Primary cardiac tumors are extremely uncommon. Here, we report the case of a patient with a primary left ventricularinterstitial tumor presenting with hemodynamically unstable ventricular tachycardia. In response to hemodynamicallyunstable ventricular tachycardia, an implantable cardioverter-defibrillator was inserted. One month after defibrillatorimplantation, the patient developed episodes of high ventricular tachycardia that could not be effectively terminatedby catheter radiofrequency ablation, thus further confirming that the ventricular tachycardia was induced by the leftventricular interstitial tumor. The patient is doing well on medical therapy to date.
{"title":"A Rare Case of a Primary Cardiac Tumor Presenting as Fatal Ventricular Tachycardia","authors":"Xu-Dong Guo","doi":"10.15212/cvia.2022.0014","DOIUrl":"https://doi.org/10.15212/cvia.2022.0014","url":null,"abstract":"Primary cardiac tumors are extremely uncommon. Here, we report the case of a patient with a primary left ventricularinterstitial tumor presenting with hemodynamically unstable ventricular tachycardia. In response to hemodynamicallyunstable ventricular tachycardia, an implantable cardioverter-defibrillator was inserted. One month after defibrillatorimplantation, the patient developed episodes of high ventricular tachycardia that could not be effectively terminatedby catheter radiofrequency ablation, thus further confirming that the ventricular tachycardia was induced by the leftventricular interstitial tumor. The patient is doing well on medical therapy to date.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67305533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Inflammation plays a role in coronary artery disease (CAD). The neutrophil/lymphocyte ratio (NLR),monocyte/lymphocyte ratio (MLR) and platelet/lymphocyte ratio (PLR) are blood parameters associated with inflammation.We aimed to perform a systematic comparison and study the predictive values of these inflammatory parameterswith respect to CAD stage.Method: A total of 513 patients who had undergone coronary angiography (CAG) were retrospectively analyzed.Clinical status, lipid profiles, CAG scans and hematological parameters were collected. NLR, MLR and PLR were calculated. All patients were classified into a normal coronary group (n = 133), coronary atherosclerosis (CA) group (n = 149), chronic coronary syndrome (CCS) group (n = 175) or acute myocardial infarction (AMI) group (n = 56). NLR, MLR and PLR were compared among groups.Results: NLR and MLR were higher in the CCS and AMI groups. PLR was higher in the AMI group. The AMI grouphad higher NLR, PLR and MLR than the CCS group. Logistic regression analysis revealed that NLR (OR:1.227, 95%CI: 1.016–1.482. P < 0.05) had a strong significant correlation with CAD. Area under the ROC curve of NLR was 0.580(95% CI = 0.516–0.644) in predicting CCS and 0.727 (95% CI = 0.642–0.811) in predicting AMI.Conclusion: NLR may be associated with the occurrence and progression of CAD, and may serve as a marker of inflammation.
简介:炎症在冠状动脉疾病(CAD)中起着重要作用。中性粒细胞/淋巴细胞比值(NLR)、单核细胞/淋巴细胞比值(MLR)和血小板/淋巴细胞比值(PLR)是与炎症相关的血液参数。我们的目的是进行系统的比较和研究这些炎症参数对CAD分期的预测值。方法:对513例行冠状动脉造影(CAG)的患者进行回顾性分析。收集患者的临床状况、血脂、CAG扫描和血液学参数。计算NLR、MLR和PLR。将所有患者分为冠状动脉正常组(133例)、冠状动脉粥样硬化组(149例)、慢性冠状动脉综合征组(175例)和急性心肌梗死组(56例)。组间NLR、MLR、PLR比较。结果:心肌梗死组和心肌梗死组NLR和MLR均高于心肌梗死组。AMI组PLR较高。AMI组NLR、PLR、MLR均高于CCS组。Logistic回归分析显示NLR (OR:1.227, 95%CI: 1.016 ~ 1.482)。P < 0.05)与CAD有很强的相关性。NLR预测CCS的ROC曲线下面积为0.580(95% CI = 0.516 ~ 0.644)，预测AMI的ROC曲线下面积为0.727 (95% CI = 0.642 ~ 0.811)。结论:NLR可能与冠心病的发生发展有关，并可作为炎症的标志。
{"title":"The Neutrophil/Lymphocyte Ratio is Associated with Different Stages of Development of Coronary Artery Disease","authors":"Jianlin Du","doi":"10.15212/cvia.2022.0018","DOIUrl":"https://doi.org/10.15212/cvia.2022.0018","url":null,"abstract":"Introduction: Inflammation plays a role in coronary artery disease (CAD). The neutrophil/lymphocyte ratio (NLR),monocyte/lymphocyte ratio (MLR) and platelet/lymphocyte ratio (PLR) are blood parameters associated with inflammation.We aimed to perform a systematic comparison and study the predictive values of these inflammatory parameterswith respect to CAD stage.Method: A total of 513 patients who had undergone coronary angiography (CAG) were retrospectively analyzed.Clinical status, lipid profiles, CAG scans and hematological parameters were collected. NLR, MLR and PLR were calculated. All patients were classified into a normal coronary group (n = 133), coronary atherosclerosis (CA) group (n = 149), chronic coronary syndrome (CCS) group (n = 175) or acute myocardial infarction (AMI) group (n = 56). NLR, MLR and PLR were compared among groups.Results: NLR and MLR were higher in the CCS and AMI groups. PLR was higher in the AMI group. The AMI grouphad higher NLR, PLR and MLR than the CCS group. Logistic regression analysis revealed that NLR (OR:1.227, 95%CI: 1.016–1.482. P < 0.05) had a strong significant correlation with CAD. Area under the ROC curve of NLR was 0.580(95% CI = 0.516–0.644) in predicting CCS and 0.727 (95% CI = 0.642–0.811) in predicting AMI.Conclusion: NLR may be associated with the occurrence and progression of CAD, and may serve as a marker of inflammation.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":"13 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67305858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: We aimed to observe the improvements in cardiac function indexes and the occurrence of adverse events in patients with heart failure with reduced ejection fraction (HFrEF) after dapagliflozin administration in a real-world setting.Methods: We retrospectively enrolled 201 patients with HFrEF who were treated at a tertiary hospital in Zhengzhou and started to take dapagliflozin (10 mg/d) from March 2020 to June 2021. Their New York Heart Association (NYHA) functional class, cardiac ultrasound indexes, laboratory indexes, and vital signs between baseline and the last follow-up visit were compared, and their adverse events during the follow-up period were recorded.Results: The follow-up period was 173 (67–210) days. The cardiac function indexes of patients at follow-up, compared with baseline, indicated significant improvement (proportion of NYHA functional class I and II: 40.8% vs. 56.2%; left ventricular ejection fraction: 28.4 ± 5.3% vs. 34.7 ± 5.9%; left ventricular end-diastolic diameter: 70.1 ± 6.4 mm vs. 64.7 ± 5.6 mm; N-terminal pro-B-type natriuretic peptide: 5421.9 ± 2864.4 pg/mL vs. 2842.8 ± 1703.4 pg/mL at baseline vs. at follow-up; all P < 0.05). The rates of hypotension, deterioration of renal function, and genital infection during the follow-up period were 6.5%, 4.0%, and 3.5%, respectively.Conclusions: We believe that dapagliflozin is safe and effective in patients with HFrEF in the real world.
目的:我们的目的是观察在现实环境中服用达格列净后，心力衰竭并射血分数降低(HFrEF)患者心功能指标的改善和不良事件的发生。方法:回顾性纳入201例HFrEF患者，这些患者于2020年3月至2021年6月在郑州市某三级医院接受治疗，并开始服用达格列净(10mg /d)。比较两组患者的纽约心脏协会(NYHA)功能分级、心脏超声指标、实验室指标以及基线与末次随访的生命体征，记录随访期间的不良事件。结果:随访期173 (67 ~ 210)d。随访时患者心功能指标与基线相比有显著改善(NYHA功能I级和II级比例:40.8% vs. 56.2%;左室射血分数:28.4±5.3% vs. 34.7±5.9%;左室舒张末期内径:70.1±6.4 mm vs. 64.7±5.6 mm;n端前b型利钠肽:基线和随访时分别为5421.9±2864.4 pg/mL和2842.8±1703.4 pg/mL;P < 0.05)。随访期间低血压、肾功能恶化和生殖器感染发生率分别为6.5%、4.0%和3.5%。结论:我们认为，在现实世界中，达格列净对HFrEF患者是安全有效的。
{"title":"Dapagliflozin in Heart Failure with Reduced Ejection Fraction: A Real-World Study","authors":"Yanzhou Zhang","doi":"10.15212/cvia.2022.0005","DOIUrl":"https://doi.org/10.15212/cvia.2022.0005","url":null,"abstract":"Aims: We aimed to observe the improvements in cardiac function indexes and the occurrence of adverse events in patients with heart failure with reduced ejection fraction (HFrEF) after dapagliflozin administration in a real-world setting.Methods: We retrospectively enrolled 201 patients with HFrEF who were treated at a tertiary hospital in Zhengzhou and started to take dapagliflozin (10 mg/d) from March 2020 to June 2021. Their New York Heart Association (NYHA) functional class, cardiac ultrasound indexes, laboratory indexes, and vital signs between baseline and the last follow-up visit were compared, and their adverse events during the follow-up period were recorded.Results: The follow-up period was 173 (67–210) days. The cardiac function indexes of patients at follow-up, compared with baseline, indicated significant improvement (proportion of NYHA functional class I and II: 40.8% vs. 56.2%; left ventricular ejection fraction: 28.4 ± 5.3% vs. 34.7 ± 5.9%; left ventricular end-diastolic diameter: 70.1 ± 6.4 mm vs. 64.7 ± 5.6 mm; N-terminal pro-B-type natriuretic peptide: 5421.9 ± 2864.4 pg/mL vs. 2842.8 ± 1703.4 pg/mL at baseline vs. at follow-up; all P < 0.05). The rates of hypotension, deterioration of renal function, and genital infection during the follow-up period were 6.5%, 4.0%, and 3.5%, respectively.Conclusions: We believe that dapagliflozin is safe and effective in patients with HFrEF in the real world.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67304968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: The use of current robotic systems to assist in percutaneous coronary intervention (PCI) fundamentallydiffers from performing conventional PCI. To overcome this problem, we developed a novel master-slave roboticcontrol system to assist in PCI, and evaluated its safety and feasibility in the delivery and manipulation of coronaryguidewires in vitro and in vivo.Methods: The novel robotic assist PCI system is composed of three parts: 1) a master actuator, which imitates thetraditional torque used by surgeons in conventional PCI, 2) a slave actuator, including a guidewire delivery system andforce monitoring equipment, and 3) a local area network based communication system.Results: The experiment was performed in six pigs. Both robotic and manual control completed the operation with no device- or procedure-associated complications. An experienced interventional cardiologist who was a first-time userof the novel robotic PCI system was able to advance the guidewire into a distal branch of a coronary artery within asimilar time to that required with the manual procedure.Conclusion: This early in vivo experiment with the novel robotic assisted PCI control system demonstrated that its feasibility, safety, and procedural effectiveness are comparable to those of manual operation. The novel robotic-assisted PCI control system required significantly less time to learn than other currently available systems.
{"title":"A Novel Robotic Control System Mimics Doctor’s Operation to Assist Percutaneous Coronary Intervention","authors":"Ping Zhang","doi":"10.15212/cvia.2022.0003","DOIUrl":"https://doi.org/10.15212/cvia.2022.0003","url":null,"abstract":"Objectives: The use of current robotic systems to assist in percutaneous coronary intervention (PCI) fundamentallydiffers from performing conventional PCI. To overcome this problem, we developed a novel master-slave roboticcontrol system to assist in PCI, and evaluated its safety and feasibility in the delivery and manipulation of coronaryguidewires in vitro and in vivo.Methods: The novel robotic assist PCI system is composed of three parts: 1) a master actuator, which imitates thetraditional torque used by surgeons in conventional PCI, 2) a slave actuator, including a guidewire delivery system andforce monitoring equipment, and 3) a local area network based communication system.Results: The experiment was performed in six pigs. Both robotic and manual control completed the operation with no device- or procedure-associated complications. An experienced interventional cardiologist who was a first-time userof the novel robotic PCI system was able to advance the guidewire into a distal branch of a coronary artery within asimilar time to that required with the manual procedure.Conclusion: This early in vivo experiment with the novel robotic assisted PCI control system demonstrated that its feasibility, safety, and procedural effectiveness are comparable to those of manual operation. The novel robotic-assisted PCI control system required significantly less time to learn than other currently available systems.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":"93 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67305341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hypertensive-Like Reaction: A Definition for Normotensive Individuals with Symptoms Associated with Elevated Blood Pressure","authors":"Yifang Guo","doi":"10.15212/cvia.2022.0004","DOIUrl":"https://doi.org/10.15212/cvia.2022.0004","url":null,"abstract":"<jats:p> </jats:p>","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67305417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Myocardial infarction (MI) is associated with high rates of death and disability, and is the main cause of death due tocardiovascular disease and the most frequent cause of death in the developed world. Recent studies have shown that, in addition to traditional risk factors, such as hypertension, diabetes, hyperlipidemia, obesity, smoking and the environment, the gut microbiota plays an important role in MI development and progression. The discovery of an enteric-cardioid axis provides a new route to examine the complex mechanism of MI and has become a research hotspot in recent years. Experiments have suggested that probiotics decrease ischemia/reperfusion injury and inflammation, regulate lipid metabolism and decrease the myocardial infarction area. In this review, we discuss the relationship between probiotics and MI as well as potential underlying mechanisms, to provide new ideas for the prevention and treatment of MI.
{"title":"Application Potential of Probiotics in Acute Myocardial Infarction","authors":"Hui Jiang","doi":"10.15212/cvia.2022.0019","DOIUrl":"https://doi.org/10.15212/cvia.2022.0019","url":null,"abstract":"Myocardial infarction (MI) is associated with high rates of death and disability, and is the main cause of death due tocardiovascular disease and the most frequent cause of death in the developed world. Recent studies have shown that, in addition to traditional risk factors, such as hypertension, diabetes, hyperlipidemia, obesity, smoking and the environment, the gut microbiota plays an important role in MI development and progression. The discovery of an enteric-cardioid axis provides a new route to examine the complex mechanism of MI and has become a research hotspot in recent years. Experiments have suggested that probiotics decrease ischemia/reperfusion injury and inflammation, regulate lipid metabolism and decrease the myocardial infarction area. In this review, we discuss the relationship between probiotics and MI as well as potential underlying mechanisms, to provide new ideas for the prevention and treatment of MI.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67305487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Atrial fibrillation is the most common arrhythmia leading to cardiogenic stroke. Without membranous sructure betweenepicardial adipose tissue and atrial myocardium, epicardial adipose tissue directly covers the surface of the atrial myocardium.The formation of an epicardial adipose tissue inflammatory microenvironment, fibrosis, infiltration by epicardialadipose tissue, autonomic dysfunction and oxidative stress are important mechanisms that trigger and maintainatrial fibrillation. Those mechanisms are reviewed herein.
{"title":"Role of Epicardial Adipose Tissue in Triggering and Maintaining Atrial Fibrillation","authors":"Ye Tian","doi":"10.15212/cvia.2022.0012","DOIUrl":"https://doi.org/10.15212/cvia.2022.0012","url":null,"abstract":"Atrial fibrillation is the most common arrhythmia leading to cardiogenic stroke. Without membranous sructure betweenepicardial adipose tissue and atrial myocardium, epicardial adipose tissue directly covers the surface of the atrial myocardium.The formation of an epicardial adipose tissue inflammatory microenvironment, fibrosis, infiltration by epicardialadipose tissue, autonomic dysfunction and oxidative stress are important mechanisms that trigger and maintainatrial fibrillation. Those mechanisms are reviewed herein.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67305726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stress-induced cardiomyopathy, in contrast to acute myocardial infarction, is a type of acute heart failure characterizedby reversible left ventricular dysfunction. Cardiac imaging primarily reveals left ventricle myocardial stunning, 81.7%of which is apical type. Emotional or psychological stress usually precedes the onset of stress-induced cardiomyopathy,which is increasingly being recognized as a unique neurogenic myocardial stunning disease. To distinguish betweenacute myocardial infarction and acute viral or auto-immune myocarditis, this review summarizes specific mechanismsof myocardial stunning in stress-induced cardiomyopathy, such as calcium disorders, metabolic alterations, anatomicaland histological variations in different parts of the left ventricle, and microvascular dysfunction.
{"title":"Mechanisms of Myocardial Stunning in Stress-Induced Cardiomyopathy*","authors":"Dechun Yin","doi":"10.15212/cvia.2022.0010","DOIUrl":"https://doi.org/10.15212/cvia.2022.0010","url":null,"abstract":"Stress-induced cardiomyopathy, in contrast to acute myocardial infarction, is a type of acute heart failure characterizedby reversible left ventricular dysfunction. Cardiac imaging primarily reveals left ventricle myocardial stunning, 81.7%of which is apical type. Emotional or psychological stress usually precedes the onset of stress-induced cardiomyopathy,which is increasingly being recognized as a unique neurogenic myocardial stunning disease. To distinguish betweenacute myocardial infarction and acute viral or auto-immune myocarditis, this review summarizes specific mechanismsof myocardial stunning in stress-induced cardiomyopathy, such as calcium disorders, metabolic alterations, anatomicaland histological variations in different parts of the left ventricle, and microvascular dysfunction.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67305454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep is essential to the normal psychological and physiological activities of the human body. Increasing evidenceindicates that sleep deprivation is associated with the occurrence, development, and poor treatment effects of variousarrhythmias. Sleep deprivation affects not only the peripheral nervous system but also the central nervous system,which regulates the occurrence of arrhythmias. In addition, sleep deprivation is associated with apoptotic pathways,mitochondrial energy metabolism disorders, and immune system dysfunction. Although studies increasingly suggestthat pathological sleep patterns are associated with various atrial and ventricular arrhythmias, further research is neededto identify specific mechanisms and recommend therapeutic interventions. This review summarizes the findings ofsleep deprivation in animal experiments and clinical studies, current challenges, and future research directions in thefield of arrhythmias.
{"title":"The Role of Sleep Deprivation in Arrhythmias","authors":"Dechun Yin","doi":"10.15212/cvia.2022.0013","DOIUrl":"https://doi.org/10.15212/cvia.2022.0013","url":null,"abstract":"Sleep is essential to the normal psychological and physiological activities of the human body. Increasing evidenceindicates that sleep deprivation is associated with the occurrence, development, and poor treatment effects of variousarrhythmias. Sleep deprivation affects not only the peripheral nervous system but also the central nervous system,which regulates the occurrence of arrhythmias. In addition, sleep deprivation is associated with apoptotic pathways,mitochondrial energy metabolism disorders, and immune system dysfunction. Although studies increasingly suggestthat pathological sleep patterns are associated with various atrial and ventricular arrhythmias, further research is neededto identify specific mechanisms and recommend therapeutic interventions. This review summarizes the findings ofsleep deprivation in animal experiments and clinical studies, current challenges, and future research directions in thefield of arrhythmias.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":"221 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67305897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This study was aimed at investigating the effects of preoperative treatment with a loading dose of statinscombined with a PCSK9 inhibitor on coronary blood perfusion and short-term cardiovascular adverse events in patientswith ST-segment elevation myocardial infarction (STEMI).Method: Sixty-five patients with STEMI who had visited the Shanxi Cardiovascular Disease Hospital between May2018 and May 2021 were enrolled in the study. The enrolled patients had no history of oral statins or antiplatelet therapy.The patients were divided into a combined treatment group (loading dose of statins combined with PCSK9 inhibitors, 35patients) and a routine treatment group (loading dose of statins only, 30 patients). The primary endpoints were thrombolysisin myocardial infarction (TIMI) blood flow grading, corrected TIMI frame count (CTFC), and TIMI myocardial perfusiongrading (TMPG), immediately after and 30 days after the operation. The secondary endpoint was a composite endpoint ofcardiovascular death, nonfatal myocardial infarction, and target vessel revascularization 30 days after the operation.Results: The combined treatment group had significantly lower CTFC (14.09 ± 8.42 vs 26 ± 12.42, P = 0.04) and betterTMPG (2.74 ± 0.61 vs 2.5 ± 0.73, P = 0.04) than the routine treatment group immediately after the operation. Similarly,the combined treatment group had a significantly lower CTFC (16.29 ± 7.39 vs 26.23 ± 11.53, P = 0.04) and significantlybetter TMPG (2.94 ± 0.24 vs 2.76 ± 0.43, P = 0.01) than the routine treatment group 1 month after the operation.Conclusion: Preoperative treatment with a loading dose of high-intensity statins combined with PCSK9 inhibitorsincreased coronary blood flow and myocardial perfusion after emergency thrombus aspiration in patients withSTEMI. However, the treatment did not significantly decrease the incidence of cardiovascular death, nonfatal myocardialinfarction, or target vessel revascularization.
目的:本研究旨在探讨术前负荷剂量的他汀类药物联合PCSK9抑制剂对st段抬高型心肌梗死(STEMI)患者冠状动脉血流灌注和短期心血管不良事件的影响。方法:2018年5月至2021年5月在山西省心血管病医院就诊的STEMI患者65例纳入研究。纳入的患者没有口服他汀类药物或抗血小板治疗史。将患者分为联合治疗组(他汀类药物联合PCSK9抑制剂负荷剂量，35例)和常规治疗组(他汀类药物负荷剂量，30例)。主要终点是溶栓心肌梗死(TIMI)血流分级，校正后的TIMI框架计数(CTFC)和TIMI心肌灌注分级(TMPG)，即刻和术后30天。次要终点是心血管死亡、非致死性心肌梗死和术后30天靶血管重建术的复合终点。结果:术后即刻联合治疗组CTFC(14.09±8.42 vs 26±12.42,P = 0.04)显著低于常规治疗组，tmpg(2.74±0.61 vs 2.5±0.73,P = 0.04)显著优于常规治疗组。术后1个月，联合治疗组CTFC(16.29±7.39 vs 26.23±11.53,P = 0.04)显著低于常规治疗组，TMPG(2.94±0.24 vs 2.76±0.43,P = 0.01)显著优于常规治疗组。结论:术前负荷剂量的高强度他汀类药物联合PCSK9抑制剂可增加stemi患者急诊血栓抽吸后冠状动脉血流量和心肌灌注。然而，治疗并没有显著降低心血管死亡、非致死性心肌梗死或靶血管重建术的发生率。
{"title":"Effects of Loading-Dose Statins Combined with PCSK9 Inhibitor Pre-Treatment before Primary Percutaneous Coronary Intervention on the Short-Term Prognosis in Patients with ST-Segment Elevation Myocardial Infarction","authors":"J. An","doi":"10.15212/cvia.2022.0011","DOIUrl":"https://doi.org/10.15212/cvia.2022.0011","url":null,"abstract":"Objective: This study was aimed at investigating the effects of preoperative treatment with a loading dose of statinscombined with a PCSK9 inhibitor on coronary blood perfusion and short-term cardiovascular adverse events in patientswith ST-segment elevation myocardial infarction (STEMI).Method: Sixty-five patients with STEMI who had visited the Shanxi Cardiovascular Disease Hospital between May2018 and May 2021 were enrolled in the study. The enrolled patients had no history of oral statins or antiplatelet therapy.The patients were divided into a combined treatment group (loading dose of statins combined with PCSK9 inhibitors, 35patients) and a routine treatment group (loading dose of statins only, 30 patients). The primary endpoints were thrombolysisin myocardial infarction (TIMI) blood flow grading, corrected TIMI frame count (CTFC), and TIMI myocardial perfusiongrading (TMPG), immediately after and 30 days after the operation. The secondary endpoint was a composite endpoint ofcardiovascular death, nonfatal myocardial infarction, and target vessel revascularization 30 days after the operation.Results: The combined treatment group had significantly lower CTFC (14.09 ± 8.42 vs 26 ± 12.42, P = 0.04) and betterTMPG (2.74 ± 0.61 vs 2.5 ± 0.73, P = 0.04) than the routine treatment group immediately after the operation. Similarly,the combined treatment group had a significantly lower CTFC (16.29 ± 7.39 vs 26.23 ± 11.53, P = 0.04) and significantlybetter TMPG (2.94 ± 0.24 vs 2.76 ± 0.43, P = 0.01) than the routine treatment group 1 month after the operation.Conclusion: Preoperative treatment with a loading dose of high-intensity statins combined with PCSK9 inhibitorsincreased coronary blood flow and myocardial perfusion after emergency thrombus aspiration in patients withSTEMI. However, the treatment did not significantly decrease the incidence of cardiovascular death, nonfatal myocardialinfarction, or target vessel revascularization.","PeriodicalId":41559,"journal":{"name":"Cardiovascular Innovations and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67305590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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