa Wanas, Shimaa Saad El-Din, S. Amer, Alshaimaa Hamed","doi":"10.21608/puj.2022.119638.1153","DOIUrl":"https://doi.org/10.21608/puj.2022.119638.1153","url":null,"abstract":"","PeriodicalId":41408,"journal":{"name":"Parasitologists United Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47331262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The amazing eradication story and current situation of malaria in Cyprus","authors":"Emrah Guler, M. Guvenir, K. Suer","doi":"10.21608/puj.2022.118294.1149","DOIUrl":"https://doi.org/10.21608/puj.2022.118294.1149","url":null,"abstract":"","PeriodicalId":41408,"journal":{"name":"Parasitologists United Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44297691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on The Antiparasitic Properties of Inorganic Silver Nanoparticles (AgNps)","authors":"M. Gomaa","doi":"10.21608/puj.2022.108173.1145","DOIUrl":"https://doi.org/10.21608/puj.2022.108173.1145","url":null,"abstract":"","PeriodicalId":41408,"journal":{"name":"Parasitologists United Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44301750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of coconut oil as a therapeutic agent with potential anti-cancer activity in immunosuppressed mice with cryptosporidiosis: Parasitological, histopathological and immunohistochemical studies","authors":"H. Abdelmaksoud, T. Aboushousha, A. Ashkar","doi":"10.21608/puj.2022.95720.1133","DOIUrl":"https://doi.org/10.21608/puj.2022.95720.1133","url":null,"abstract":"","PeriodicalId":41408,"journal":{"name":"Parasitologists United Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49100021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seropositivity of toxoplasmosis among hemodialysis children patients at Zagazig University Pediatrics Hospital, Egypt","authors":"M. Sarhan","doi":"10.21608/puj.2022.105855.1144","DOIUrl":"https://doi.org/10.21608/puj.2022.105855.1144","url":null,"abstract":"","PeriodicalId":41408,"journal":{"name":"Parasitologists United Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42896039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of intestinal parasites in a cohort of diarrheic Egyptian children: Predominance of Cryptosporidium using nested PCR assay","authors":"Ayman Abdel-Maogod, Ahmed M. S. Bayoumy, K. Hassan, M. El-Faramawy, A. Ibrahim, A. El-Badry","doi":"10.21608/puj.2022.113697.1147","DOIUrl":"https://doi.org/10.21608/puj.2022.113697.1147","url":null,"abstract":"","PeriodicalId":41408,"journal":{"name":"Parasitologists United Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44267608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug resistance, recent advances in identification of potential drug targets and development of novel drugs in parasitic diseases. I. Drug resistance","authors":"S. Abaza","doi":"10.21608/puj.2021.103436.1141","DOIUrl":"https://doi.org/10.21608/puj.2021.103436.1141","url":null,"abstract":"","PeriodicalId":41408,"journal":{"name":"Parasitologists United Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46286101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of potential prophylactic and therapeutic effect of azoximer bromide (polyoxidonium) on experimental cryptosporidiosis in immunocompromised mice","authors":"A. Atia, M. El Sobky, N. Harba, Rasha Elmehy, Dina Allam, Noha Abou Hussien","doi":"10.21608/puj.2021.102944.1140","DOIUrl":"https://doi.org/10.21608/puj.2021.102944.1140","url":null,"abstract":"Background: Considering the broad burden of cryptosporidiosis, there is still a limited choice of curative treatments. Nitazoxanide (NTZ) is the only anti-cryptosporidial agent currently available. Unfortunately, it showed low efficacy in children and AIDS patients. Accordingly, supplementation with immune-stimulation drugs is feasible. Objective: To demonstrate the prophylactic immunomodulating effect of the immunostimulant Azoximer Bromide (AZB) and evaluate its potential therapeutic efficacy when combined with NTZ, for treatment of cryptosporidiosis in experimentally immunosuppressed mice. Material and Methods: Ninety laboratory bred Swiss albino male mice were immunosuppressed and divided into three groups (30 mice each): control group (GI); prophylactic group, AZB treated then infected (GII); therapeutic group, oocysts infected then treated (GIII). Each group was divided equally into 3 sub-groups (10 mice each). Controls included: GIa, non-infected control negative; GIb, oocysts infected control positive; GIc, non-infected AZB treated drug control. Prophylactic subgroups included: GIIa, received AZB booster injection; GIIb, NTZ treated; GIIc, AZB+ NTZ treated. Therapeutic subgroups included: GIIIa, AZB treated; GIIIb, NTZ treated; GIIIc, AZB+NTZ treated. Oocysts shedding and the efficacy percentage of each drug were calculated. Other parameters used included histopathological examination and immunohistochemical assessment of small intestine and lung tissues, and serum analyses for biochemical, immunological and antioxidants evaluations. Results: The prophylactic effect of AZB alone and its therapeutic effect when combined with NTZ gave the best reduction rate of oocyst shedding with marked improvement in histopathological features, and significantly reduced hepatic enzymes. Additionally, AZB enhanced the mice immunogenicity with significant upregulation of interleukin (IL)-1β, IL-6, tumor necrotic factor (TNF)-α and interferon (INF)-γ; overexpression of CD3 protein in pulmonary tissue, and significant elevation of antioxidant activity. Conclusion: A powerful effect was achieved by AZB when administered with NTZ for treatment of experimental cryptosporidiosis with elicited high immune response of immunosuppressed mice. PARASITOLOGISTS UNITED JOURNAL 294 and plays an important role in both innate and adaptive immune responses[8]. In the acute phase of infection, Cryptosporidium spp. sporozoites induce the production of IL-12 by macrophages and dendritic cells[9] that acts synergistically with IL-18 and TNF-α to activate natural killer (NK) cells[10]. In addition, TNF-α prevents the establishment of Cryptosporidium spp. infection in enterocytes[11]. Besides, other proinflammatory cytokines (IL-1, IL-6) released by multiple immunocompetent cells exert protective effect[12]. Adequate T helper cell responses are critical for hosts to orchestrate enough defensive mechanisms for infection control. This suggests a major role for host immune factors i","PeriodicalId":41408,"journal":{"name":"Parasitologists United Journal","volume":"1 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42254334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptions on therapeutic modalities regarding the virulence and immunity of cutaneous leishmaniasis","authors":"E. E. El Saftawy, Ahmed B. Hamed, A. Sameh, R. Sarhan","doi":"10.21608/puj.2021.95583.1132","DOIUrl":"https://doi.org/10.21608/puj.2021.95583.1132","url":null,"abstract":"Despite the wide variety of Leishmania spp. virulence, the present repertoire of drugs has limited effects, showing increased resistance. The effect depends on host immune factors which differ between immunocompetent and immunocompromised patients, and among various clinical forms of the disease. Recently, metallocomplexes have been increasingly shown to be potent delivery systems for conventional treatments. Additionally, lasers were suggested as an efficacious treatment tool due to their potentials in the clinical applications and resolution of the disease. This review suggests that the promising leishmanicidal activity of the metallocomplexes and laser treatment comprise a new hopeful alternative in the search for definitive cutaneous leishmaniasis (CL) cure. PARASITOLOGISTS UNITED JOURNAL 230 subsets of CD4+ and CD8+ T cells, and their cytokines profiles[16] as well as the triggered production of reactive oxygen species (ROS) and nitric oxide (NO) in mouse macrophages[17]. Interestingly, co-treatment of infected macrophages with exogenous IFN-γ and TNF-α can considerably destroy the parasites and lead to SbV accumulation[16]. It is also organ-dependent, being more efficient in the liver than the spleen or bone marrow[18] due to the pharmacokinetic profile of the drug[19]. Side effects and drug resistance: Injection pain and systemic side effects have been recorded[20]. Sodium antimony gluconate despite being described with minor side effects at the therapeutic doses[6], has cumulative effects such as acute interstitial nephritis and cardiotoxicity during or after a long course of drug administration[20,21]. Dangerous cardiotoxicity features occur in 50% of the patients and include a concave ST segment, corrected QT interval prolongation followed by multiple ventricular ectopic foci, then ventricular tachycardia, torsade de pointes, ventricular fibrillation[15] and diminution in the height of T waves and T-wave inversion[22]. This was attributed to the high affinity for sulfhydryl groups that affect the calcium channels[23]. In accordance, it has been found to prolong the action potential of ventricular myocytes in guinea pigs at therapeutic doses with developed QT prolongation and life-threatening arrhythmias[24]. Higher doses of SbV were found to be associated with increased pancreatitis[25] especially in AIDS patients[26]. In New World CL, elevation of pancreatic and liver enzymes was also observed in a study at the dose of 20 mg/ kg/d for 20 d[27]. In Brazil, a higher frequency of skin reactions was observed in some patients with CL treated with meglumine antimoniate, due to the greater concentrations of total and trivalent antimony, lead, cadmium, arsenic and lower values of osmolarity and pH[28]. These effects can lead to cessation of treatment before attaining curative levels[29]. Additionally, the emergence of parasite resistance against SbIII was recorded in some areas suffering from VL e.g., India[30-32]. Drug resistance was suggeste","PeriodicalId":41408,"journal":{"name":"Parasitologists United Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42628505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of H. Pylori and/or Toxoplasma Gondii Infection on Recurrence of Gastritis and Gastric ulcer","authors":"Waleed E. Elawamy, Amany A Ghazy, Ahmed Haydara, A. Taha","doi":"10.21608/puj.2021.96310.1134","DOIUrl":"https://doi.org/10.21608/puj.2021.96310.1134","url":null,"abstract":"","PeriodicalId":41408,"journal":{"name":"Parasitologists United Journal","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46857731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}