Pub Date : 2023-06-01DOI: 10.4103/jmms.jmms_178_22
Vishal Mangal, Vivek Kumar, Khushboo, K. Kaur
Suicide is an act of intentionally taking one's own life. In India, hanging remains the most common means of committing suicide. Complete hanging is when no body part touches the ground or any surface. Poor prognosis is associated with a Glasgow coma scale <8, systolic blood pressure <90 mmHg, head imaging consistent with anoxic brain injury, and hanging time longer than 5 min. In suicidal hanging, death is mainly due to hypoxia, asphyxia, or both. Currently, there are no standardized protocols for the management of hanging patients. We present a case of a 31-year-old female who was brought to our hospital after 20 min of bringing her down following complete hanging in a critical condition. She was successfully managed with mechanical ventilation, inotropes, and supportive care. She was discharged on the 7th day in walking condition without any neurological deficit.
{"title":"Successful management of a case of complete hanging: Life does not end by choice","authors":"Vishal Mangal, Vivek Kumar, Khushboo, K. Kaur","doi":"10.4103/jmms.jmms_178_22","DOIUrl":"https://doi.org/10.4103/jmms.jmms_178_22","url":null,"abstract":"Suicide is an act of intentionally taking one's own life. In India, hanging remains the most common means of committing suicide. Complete hanging is when no body part touches the ground or any surface. Poor prognosis is associated with a Glasgow coma scale <8, systolic blood pressure <90 mmHg, head imaging consistent with anoxic brain injury, and hanging time longer than 5 min. In suicidal hanging, death is mainly due to hypoxia, asphyxia, or both. Currently, there are no standardized protocols for the management of hanging patients. We present a case of a 31-year-old female who was brought to our hospital after 20 min of bringing her down following complete hanging in a critical condition. She was successfully managed with mechanical ventilation, inotropes, and supportive care. She was discharged on the 7th day in walking condition without any neurological deficit.","PeriodicalId":41773,"journal":{"name":"Journal of Marine Medical Society","volume":"25 1","pages":"111 - 113"},"PeriodicalIF":0.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42537001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Rai, K. Yasaswi, Rishi Raj, R. Hiremath, Sandhya Ghodke
Hydatidiform mole with the coexisting live fetus is a rare entity occurring in 0.005%–0.01% of all pregnancies. With the introduction of assisted reproductive techniques (ARTs), a significant rise in the incidence of multiple pregnancies has been reported. Here, we report two cases of molar pregnancies with a coexisting live fetus conceived following assisted conception. In our first case, pregnancy was continued and delivered a term live infant. The second case was aborted at 16 weeks' gestation due to maternal complications. These two patients needed chemotherapy due to persistent gestational trophoblastic disease. The rarity of this condition poses several diagnostic and management challenges, especially conceiving after ART the decision of termination for such couples.
{"title":"Molar pregnancy with a coexistent fetus following assisted reproductive techniques: Two case reports","authors":"S. Rai, K. Yasaswi, Rishi Raj, R. Hiremath, Sandhya Ghodke","doi":"10.4103/jmms.jmms_90_22","DOIUrl":"https://doi.org/10.4103/jmms.jmms_90_22","url":null,"abstract":"Hydatidiform mole with the coexisting live fetus is a rare entity occurring in 0.005%–0.01% of all pregnancies. With the introduction of assisted reproductive techniques (ARTs), a significant rise in the incidence of multiple pregnancies has been reported. Here, we report two cases of molar pregnancies with a coexisting live fetus conceived following assisted conception. In our first case, pregnancy was continued and delivered a term live infant. The second case was aborted at 16 weeks' gestation due to maternal complications. These two patients needed chemotherapy due to persistent gestational trophoblastic disease. The rarity of this condition poses several diagnostic and management challenges, especially conceiving after ART the decision of termination for such couples.","PeriodicalId":41773,"journal":{"name":"Journal of Marine Medical Society","volume":"25 1","pages":"103 - 106"},"PeriodicalIF":0.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41318517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.4103/jmms.jmms_165_22
Neha Singh, T. Seth, S. Tyagi
Introduction: Hemoglobin D Punjab is a common hemoglobin D variant, which is essentially known to cause a mild disease even in homozygous state. Heterozygous state of hemoglobin D Punjab with sickle cell is the only presentation when a severe disease may be expected. We aim to study the spectrum of clinical and haematological profile of all case of haemoglobin D, reported at an apex referral centre of the country. Material and Methods: This is a record based retrospective study of cases of hemoglobin D Punjab from hematology OPD of a apex medical care centre. The clinical and hematological findings of 30 cases with genotype/phenotype of hemoglobin D Punjab were recorded from physical records and electronic data maintained at the institute. The cases were divided into homozygous Hb D Punjab, Double heterozygous hemoglobin S and D, Hemoglobin D-β-thalassemia, and Hemoglobin D trait. Results: The reported 30 cases consisted of 3 cases of homozygous Hb D Punjab, 8 cases of co-mutation of Hb D and beta thalassemia, 6 cases of co-mutation of Hb D with sickle cell and 13 cases of Hb D trait. All three cases of Hb D disease were mild to moderately symptomatic with co-existent splenomegaly. Out of the 8 cases reported of Hb D-β-thalassemia, three cases were found to have moderate anemia and one with severe anemia. The MCV of all participants were reduced, while, MCHC of all cases was within normal range. Among the 6 cases of compound heterozygous Hb D and S Disease two had hemolytic faces and three cases had splenomegaly. Blood transfusion was required by four out of six cases at varied frequency. Conclusion: We find the spectrum of symptoms presented by the cases of hemoglobin D Punjab is varied and few cases may require blood transfusion and medical care with follow up even in absence of heterozygous hemoglobin S inheritance.
引言：旁遮普邦血红蛋白D是一种常见的血红蛋白D变体，即使在纯合状态下也会导致轻度疾病。旁遮普邦血红蛋白D与镰状细胞的杂合状态是可能出现严重疾病的唯一表现。我们的目的是研究在该国最高转诊中心报告的所有血红蛋白D病例的临床和血液学特征谱。材料和方法：这是一项基于记录的回顾性研究，对一家顶级医疗保健中心血液科门诊的旁遮普邦血红蛋白D病例进行了回顾性研究。旁遮普省30例血红蛋白D基因型/表型病例的临床和血液学结果记录在研究所保存的物理记录和电子数据中。病例分为纯合Hb D Punjab、双杂合血红蛋白S和D、血红蛋白D-β-地中海贫血和血红蛋白D性状。结果：报告的30例病例包括3例纯合型Hb D Punjab，8例Hb D与β-地中海贫血共突变，6例血红蛋白D与镰状细胞共突变，13例Hb D性状。三例Hb D疾病均为轻度至中度症状，并伴有脾肿大。在报告的8例Hb D-β地中海贫血病例中，发现3例中度贫血，1例重度贫血。所有参与者的MCV均降低，而所有病例的MCHC均在正常范围内。在6例复合杂合Hb D和S疾病中，2例出现溶血性面孔，3例出现脾肿大。六分之四的病例需要不同频率的输血。结论：我们发现旁遮普邦血红蛋白D病例的症状谱各不相同，即使没有杂合血红蛋白S遗传，也很少有病例需要输血和医疗护理。
{"title":"Review of clinical and hematological profile of hemoglobin D cases in a single centre","authors":"Neha Singh, T. Seth, S. Tyagi","doi":"10.4103/jmms.jmms_165_22","DOIUrl":"https://doi.org/10.4103/jmms.jmms_165_22","url":null,"abstract":"Introduction: Hemoglobin D Punjab is a common hemoglobin D variant, which is essentially known to cause a mild disease even in homozygous state. Heterozygous state of hemoglobin D Punjab with sickle cell is the only presentation when a severe disease may be expected. We aim to study the spectrum of clinical and haematological profile of all case of haemoglobin D, reported at an apex referral centre of the country. Material and Methods: This is a record based retrospective study of cases of hemoglobin D Punjab from hematology OPD of a apex medical care centre. The clinical and hematological findings of 30 cases with genotype/phenotype of hemoglobin D Punjab were recorded from physical records and electronic data maintained at the institute. The cases were divided into homozygous Hb D Punjab, Double heterozygous hemoglobin S and D, Hemoglobin D-β-thalassemia, and Hemoglobin D trait. Results: The reported 30 cases consisted of 3 cases of homozygous Hb D Punjab, 8 cases of co-mutation of Hb D and beta thalassemia, 6 cases of co-mutation of Hb D with sickle cell and 13 cases of Hb D trait. All three cases of Hb D disease were mild to moderately symptomatic with co-existent splenomegaly. Out of the 8 cases reported of Hb D-β-thalassemia, three cases were found to have moderate anemia and one with severe anemia. The MCV of all participants were reduced, while, MCHC of all cases was within normal range. Among the 6 cases of compound heterozygous Hb D and S Disease two had hemolytic faces and three cases had splenomegaly. Blood transfusion was required by four out of six cases at varied frequency. Conclusion: We find the spectrum of symptoms presented by the cases of hemoglobin D Punjab is varied and few cases may require blood transfusion and medical care with follow up even in absence of heterozygous hemoglobin S inheritance.","PeriodicalId":41773,"journal":{"name":"Journal of Marine Medical Society","volume":"25 1","pages":"74 - 79"},"PeriodicalIF":0.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42893261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Patient care: A forgotten art – Ten-point solution for better patient care","authors":"S. Shaw, Maj Divyanshi, A. Singhal","doi":"10.4103/jmms.jmms_43_23","DOIUrl":"https://doi.org/10.4103/jmms.jmms_43_23","url":null,"abstract":"","PeriodicalId":41773,"journal":{"name":"Journal of Marine Medical Society","volume":"25 1","pages":"1 - 2"},"PeriodicalIF":0.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45537487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.4103/jmms.jmms_119_22
Ritika Biswas, R. Bandyopadhyay, Sanghamitra Saren, Suparna Banerjee
Introduction: Concurrent chemo-radiation with 100m/m2 three weekly cisplatin is the standard of care in inoperable locally advanced head and neck cancer (LAHNC) but is associated with significant toxicities. The objective of the study was to assess the tumour response and toxicities in the three weekly and lower dose weekly cisplatin based chemo radiation regimens. Methodology: The prospective study was conducted in a peripheral medical college from May 2020 to July 2021. One hundred and twelve patients were recruited, 56 in each arm. The three weekly arms received 100mg/m2 cisplatin whereas the weekly arm received weekly 40mg/m2 cisplatin both concurrently with radiation dose of 70 Gray in 35 fractions over seven weeks. One-way analysis of variance was used to compare means of three or more samples for numerical data. Unpaired proportions were compared by Chi-square test or Fischer's exact test. Results: One hundred patients completed the study and were evaluable, 42 in the three weekly arm and 48 in the weekly arm. Disease response at 12 months in the two arms was not statistically significant. The toxicities were lower in weekly arm as compared to three weekly arms but were not statistically significant. Conclusion: The study confirms that weekly concurrent cisplatin is an acceptable alternative treatment to three weekly regimens in inoperable LAHNC. The lower dose weekly concurrent cisplatin regime is better tolerated in our patients with increased treatment compliance.
{"title":"An observational comparative study of weekly and 3 weekly concurrent cisplatin-based chemoradiotherapy in locally advanced head-and-neck cancer in a peripheral medical college","authors":"Ritika Biswas, R. Bandyopadhyay, Sanghamitra Saren, Suparna Banerjee","doi":"10.4103/jmms.jmms_119_22","DOIUrl":"https://doi.org/10.4103/jmms.jmms_119_22","url":null,"abstract":"Introduction: Concurrent chemo-radiation with 100m/m2 three weekly cisplatin is the standard of care in inoperable locally advanced head and neck cancer (LAHNC) but is associated with significant toxicities. The objective of the study was to assess the tumour response and toxicities in the three weekly and lower dose weekly cisplatin based chemo radiation regimens. Methodology: The prospective study was conducted in a peripheral medical college from May 2020 to July 2021. One hundred and twelve patients were recruited, 56 in each arm. The three weekly arms received 100mg/m2 cisplatin whereas the weekly arm received weekly 40mg/m2 cisplatin both concurrently with radiation dose of 70 Gray in 35 fractions over seven weeks. One-way analysis of variance was used to compare means of three or more samples for numerical data. Unpaired proportions were compared by Chi-square test or Fischer's exact test. Results: One hundred patients completed the study and were evaluable, 42 in the three weekly arm and 48 in the weekly arm. Disease response at 12 months in the two arms was not statistically significant. The toxicities were lower in weekly arm as compared to three weekly arms but were not statistically significant. Conclusion: The study confirms that weekly concurrent cisplatin is an acceptable alternative treatment to three weekly regimens in inoperable LAHNC. The lower dose weekly concurrent cisplatin regime is better tolerated in our patients with increased treatment compliance.","PeriodicalId":41773,"journal":{"name":"Journal of Marine Medical Society","volume":"25 1","pages":"31 - 35"},"PeriodicalIF":0.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46782564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gitanjali Jain, K. Adhikari, G. Vasnik, Daljit Singh, Venkatesan Somasundaram, R. Gupta, P. Dudeja, S. Shaw
Background: Late Vitamin K deficiency bleeding, is a disease of exclusively breast-fed infants attributable to poor content of Vitamin K in breast milk. We aimed to estimate the prevalence of subclinical Vitamin K deficiency, at 3 months of age in exclusively breast-fed term infants who were administered routine Vitamin K 1 mg intramuscular at birth. Methods: This prospective observational study was conducted between June 2018 and June 2020 in a Tertiary Care Teaching Hospital in Western India. Consecutive inborn infants, having received Injection Vitamin K at birth and on exclusive breast feeds attending immunization at 3 months of age were included. Half milliliter of venous blood was withdrawn for the estimation of Proteins Induced by Vitamin K Absence or Antagonist-II (PIVKA-II). Subclinical Vitamin K deficiency was defined as PIVKA-II level of more than 2 ng/mL. Results: The mean age of infants was 3.2 ± 0.2 months and the PIVKA II levels ranged from 0.19 to 10.07 ng/ml. Subclinical Vitamin K deficiency was present in 62 (32.63%) out of 190 infants. Conclusion: Significantly raised PIVKA II levels (>2 ng/mL) were detectable in 32.6% of infants after 3 months of age who had received 1 mg of Vitamin K at birth.
{"title":"Prevalence of subclinical Vitamin K deficiency in early infancy in exclusively breast-fed term infants","authors":"Gitanjali Jain, K. Adhikari, G. Vasnik, Daljit Singh, Venkatesan Somasundaram, R. Gupta, P. Dudeja, S. Shaw","doi":"10.4103/jmms.jmms_75_22","DOIUrl":"https://doi.org/10.4103/jmms.jmms_75_22","url":null,"abstract":"Background: Late Vitamin K deficiency bleeding, is a disease of exclusively breast-fed infants attributable to poor content of Vitamin K in breast milk. We aimed to estimate the prevalence of subclinical Vitamin K deficiency, at 3 months of age in exclusively breast-fed term infants who were administered routine Vitamin K 1 mg intramuscular at birth. Methods: This prospective observational study was conducted between June 2018 and June 2020 in a Tertiary Care Teaching Hospital in Western India. Consecutive inborn infants, having received Injection Vitamin K at birth and on exclusive breast feeds attending immunization at 3 months of age were included. Half milliliter of venous blood was withdrawn for the estimation of Proteins Induced by Vitamin K Absence or Antagonist-II (PIVKA-II). Subclinical Vitamin K deficiency was defined as PIVKA-II level of more than 2 ng/mL. Results: The mean age of infants was 3.2 ± 0.2 months and the PIVKA II levels ranged from 0.19 to 10.07 ng/ml. Subclinical Vitamin K deficiency was present in 62 (32.63%) out of 190 infants. Conclusion: Significantly raised PIVKA II levels (>2 ng/mL) were detectable in 32.6% of infants after 3 months of age who had received 1 mg of Vitamin K at birth.","PeriodicalId":41773,"journal":{"name":"Journal of Marine Medical Society","volume":"25 1","pages":"55 - 57"},"PeriodicalIF":0.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41586627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Pendharkar, R. Mehta, Barun K. Chakrabarty, Arijit Sen
Squamous cell carcinomas (SCCs) occurring in the bones are largely metastatic in nature and primary intraosseous squamous cell carcinomas (PIOSCCs) are extremely rare. They tend to involve skull bones more frequently than the other bones. We present the case of a 52-year-old male, presenting with pain in the lower jaw, which was diagnosed with PIOSCC on histopathology.
{"title":"Primary intraosseous squamous cell carcinoma presenting as lytic lesion in mandible: Common presentation of an uncommon illness","authors":"C. Pendharkar, R. Mehta, Barun K. Chakrabarty, Arijit Sen","doi":"10.4103/jmms.jmms_68_22","DOIUrl":"https://doi.org/10.4103/jmms.jmms_68_22","url":null,"abstract":"Squamous cell carcinomas (SCCs) occurring in the bones are largely metastatic in nature and primary intraosseous squamous cell carcinomas (PIOSCCs) are extremely rare. They tend to involve skull bones more frequently than the other bones. We present the case of a 52-year-old male, presenting with pain in the lower jaw, which was diagnosed with PIOSCC on histopathology.","PeriodicalId":41773,"journal":{"name":"Journal of Marine Medical Society","volume":"25 1","pages":"100 - 102"},"PeriodicalIF":0.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46493263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.4103/jmms.jmms_123_22
Anmol Sharma, R. Batlish, Khan Ali
Background and Objectives: Habitability onboard a warship is multifactorial and constitutes the environment in which the crew operates and accommodates while at sea or at harbor. Maritime work environment is a complex man-machine interaction, with human being the dynamic component as the machine is mostly run by set protocols and algorithms. Efficiency of the dynamic aspect of the man machine interaction is driven by multiple correlated and interrelated factors which can be linked to the ambient and external environment in nature. This study was therefore conducted to survey upon the crew serving onboard Indian Naval Ships as to assess crew perception toward various habitability factors onboard. Materials and Methods: The descriptive study was carried on board various naval warships. A questionnaire-based analysis was conducted on 384 personnel on active duty. Results: Majority of participants agreed that habitability factors have a direct impact on their efficiency while working. Food, ventilation, and adequate living spaces are most crucial with the maximum positive impact on the crew as determined by the survey. Interpretation and Conclusion: Subsequent increase in the quality and variety of equipment with an ergonomical approach is the way forward for an efficient and happy crew. A happy and satisfied seafarer on board a ship is the pivot point to determine the efforts in place and the mission in hand.
{"title":"Assessment of perception of crew on habitability factors onboard naval afloat units assessment of perception of crew regarding habitability factors onboard naval afloat units","authors":"Anmol Sharma, R. Batlish, Khan Ali","doi":"10.4103/jmms.jmms_123_22","DOIUrl":"https://doi.org/10.4103/jmms.jmms_123_22","url":null,"abstract":"Background and Objectives: Habitability onboard a warship is multifactorial and constitutes the environment in which the crew operates and accommodates while at sea or at harbor. Maritime work environment is a complex man-machine interaction, with human being the dynamic component as the machine is mostly run by set protocols and algorithms. Efficiency of the dynamic aspect of the man machine interaction is driven by multiple correlated and interrelated factors which can be linked to the ambient and external environment in nature. This study was therefore conducted to survey upon the crew serving onboard Indian Naval Ships as to assess crew perception toward various habitability factors onboard. Materials and Methods: The descriptive study was carried on board various naval warships. A questionnaire-based analysis was conducted on 384 personnel on active duty. Results: Majority of participants agreed that habitability factors have a direct impact on their efficiency while working. Food, ventilation, and adequate living spaces are most crucial with the maximum positive impact on the crew as determined by the survey. Interpretation and Conclusion: Subsequent increase in the quality and variety of equipment with an ergonomical approach is the way forward for an efficient and happy crew. A happy and satisfied seafarer on board a ship is the pivot point to determine the efforts in place and the mission in hand.","PeriodicalId":41773,"journal":{"name":"Journal of Marine Medical Society","volume":"25 1","pages":"86 - 90"},"PeriodicalIF":0.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48994426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.4103/jmms.jmms_181_22
Soumya Dey, A. Basu, Suparna Banerjee, R. Bandyopadhyay
Introduction: The deterioration of health caused by colorectal Cancer (CRC) and its treatment leads to physiological, functional, and social damage impairing a CRC patient's health-related quality of life (HRQoL). The study was done to estimate the factors affecting the HR QoL among patients with CRC. Methodology: Fifty-four CRC patients who had completed the treatment with surgery/chemotherapy/radiotherapy in a peripheral Medical College between May 2021 and April 2022 were enrolled. The objective was to assess patient's perceived global health status and QoL (GHS/QoL), functional outcomes, and symptoms measured by the European organization for research and treatment of cancer Quality of life questionnaire core (QLQ-C30) and the CRC-specific QLQ-CR29 and to determine the demographics, clinical, treatment factors and symptom scales of the QLQ-C30/QLQ-CR29 that are associated with of GHS/QoL in patients with CRC Results: The mean age was 46 years, 59% were male, 41% had other long-term medical conditions, an ostomy was present in 30% and 41% of respondents had multimodal CRC treatment with surgery, radiotherapy, and chemotherapy. The final analysis of stepwise multiple regression revealed that four variables namely physical functioning, sexual interest, body image, and fatigue remained significant independent predictors of overall HRQoL score in CRC survivors accounting for 67.4% of the variation in overall HRQoL. Physical functioning made the strongest contribution. Women, at the extremes of the age groups (≥60 years), with an ostomy, without a spouse/partner, and those with other medical conditions in addition reported poorer functioning, symptoms, or overall HRQoL. Conclusions: The current study identifies factors associated with overall HRQoL among CRC survivors. Functional capacity and CRC-related problems were most strongly associated with overall HRQoL among CRC survivors. Greater efforts to identify CRC-related symptoms and diminished physical functional capacity among CRC survivors are warranted in an attempt to improve their overall HRQoL.
{"title":"Factors affecting health-related quality of life among patients with colorectal cancer using the european organization for research and treatment of cancer quality of life core questionnaire-CR29","authors":"Soumya Dey, A. Basu, Suparna Banerjee, R. Bandyopadhyay","doi":"10.4103/jmms.jmms_181_22","DOIUrl":"https://doi.org/10.4103/jmms.jmms_181_22","url":null,"abstract":"Introduction: The deterioration of health caused by colorectal Cancer (CRC) and its treatment leads to physiological, functional, and social damage impairing a CRC patient's health-related quality of life (HRQoL). The study was done to estimate the factors affecting the HR QoL among patients with CRC. Methodology: Fifty-four CRC patients who had completed the treatment with surgery/chemotherapy/radiotherapy in a peripheral Medical College between May 2021 and April 2022 were enrolled. The objective was to assess patient's perceived global health status and QoL (GHS/QoL), functional outcomes, and symptoms measured by the European organization for research and treatment of cancer Quality of life questionnaire core (QLQ-C30) and the CRC-specific QLQ-CR29 and to determine the demographics, clinical, treatment factors and symptom scales of the QLQ-C30/QLQ-CR29 that are associated with of GHS/QoL in patients with CRC Results: The mean age was 46 years, 59% were male, 41% had other long-term medical conditions, an ostomy was present in 30% and 41% of respondents had multimodal CRC treatment with surgery, radiotherapy, and chemotherapy. The final analysis of stepwise multiple regression revealed that four variables namely physical functioning, sexual interest, body image, and fatigue remained significant independent predictors of overall HRQoL score in CRC survivors accounting for 67.4% of the variation in overall HRQoL. Physical functioning made the strongest contribution. Women, at the extremes of the age groups (≥60 years), with an ostomy, without a spouse/partner, and those with other medical conditions in addition reported poorer functioning, symptoms, or overall HRQoL. Conclusions: The current study identifies factors associated with overall HRQoL among CRC survivors. Functional capacity and CRC-related problems were most strongly associated with overall HRQoL among CRC survivors. Greater efforts to identify CRC-related symptoms and diminished physical functional capacity among CRC survivors are warranted in an attempt to improve their overall HRQoL.","PeriodicalId":41773,"journal":{"name":"Journal of Marine Medical Society","volume":"25 1","pages":"80 - 85"},"PeriodicalIF":0.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43756233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Muthanna, Ratan Sadangi, Bharat Hosur, N. Jain, I. Monga
Background: Coronary artery disease (CAD) is associated with significant mortality and morbidity. Atherosclerosis is the most common pathophysiology behind this condition. This manifests as an increase in arterial wall intima-media thickness and subsequent plaque formation in the asymptomatic phase. Objectives: To measure the carotid intima-media thickness (CIMT) value of carotid arteries in patients with angiographically diagnosed CAD and also asses the carotids for the presence of plaques and if present to characterize them. Materials and Methods: A total of 100 angiographically diagnosed CAD patients were included in the descriptive study and data were analyzed regarding the increased CIMT, and plaques in the carotid arteries in relation to the corresponding coronary disease. Results: Raised CIMT values were found in 47 out of 100 patients. A linear proportional relationship of mean CIMT values with the number of involved coronary arteries was also observed. A total of 62 plaques were demonstrated in 43 patients. Majority of the plaques (65%) had a smooth surface with uniform outlines. Eighteen plaques were found to have irregular surface outlines (29%), whereas four out of 62 plaques (6%) had ulcerated surfaces. Conclusion: There is increased CIMT prevalence and its linear proportional relationship with an increased number of affected coronary vessels in patients with CAD. Furthermore, an increased prevalence of carotid plaques is present in these patients. Hence, the increased CIMT and the presence of carotid plaques may act as surrogate markers for risk stratification in a patient with CAD.
{"title":"Sonographic evaluation of carotid intima-media thickness and carotid plaques in coronary artery disease patients","authors":"B. Muthanna, Ratan Sadangi, Bharat Hosur, N. Jain, I. Monga","doi":"10.4103/jmms.jmms_71_22","DOIUrl":"https://doi.org/10.4103/jmms.jmms_71_22","url":null,"abstract":"Background: Coronary artery disease (CAD) is associated with significant mortality and morbidity. Atherosclerosis is the most common pathophysiology behind this condition. This manifests as an increase in arterial wall intima-media thickness and subsequent plaque formation in the asymptomatic phase. Objectives: To measure the carotid intima-media thickness (CIMT) value of carotid arteries in patients with angiographically diagnosed CAD and also asses the carotids for the presence of plaques and if present to characterize them. Materials and Methods: A total of 100 angiographically diagnosed CAD patients were included in the descriptive study and data were analyzed regarding the increased CIMT, and plaques in the carotid arteries in relation to the corresponding coronary disease. Results: Raised CIMT values were found in 47 out of 100 patients. A linear proportional relationship of mean CIMT values with the number of involved coronary arteries was also observed. A total of 62 plaques were demonstrated in 43 patients. Majority of the plaques (65%) had a smooth surface with uniform outlines. Eighteen plaques were found to have irregular surface outlines (29%), whereas four out of 62 plaques (6%) had ulcerated surfaces. Conclusion: There is increased CIMT prevalence and its linear proportional relationship with an increased number of affected coronary vessels in patients with CAD. Furthermore, an increased prevalence of carotid plaques is present in these patients. Hence, the increased CIMT and the presence of carotid plaques may act as surrogate markers for risk stratification in a patient with CAD.","PeriodicalId":41773,"journal":{"name":"Journal of Marine Medical Society","volume":"25 1","pages":"58 - 63"},"PeriodicalIF":0.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42117697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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