Magda Grześkiewicz, Joanna Elżbieta Kobak, Hubert Drewniak, Piotr Terlecki, Stanisław Przywara
Irisin is a recently discovered hormone, synthesized mainly by the muscles. Expression of irisin and its precursor named FNDC5 was also found in the heart, kidneys, liver, pancreas, adipose tissue, and brain including cortical neurons, hippocampus, cerebellum, hypothalamus, and spinal cord. The purpose of this study is to review the latest research on the properties of the irisin and its cytoprotective effect against neuronal damage and to draw attention to its possible clinical use in the treatment of stroke. Notch pathway activity increases after ischemic damage, stimulating the repair of the affected brain area. Irisin activates the Notch pathway which inhibits the activity of microglia, secretion of inflammatory factors, and finally leads to reduction of the brain edema. Studies revealed that irisin increases levels of brain-derived neurotrophic factor (BDNF), leading to enhancement of survival and migration of the neurons, and protecting nerve cells from damage during the ischemic stroke. It was also found that irisin maintains mitochondrial integrity, reduces oxidative stress, and exerts a protective effect on the blood-brain barrier. Irisin entails a neuroprotective effect, reducing the extent of the infarcted area and the degree of brain damage. Stimulation of the irisin expression by physical activity or its exogenous administration remains the subject of research that raises hope for development of the new therapeutic options for diseases, especially ischemic stroke.
{"title":"Irisin — the future of ischemic stroke therapy?","authors":"Magda Grześkiewicz, Joanna Elżbieta Kobak, Hubert Drewniak, Piotr Terlecki, Stanisław Przywara","doi":"10.5603/aa.2023.0006","DOIUrl":"https://doi.org/10.5603/aa.2023.0006","url":null,"abstract":"Irisin is a recently discovered hormone, synthesized mainly by the muscles. Expression of irisin and its precursor named FNDC5 was also found in the heart, kidneys, liver, pancreas, adipose tissue, and brain including cortical neurons, hippocampus, cerebellum, hypothalamus, and spinal cord. The purpose of this study is to review the latest research on the properties of the irisin and its cytoprotective effect against neuronal damage and to draw attention to its possible clinical use in the treatment of stroke. Notch pathway activity increases after ischemic damage, stimulating the repair of the affected brain area. Irisin activates the Notch pathway which inhibits the activity of microglia, secretion of inflammatory factors, and finally leads to reduction of the brain edema. Studies revealed that irisin increases levels of brain-derived neurotrophic factor (BDNF), leading to enhancement of survival and migration of the neurons, and protecting nerve cells from damage during the ischemic stroke. It was also found that irisin maintains mitochondrial integrity, reduces oxidative stress, and exerts a protective effect on the blood-brain barrier. Irisin entails a neuroprotective effect, reducing the extent of the infarcted area and the degree of brain damage. Stimulation of the irisin expression by physical activity or its exogenous administration remains the subject of research that raises hope for development of the new therapeutic options for diseases, especially ischemic stroke.","PeriodicalId":41754,"journal":{"name":"Acta Angiologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135419803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Wachsmann-Maga, M. Kaszuba, M. Maga, A. Włodarczyk, J. Krężel, P. Kaczmarczyk, Katarzyna Bogucka, P. Maga
{"title":"Leukotrienes in the atherosclerotic cardiovascular diseases — a systematic review","authors":"A. Wachsmann-Maga, M. Kaszuba, M. Maga, A. Włodarczyk, J. Krężel, P. Kaczmarczyk, Katarzyna Bogucka, P. Maga","doi":"10.5603/aa.2022.0013","DOIUrl":"https://doi.org/10.5603/aa.2022.0013","url":null,"abstract":"","PeriodicalId":41754,"journal":{"name":"Acta Angiologica","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41388903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fenestration and duplication of contralateral internal jugular veins with concomitant cerebral arteries malformations","authors":"Mateusz Winder, J. Pilch-Kowalczyk","doi":"10.5603/aa.2022.0018","DOIUrl":"https://doi.org/10.5603/aa.2022.0018","url":null,"abstract":"","PeriodicalId":41754,"journal":{"name":"Acta Angiologica","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42207575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Brazis, P. Wierzchowski, A. Migdalski, A. Jawień
{"title":"Severe acute kidney injury after pharmacomechanical thrombectomy for acute limb ischemia","authors":"P. Brazis, P. Wierzchowski, A. Migdalski, A. Jawień","doi":"10.5603/aa.2022.0016","DOIUrl":"https://doi.org/10.5603/aa.2022.0016","url":null,"abstract":"","PeriodicalId":41754,"journal":{"name":"Acta Angiologica","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41404306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Urszula Szymańska, M. Kurzyna, P. Kułak, D. Kosior
{"title":"In-hospital diagnostic strategies for acute pulmonary embolism — results of a single-center study based on the experience of a multi-profile clinical hospital","authors":"Urszula Szymańska, M. Kurzyna, P. Kułak, D. Kosior","doi":"10.5603/aa.2022.0014","DOIUrl":"https://doi.org/10.5603/aa.2022.0014","url":null,"abstract":"","PeriodicalId":41754,"journal":{"name":"Acta Angiologica","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43886431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anders Wanhainen, Fabio Verzini, Isabelle Van Herzeele, Eric Allaire, Matthew Bown, Tina Cohnert, Florian Dick, Joost van Herwaarden, Christos Karkos, Mark Koelemay, Tilo Kölbel, Ian Loftus, Kevin Mani, Germano Melissano, Janet Powell, Zoltán Szeberin
{"title":"Wytyczne Europejskiego Towarzystwa Chirurgii Naczyniowej (ESVS) w zakresie diagnostyki i leczenia tętniaków aorty brzusznej i tętnic biodrowych — wersja 2019","authors":"Anders Wanhainen, Fabio Verzini, Isabelle Van Herzeele, Eric Allaire, Matthew Bown, Tina Cohnert, Florian Dick, Joost van Herwaarden, Christos Karkos, Mark Koelemay, Tilo Kölbel, Ian Loftus, Kevin Mani, Germano Melissano, Janet Powell, Zoltán Szeberin","doi":"10.5603/aa.2022.0012","DOIUrl":"https://doi.org/10.5603/aa.2022.0012","url":null,"abstract":"","PeriodicalId":41754,"journal":{"name":"Acta Angiologica","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44700178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Commentary to the guidelines: “Guidelines on the prevention and treatment of venous thromboembolism in cancer patients treated surgically, including patients under 18 years of age”","authors":"Z. Krasiński, B. Krasińska","doi":"10.5603/aa.2022.0006","DOIUrl":"https://doi.org/10.5603/aa.2022.0006","url":null,"abstract":"","PeriodicalId":41754,"journal":{"name":"Acta Angiologica","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47240294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Deep vein thrombosis of the lower limbs in injection drug users: case series","authors":"Jędrzej Fischer, W. Kwiatkowska, W. Witkiewicz","doi":"10.5603/aa.2022.0007","DOIUrl":"https://doi.org/10.5603/aa.2022.0007","url":null,"abstract":"","PeriodicalId":41754,"journal":{"name":"Acta Angiologica","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46460208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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