Dobrin Vassilev, Niya Mileva, Panayot Panayotov, Krasimir Kostov, Kenan Yumerov, Nikolay Petkov, Carlos Collet, Gianluca Rigatelli, Robert J. Gil, Thach Nguyen
Introduction: Revascularization of bifurcation lesions remains an interventional challenge. Intracoronary electrocardiograms can predict the functional significance of side branch stenosis after bifurcation stenting. Aim: This study was aimed at evaluating the effects of an intracoronary ECG electrocardiography (icECG)-guided revascularization strategy, compared with the currently accepted standard of care, on the clinical outcomes of patients after coronary bifurcation stenting. Methods: Patients with coronary bifurcation lesions who underwent percutaneous revascularization were enrolled in a prospective all-comers’ registry. Clinical outcomes were compared between patients who underwent icECG-guided revascularization versus the current standard of care (SOC), provisional stenting. Results: A total of 768 patients were included in the analysis: 349 were treated with an icECG-guided strategy, and 419 received SOC. The overall all-cause death rate was 23.2%, and the cardiovascular death rate was 15.9%. Patients with icECG guidance had significantly lower all-cause mortality (20.3% vs. 25.5% for icECG vs. SOC, log-rank P = 0.006) and cardiovascular mortality (12.6% vs. 18.6% for icECG vs. SOC, log-rank P = 0.004). The decrease in mortality was most pronounced in patients with no increase or a moderate increase in troponin post-PCI, or with higher-than-normal baseline troponin concentrations. Conclusion: An icECG-guided strategy for coronary bifurcation PCI led to lower patient mortality than the provisional stenting strategy.
分支病变的血运重建仍然是一个介入治疗的挑战。冠状动脉内心电图可预测分支支架置入术后侧支狭窄的功能意义。目的:本研究旨在评估冠脉内心电图的影响心电描记法(icECG)引导血管再生策略,与目前接受标准治疗相比,在冠状动脉分叉支架植入后病人的临床结果。方法:接受经皮血管重建术的冠状动脉分叉病变患者纳入前瞻性所有患者登记。临床结果比较了接受icecg引导下的血运重建术与目前的标准护理(SOC)临时支架植入术的患者。结果:共有768例患者纳入分析:349例采用icecg指导策略，419例接受SOC治疗。全因死亡率为23.2%，心血管死亡率为15.9%。在icECG指导下，患者的全因死亡率(icECG vs SOC为20.3%，log-rank P = 0.006)和心血管死亡率(icECG vs SOC为12.6%，log-rank P = 0.004)显著降低。在pci术后肌钙蛋白无升高或中度升高，或肌钙蛋白基线浓度高于正常水平的患者中，死亡率的降低最为明显。结论:icecg引导下冠状动脉分叉PCI的患者死亡率低于临时支架置入策略。
{"title":"Intracoronary Electrocardiography-guided Strategy for the Treatment of Coronary Bifurcation Lesions","authors":"Dobrin Vassilev, Niya Mileva, Panayot Panayotov, Krasimir Kostov, Kenan Yumerov, Nikolay Petkov, Carlos Collet, Gianluca Rigatelli, Robert J. Gil, Thach Nguyen","doi":"10.15212/cvia.2023.0055","DOIUrl":"https://doi.org/10.15212/cvia.2023.0055","url":null,"abstract":"Introduction: Revascularization of bifurcation lesions remains an interventional challenge. Intracoronary electrocardiograms can predict the functional significance of side branch stenosis after bifurcation stenting. Aim: This study was aimed at evaluating the effects of an intracoronary ECG electrocardiography (icECG)-guided revascularization strategy, compared with the currently accepted standard of care, on the clinical outcomes of patients after coronary bifurcation stenting. Methods: Patients with coronary bifurcation lesions who underwent percutaneous revascularization were enrolled in a prospective all-comers’ registry. Clinical outcomes were compared between patients who underwent icECG-guided revascularization versus the current standard of care (SOC), provisional stenting. Results: A total of 768 patients were included in the analysis: 349 were treated with an icECG-guided strategy, and 419 received SOC. The overall all-cause death rate was 23.2%, and the cardiovascular death rate was 15.9%. Patients with icECG guidance had significantly lower all-cause mortality (20.3% vs. 25.5% for icECG vs. SOC, log-rank P = 0.006) and cardiovascular mortality (12.6% vs. 18.6% for icECG vs. SOC, log-rank P = 0.004). The decrease in mortality was most pronounced in patients with no increase or a moderate increase in troponin post-PCI, or with higher-than-normal baseline troponin concentrations. Conclusion: An icECG-guided strategy for coronary bifurcation PCI led to lower patient mortality than the provisional stenting strategy.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":"126 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136259078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Significance: Heart failure, a disease with extremely high incidence, is closely associated with inflammation and oxidative stress. The Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) pathway plays an important role in the occurrence and development of heart failure. Recent advances: Previous studies have shown that TLR4/NF-κB causes heart failure by inducing oxidative stress and inflammation; damaging the endothelia; promoting fibrosis; and inducing myocardial hypertrophy, apoptosis, pyroptosis, and autophagy. Critical issues: Understanding the pathogenesis of heart failure is essential for the treatment of this disease. In this review, we outline the mechanisms underlying TLR4/NF-κB pathway-mediated heart failure and discuss drugs that alleviate heart failure by regulating the TLR4/NF-κB pathway. Future directions: During TLR4/NF-κB overactivation, interventions targeting specific receptor antagonists may effectively alleviate heart failure, thus providing a basis for the development of new anti-heart failure drugs.
意义:心力衰竭是一种发病率极高的疾病，与炎症和氧化应激密切相关。toll样受体4 (TLR4)/核因子κ b (NF-κB)通路在心力衰竭的发生发展中起重要作用。近期研究进展:已有研究表明，TLR4/NF-κB通过诱导氧化应激和炎症导致心力衰竭;破坏内皮细胞;促进纤维化;并诱导心肌肥大、凋亡、焦亡和自噬。关键问题:了解心力衰竭的发病机制对治疗此病至关重要。在这篇综述中，我们概述了TLR4/NF-κB途径介导心力衰竭的机制，并讨论了通过调节TLR4/NF-κB途径缓解心力衰竭的药物。未来发展方向:在TLR4/NF-κB过度激活过程中，针对特异性受体拮抗剂的干预可能会有效缓解心力衰竭，从而为开发新的抗心力衰竭药物提供基础。
{"title":"Inappropriate Activation of TLR4/NF-κB is a Cause of Heart Failure","authors":"Jiedong Zhou, Hui Lin, Tingting Lv, Jinjin Hao, Hanlin Zhang, Shimin Sun, Juntao Yang, J. Chi, Hangyuan Guo","doi":"10.15212/cvia.2022.0020","DOIUrl":"https://doi.org/10.15212/cvia.2022.0020","url":null,"abstract":"\u0000Significance: Heart failure, a disease with extremely high incidence, is closely associated with inflammation and oxidative stress. The Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) pathway plays an important role in the occurrence and development of heart failure.\u0000\u0000Recent advances: Previous studies have shown that TLR4/NF-κB causes heart failure by inducing oxidative stress and inflammation; damaging the endothelia; promoting fibrosis; and inducing myocardial hypertrophy, apoptosis, pyroptosis, and autophagy.\u0000\u0000Critical issues: Understanding the pathogenesis of heart failure is essential for the treatment of this disease. In this review, we outline the mechanisms underlying TLR4/NF-κB pathway-mediated heart failure and discuss drugs that alleviate heart failure by regulating the TLR4/NF-κB pathway.\u0000\u0000Future directions: During TLR4/NF-κB overactivation, interventions targeting specific receptor antagonists may effectively alleviate heart failure, thus providing a basis for the development of new anti-heart failure drugs.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42803145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Meta-analysis was performed to evaluate the effect of staged revascularization with concomitant chronic total occlusion (CTO) in the non-infarct-associated artery (non-IRA) in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (p-PCI). Methods: Various electronic databases were searched for studies published from inception to June, 2021. The primary endpoint was all-cause death, and the secondary endpoint was a composite of major adverse cardiac events (MACEs). Odds ratios (ORs) were pooled with 95% confidence intervals (CIs) for dichotomous data. Results: Seven studies involving 1540 participants were included in the final analysis. Pooled analyses revealed that patients with successful staged revascularization for CTO in non-IRA with STEMI treated with p-PCI had overall lower all-cause death (OR, 0.46; 95% CI, 0.23–0.95), cardiac death (OR, 0.43; 95% CI, 0.20–0.91), MACEs (OR, 0.47; 95% CI, 0.32–0.69) and heart failure (OR, 0.57; 95% CI, 0.37–0.89) compared with the occluded CTO group. No significant differences were observed between groups regarding myocardial infarction and re-peated revascularization. Conclusions: Successful revascularization of CTO in the non-IRA was associated with better outcomes in patients with STEMI treated with p-PCI.
{"title":"Corrigendum to: Staged Revascularization for Chronic Total Occlusion in the Non-IRA in Patients with ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: An Updated Systematic Review and Meta-analysis","authors":"Yu Geng, Yintang Wang, Lianfeng Liu, Guobin Miao, Ou Zhang, Yajun Xue, Ping Zhang","doi":"10.15212/cvia.2022.0022","DOIUrl":"https://doi.org/10.15212/cvia.2022.0022","url":null,"abstract":"Objectives: Meta-analysis was performed to evaluate the effect of staged revascularization with concomitant chronic total occlusion (CTO) in the non-infarct-associated artery (non-IRA) in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (p-PCI). Methods: Various electronic databases were searched for studies published from inception to June, 2021. The primary endpoint was all-cause death, and the secondary endpoint was a composite of major adverse cardiac events (MACEs). Odds ratios (ORs) were pooled with 95% confidence intervals (CIs) for dichotomous data. Results: Seven studies involving 1540 participants were included in the final analysis. Pooled analyses revealed that patients with successful staged revascularization for CTO in non-IRA with STEMI treated with p-PCI had overall lower all-cause death (OR, 0.46; 95% CI, 0.23–0.95), cardiac death (OR, 0.43; 95% CI, 0.20–0.91), MACEs (OR, 0.47; 95% CI, 0.32–0.69) and heart failure (OR, 0.57; 95% CI, 0.37–0.89) compared with the occluded CTO group. No significant differences were observed between groups regarding myocardial infarction and re-peated revascularization. Conclusions: Successful revascularization of CTO in the non-IRA was associated with better outcomes in patients with STEMI treated with p-PCI.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48490238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The 33rd Great Wall International Congress of Cardiology Asian Heart Society Congress 2022","authors":"","doi":"10.15212/cvia.2022.0015","DOIUrl":"https://doi.org/10.15212/cvia.2022.0015","url":null,"abstract":"","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46856074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In Memoriam: C. Richard Conti, MD (1934 ‐ 2022), Founding Editor-in-Chief of Cardiovascular Innovations and Applications","authors":"","doi":"10.15212/cvia.2022.0008","DOIUrl":"https://doi.org/10.15212/cvia.2022.0008","url":null,"abstract":"","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45652602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Feng, Guoyou Qin, Tao Zhang, Zheng Chen, Yang Zhao
Statistical analysis is critical in medical research. The objective of this article is to summarize the appropriate use and reporting of commonly used statistical methods in medical research, on the basis of existing statistical guidelines and the authors’ experience in reviewing manuscripts, to provide recommendations for statistical applications and reporting.
{"title":"Common Statistical Methods and Reporting of Results in Medical Research","authors":"G. Feng, Guoyou Qin, Tao Zhang, Zheng Chen, Yang Zhao","doi":"10.15212/cvia.2022.0001","DOIUrl":"https://doi.org/10.15212/cvia.2022.0001","url":null,"abstract":"Statistical analysis is critical in medical research. The objective of this article is to summarize the appropriate use and reporting of commonly used statistical methods in medical research, on the basis of existing statistical guidelines and the authors’ experience in reviewing\u0000 manuscripts, to provide recommendations for statistical applications and reporting.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46672010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The Synergy Between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score (SS) hassignificantly improved angiographic risk stratification. By analyzing angiographic variables, this score characterizescoronary artery disease qualitatively and quantitatively. To date, combining this score with other non-angiographic clinicalscores has broadened perspectives regarding risk estimation, and future research on this topic appears promising.
{"title":"The Clinical Value of Syntax Scores in Predicting Coronary Artery Disease Outcomes","authors":"Lutfu Askin","doi":"10.15212/cvia.2022.0002","DOIUrl":"https://doi.org/10.15212/cvia.2022.0002","url":null,"abstract":"The Synergy Between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score (SS) hassignificantly improved angiographic risk stratification. By analyzing angiographic variables, this score characterizescoronary artery disease qualitatively and quantitatively. To date, combining this score with other non-angiographic clinicalscores has broadened perspectives regarding risk estimation, and future research on this topic appears promising.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67305203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Paroxysmal atrial fibrillation can be triggered by non-pulmonary vein foci, such as the superior venacava. Here, we report the case of a patient with a 6-year history of paroxysmal atrial fibrillation who received cryoballoon ablation in 2012 but relapsed in 2014. He then received cardiac radiofrequency ablation, which successfully isolated the left pulmonary vein and superior vena cava, but the arrhythmia recently relapsed again. The tachycardia wasfinally successfully terminated by ablation on the free wall without recurrence during a 2-year following up.Conclusion: Superior vena cava isolation may not require ablation isolation with a full circle way and can be ccomplishedby ablating several connection points between the superior vena cava and the right atrium.
{"title":"Termination of Recurrent Atrial Fibrillation by Superior Vena Cava Isolation: A Case Report","authors":"Dechun Yin","doi":"10.15212/cvia.2022.0017","DOIUrl":"https://doi.org/10.15212/cvia.2022.0017","url":null,"abstract":"Background: Paroxysmal atrial fibrillation can be triggered by non-pulmonary vein foci, such as the superior venacava. Here, we report the case of a patient with a 6-year history of paroxysmal atrial fibrillation who received cryoballoon ablation in 2012 but relapsed in 2014. He then received cardiac radiofrequency ablation, which successfully isolated the left pulmonary vein and superior vena cava, but the arrhythmia recently relapsed again. The tachycardia wasfinally successfully terminated by ablation on the free wall without recurrence during a 2-year following up.Conclusion: Superior vena cava isolation may not require ablation isolation with a full circle way and can be ccomplishedby ablating several connection points between the superior vena cava and the right atrium.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":"27 3 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67305743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: A non-invasive predictive model has not been established to identify the severity of coronary lesions inyoung adults with acute coronary syndrome (ACS).Methods: In this retrospective study, 1088 young adults (≤45 years of age) first diagnosed with ACS who underwentcoronary angiography were enrolled and randomized 7:3 into training or testing datasets. To build the nomogram, wedetermined optimal predictors of coronary lesion severity with the Least Absolute Shrinkage and Selection Operatorand Random Forest algorithm. The predictive accuracy of the nomogram was assessed with calibration plots, and performancewas assessed with the receiver operating characteristic curve, decision curve analysis and the clinical impact curve.Results: Seven predictors were identified and integrated into the nomogram: age, hypertension, diabetes, body massindex, low-density lipoprotein cholesterol, mean platelet volume and C-reactive protein. Receiver operating characteristicanalyses demonstrated the nomogram’s good discriminatory performance in predicting severe coronary arterydisease in young patients with ACS in the training (area under the curve 0.683, 95% confidence interval [0.645–0.721])and testing (area under the curve 0.670, 95% confidence interval [0.611–0.729]) datasets. The nomogram was also well-calibrated in both the training (P = 0.961) and testing (P = 0.302) datasets. Decision curve analysis and the clinicalimpact curve indicated the model’s good clinical utility.Conclusion: A simple and practical nomogram for predicting coronary artery disease severity in young adults ≤45 yearsof age with ACS was established and validated.
{"title":"Nomogram for Predicting the Severity of Coronary Artery Disease in Young Adults ≤45 Years of Age with Acute Coronary Syndrome","authors":"Wenbin Zhang","doi":"10.15212/cvia.2022.0016","DOIUrl":"https://doi.org/10.15212/cvia.2022.0016","url":null,"abstract":"Background: A non-invasive predictive model has not been established to identify the severity of coronary lesions inyoung adults with acute coronary syndrome (ACS).Methods: In this retrospective study, 1088 young adults (≤45 years of age) first diagnosed with ACS who underwentcoronary angiography were enrolled and randomized 7:3 into training or testing datasets. To build the nomogram, wedetermined optimal predictors of coronary lesion severity with the Least Absolute Shrinkage and Selection Operatorand Random Forest algorithm. The predictive accuracy of the nomogram was assessed with calibration plots, and performancewas assessed with the receiver operating characteristic curve, decision curve analysis and the clinical impact curve.Results: Seven predictors were identified and integrated into the nomogram: age, hypertension, diabetes, body massindex, low-density lipoprotein cholesterol, mean platelet volume and C-reactive protein. Receiver operating characteristicanalyses demonstrated the nomogram’s good discriminatory performance in predicting severe coronary arterydisease in young patients with ACS in the training (area under the curve 0.683, 95% confidence interval [0.645–0.721])and testing (area under the curve 0.670, 95% confidence interval [0.611–0.729]) datasets. The nomogram was also well-calibrated in both the training (P = 0.961) and testing (P = 0.302) datasets. Decision curve analysis and the clinicalimpact curve indicated the model’s good clinical utility.Conclusion: A simple and practical nomogram for predicting coronary artery disease severity in young adults ≤45 yearsof age with ACS was established and validated.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67305659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Premature ventricular complexes (PVCs) from the proximal left bundle branch (LBB) can be ablated inthe left ventricular outflow tract but can easily damage normal conduction bundles. Here, we report a case of successfulablation of PVCs from the proximal LBB within the right coronary cusp (RCC).Case presentation: Our patient was a 70-year-old woman with PVCs from the proximal LBB that were successfully ablated via the RCC through radiofrequency catheter ablation with a 3D mapping system; she had a complication of incomplete right bundle branch block (RBBB) and remained asymptomatic during follow-up.Conclusion: The RCC provides an alternative approach for ablating PVCs originating from the proximal LBB, owing to the close relationship between the RCC and proximal LBB.
{"title":"A Case of Premature Ventricular Complexes from the Proximal Left Bundle Branch Successfully Ablated from the Right Coronary Cusp","authors":"Jianhua Fan","doi":"10.15212/cvia.2022.0006","DOIUrl":"https://doi.org/10.15212/cvia.2022.0006","url":null,"abstract":"Background: Premature ventricular complexes (PVCs) from the proximal left bundle branch (LBB) can be ablated inthe left ventricular outflow tract but can easily damage normal conduction bundles. Here, we report a case of successfulablation of PVCs from the proximal LBB within the right coronary cusp (RCC).Case presentation: Our patient was a 70-year-old woman with PVCs from the proximal LBB that were successfully ablated via the RCC through radiofrequency catheter ablation with a 3D mapping system; she had a complication of incomplete right bundle branch block (RBBB) and remained asymptomatic during follow-up.Conclusion: The RCC provides an alternative approach for ablating PVCs originating from the proximal LBB, owing to the close relationship between the RCC and proximal LBB.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":"58 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67305367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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