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Epstein–Barr virus infection in children presenting with acute cervical lymphadenopathy 以急性颈部淋巴结病为表现的儿童感染eb病毒
Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2023-01-01 DOI: 10.4103/jmms.jmms_29_23
Bal Mukund, Priyanka Augustya, Ashok Bhandari
Introduction: The aim of this study was to estimate the prevalence of Epstein–Barr virus (EBV) infection among children presenting with acute cervical lymphadenopathy and describe the clinical characteristics of children with primary EBV-induced cervical lymphadenopathy. Materials and Methods: This was a prospective observational study in a tertiary care hospital. Results: Twenty-two children out of 127 patients evaluated had primary EBV infection among children presenting with acute cervical lymphadenopathy. The most common symptoms noted were fever (95.5%), loss of appetite (63%), and sore throat (45.5%). Posterior and anterior cervical lymph nodes (99.5% and 86.4%) were most commonly affected with a frequency of 2–6 nodes (mean of 3 nodes) and an average size of 2.4 cm (range: 2–6 cm). Maculopapular, nonpruritic rash was noted in 27.3% and Hoagland sign in 9.1% of cases. Hepatomegaly and clinical splenomegaly were noted in 81% and 59%, respectively, among EBV-positive patients. Conclusion: EBV primary infection is a common cause of acute cervical lymphadenopathy among Indian children with EBV responsible for approximately 17% of such clinical presentation. A high index of clinical suspicion and timely diagnosis of EBV in these children will be useful in limiting investigations and avoidable use of antibiotics by clinicians in such presentation.
前言:本研究的目的是估计eb病毒(EBV)感染在急性宫颈淋巴结病患儿中的患病率,并描述原发性EBV诱导的宫颈淋巴结病患儿的临床特征。材料和方法:这是一项在三级保健医院进行的前瞻性观察性研究。结果:在127例以急性颈淋巴肿大为表现的儿童中,22例为原发性EBV感染。最常见的症状是发烧(95.5%)、食欲不振(63%)和喉咙痛(45.5%)。后颈淋巴结和前颈淋巴结(99.5%和86.4%)最常见,2-6个淋巴结(平均3个),平均大小为2.4 cm(范围:2-6 cm)。斑丘疹的,nonpruritic皮疹在27.3%,霍格兰签署在9.1%的情况下。ebv阳性患者肝肿大和临床脾肿大分别占81%和59%。结论:EBV原发性感染是印度儿童急性宫颈淋巴结病的常见原因,EBV约占此类临床表现的17%。在这些儿童中,临床怀疑和及时诊断EBV的高指数将有助于限制临床医生在这种情况下的调查和可避免的抗生素使用。
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引用次数: 0
Quiz in PG teaching: Are we adapted to new methods in learning? PG教学中的小测验:我们是否适应新的学习方法?
Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2023-01-01 DOI: 10.4103/jmms.jmms_8_23
Anuj Singhal, Rajat Shukla, SubashChandra Shaw, Mahesh Manthene, Shrimukta Sahoo, Aditya Singhal
Introduction: Traditional methods of teaching residents in medicine are lectures, symposiums, case presentations and CMEs. Students have different levels of attitude about learning and responses to specific environments. A sound understanding of the changing trends in medical education is crucial to the accurate implementation of adequate training protocols which helps in good perception of subject by students. Novel ideas and concepts must pave way for modern methodologies of teaching. Methodology: We administered the peer validated questionnaire to 30 Junior residents(JRs) who participated in the quiz on Diabetes. JRs were informed about quiz 10 days prior and adequate material was shared with them. Results: More than half of the students (56.7%) responded that the quiz was better enjoyed than discussing the similar topic in class room teaching, maximum students (86.7%) responded that the quiz should be inculcated in postgraduate curriculum. Conclusion: This kind of novel methods helps the students to have good understanding and perception of the subject rather than routine teaching methods and helps to make an impact.
导读:传统的住院医师医学教学方法是讲座、专题讨论会、病例报告和cme。学生有不同程度的学习态度和对特定环境的反应。充分了解医学教育的变化趋势对于准确实施适当的培训方案至关重要,这有助于学生对主题有良好的认识。新颖的思想和概念必须为现代教学方法铺平道路。方法:我们对30名参加糖尿病测试的初级居民(JRs)进行了同伴验证问卷调查。JRs提前10天被告知测验,并与他们分享足够的材料。结果:超过一半的学生(56.7%)认为测验比课堂上讨论类似话题更有趣,最多的学生(86.7%)认为应该在研究生课程中灌输测验。结论:这种新颖的教学方法比常规的教学方法更有助于学生对学科有更好的理解和感知,有助于产生影响。
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引用次数: 0
Spectrum of cardiovascular manifestations in homozygous familial hypercholesterolemia 纯合子家族性高胆固醇血症的心血管表现谱
IF 0.3 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2023-01-01 DOI: 10.4103/jmms.jmms_30_22
N. Bajaj, Balbir Singh, Ananthkrishnan Ramamoorthy, Arijit Ghosh
Homozygous familial hypercholesterolemia (HoFH) is a rare, primarily an autosomal dominant genetic disorder that causes markedly elevated low-density lipoprotein (LDL) cholesterol levels predisposing patients to risk of developing premature atherosclerotic cardiovascular diseases. Disease manifestations usually develop in 1st or 2nd decade of life and severity depends on the duration of exposure to elevated LDL cholesterol levels. The mainstay in management is early recognition and treatment with various lipid-lowering agents including lipid-apheresis in severe cases not responding to drug therapy. We report three cases of HoFH presenting to our institute in their 2nd decade of life with different cutaneous and cardiovascular manifestations and discuss challenges in their management.
纯合子家族性高胆固醇血症(HoFH)是一种罕见的常染色体显性遗传病,可导致低密度脂蛋白(LDL)胆固醇水平显著升高,使患者易患过早动脉粥样硬化性心血管疾病。疾病表现通常发生在生命的第一个或第二个十年,严重程度取决于暴露于高LDL胆固醇水平的持续时间。治疗的主要方法是早期识别和使用各种降脂剂进行治疗,包括在药物治疗无效的严重病例中使用脂质分离术。我们报告三例HoFH患者在其生命的第二个十年中出现不同的皮肤和心血管表现,并讨论他们的管理挑战。
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引用次数: 0
Novel versus traditional serum biomarkers in predicting the response to anti-tubercular therapy in pulmonary tuberculosis patients: A prospective study 预测肺结核患者抗结核治疗反应的新型与传统血清生物标志物:一项前瞻性研究
Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2023-01-01 DOI: 10.4103/jmms.jmms_185_22
Vishal Mangal, Anuj Singhal, Gaurav Vohra, Santosh Karade, AS Menon, KaminderBir Kaur
Background India ranks first in the global share of tuberculosis (TB). Active TB is also associated with elevated levels of B-Cell growth factors like B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL). We aimed to study the circulating levels of ferritin, high-sensitivity C-reactive protein (hsCRP), BAFF, and APRIL in sputum-positive and sputum-negative active pulmonary TB (PTB) patients. Materials and Methods We enrolled 90 sputum positive and 90 sputum-negative newly diagnosed PTB patients. All the patients underwent estimation of serum ferritin, hsCRP, BAFF, and APRIL before initiation of f Anti-Tubercular therapy (ATT), after 1 month of ATT, and after 2 months of ATT. We compared the change in the cytokines mentioned above in PTB subjects at baseline, after 01 and 02 months of the intensive phase of standard anti-tubercular therapy. Results There was a significant difference between the serum BAFF levels at all times between the sputum-positive and sputum-negative groups (P < 0.001). There was a considerable increase in the APRIL level 2 months after initiation of ATT in both the groups (sputum positive group P = 0.004) (sputum negative group P < 0.001). There was a significant decrease in serum ferritin level and hsCRP after 2 months of ATT compared to baseline (P < 0.001) in both sputum positive and negative groups. Conclusion Serum ferritin, hsCRP, and APRIL levels can be used to assess the treatment response in both sputum-positive and sputum-negative cases. Serum BAFF levels >587 pg/ml at baseline implies high probability of sputum smear positivity in a patient with PTB.
印度在全球结核病发病率中排名第一。活动性结核病还与b细胞生长因子(如b细胞活化因子(BAFF))和增殖诱导配体(APRIL))水平升高有关。我们旨在研究痰阳性和痰阴性活动性肺结核(PTB)患者血液中铁蛋白、高敏c反应蛋白(hsCRP)、BAFF和APRIL的水平。材料与方法本研究纳入90例痰液阳性和90例痰液阴性的新诊断肺结核患者。所有患者在开始抗结核治疗(ATT)前、ATT治疗1个月后和ATT治疗2个月后都进行了血清铁蛋白、hsCRP、BAFF和APRIL的评估。我们比较了PTB患者在基线、标准抗结核强化治疗01个月和02个月后上述细胞因子的变化。结果痰液阳性组与痰液阴性组血清BAFF水平各时间点差异均有统计学意义(P < 0.001)。两组患者在ATT治疗2个月后的4月水平均有显著升高(痰液阳性组P = 0.004)(痰液阴性组P < 0.001)。与基线相比,ATT治疗2个月后痰液阳性和阴性组血清铁蛋白水平和hsCRP均显著降低(P < 0.001)。结论血清铁蛋白、hsCRP和APRIL水平可用于评价痰液阳性和痰液阴性患者的治疗效果。基线时血清BAFF水平>587 pg/ml提示PTB患者痰涂片阳性的可能性很大。
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引用次数: 0
Comparative analysis of preoperative high-resolution computed tomography temporal bone and intraoperative surgical findings in cases of cholesteatoma 胆脂瘤患者术前高分辨率计算机断层扫描颞骨与术中手术结果的比较分析
IF 0.3 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2023-01-01 DOI: 10.4103/jmms.jmms_64_22
RanjitSingh Lahel, S. Tripathi, A. Chail
Introduction: Cholesteatoma has been described as an accumulation of desquamated keratin debris in a pocket of squamous epithelium over a matrix within the middle ear cleft. A prospective study was carried out to establish a correlation between preoperative high-resolution computed tomography (HRCT) temporal bone findings with intraoperative findings in cases of cholesteatoma. Methods: Fifty patients of chronic otitis media, active squamous type, i.e. clinically suspected cholesteatoma, scheduled to undergo tympanomastoid exploration were selected. The positive and negative findings of the scan were documented as per the parameters to be analyzed. The important intraoperative surgical findings were then analyzed with preoperative HRCT findings. Results: Agreement between surgical and HRCT findings ranged from 86% (facial canal erosion) to 100% (external bony canal involvement). HRCT had higher detection rate as compared to surgery for scutum erosion (40% vs. 36%), tegmen erosion (6% vs. 4%), facial canal erosion (28% vs. 14%), lateral semicircular canal erosion (6% vs. 2%), incus erosion (78% vs. 64%), sinus tympani involvement (14% vs. 4%), attic involvement (44% vs. 42%), mastoid involvement (88% vs. 80%), and aditus widening (54% vs. 44%). The higher detection of scutum erosion, tegmen erosion, facial canal erosion, lateral semicircular canal erosion, and incus erosion is probably due to partial volume averaging. Conclusion: The findings of the present study showed that HRCT is an essential and indispensable tool for preoperative evaluation of cholesteatoma. It was highly sensitive and adequately specific for a significant number of findings. These findings are pivotal in planning the surgery and preparing for necessary anticipatory reconstructive procedures.
引言:胆脂瘤被描述为脱落的角蛋白碎片在中耳裂基质上的鳞状上皮袋中积聚。一项前瞻性研究旨在建立胆脂瘤患者术前高分辨率计算机断层扫描(HRCT)颞骨表现与术中表现之间的相关性。方法:选择50例活动性鳞状型慢性中耳炎患者,即临床怀疑的胆脂瘤患者,计划进行鼓室乳突探查。根据待分析的参数记录扫描的阳性和阴性结果。然后将术中重要的手术结果与术前HRCT结果进行分析。结果:手术和HRCT检查结果的一致性在86%(面管侵蚀)到100%(外部骨管受累)之间。与手术相比,HRCT对盾部侵蚀(40%vs.36%)、被盖侵蚀(6%vs.4%)、面管侵蚀(28%vs.14%)、外半规管侵蚀(6%-2%)、砧骨侵蚀(78%vs.64%)、鼓室窦受累(14%-4%)、阁楼受累(44%vs.42%)、乳突受累(88%vs.80%)和扩底(54%vs.44%)的检出率更高。盾部侵蚀、被盖侵蚀、面管侵蚀、侧半规管侵蚀和砧骨侵蚀的检出率较高可能是由于部分体积平均。结论:HRCT是胆脂瘤术前评估必不可少的工具。它对大量调查结果具有高度敏感性和充分的针对性。这些发现对计划手术和准备必要的预期重建程序至关重要。
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引用次数: 0
Assessment of peripheral vestibular apparatus in patients with peripheral vestibular symptoms using videonystagmography in tertiary care center 三级保健中心用视震图评估有外周前庭症状患者的外周前庭器官
Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2023-01-01 DOI: 10.4103/jmms.jmms_25_23
LakkuV Manohar Reddy, Rahul Naga, DK Gupta, Sunil Mathews
Introduction Vertigo, dizziness, giddiness, and unsteadiness are all quite frequent symptoms that affect a large proportion of the population. Due to the challenges associated with effectively diagnosing and documenting vestibular illnesses, figures on their prevalence, frequency of occurrence, and social impact vary greatly. Benign paroxysmal positional vertigo (BPPV) is the most common cause of vertigo of vestibular origin. Positional nystagmus is most frequently seen in benign paroxysmal positional vertigo (BPPV) associated with peripheral vestibular diseases. Videonystagmography (VNG) tests are an excellent diagnostic tool for distinguishing peripheral from central vestibular abnormalities, provided they are conducted and interpreted by doctors rather than technicians. The current study utilized VNG to evaluate vestibular apparatus function in patients with peripheral vestibular symptoms (dizziness/imbalance/giddiness/vertigo). Methods Prospective observational study comparing efficacy of assessment of vestibular apparatus using clinical vestibular assessment versus VNG in patients having vestibular symptoms. Results With clinical vestibular assessment test, 13 out of 50 symptomatic patients had no nystagmus. When VNG was performed on these patients, 10 out of these 13 patients had shown positive findings, whereas only three patients had negative findings. Our study finds that VNG along with clinical evaluation is more effective in diagnosing vestibular disorders when compared with clinical evaluation alone and this was statistically significant. Conclusion Based on our results, VNG is the better modality for the assessment of vestibular apparatus in patients with peripheral vestibular symptoms for diagnosis and treatment.
眩晕、头晕、头晕和身体不稳都是相当常见的症状,影响了很大一部分人群。由于与有效诊断和记录前庭疾病相关的挑战,其患病率,发生频率和社会影响的数据差异很大。良性阵发性位置性眩晕(BPPV)是前庭源性眩晕最常见的病因。位置性眼球震颤最常见于与周围前庭疾病相关的良性阵发性位置性眩晕(BPPV)。如果是由医生而不是技术人员进行和解释,视频震跳图(VNG)测试是区分外周和中央前庭异常的极好诊断工具。本研究利用VNG评估有外周前庭症状(头晕/不平衡/头晕/眩晕)患者的前庭器官功能。方法前瞻性观察研究,比较临床前庭评估与VNG对有前庭症状患者前庭器官评估的疗效。结果50例有症状的患者中,13例无眼震。当对这些患者进行VNG时,这13例患者中有10例显示阳性结果,而只有3例显示阴性结果。我们的研究发现VNG结合临床评估对前庭疾病的诊断比单独的临床评估更有效,且具有统计学意义。结论VNG是评估前庭周围症状患者前庭器官功能的较好方法,可用于诊断和治疗。
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引用次数: 0
Phacoemulsification under peribulbar anesthesia: To patch or not 球周麻醉下超声乳化术:是否贴片
Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2023-01-01 DOI: 10.4103/jmms.jmms_176_22
Harikrishnan Vannadil, Archana Singh, Ranjit Goenka, Sunandan Bhatta
Introduction Anesthesia for cataract surgeries is undertaken in various forms. In cases under peribulbar anesthesia, there exists a practice of patching the eye for varying duration. This study has been conducted to look into the difference in the outcome and comfort of the patient with respect to the use of eye patch in an objective way. Materials and Methods This is a prospective randomized observational study with controls conducted at an Ophthalmology Department of a Tertiary Care Hospital. All patients undergoing uneventful phacoemulsification with posterior chamber intraocular lens implant surgery for age-related cataracts meeting the inclusion criteria were recruited for the study. Results Two hundred and seven patients were included and randomly allotted to the patch and no-patch group. The mean pain score for the no-patch group was 2.930 (standard deviation [SD] =1.4231), while the same for the patch group was 2.879 (SD = 1.3438). The symptom of watering in patch group was significantly lower than the no-patch group with a P = 0.013 by Pearson’s Chi-square test. The mean postoperative day (POD) 1 DVA among the cases was found to be 0.440 LogMAR (SD = 0.3114) and the same for controls was 0.715 LogMAR (SD = 0.2858). On the 2nd POD, the DVA of the cases improved to 0.162 LogMAR (SD = 0.1819) while that of controls were 0.419 LogMAR (SD = 0.2758). However, the visual acuity of both groups was comparable at the end of the 7th POD. The patients without patch demonstrated significantly better visual acuity on the 1st POD. This group of patients also had statistically significant reduction in the conjunctival congestion, aqueous flare, aqueous cells, and corneal edema. The beneficial outcome on the 1st POD is likely due to the early use of topical drugs which is facilitated by the absence of eye patch. However, the final outcome seems independent of the use of patching. Conclusion Using an eye patch for the patient undergoing a routine phacoemulsification surgery under peribulbar block does not seem to have any additional benefit.
白内障手术麻醉有多种形式。在球周麻醉的情况下,有一种做法是在不同的时间内补眼。本研究旨在客观地探讨使用眼罩对患者的疗效和舒适度的影响。材料和方法本研究是在某三级医院眼科进行的一项前瞻性随机观察性对照研究。所有符合入选标准的老年性白内障行白内障超声乳化术合并后房型人工晶状体植入术的患者均被纳入研究。结果纳入227例患者,随机分为贴片组和不贴片组。无贴片组平均疼痛评分为2.930分(标准差[SD] =1.4231),贴片组平均疼痛评分为2.879分(标准差[SD] = 1.3438)。经Pearson卡方检验,贴片组患者饮水症状显著低于无贴片组,P = 0.013。病例术后平均日(POD) 1 DVA为0.440 LogMAR (SD = 0.3114),对照组为0.715 LogMAR (SD = 0.2858)。第2次POD时,两组DVA分别为0.162 LogMAR (SD = 0.1819)和0.419 LogMAR (SD = 0.2758)。然而,在第7次POD结束时,两组的视力相当。未配戴贴片的患者在第1次POD时视力明显改善。这组患者在结膜充血、水焰、水细胞和角膜水肿方面也有统计学上显著的减少。第一次POD的有益结果可能是由于早期使用局部药物,这是由于没有眼罩而促进的。然而,最终的结果似乎与补丁的使用无关。结论在球周阻滞下进行常规超声乳化手术的患者使用眼罩似乎没有任何额外的好处。
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引用次数: 0
Partnership working between nurses and patients' families in the critical care environment. 重症监护环境中护士与病人家属之间的合作。
Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2022-08-03 Epub Date: 2022-06-06 DOI: 10.7748/ns.2022.e11669
Lucy Kirkham

When an individual becomes critically ill, they may be admitted to a critical care environment, which can have significant effects on themselves and their family. There is a wealth of literature exploring the experiences and priorities of patients and their families in relation to critical care, but also a lack of research on practical interventions that can improve care delivery in this setting. This article explores partnership working between nurses and patients' families in the critical care environment and examines the barriers to, and facilitators of, family-centred care. The author draws on the literature to consider interventions that could enhance family-centred care in this setting, and makes some recommendations for practice.

当一个人病危时,他可能会被送入重症监护环境,这可能会对他本人及其家人产生重大影响。有大量文献探讨了病人及其家属在危重症护理方面的经历和优先考虑事项,但也缺乏能改善这种环境下护理服务的实际干预措施的研究。本文探讨了危重症护理环境中护士与患者家属之间的合作关系,并研究了以家庭为中心的护理的障碍和促进因素。作者借鉴文献,考虑了在这种环境下可以加强以家庭为中心的护理的干预措施,并对实践提出了一些建议。
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引用次数: 0
Knowledge, attitude, and practice of labor analgesia in antenatal women in India: An observational study 印度产前妇女分娩镇痛的知识、态度和实践:一项观察性研究
IF 0.3 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2022-07-01 DOI: 10.4103/jmms.jmms_192_20
D. Paul, Nipun Gupta, A. Patra, Saurav, G. Prasad
Background: The concept of labor analgesia is widely unknown to the antenatal women and parturients in the Indian medical setup. Aims: The aim of this study was to assess the knowledge, attitude, and practice of labor analgesia in antenatal women visiting the antenatal clinic in a tertiary care hospital. Methodology: One hundred twenty women in the antenatal period between the age group of 18 and 40 years attending the antenatal clinic were included in the study. A Google form-based questionnaire was used to collect data. Statistical Analysis: Ordinal and nominal data were presented as numbers and percentages. Bar diagrams and pie charts were used for graphical representation. Results: Twenty-one (17.5%) respondents, out of 120, were aware of labor analgesia. Among the rest 99, 13 participants did not have knowledge nor they wanted to gather information further. Out of 86 unaware respondents, 62 (72.1%) were interested in acquiring the knowledge of labor analgesia and rather would be comfortable if the treating obstetrician imparts the information; 46 (53.5%) of them wanted the information to be imparted during the obstetric consultation sessions and 10 (11.6%) respondents considered the best time for gathering awareness for labor analgesia at, or after the onset of labor pain. The major concerns of the respondents for labor analgesia were the safety of their health and the effect on the baby. Conclusions: Awareness of labor analgesia in Indian antenatal women is low. The treating obstetrician should impart knowledge regarding labor analgesia in the pre- and antenatal period which should be supplemented with more emphasis during the prelabor period.
背景:分娩镇痛的概念对于印度医疗机构中的产前妇女和产妇来说是广泛未知的。目的:本研究的目的是评估在三级护理医院产前诊所就诊的产前妇女对分娩镇痛的知识、态度和实践。方法:120名18至40岁的产前妇女参加了这项研究。一份基于谷歌表格的问卷被用来收集数据。统计分析:序号和标称数据以数字和百分比表示。条形图和饼图用于图形表示。结果:在120名受访者中,有21名(17.5%)的人知道分娩镇痛。在其余99名参与者中,有13名参与者既不了解情况,也不想进一步收集信息。在86名不知情的受访者中,62人(72.1%)对获得分娩镇痛知识感兴趣,如果产科医生提供信息,他们会感到舒适;其中46人(53.5%)希望在产科咨询期间提供信息,10人(11.6%)认为在分娩疼痛开始时或之后是提高分娩镇痛意识的最佳时间。受访者对分娩镇痛的主要担忧是他们的健康安全和对婴儿的影响。结论:印度产前妇女对分娩镇痛的认识较低。治疗产科医生应在分娩前和分娩前传授有关分娩镇痛的知识,在分娩前应更加重视这些知识的补充。
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引用次数: 1
A case of right internal carotid artery thrombosis in case of mild COVID-19 pneumonia 新冠肺炎并发右颈内动脉血栓1例
IF 0.3 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2022-07-01 DOI: 10.4103/jmms.jmms_121_21
D. Paul, R. Goyal, Bhavana Hooda, K. Kaur
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引用次数: 0
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Journal of Marine Medical Society
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