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Current evidence of rivaroxaban in cancer-associated thrombosis 利伐沙班治疗癌症相关血栓的最新证据
IF 0.2 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2018-10-25 DOI: 10.5603/AA.2018.0018
Grzegorz Halena, A. Kulik
Patients with cancer have a high risk of developing cancer-associated thrombosis (CAT). Current guidelines suggest preferential use of low molecular weight heparins (LMWH) in CAT. The real-world data show that compliance with recommended LMWH therapy in cancer patients is low. Many patients discontinue injectable anticoagulants prematurely, in some cases even after a month, despite a high recurrence rate in this population. In recent years an increasing number of cancer patients are treated with direct oral anticoagulants, mainly rivaroxaban. Recent data confirming the safety and efficacy of rivaroxaban are starting to emerge and support the growing trend of using direct oral anticoagulants in cancer patients. If positive results of the recently completed SELECT-D trial are confirmed in the upcoming trials and registries of CALLISTO project, the guidelines for the treatment of CAT will have to be revised in favour of DOAC use in cancer-associated thrombosis.
癌症患者发生癌症相关血栓形成(CAT)的风险很高。目前的指南建议在CAT中优先使用低分子肝素(LMWH)。真实世界的数据显示,癌症患者对推荐的低分子肝素治疗的依从性较低。许多患者过早停止注射抗凝剂,在某些情况下甚至在一个月后停止,尽管这一人群的复发率很高。近年来,越来越多的癌症患者接受直接口服抗凝剂治疗,主要是利伐沙班。最近证实利伐沙班安全性和有效性的数据开始出现,并支持癌症患者直接口服抗凝剂的增长趋势。如果最近完成的SELECT-D试验的阳性结果在即将到来的CALLISTO项目试验和注册中得到证实,则必须修订CAT治疗指南,以支持DOAC用于癌症相关血栓形成。
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引用次数: 1
Evaluation of the healing progress of phlegmon related to type 2 diabetes treated with the local hyperbaric oxygen therapy 局部高压氧治疗2型糖尿病相关痰的疗效评价
IF 0.2 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2018-10-25 DOI: 10.5603/AA.2018.0017
J. Pasek, G. Cieślar, A. Sieroń
Introduction. Phlegmon is a disease which causes purulent inflammation of the subcutaneous tissue, being of unlimited character. This disease does not only affect the external coverings of the body; it may also be transmitted to the internal organs, and lead to their insufficiency. Case report. The study presents the results of the physical therapy applied to phlegmon located in the right shank and foot of a 57-year old patient with type 2 diabetes after an ineffective typical symptomatic treatment. A local hyperbaric oxygen therapy has been used in this treatment which utilizes the therapeutic effect of gases with high oxygen content close to 100%,exceeding the pressure of one atmosphere. Results. After completion of the 4-month therapy complete regression of pain symptoms was achieved assessed accordingly to the VAS scale, as well as the complete healing of wounds, reduction of the inflammatory reaction and skin congestion, thanks to which the amputation of the limb turned out not to be necessary. The thermographic assessment performed after the completion of the treatment confirmed normalization of the previously reduced temperature of tissues in the area of healed wounds. Conclusions. The obtained initial results indicate that the therapy with the use of the local hyperbaric oxygen therapy may constitute a useful adjunctive method for treatment of patients whose wounds are hard to heal, including wounds with inflammatory origin.
介绍。痰是一种引起皮下组织化脓性炎症的疾病,具有无限的性质。这种疾病不仅影响身体的外部覆盖物;它也可能传播到内部器官,并导致其功能不足。病例报告。本文报道了57岁2型糖尿病患者右小腿和足部痰经典型对症治疗无效后的物理治疗结果。在这种治疗中使用了局部高压氧治疗,它利用接近100%的高氧含量气体的治疗效果,超过一个大气压的压力。结果。完成4个月的治疗后,疼痛症状完全消退,根据VAS评分进行评估,伤口完全愈合,炎症反应和皮肤充血减少,因此无需截肢。治疗完成后进行的热成像评估证实了愈合伤口区域组织先前降低的温度的正常化。结论。所获得的初步结果表明,局部高压氧治疗可能是一种有用的辅助方法,用于治疗伤口难以愈合的患者,包括炎症性伤口。
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引用次数: 5
Aorto-renal bifurcation stenting in a juvenile non-specific aorto-arteritis: case report 主动脉-肾分叉支架置入术治疗青少年非特异性大动脉炎1例
IF 0.2 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2018-04-12 DOI: 10.5603/AA.2018.0004
Amro Alsharabi, T. Jakimowicz, P. Hammer, S. Nazarewski
Takayasu Arteritis (TA) is a granulomatous inflammation of unknown aetiology affecting the aorta and its major branches with usual affliction among patients younger than 50 years and rarely among children. We present a 7-years old boy referred for evaluation of hypertension. He had a significant blood pressure difference between right arm, left arm and lower limbs. Computed tomography imaging of thorax and abdomen showed stenosis of left subclavian artery, left renal artery and juxtarenal aorta which was subsequently confirmed on aortogram. He underwent percutaneous endovascular therapy with aorto-renal bifurcation stenting with reduction of blood pressure and gradient. Renal angioplasty with stenting remains a challenging procedure in patients with tight ostial lesion, and juxtarenal aortic involvement in lieu of precise stent placement and avoiding side branch occlusion.
大动脉炎(TA)是一种病因不明的肉芽肿性炎症,影响主动脉及其主要分支,通常发生在50岁以下的患者中,很少发生在儿童中。我们介绍一名7岁男孩,他被转诊进行高血压评估。他的右臂、左臂和下肢之间的血压有显著差异。胸部和腹部的计算机断层扫描成像显示左锁骨下动脉、左肾动脉和近主动脉狭窄,随后在主动脉图上得到证实。他接受了经皮血管内治疗,主动脉-肾分叉处支架植入,降低了血压和梯度。肾血管成形术和支架置入术对于狭窄的开口病变和近主动脉受累的患者来说仍然是一项具有挑战性的手术,而不是精确的支架置入和避免侧支闭塞。
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引用次数: 0
The role of alpha-1-antitrypsin protein in the pathogenesis of abdominal aortic aneurysm α -1-抗胰蛋白酶蛋白在腹主动脉瘤发病中的作用
IF 0.2 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2018-04-12 DOI: 10.5603/AA.2018.0006
Agata Dżeljilji, J. Chorostowska-Wynimko, D. Szewczyk, Wojciech Popiołek, Artur Kierach, P. Andziak
Alpha-1-antitrypsin is a potent antiprotease playing an important role in maintaining protease-antiprotease balance. It protects the structures of extracellular matrix against destruction by proteolytic enzymes. Loss of elasticity occurs when increased protease activity is accompanied by qualitative impairment or reduced concentrations of antiproteases. Alpha-1-antitrypsin deficiency is a risk factor for obstructive lung disease, including emphysema, liver and kidney disorders and, less often, follicular panniculitis, granulomatosis with polyangiitis (previously Wegener’s granulomatosis). Literature also emphasises the role of AAT in the development of aortic aneurysms, and results of biochemical studies support this theory. Aortic aneurysm is an important clinical problem, unceasingly associated with high mortality. For this reason, it is exceptionally important to identify its risk factors. Studies on the relationship between AAT and development of AAA (abdominal aortic aneurysm) have been conducted since the 1990s. Due to the development in molecular diagnostic techniques, new reports on the topic appeared over the last decade.
α -1-抗胰蛋白酶是一种有效的抗蛋白酶,在维持蛋白酶-抗蛋白酶平衡中起重要作用。它保护细胞外基质结构免受蛋白水解酶的破坏。当蛋白酶活性的增加伴随着定性损伤或抗蛋白酶浓度的降低时,就会发生弹性的丧失。α -1-抗胰蛋白酶缺乏症是阻塞性肺病的危险因素,包括肺气肿、肝脏和肾脏疾病,以及少见的滤泡性血管炎、肉芽肿伴多血管炎(以前称为韦格纳肉芽肿病)。文献也强调了AAT在主动脉瘤发展中的作用,生化研究结果支持这一理论。主动脉瘤是一种重要的临床疾病,其死亡率一直居高不下。因此,确定其风险因素尤为重要。自20世纪90年代以来,人们开始研究AAT与腹主动脉瘤(AAA)发展的关系。由于分子诊断技术的发展,在过去十年中出现了关于该主题的新报告。
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引用次数: 2
Critical limb ischemia caused by adductor canal compression syndrome — case report with the review of the literature 内收管压迫综合征引起的严重肢体缺血1例并文献复习
IF 0.2 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2018-04-12 DOI: 10.5603/AA.2018.0003
Piotr Kaszczewski, T. Ostrowski, J. Żyłkowski, Z. Gałązka
We report a case of a 55-year-old male who was diagnosed with the adductor canal compression syndrome – a rarely described nontraumatic disorder of the lower limb resulting from the external compression of the superficial femoral artery in the adductor canal, that may present with the symptoms ranging from intermittent exercise-induced claudication up to arterial obstruction and critical limb ischemia.
我们报告一例55岁男性患者被诊断为内收管压迫综合征,这是一种罕见的下肢非创伤性疾病,由股浅动脉外压迫内收管引起,其症状可能从间歇性运动引起的跛行到动脉阻塞和严重肢体缺血。
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引用次数: 1
Aorto-renal Bifurcation Stenting in a Juvenile Non-specific Aorto-Arteritis: case report 主动脉-肾分叉支架置入术治疗青少年非特异性大动脉炎1例
IF 0.2 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2018-04-12 DOI: 10.5603/AA.2018.0005
S. Sinha, V. Krishna, N. Khanna, Lawrence Rajan, M. Jha, V. Mishra, M. Asif, R. Thakur, Mahmadula Razi
Takayasu Arteritis (TA) is a granulomatous inflammation of unknown aetiology affecting the aorta and its major branches with usual affliction among patients younger than 50 years and rarely among children. We present a 7-years old boy referred for evaluation of hypertension. He had a significant blood pressure difference between right arm, left arm and lower limbs. Computed tomography imaging of thorax and abdomen showed stenosis of left subclavian artery, left renal artery and juxtareanl aorta which was subsequently confirmed on aortogram. He underwent percutaneous endovascular therapy with aorto-renal bifurcation stenting with reduction of blood pressure and gradient. Renal angioplasty with stenting remains a challenging procedure in patients with tight ostial lesion, and juxtarenal aortic involvement in lieu of precise stent placement and avoiding side branch occlusion.
高须动脉炎(Takayasu Arteritis, TA)是一种影响主动脉及其主要分支的肉芽肿性炎症,病因不明,常见于50岁以下的患者,很少发生在儿童中。我们报告一名7岁男童接受高血压评估。他的右臂、左臂和下肢的血压差异很大。胸腹ct示左锁骨下动脉、左肾动脉及肾旁主动脉狭窄,经主动脉造影证实。他接受了经皮主动脉-肾分叉血管内支架治疗,血压和梯度降低。肾血管成形术与支架植入术仍然是一个具有挑战性的程序,在狭窄的口病变,并累及肾旁主动脉代替精确支架置入和避免侧支闭塞的患者。
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引用次数: 0
Cultural and psychological determinants of pain assessment during lower limb angioplasty 下肢血管成形术中疼痛评估的文化和心理因素
IF 0.2 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2018-04-12 DOI: 10.5603/AA.2018.0002
M. Stanisić, T. Rzepa, Jarosław Nakonieczny, Przemysław Kubaszewski, Maciej Putowski, M. Popek, Athanasios Liougkos
Introduction. It is a common unofficial perception of surgeons performing endovascular operations that patients living in the different social and economic environment assess pain differently during peripheral angioplasty procedures. The objective was to examine the differences in assessing pain experienced during endovascular arterial interventions on lower limbs, by Polish and German patients, and to analyse the psychological determinants of the assumed differences, by referring to mental dispositions such as optimism and satisfaction with own life quality. Material and methods. 101 patients were qualified for endovascular intervention on lower limbs arteries — 51 Germans (M = 67.31; SD = 9.82) and 50 Poles (age M = 67.88; SD = 8.4). 37 women and 64 men were classified as Rutherford category 2–3. Three scales were applied: 1. Life Orientation Test-Revised 2. Satisfaction With Life Scale 3. Pain Appraisal Scale which comprises emoticons showing subsequent degrees of sustained pain and the corresponding Visual Analogue Scale. Results. The patients from Poland graded their life quality lower than the German patients (M = 23.44; SD = 5.977 and M = 25.94; SD = 5.584). The Poles presented a lower level of optimism (M = 15.04; SD = 3.703 vs M = 15.8; SD = 3.516). The Polish patients classified the level of pain during lower limb angioplasty as higher than in German patients (M = 4.22; SD = 2.999 and M = 2.88; SD = 2.215) (p < 0.012). Conclusions. Resistance to pain experienced during endovascular procedures probably depends on the assessment of the patient’s current life situation, determined by satisfaction with own life quality and related optimism. With great caution, it might also be supposed that resistance to pain depends on the life standard typical of a given population
介绍。在进行血管内手术的外科医生中,一种常见的非官方看法是,生活在不同社会和经济环境中的患者在周围血管成形术中对疼痛的评估不同。目的是检查波兰和德国患者在下肢血管内动脉介入治疗期间评估疼痛的差异,并通过参考心理倾向,如乐观和对自己生活质量的满意度,分析假设差异的心理决定因素。材料和方法。101例患者符合下肢动脉血管内介入治疗条件——51例德国人(M = 67.31;SD = 9.82)和50个波兰人(年龄M = 67.88;Sd = 8.4)。37名女性和64名男性被归类为卢瑟福2-3类。采用三种量表:1。人生取向测验生活满意度量表疼痛评估量表,包括显示后续持续疼痛程度的表情符号和相应的视觉模拟量表。结果。波兰患者的生活质量评分低于德国患者(M = 23.44;SD = 5.977, M = 25.94;Sd = 5.584)。波兰人的乐观程度较低(M = 15.04;SD = 3.703 vs M = 15.8;Sd = 3.516)。波兰患者在下肢血管成形术中疼痛程度高于德国患者(M = 4.22;SD = 2.999, M = 2.88;SD = 2.215) (p < 0.012)。结论。在血管内手术过程中对疼痛的抵抗可能取决于对患者当前生活状况的评估,由对自身生活质量的满意度和相关的乐观情绪决定。谨慎起见,我们也可以假设,对疼痛的抵抗力取决于特定人群的典型生活标准
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引用次数: 0
Perthes syndrome: a pediatric case Perthes综合征:一例儿科病例
IF 0.2 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2017-12-28 DOI: 10.5603/AA.2017.0017
F. Fitouri, S. Sahli, Y. Houas, N. Sassi, M. Hamzaoui
The traumatic asphyxia or Perthes syndrome is uncommon. It is a clinical syndrome associating an ecchymotic mask consisting of cervicofacial cyanosis, petechiae and subconjunctival hemorrhage to neurological and ocu¬lar symptoms. The authors report a pediatric case of 8-year-old boy who was a highway accident victim. He presented a cervicofacial cyanosis, petechiae and immediate massive bilateral sub-conjunctival hemorrhage. The attitude was limited to a clinical monitoring. The decline is twelve months.
创伤性窒息或Perthes综合征并不常见。这是一种临床综合征,将由颈面部发绀、瘀点和结膜下出血组成的瘀斑面具与神经和眼部症状联系起来。作者报告了一个8岁男孩的儿科病例,他是一名高速公路事故的受害者。他表现为颈面部发绀、瘀点和立即出现的双侧结膜下大出血。这种态度仅限于临床监测。下降了十二个月。
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引用次数: 1
Radial artery pseudoaneurysm (RAP) following transradial intervention — an extremely rare complication successfully managed by surgery: case report 桡动脉假性动脉瘤(RAP)经桡动脉介入治疗后-一种极其罕见的并发症,手术成功处理:病例报告
IF 0.2 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2017-12-28 DOI: 10.5603/AA.2017.0018
S. Sinha, M. Jha, V. Mishra, Mahmadula Razi, A. Mahrotra, M. Asif, Nasar Abdali, V. Chaturvedi, L. Rekwal
The transradial access for diagnostic and therapeutic purpose is becoming increasingly popular, mainly because of its lack of complications. Radial artery pseudoaneurysm (RAP) is an extremely rare complication, so many of its clinical features are unknown and treatment is not systematic. Therapeutic options are conservative management, ultrasound-guided compression, thrombin injection and surgical intervention. Here, we report a 43-year old female who underwent transradial percutaneous angioplasty of left anterior descending artery. During cannulation of her radial artery, multiple puncture attempts were done. Upon removal of the transra¬dial compression band (TR Band), forearm ecchymosis and small hematoma were noted with mild pain. Tight compression bandage was applied but on the following day, she had complaints of increasing right forearm pain and tenderness. Physical evaluation revealed increased swelling of the right forearm and an ultrasound of the right forearm demonstrated a RAP of the right radial artery measuring up to 3.9x1.9 cm with 3.4 mm neck. Tight compression bandage was further prolonged following ultrasound compression with vascular probe which failed to alleviate her complaints. Following failure of conservative therapy and in lieu of her symptoms, surgical exploration, clot removal and successful repair was done.
经桡骨入路作为诊断和治疗目的越来越受欢迎,主要是因为其并发症少。桡动脉假性动脉瘤(RAP)是一种极为罕见的并发症,因此其许多临床特征尚不清楚,治疗也不系统。治疗选择为保守管理、超声引导下的压迫、凝血酶注射和手术干预。在此,我们报告一位43岁女性接受经桡动脉经皮左前降支血管成形术。在桡动脉插管期间,多次穿刺尝试。取下经颞加压带(TR带)后,发现前臂淤斑和小血肿,伴有轻度疼痛。使用了紧压绷带,但在第二天,她有右前臂疼痛和压痛增加的主诉。体格检查显示右前臂肿胀增加,右前臂超声显示右桡动脉RAP达3.9x1.9 cm,颈长3.4 mm。超声血管探头压迫后,进一步延长了严密的压迫绷带,但未能减轻她的症状。保守治疗失败后,代替她的症状,手术探查,血块清除和成功修复。
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引用次数: 2
Balloon-grab technique to bridge steep renal artery during endovascular thoracoabdominal aortic aneurysm repair: technical note 胸腹主动脉瘤腔内修复术中球囊抓取技术桥接陡峭肾动脉:技术要点
IF 0.2 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2017-12-28 DOI: 10.5603/AA.2017.0016
Michał Macech, T. Jakimowicz, P. Hammer, T. Grochowiecki, S. Nazarewski
The aim of the study is to describe an endovascular manoeuvre that can help in the cannulation and stenting of difficult renal arteries in endovascular thoracoabdominal aortic aneurysm exclusion (EVAR) with a branched stent graft. Routinely, dedicated branch and target vessels are cannulated in antegrade fashion through a transaxillary approach. If renal arteries are steep, tortuous, and unfavourable, cannulation failure can preclude a successful endovascular procedure. In that situation, the guidewire slips off the artery. However, another guidewire and balloon can be introduced to the target vessel through femoral access. Expansion of an additional percutaneous transluminal angioplasty (PTA) balloon in the target vessel grabs the guidewire or catheter cannulated in typical fashion and prevents it from slipping off. At this point, a stiffer wire can be introduced, and the covered stent easily bridges the target vessel. The rest of the procedure is continued typically. Expansion of an additionally introduced balloon allows the surgeon to grab the guidewire in the renal artery, thus excluding an aneurysm during EVAR. Our early experience shows that this method is effective and durable.
该研究的目的是描述一种血管内操作,可以帮助在血管内胸腹主动脉瘤排除(EVAR)与分支支架移植困难的肾动脉插管和支架术。通常,通过腋窝入路顺行插管专用分支和靶血管。如果肾动脉陡峭、弯曲和不利,插管失败可能会妨碍血管内手术的成功。在这种情况下,导丝会从动脉中滑落。然而,另一个导丝和球囊可以通过股骨通道引入目标血管。在靶血管中进行额外的经皮腔内血管成形术(PTA)球囊扩张,以典型的方式抓住导丝或导管,防止其滑落。在这一点上,可以引入更硬的金属丝,覆盖支架很容易桥接目标血管。该过程的其余部分通常继续进行。另外引入的球囊扩张使外科医生能够抓住肾动脉中的导丝,从而在EVAR期间排除动脉瘤。我们早期的经验表明,这种方法是有效和持久的。
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引用次数: 2
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Acta Angiologica
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