Introduction: Lung cancer has the highest incidence and mortality among malignancies in many countries. 18 F-Fluorodeoxyglucose ( 18 F-FDG) positron emission tomography/computed tomography (PET/CT) is commonly indicated for the preoperative nodal staging of non–small-cell lung carcinoma. While maximum standardised uptake value (SUV max ), visual scoring systems and nodal diameter have been proposed to distinguish benign from malignant nodes, studies comparing the different measurements have been limited. Correct nodal staging is crucial in determining if treatment intent is curative or palliative. This study aimed to evaluate the accuracies of nodal staging in 18 F-FDG PET/CT based on different methods. Methods: A total of 467 mediastinal/extramediastinal lymph nodes from 97 patients, who underwent staging 18 F-FDG PET/CT at our centre for non–small-cell lung carcinoma, were retrospectively reviewed. The nodes were evaluated based on SUV max , five-point visual interpretation score, and diameter. Their sensitivities, specificities and accuracies were compared with histology using receiver operating characteristics curves and areas under the curves (AUCs). Subgroup analyses based on T staging, histology, epidermal growth factor receptor (EGFR) status, lymph node locations, and tumour SUV max were also investigated. Results: The diagnostic performance of visual score (at optimal cut-off of 3) yielded the highest specificity (0.932), accuracy (0.916), positive predictive value (0.623), and negative predictive value (0.972), results of which were similar to SUV max of 2.5 and better than nodal diameter of 10 mm. Subgroup analyses showed that visual interpretation achieved satisfactory AUCs in different T stages, histologies, EGFR statuses, locations of lymph nodes, and tumour SUVs max . Conclusion: The five-point visual interpretation is a convenient diagnostic tool with performance better than nodal diameter, and similar to that of SUV max .
{"title":"Diagnostic Accuracy of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Preoperative Mediastinal/Extramediastinal Nodal Staging of Non–Small-Cell Lung Carcinoma","authors":"Ks Ng, Kk Ng, K. Chu, B. Kung, T. Au Yong","doi":"10.12809/hkjr2317503","DOIUrl":"https://doi.org/10.12809/hkjr2317503","url":null,"abstract":"Introduction: Lung cancer has the highest incidence and mortality among malignancies in many countries. 18 F-Fluorodeoxyglucose ( 18 F-FDG) positron emission tomography/computed tomography (PET/CT) is commonly indicated for the preoperative nodal staging of non–small-cell lung carcinoma. While maximum standardised uptake value (SUV max ), visual scoring systems and nodal diameter have been proposed to distinguish benign from malignant nodes, studies comparing the different measurements have been limited. Correct nodal staging is crucial in determining if treatment intent is curative or palliative. This study aimed to evaluate the accuracies of nodal staging in 18 F-FDG PET/CT based on different methods. Methods: A total of 467 mediastinal/extramediastinal lymph nodes from 97 patients, who underwent staging 18 F-FDG PET/CT at our centre for non–small-cell lung carcinoma, were retrospectively reviewed. The nodes were evaluated based on SUV max , five-point visual interpretation score, and diameter. Their sensitivities, specificities and accuracies were compared with histology using receiver operating characteristics curves and areas under the curves (AUCs). Subgroup analyses based on T staging, histology, epidermal growth factor receptor (EGFR) status, lymph node locations, and tumour SUV max were also investigated. Results: The diagnostic performance of visual score (at optimal cut-off of 3) yielded the highest specificity (0.932), accuracy (0.916), positive predictive value (0.623), and negative predictive value (0.972), results of which were similar to SUV max of 2.5 and better than nodal diameter of 10 mm. Subgroup analyses showed that visual interpretation achieved satisfactory AUCs in different T stages, histologies, EGFR statuses, locations of lymph nodes, and tumour SUVs max . Conclusion: The five-point visual interpretation is a convenient diagnostic tool with performance better than nodal diameter, and similar to that of SUV max .","PeriodicalId":41549,"journal":{"name":"Hong Kong Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49180439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Eosinophilic Meningitis and Pneumonitis due to Angiostrongyliasis: a Case Report","authors":"YM Leng, Allen Li","doi":"10.12809/hkjr2317235","DOIUrl":"https://doi.org/10.12809/hkjr2317235","url":null,"abstract":"","PeriodicalId":41549,"journal":{"name":"Hong Kong Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44667614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence and Clinical Significance of Incidental Extracardiac Findings during Cardiac Magnetic Resonance Imaging: a Retrospective Study","authors":"HS Abdel Rahman, Amal Shawky, EM Mehana","doi":"10.12809/hkjr2317444","DOIUrl":"https://doi.org/10.12809/hkjr2317444","url":null,"abstract":"","PeriodicalId":41549,"journal":{"name":"Hong Kong Journal of Radiology","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41713639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Artificial Ascites and Hydrodissection in Percutaneous Thermal Ablation Cases at a Tertiary Institution: A Pictorial Essay","authors":"R. Mak, Jb Chiang, H. Fung, W. Poon","doi":"10.12809/hkjr2317539","DOIUrl":"https://doi.org/10.12809/hkjr2317539","url":null,"abstract":"","PeriodicalId":41549,"journal":{"name":"Hong Kong Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45560791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Ho, L. Xiao, K. Kwok, S. Yang, Bwh Fung, Kch Yu, W. Chong, Tw Yeung, A. Li
{"title":"Common Artifacts in Magnetic Resonance Imaging: A Pictorial Essay","authors":"C. Ho, L. Xiao, K. Kwok, S. Yang, Bwh Fung, Kch Yu, W. Chong, Tw Yeung, A. Li","doi":"10.12809/hkjr2317476","DOIUrl":"https://doi.org/10.12809/hkjr2317476","url":null,"abstract":"","PeriodicalId":41549,"journal":{"name":"Hong Kong Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46609723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Procaccini, A. Bernardini, A. Costanzi, E. Algeri, A. Gennarelli, E. Mincuzzi, N. Caputo
{"title":"Incidental Computed Tomography Angiography Finding of a Delayed Asymptomatic Ascending Aortic Dissection after Transcatheter Aortic Value Implantation: a Case Report","authors":"L. Procaccini, A. Bernardini, A. Costanzi, E. Algeri, A. Gennarelli, E. Mincuzzi, N. Caputo","doi":"10.12809/hkjr2317445","DOIUrl":"https://doi.org/10.12809/hkjr2317445","url":null,"abstract":"","PeriodicalId":41549,"journal":{"name":"Hong Kong Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44581967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"90Yttrium Selective Internal Radiation Therapy in Unresectable or Otherwise High-Risk Hepatocellular Carcinoma: Single-Centre Experience","authors":"K. Leung, M. Lim","doi":"10.12809/hkjr2317620","DOIUrl":"https://doi.org/10.12809/hkjr2317620","url":null,"abstract":"","PeriodicalId":41549,"journal":{"name":"Hong Kong Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42825580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Underdiagnosed Wernicke’s Encephalopathy in Children: Spectrum of Imaging Findings in Three Local Cases","authors":"Ys. Lee, Kc Wong, E. Kan","doi":"10.12809/hkjr2317425","DOIUrl":"https://doi.org/10.12809/hkjr2317425","url":null,"abstract":"","PeriodicalId":41549,"journal":{"name":"Hong Kong Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46177399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eyh Chuk, J. Chow, K. Cheung, Ssw Tse, R. Ho, H. Wong, Any Yeung, K. Wong
Objective: Baseline lymphopenia is associated with poor prognosis in various malignancies. This study aimed to examine the prognostic value of pretreatment lymphocyte count in cervical cancer patients in Hong Kong. Methods: A cohort of 198 cases of cervical cancer patients without evidence of metastatic disease (i.e., International Federation of Gynecology and Obstetrics stage IB to IVA), who completed definitive chemoradiotherapy from January 2009 to December 2014 was analysed. Baseline clinical and pretreatment blood test data were collected. Definitive treatment had included external radiotherapy and brachytherapy with concurrent weekly cisplatin 40 mg/m 2 . Log-rank tests and multivariable Cox regression were used to evaluate the association between haematological parameters and survival. Study endpoints were overall survival (OS), recurrence-free survival (RFS), and late radiation-induced grade 3-4 toxicity. Results: Median follow-up period was 6.52 years. A pretreatment absolute lymphocyte count ≤1.7 × 10 9 /L was associated with a significantly worse 5-year OS (68.7% vs. 84.4%, p = 0.005). Multivariate analysis confirmed pretreatment lymphocyte count to be an independent predictor of RFS (adjusted hazard ratio = 0.58; 95% confidence interval [CI] = 0.34-0.99, p = 0.046) and OS (adjusted hazard ratio = 0.47; 95% CI = 0.25-0.88, p = 0.018). Absolute lymphocyte count was not associated with late grade 3-4 radiation toxicity. Conclusion: Our data in a local cohort add evidence to findings in other studies that pretreatment absolute lymphocyte count is an independent predictor of both OS and RFS in cervical cancer patients receiving definitive chemoradiotherapy
{"title":"Absolute Lymphocyte Count in Cervical Cancer Patients Prior to Definitive Chemoradiotherapy: a Prognostic Indicator?","authors":"Eyh Chuk, J. Chow, K. Cheung, Ssw Tse, R. Ho, H. Wong, Any Yeung, K. Wong","doi":"10.12809/hkjr2217467","DOIUrl":"https://doi.org/10.12809/hkjr2217467","url":null,"abstract":"Objective: Baseline lymphopenia is associated with poor prognosis in various malignancies. This study aimed to examine the prognostic value of pretreatment lymphocyte count in cervical cancer patients in Hong Kong. Methods: A cohort of 198 cases of cervical cancer patients without evidence of metastatic disease (i.e., International Federation of Gynecology and Obstetrics stage IB to IVA), who completed definitive chemoradiotherapy from January 2009 to December 2014 was analysed. Baseline clinical and pretreatment blood test data were collected. Definitive treatment had included external radiotherapy and brachytherapy with concurrent weekly cisplatin 40 mg/m 2 . Log-rank tests and multivariable Cox regression were used to evaluate the association between haematological parameters and survival. Study endpoints were overall survival (OS), recurrence-free survival (RFS), and late radiation-induced grade 3-4 toxicity. Results: Median follow-up period was 6.52 years. A pretreatment absolute lymphocyte count ≤1.7 × 10 9 /L was associated with a significantly worse 5-year OS (68.7% vs. 84.4%, p = 0.005). Multivariate analysis confirmed pretreatment lymphocyte count to be an independent predictor of RFS (adjusted hazard ratio = 0.58; 95% confidence interval [CI] = 0.34-0.99, p = 0.046) and OS (adjusted hazard ratio = 0.47; 95% CI = 0.25-0.88, p = 0.018). Absolute lymphocyte count was not associated with late grade 3-4 radiation toxicity. Conclusion: Our data in a local cohort add evidence to findings in other studies that pretreatment absolute lymphocyte count is an independent predictor of both OS and RFS in cervical cancer patients receiving definitive chemoradiotherapy","PeriodicalId":41549,"journal":{"name":"Hong Kong Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45279023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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