M. Çildağ, V. Öztürk, Recep Özgür, Ömer Faruk Kutsi Köseoğlu
Background: The purpose of this study was to determine the primary patency rate of endovascular interventions in hemodialysis patients who had central venous stenosis or occlusion. Material and Methods: Twenty-seven hemodialysis patients, who underwent endovascular intervention between January 2013 and January 2018 for central venous stenosis or total obstruction, were included in the study. Endovascular interventions consisted of percutaneous transluminal angioplasty (PTA) or stent implantation. Primary patency rate of endovascular intervention at the sixth and twelfth months were evaluated. Results: Stent implantation and PTA were used in 5 patients and 22 patients, respectively. 14 patients had stenosis and 13 patients had occlusion. The total procedural success rate was 81%, 86% in stenosis and 77% in occlusion. There was no procedure-related complication. The primary patency for PTA at 6 and 12 months were 40% and 10%, respectively. For stent implantation, primary patency rate at 6 and 12 months was 70% and 30%, respectively. Conclusion: Endovascular interventions for central venous stenosis and occlusion are safe, with low rates of technical failure and they can be first-line treatment for central venous stenosis or occlusion in hemodialysis patients.
{"title":"Primary Patency Rates of Endovascular Interventions in Hemodialysis Patients with Central Venous Stenosis and Occlusions","authors":"M. Çildağ, V. Öztürk, Recep Özgür, Ömer Faruk Kutsi Köseoğlu","doi":"10.5603/AA.2021.0003","DOIUrl":"https://doi.org/10.5603/AA.2021.0003","url":null,"abstract":"Background: The purpose of this study was to determine the primary patency rate of endovascular interventions in hemodialysis patients who had central venous stenosis or occlusion. \u0000Material and Methods: Twenty-seven hemodialysis patients, who underwent endovascular intervention between January 2013 and January 2018 for central venous stenosis or total obstruction, were included in the study. Endovascular interventions consisted of percutaneous transluminal angioplasty (PTA) or stent implantation. Primary patency rate of endovascular intervention at the sixth and twelfth months were evaluated. \u0000Results: Stent implantation and PTA were used in 5 patients and 22 patients, respectively. 14 patients had stenosis and 13 patients had occlusion. The total procedural success rate was 81%, 86% in stenosis and 77% in occlusion. There was no procedure-related complication. The primary patency for PTA at 6 and 12 months were 40% and 10%, respectively. For stent implantation, primary patency rate at 6 and 12 months was 70% and 30%, respectively. \u0000Conclusion: Endovascular interventions for central venous stenosis and occlusion are safe, with low rates of technical failure and they can be first-line treatment for central venous stenosis or occlusion in hemodialysis patients.","PeriodicalId":41754,"journal":{"name":"Acta Angiologica","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47920600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chronic venous disease (CVD) is defined as any morphological and functional abnormalities of long duration manifested either by symptoms and/or signs indicating the need for investigation and/or care. The pathophysiological mechanism of CVD can be characterized by reflux, obstruction, or a combination of both, which leads to increased venous pressure. Compression therapy remains the gold standard of the conservative treatment of CVD in all stages. The possible forms of compression therapy are elastic stocking, non-elastic and elastic bandages, and intermittent pneumatic compression. Compression bandages have been proven to improve the healing of venous ulcers, in comparison with standard care without compression therapy. In the last years, inflammation has been shown to play an important role in the pathophysiology of CVD. The influence of the altered shear stress on the endothelial cells (EC) causes EC to release inflammatory molecules, chemokines, vasoactive agents, express selectins, and prothrombotic precursors such as ICAM-1, MCP-1, MIP 1β, VCAM, L-selectin, E-selectin, IL-1β, IL-4, IL-6, IL-8, IL-12p40, IL-13, G-CSF, GM-CSF, IFN-γ, TNF-α, MIP-1α. Several studies were performed to investigate the influence of compression therapy on the level of various inflammatory biomarkers in patients with CVD. In these studies level of the most inflammatory molecules, such as IL-1β, IL-6, IL-8, IL-12p40, G-CSF, GM-CSF, IFN-γ, TNF-α, VEGF, MMP 3, 8, 9 and TIMP-1 decreased after the therapy.
{"title":"The influence of compression therapy on the level of inflammatory biomarkers in patients with chronic venous disease.","authors":"J. Tkaczyk, S. Przywara, J. Iłżecka, M. Iłżecki","doi":"10.5603/AA.2021.0004","DOIUrl":"https://doi.org/10.5603/AA.2021.0004","url":null,"abstract":"Chronic venous disease (CVD) is defined as any morphological and functional abnormalities of long duration manifested either by symptoms and/or signs indicating the need for investigation and/or care. The pathophysiological mechanism of CVD can be characterized by reflux, obstruction, or a combination of both, which leads to increased venous pressure. \u0000Compression therapy remains the gold standard of the conservative treatment of CVD in all stages. The possible forms of compression therapy are elastic stocking, non-elastic and elastic bandages, and intermittent pneumatic compression. Compression bandages have been proven to improve the healing of venous ulcers, in comparison with standard care without compression therapy. \u0000In the last years, inflammation has been shown to play an important role in the pathophysiology of CVD. The influence of the altered shear stress on the endothelial cells (EC) causes EC to release inflammatory molecules, chemokines, vasoactive agents, express selectins, and prothrombotic precursors such as ICAM-1, MCP-1, MIP 1β, VCAM, L-selectin, E-selectin, IL-1β, IL-4, IL-6, IL-8, IL-12p40, IL-13, G-CSF, GM-CSF, IFN-γ, TNF-α, MIP-1α. \u0000Several studies were performed to investigate the influence of compression therapy on the level of various inflammatory biomarkers in patients with CVD. In these studies level of the most inflammatory molecules, such as IL-1β, IL-6, IL-8, IL-12p40, G-CSF, GM-CSF, IFN-γ, TNF-α, VEGF, MMP 3, 8, 9 and TIMP-1 decreased after the therapy.","PeriodicalId":41754,"journal":{"name":"Acta Angiologica","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44122114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Surma, Karolina Stolorz, Oskar Sierka, A. Sieron, Marta Lesiak
Aortic aneurysm is defined as a pathologically dilated segment of the main artery. There are three main types of aortic aneurysms: real, pseudo and dissecting. The most common aneurysms are abdominal aortic aneurysms defined as vasodilatation equal to or above 30 mm. Abdominal aortic aneurysm development is usually asymptomatic. Many various risk factors have been linked to AAA development. The pathophysiology of AAA is associated with inflammation, smooth muscle cells apoptosis and matrix degradation. The changes always result from imbalance between active matrix metalloproteinases (MMPs) and their inhibitors – TIMPs. Abdominal aorta is the most common location for the aneurysm. The risk of developing AAA increases with age. It is more common in men. Its rupture is associated with a high risk of death. The pathogenesis of AAA is complex and still not fully understood. In pathophysiological processes, aortic wall degeneration and atherosclerosis dominate. The factors involved in the pathogenesis of AAA and TAA are not quite the same. Important factors involved in the formation of AAA and increasing the risk of its rupture are MMPs. Also, polymorphisms of numerous genes have been associated with the risk of developing AAA. The two groups of factors related to AAA formation and development are presented and discussed in this work.
{"title":"The role of selected metalloproteinases and some genetic factors in the pathogenesis of abdominal aortic aneurysm","authors":"S. Surma, Karolina Stolorz, Oskar Sierka, A. Sieron, Marta Lesiak","doi":"10.5603/AA.2021.0005","DOIUrl":"https://doi.org/10.5603/AA.2021.0005","url":null,"abstract":"Aortic aneurysm is defined as a pathologically dilated segment of the main artery. There are three main types of aortic aneurysms: real, pseudo and dissecting. The most common aneurysms are abdominal aortic aneurysms defined as vasodilatation equal to or above 30 mm. Abdominal aortic aneurysm development is usually asymptomatic. Many various risk factors have been linked to AAA development. The pathophysiology of AAA is associated with inflammation, smooth muscle cells apoptosis and matrix degradation. The changes always result from imbalance between active matrix metalloproteinases (MMPs) and their inhibitors – TIMPs. \u0000 Abdominal aorta is the most common location for the aneurysm. The risk of developing AAA increases with age. It is more common in men. Its rupture is associated with a high risk of death. The pathogenesis of AAA is complex and still not fully understood. In pathophysiological processes, aortic wall degeneration and atherosclerosis dominate. The factors involved in the pathogenesis of AAA and TAA are not quite the same. Important factors involved in the formation of AAA and increasing the risk of its rupture are MMPs. Also, polymorphisms of numerous genes have been associated with the risk of developing AAA. The two groups of factors related to AAA formation and development are presented and discussed in this work.","PeriodicalId":41754,"journal":{"name":"Acta Angiologica","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49032903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dorothee Hausmann, Ahmed Maher, D. Sieroń, A. Huber, V. Obmann, L. Ebner, A. Christe
Background: In areas of pulmonary embolism (PE), the enhancement of pulmonary veins on computed tomography pulmonary angiography (CTPA) should be decreased due to reduced arterial perfusion. Purpose: The purpose of this study was to investigate the accuracy of contrast density measurements (differences) in all pulmonary veins and the left atrium for the prediction of PE. Materials and Methods: 75 patients with PE and 22 patients without PE on CTPA were included. 4 readers measured the enhancement of the blood in the pulmonary vein immediately before the entrance to the left atrium, right after the aperture, in the center of the left atrium, in the pulmonary trunk and in the aorta. Enhancement of the pulmonary veins with and without upstream PE, and ROC curves with HU thresholds for optimal sensitivity and specificity for PE were calculated. Results: More PEs were found in the right and lower lobes. PE-affected lobes demonstrated 13.8+/-45 HU less enhancement in the pulmonary vein, compared to a paired non-affected pulmonary vein of the same patient (P < 0.0001). On average, non-affected pulmonary veins demonstrated no difference in enhancement compared to each other: 0.2 +/-21 HU. The optimal cutoff level in the ROC curve analysis for PE affection proved to be decreasing enhancement in the pulmonary vein of more than 10 HU, compared to the atrium. Conclusion: Decreasing enhancement in the pulmonary vein of more than 10 HU compared to the atrium could provide additional information and confidence in the diagnosis of PE.
{"title":"Detection of Pulmonary Embolism on CT-Angiography Using Contrast Attenuation of Pulmonary Veins","authors":"Dorothee Hausmann, Ahmed Maher, D. Sieroń, A. Huber, V. Obmann, L. Ebner, A. Christe","doi":"10.5603/AA.2021.0001","DOIUrl":"https://doi.org/10.5603/AA.2021.0001","url":null,"abstract":"Background: In areas of pulmonary embolism (PE), the enhancement of pulmonary veins on computed tomography pulmonary angiography (CTPA) should be decreased due to reduced arterial perfusion. Purpose: The purpose of this study was to investigate the accuracy of contrast density measurements (differences) in all pulmonary veins and the left atrium for the prediction of PE. Materials and Methods: 75 patients with PE and 22 patients without PE on CTPA were included. 4 readers measured the enhancement of the blood in the pulmonary vein immediately before the entrance to the left atrium, right after the aperture, in the center of the left atrium, in the pulmonary trunk and in the aorta. Enhancement of the pulmonary veins with and without upstream PE, and ROC curves with HU thresholds for optimal sensitivity and specificity for PE were calculated. Results: More PEs were found in the right and lower lobes. PE-affected lobes demonstrated 13.8+/-45 HU less enhancement in the pulmonary vein, compared to a paired non-affected pulmonary vein of the same patient (P < 0.0001). On average, non-affected pulmonary veins demonstrated no difference in enhancement compared to each other: 0.2 +/-21 HU. The optimal cutoff level in the ROC curve analysis for PE affection proved to be decreasing enhancement in the pulmonary vein of more than 10 HU, compared to the atrium. Conclusion: Decreasing enhancement in the pulmonary vein of more than 10 HU compared to the atrium could provide additional information and confidence in the diagnosis of PE.","PeriodicalId":41754,"journal":{"name":"Acta Angiologica","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43528979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Dybowska, Marta Michalina Zagroba, M. Szturmowicz, M. Sobiecka, K. Lewandowska, A. Józwik, W. Tomkowski
Venous thromboembolism occurs ten times more often among pregnant women comparing to non-pregnant ones. Pulmonary embolism remains the leading cause of death in pregnancy and puerperium. Research goal The aim of the study was to investigate knowledge of pregnant or puerperal women about venous thromboembolism. Material and methods The study was conducted from October 2017 to January 2018 in a group of 204 women. The diagnostic survey method was applied with the use of the self-designed questionnaire. The survey was conducted using the Google Form. Results Knowledge of venous thromboembolism was confirmed by less than 40.0% [CI 33.7, 47.0] of respondents. Less than a quarter of them received the information about the risk of pregnancy-related VTE from medical personnel, about 30% - from the Internet. Over 20% [CI 15.2, 26.1] admitted that they did not know any symptoms of this disease. Conclusions The survey showed marked deficiencies in knowledge concerning symptoms, risk factors and prevention of VTE among pregnant women. Therefore a special emphasis should be placed on education provided by medical staff in this group of patients.
{"title":"Knowledge of pregnant women about venous thromboembolism","authors":"M. Dybowska, Marta Michalina Zagroba, M. Szturmowicz, M. Sobiecka, K. Lewandowska, A. Józwik, W. Tomkowski","doi":"10.5603/AA.2021.0002","DOIUrl":"https://doi.org/10.5603/AA.2021.0002","url":null,"abstract":"Venous thromboembolism occurs ten times more often among pregnant women comparing to non-pregnant ones. Pulmonary embolism remains the leading cause of death in pregnancy and puerperium. \u0000Research goal \u0000The aim of the study was to investigate knowledge of pregnant or puerperal women about venous thromboembolism. \u0000Material and methods \u0000The study was conducted from October 2017 to January 2018 in a group of 204 women. The diagnostic survey method was applied with the use of the self-designed questionnaire. The survey was conducted using the Google Form. \u0000Results \u0000Knowledge of venous thromboembolism was confirmed by less than 40.0% [CI 33.7, 47.0] of respondents. Less than a quarter of them received the information about the risk of pregnancy-related VTE from medical personnel, about 30% - from the Internet. Over 20% [CI 15.2, 26.1] admitted that they did not know any symptoms of this disease. \u0000Conclusions \u0000The survey showed marked deficiencies in knowledge concerning symptoms, risk factors and prevention of VTE among pregnant women. Therefore a special emphasis should be placed on education provided by medical staff in this group of patients.","PeriodicalId":41754,"journal":{"name":"Acta Angiologica","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46988506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Kazibudzki, J. Krzywoń, T. Kwiatkowski, Katarzyna Zbierska Rubinkiewicz, Elżbieta Dobrowolska, M. Trystuła
The iatrogenic subclavian artery injury is a rare but potentially serious complication of subclavian vein cannulation. The use of endovascular techniques is an alternative to surgical repair especially in patients with concomitant diseases in whom immediate, potentially large surgery would be associated with a high risk of perioperative complications. This article discusses technical aspects of endovascular repair of iatrogenic injury of subclavian artery with implantation of covered stents based on two cases. Author’s experience and data from literature suggests that endovascular management including covered stent implantation is safe and effective treatment and should be considered as a method of choice especially among patients in poor general condition and/or major comorbidities.
{"title":"Technique of endovascular repair of iatrogenic subclavian artery injury following subclavian vein catheterization","authors":"M. Kazibudzki, J. Krzywoń, T. Kwiatkowski, Katarzyna Zbierska Rubinkiewicz, Elżbieta Dobrowolska, M. Trystuła","doi":"10.5603/AA.2020.0023","DOIUrl":"https://doi.org/10.5603/AA.2020.0023","url":null,"abstract":"The iatrogenic subclavian artery injury is a rare but potentially serious complication of subclavian vein cannulation. The use of endovascular techniques is an alternative to surgical repair especially in patients with concomitant diseases in whom immediate, potentially large surgery would be associated with a high risk of perioperative complications. This article discusses technical aspects of endovascular repair of iatrogenic injury of subclavian artery with implantation of covered stents based on two cases. Author’s experience and data from literature suggests that endovascular management including covered stent implantation is safe and effective treatment and should be considered as a method of choice especially among patients in poor general condition and/or major comorbidities.","PeriodicalId":41754,"journal":{"name":"Acta Angiologica","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48532109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A rare case of progressive upper limb-threatening ischemia is presented. The ischemia was caused by the chronic embolization from the axillary artery that was compressed by the clavicular pseudoarthrosis due to the remote in time fracture.
{"title":"Clavicular non-union as an undiagnosed cause of progressive limb-threatening upper extremity ischemia","authors":"Ł. Dzieciuchowicz, Arkadiusz Krzemiński","doi":"10.5603/AA.2020.0020","DOIUrl":"https://doi.org/10.5603/AA.2020.0020","url":null,"abstract":"A rare case of progressive upper limb-threatening ischemia is presented. The ischemia was caused by the chronic embolization from the axillary artery that was compressed by the clavicular pseudoarthrosis due to the remote in time fracture.","PeriodicalId":41754,"journal":{"name":"Acta Angiologica","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44216047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hidenori Onishi, O. Yamamura, S. Ueda, M. Shibata, S. Enomoto, Fumie Maeda, Hiromasa Tsubouchi, Takeshi Hirobe, Sadao Shimizu, Takahiro Kishimoto, Hiroshi Chiba, Kazuhiro Sasaki, K. Hanzawa, T. Hamano, Y. Nakamoto, B. Kaku, Hidekazu Terasawa
Introduction: Tsunami victims of the Great East Japan Earthquake were screened for deep-vein thrombosis (DVT) in order to compare the DVT incidence rates between temporary and non-temporary housing resident groups. Material and methods: Lower extremity venous ultrasonography was performed on 290 subjects (64 men and 226 women; mean age = 71.9 ± 7.9 years) at 44 months after the disaster. All subjects completed questionnaires to gather information about their background factors which included the Kessler Psychological Distress Scale: K6. Results: The DVT detection rate was 10.7% in the temporary group. In the non-temporary group, it was 11.3% among the subjects who previously lived in temporary housing. For the subjects who were living in their own homes it was 9.2%. Psychological distress levels measured by K6 were significantly higher in the temporary housing group than in the non-temporary housing group. The multivariate analysis showed that the background factor associated with DVT risk was SV (soleal vein) dilatation in all subjects as well as in the non-temporary housing group, while hypertension and use of sleeping pills were found to be the factors in the temporary housing group. Conclusions: DVT detection rates were similar between the temporary and non-temporary housing groups, and were higher than that in the Japanese general population. The psychological distress level of the tsunami victims measured by K6 was also higher in the temporary housing group than in the non-temporary housing group. It is necessary to establish a long-term and awareness-raising disaster victim support system.
{"title":"Deep-vein thrombosis detection rates and consideration of the living environment in a tsunami disaster area during the disaster reconstruction phase: A cross-sectional study","authors":"Hidenori Onishi, O. Yamamura, S. Ueda, M. Shibata, S. Enomoto, Fumie Maeda, Hiromasa Tsubouchi, Takeshi Hirobe, Sadao Shimizu, Takahiro Kishimoto, Hiroshi Chiba, Kazuhiro Sasaki, K. Hanzawa, T. Hamano, Y. Nakamoto, B. Kaku, Hidekazu Terasawa","doi":"10.5603/AA.2020.0025","DOIUrl":"https://doi.org/10.5603/AA.2020.0025","url":null,"abstract":"Introduction: Tsunami victims of the Great East Japan Earthquake were screened for deep-vein thrombosis (DVT) in order to compare the DVT incidence rates between temporary and non-temporary housing resident groups. Material and methods: Lower extremity venous ultrasonography was performed on 290 subjects (64 men and 226 women; mean age = 71.9 ± 7.9 years) at 44 months after the disaster. All subjects completed questionnaires to gather information about their background factors which included the Kessler Psychological Distress Scale: K6. Results: The DVT detection rate was 10.7% in the temporary group. In the non-temporary group, it was 11.3% among the subjects who previously lived in temporary housing. For the subjects who were living in their own homes it was 9.2%. Psychological distress levels measured by K6 were significantly higher in the temporary housing group than in the non-temporary housing group. The multivariate analysis showed that the background factor associated with DVT risk was SV (soleal vein) dilatation in all subjects as well as in the non-temporary housing group, while hypertension and use of sleeping pills were found to be the factors in the temporary housing group. Conclusions: DVT detection rates were similar between the temporary and non-temporary housing groups, and were higher than that in the Japanese general population. The psychological distress level of the tsunami victims measured by K6 was also higher in the temporary housing group than in the non-temporary housing group. It is necessary to establish a long-term and awareness-raising disaster victim support system.","PeriodicalId":41754,"journal":{"name":"Acta Angiologica","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49635649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Primary intestinal lymphangiectasia (PIL), also known as Waldmann’s disease, is a rare disorder manifested by the presence of dilated intestinal lymphatic ducts and leading to protein-losing enteropathy. PIL usually presents early in childhood; however, rarely may be also diagnosed in adults. Suggestive laboratory findings include hypoproteinemia, hypoalbuminemia, and hypogammaglobulinemia. Peripheral pitting edema due to hypoalbuminemia is the main clinical feature. Peripheral lymphedema is a less common symptom. We present a case of a 23-year-old woman with lymphedema of lower extremities and PIL diagnosed in childhood.
{"title":"Primary intestinal lymphangiectasia with lymphedema of lower extremities","authors":"K. Klimas, K. Drozdz, A. Chachaj, A. Szuba","doi":"10.5603/AA.2020.0021","DOIUrl":"https://doi.org/10.5603/AA.2020.0021","url":null,"abstract":"Primary intestinal lymphangiectasia (PIL), also known as Waldmann’s disease, is a rare disorder manifested by the presence of dilated intestinal lymphatic ducts and leading to protein-losing enteropathy. PIL usually presents early in childhood; however, rarely may be also diagnosed in adults. Suggestive laboratory findings include hypoproteinemia, hypoalbuminemia, and hypogammaglobulinemia. Peripheral pitting edema due to hypoalbuminemia is the main clinical feature. Peripheral lymphedema is a less common symptom. We present a case of a 23-year-old woman with lymphedema of lower extremities and PIL diagnosed in childhood.","PeriodicalId":41754,"journal":{"name":"Acta Angiologica","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49115907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Analysis of platelet function, acetylsalicylic acid (ASA) and clopidogrel resistance in patients with peripheral arterial disease (PAD) undergoing percutaneous transluminal angioplasty (PTA), the impact of procedure on this phenomenon, connection with diabetes, hypertension, smoking. Material and methods: The study included 72 patients, with a group of patients taking ASA on a permanent basis and a group of patients in whom treatment was implemented after the procedure. Patients were also divided according to the antiplatelet therapy applied, either double-therapy, or ASA monotherapy. Daily doses were 75 mg. Three methods were used for the evaluation of the platelet function: IVY bleeding time, cytometric evaluation of platelet surface antigen (CD62p and CD63) expression and hemostasis measurement by PFA-200®. Results: In the PFA-200 analysis, ASA resistance was found in 37.8% (64.7% were tobacco smokers) before surgery. Patients not taking ASA before, after PTA and first dose of ASA presented resistance in 63%. The first dose of clopidogrel after surgery was associated with resistance in 73.7%. Significant differences in the expression of CD62p and CD63 markers before and after PTA were observed. According to IVY method, aspirin resistance was found in 40% of patients permanently receiving ASA. Conclusions: Patients with PAD who undergo PTA are resistant to ASA in 40%, smoking is associated with this phenomenon. PTA increases the expression of CD62P and CD63, and thus the platelet activation, which is not adequately prevented by antiplatelet drugs at a dose of 75 mg. Dual antiplatelet therapy reduces the activation of thrombocytes more than the monotherapy of ASA.
{"title":"Assessment of platelet function and resistance to aspirin and clopidogrel in patients with peripheral arterial disease undergoing percutaneous transluminal angioplasty","authors":"Grzegorz Borowski, Aleksandra Nowaczyńska","doi":"10.5603/AA.2020.0024","DOIUrl":"https://doi.org/10.5603/AA.2020.0024","url":null,"abstract":"Introduction: Analysis of platelet function, acetylsalicylic acid (ASA) and clopidogrel resistance in patients with peripheral arterial disease (PAD) undergoing percutaneous transluminal angioplasty (PTA), the impact of procedure on this phenomenon, connection with diabetes, hypertension, smoking. Material and methods: The study included 72 patients, with a group of patients taking ASA on a permanent basis and a group of patients in whom treatment was implemented after the procedure. Patients were also divided according to the antiplatelet therapy applied, either double-therapy, or ASA monotherapy. Daily doses were 75 mg. Three methods were used for the evaluation of the platelet function: IVY bleeding time, cytometric evaluation of platelet surface antigen (CD62p and CD63) expression and hemostasis measurement by PFA-200®. Results: In the PFA-200 analysis, ASA resistance was found in 37.8% (64.7% were tobacco smokers) before surgery. Patients not taking ASA before, after PTA and first dose of ASA presented resistance in 63%. The first dose of clopidogrel after surgery was associated with resistance in 73.7%. Significant differences in the expression of CD62p and CD63 markers before and after PTA were observed. According to IVY method, aspirin resistance was found in 40% of patients permanently receiving ASA. Conclusions: Patients with PAD who undergo PTA are resistant to ASA in 40%, smoking is associated with this phenomenon. PTA increases the expression of CD62P and CD63, and thus the platelet activation, which is not adequately prevented by antiplatelet drugs at a dose of 75 mg. Dual antiplatelet therapy reduces the activation of thrombocytes more than the monotherapy of ASA.","PeriodicalId":41754,"journal":{"name":"Acta Angiologica","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43793816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：