Pub Date : 2023-06-01DOI: 10.4103/jmms.jmms_107_22
J. Chanderbhan, Aditya Gupta, Bharat Hosur, Vivek Sharda, Julie Sachdeva, G. Chowdhary, B. Muthanna, R. Saxena, G. Monga
Introduction: Working adults in high-altitude regions (HARs) are at higher risk of developing cerebral venous thrombosis (CVT) due to multiple factors. The clinico-radiological patterns pertaining to the high altitude associated with CVT can be different compared to those without HAR exposure. Objective: We aimed to study the clinico-radiological patterns of CVT in adult males diagnosed with CVT while working in mountainous regions at an altitude higher than 8000 feet above sea level. Methodology: The study population consists of adult males aged >18 years who suffered symptomatic CVT while working in mountains at high altitudes. They were divided into groups according to the altitude at which they were working as high-altitude (8202–11,483 ft), very high-altitude (11,484–19,029 ft), and extremely high-altitude (above 19,030 ft) regions. Meticulous history, clinical examination, imaging with computed tomography, magnetic resonance imaging, and laboratory investigations including procoagulation profile were done. The outcome was classified according to the modified Rankin score at 3-month follow-up. Results: Among the forty patients with CVT, 100% had a headache, 65% had vomiting, and 20% suffered convulsions at presentation. Increasing altitude was associated with higher clot load, increasing extent of involvement within the venous sinuses, and a tendency to involve deep veins in isolation or conjunction with the sinuses. Twenty-three recovered without any deficit and 15 were symptomatic without disability at the 3-month follow-up. Conclusion: In patients of CVT who are exposed to high altitudes in mountains, the increasing altitude is associated with higher clot load, increasing extent of involvement within the venous sinuses, and a tendency to involve deep veins. Polycythemia, smoking, alcohol, and deficiency of protein C are the coexisting factors.
{"title":"Clinico-radiological patterns of cerebral venous thrombosis in adult males working in the mountainous region of North India - A pilot study from tertiary care hospital","authors":"J. Chanderbhan, Aditya Gupta, Bharat Hosur, Vivek Sharda, Julie Sachdeva, G. Chowdhary, B. Muthanna, R. Saxena, G. Monga","doi":"10.4103/jmms.jmms_107_22","DOIUrl":"https://doi.org/10.4103/jmms.jmms_107_22","url":null,"abstract":"Introduction: Working adults in high-altitude regions (HARs) are at higher risk of developing cerebral venous thrombosis (CVT) due to multiple factors. The clinico-radiological patterns pertaining to the high altitude associated with CVT can be different compared to those without HAR exposure. Objective: We aimed to study the clinico-radiological patterns of CVT in adult males diagnosed with CVT while working in mountainous regions at an altitude higher than 8000 feet above sea level. Methodology: The study population consists of adult males aged >18 years who suffered symptomatic CVT while working in mountains at high altitudes. They were divided into groups according to the altitude at which they were working as high-altitude (8202–11,483 ft), very high-altitude (11,484–19,029 ft), and extremely high-altitude (above 19,030 ft) regions. Meticulous history, clinical examination, imaging with computed tomography, magnetic resonance imaging, and laboratory investigations including procoagulation profile were done. The outcome was classified according to the modified Rankin score at 3-month follow-up. Results: Among the forty patients with CVT, 100% had a headache, 65% had vomiting, and 20% suffered convulsions at presentation. Increasing altitude was associated with higher clot load, increasing extent of involvement within the venous sinuses, and a tendency to involve deep veins in isolation or conjunction with the sinuses. Twenty-three recovered without any deficit and 15 were symptomatic without disability at the 3-month follow-up. Conclusion: In patients of CVT who are exposed to high altitudes in mountains, the increasing altitude is associated with higher clot load, increasing extent of involvement within the venous sinuses, and a tendency to involve deep veins. Polycythemia, smoking, alcohol, and deficiency of protein C are the coexisting factors.","PeriodicalId":41773,"journal":{"name":"Journal of Marine Medical Society","volume":"25 1","pages":"41 - 46"},"PeriodicalIF":0.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44475387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.4103/jmms.jmms_105_22
Paresh Singhal, S. Raghavendra, Barun K. Chakrabarty, Ganesh Pendkur, C. Pendharkar, Gurpreet Sagoo
Introduction: Recurrent pregnancy loss (RPL) is a common occurrence which affects approximately 15-20% of couples. Chromosomal abnormality is an important cause of recurrent abortions especially if either of the partner is a carrier of balanced translocation. The current study aimed to determine the prevalence of chromosomal abnormalities in couples suffering from first trimester RPL and compare with normal control. Materials and Methods: A prospective case-control study, in which 261 couples with history of two or more abortions were evaluated for various chromosomal abnormalities; and compared with 190 healthy couples with no history of abortion and at least one normal biological child. Peripheral blood T-lymphocytes were cultured using RPMI-1640 medium for obtaining metaphases and chromosomal analysis. SPSS software and Student's t test were used. p value < 0.05 was considered statistically significant. Results: Among 261 couples in RPL group, 240(91.95%) had normal karyotype, 17(6.51%) had major chromosomal abnormalities and 04(1.53%) had polymorphic variants. Most of the couples had two abortions (39.8%). Females were more commonly affected with M:F=0.214. Structural abnormalities (n=12,70.59%) were more frequent than numerical abnormalities (n=5,29.41%). There was no statistical correlation between age, number of abortions and major chromosomal abnormalities (p=0.06). Conclusion: Chromosomal aberrations in carrier parents, predispose them to RPL and can also be transmitted to the offspring which may results in imbalance in their genetic constitution, thus justifying the requirement of cytogenetic testing in these patients.
{"title":"Cytogenetics evaluation of 261 couples with first-trimester recurrent pregnancy loss: A prevalent case–control study","authors":"Paresh Singhal, S. Raghavendra, Barun K. Chakrabarty, Ganesh Pendkur, C. Pendharkar, Gurpreet Sagoo","doi":"10.4103/jmms.jmms_105_22","DOIUrl":"https://doi.org/10.4103/jmms.jmms_105_22","url":null,"abstract":"Introduction: Recurrent pregnancy loss (RPL) is a common occurrence which affects approximately 15-20% of couples. Chromosomal abnormality is an important cause of recurrent abortions especially if either of the partner is a carrier of balanced translocation. The current study aimed to determine the prevalence of chromosomal abnormalities in couples suffering from first trimester RPL and compare with normal control. Materials and Methods: A prospective case-control study, in which 261 couples with history of two or more abortions were evaluated for various chromosomal abnormalities; and compared with 190 healthy couples with no history of abortion and at least one normal biological child. Peripheral blood T-lymphocytes were cultured using RPMI-1640 medium for obtaining metaphases and chromosomal analysis. SPSS software and Student's t test were used. p value < 0.05 was considered statistically significant. Results: Among 261 couples in RPL group, 240(91.95%) had normal karyotype, 17(6.51%) had major chromosomal abnormalities and 04(1.53%) had polymorphic variants. Most of the couples had two abortions (39.8%). Females were more commonly affected with M:F=0.214. Structural abnormalities (n=12,70.59%) were more frequent than numerical abnormalities (n=5,29.41%). There was no statistical correlation between age, number of abortions and major chromosomal abnormalities (p=0.06). Conclusion: Chromosomal aberrations in carrier parents, predispose them to RPL and can also be transmitted to the offspring which may results in imbalance in their genetic constitution, thus justifying the requirement of cytogenetic testing in these patients.","PeriodicalId":41773,"journal":{"name":"Journal of Marine Medical Society","volume":"25 1","pages":"11 - 17"},"PeriodicalIF":0.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49620762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Akshay R. Kothari, Vivek Phutane, S. Bajaj, R. Mukherjee, Shabeena Tawar
Background: Hand hygiene in school children is a widely recognized low-cost effective intervention for the prevention and control of many infectious diseases. Health and hygiene education in schools is now a part of the “Swachh Bharat Abhiyan” and is being implemented across most schools in India. Objectives: This study was carried out to assess the impact of intervention in the form of a health education package on change in knowledge, attitude, and practices (KAP) regarding hand hygiene among school children. Methodology: A prepost interventional study was carried out in a school located in an urban area of Pune, Maharashtra, to evaluate the effectiveness of health education intervention on KAP regarding hand hygiene among school children. A total of 115 children in the age group 10–12 years were included in the study. The baseline KAP was measured using a pretested validated questionnaire followed by intervention in the form of health education through health talks, interactive sessions, videos, and demonstrations. Postintervention assessment of KAP was done using the same questionnaire. Results: The mean age (± Standard Deviation) of the study participants was 11.2 (±-0.712) years. Boys comprised 65.2% of the study population and the remaining 34.8% were girls. The baseline survey showed that only 3.5% of school children were aware of the correct method of handwashing which improved significantly to 91% postintervention. None of the children knew the names of the diseases prevented by handwashing preintervention. This changed postintervention, where 27.8% said it prevents diarrheal diseases, 20.0% said it prevents common cold, and 52.2% said it prevents both. The practices regarding handwashing before eating meals at home, after using toilet facility, after coughing/sneezing, and after playing outside improved significantly postintervention. Conclusion: Health education is an effective intervention to improve hand-washing practices among school children and bring about behavioral change for disease prevention.
{"title":"Impact of health education on knowledge, attitude and practices regarding hand-hygiene amongst school children aged 10-12 years in Pune: An interventional study","authors":"Akshay R. Kothari, Vivek Phutane, S. Bajaj, R. Mukherjee, Shabeena Tawar","doi":"10.4103/jmms.jmms_81_22","DOIUrl":"https://doi.org/10.4103/jmms.jmms_81_22","url":null,"abstract":"Background: Hand hygiene in school children is a widely recognized low-cost effective intervention for the prevention and control of many infectious diseases. Health and hygiene education in schools is now a part of the “Swachh Bharat Abhiyan” and is being implemented across most schools in India. Objectives: This study was carried out to assess the impact of intervention in the form of a health education package on change in knowledge, attitude, and practices (KAP) regarding hand hygiene among school children. Methodology: A prepost interventional study was carried out in a school located in an urban area of Pune, Maharashtra, to evaluate the effectiveness of health education intervention on KAP regarding hand hygiene among school children. A total of 115 children in the age group 10–12 years were included in the study. The baseline KAP was measured using a pretested validated questionnaire followed by intervention in the form of health education through health talks, interactive sessions, videos, and demonstrations. Postintervention assessment of KAP was done using the same questionnaire. Results: The mean age (± Standard Deviation) of the study participants was 11.2 (±-0.712) years. Boys comprised 65.2% of the study population and the remaining 34.8% were girls. The baseline survey showed that only 3.5% of school children were aware of the correct method of handwashing which improved significantly to 91% postintervention. None of the children knew the names of the diseases prevented by handwashing preintervention. This changed postintervention, where 27.8% said it prevents diarrheal diseases, 20.0% said it prevents common cold, and 52.2% said it prevents both. The practices regarding handwashing before eating meals at home, after using toilet facility, after coughing/sneezing, and after playing outside improved significantly postintervention. Conclusion: Health education is an effective intervention to improve hand-washing practices among school children and bring about behavioral change for disease prevention.","PeriodicalId":41773,"journal":{"name":"Journal of Marine Medical Society","volume":"25 1","pages":"36 - 40"},"PeriodicalIF":0.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49447521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.4103/jmms.jmms_159_22
S. Mathews, Ruchima Dham, A. Dutta, A. Jose
There have been major advancements in the field of artificial intelligence (AI) in the last few decades and its use in otorhinolaryngology has seen promising results. In machine learning, which is a subset of AI, computers learn from historical data to gather insights and they make diagnoses about new input data, based on the information it has learned. The objective of this study was to provide a comprehensive review of current applications, future possibilities, and limitations of AI, with respect to the specialty of otorhinolaryngology. A search of the literature was performed using PubMed and Medline search engines. Search terms related to AI or machine learning in otorhinolaryngology were identified and queried to select recent and relevant articles. AI has implications in various areas of otorhinolaryngology such as automatically diagnosing hearing loss, improving performance of hearing aids, restoring speech in paralyzed individuals, predicting speech and language outcomes in cochlear implant candidates, diagnosing various otology conditions using otoscopic images, training in otological surgeries using virtual reality simulator, classifying and quantifying opacification in computed tomography images of paranasal sinuses, distinguishing various laryngeal pathologies based on laryngoscopic images, automatically segmenting anatomical structures to accelerate radiotherapy planning, and assisting pathologist in reporting of thyroid cytopathology. The results of various studies show that machine learning might be used by general practitioners, in remote areas where specialist care is not readily available and as a supportive diagnostic tool in otorhinolaryngology setups, for better diagnosis and faster decision-making.
{"title":"Computational Intelligence in Otorhinolaryngology","authors":"S. Mathews, Ruchima Dham, A. Dutta, A. Jose","doi":"10.4103/jmms.jmms_159_22","DOIUrl":"https://doi.org/10.4103/jmms.jmms_159_22","url":null,"abstract":"There have been major advancements in the field of artificial intelligence (AI) in the last few decades and its use in otorhinolaryngology has seen promising results. In machine learning, which is a subset of AI, computers learn from historical data to gather insights and they make diagnoses about new input data, based on the information it has learned. The objective of this study was to provide a comprehensive review of current applications, future possibilities, and limitations of AI, with respect to the specialty of otorhinolaryngology. A search of the literature was performed using PubMed and Medline search engines. Search terms related to AI or machine learning in otorhinolaryngology were identified and queried to select recent and relevant articles. AI has implications in various areas of otorhinolaryngology such as automatically diagnosing hearing loss, improving performance of hearing aids, restoring speech in paralyzed individuals, predicting speech and language outcomes in cochlear implant candidates, diagnosing various otology conditions using otoscopic images, training in otological surgeries using virtual reality simulator, classifying and quantifying opacification in computed tomography images of paranasal sinuses, distinguishing various laryngeal pathologies based on laryngoscopic images, automatically segmenting anatomical structures to accelerate radiotherapy planning, and assisting pathologist in reporting of thyroid cytopathology. The results of various studies show that machine learning might be used by general practitioners, in remote areas where specialist care is not readily available and as a supportive diagnostic tool in otorhinolaryngology setups, for better diagnosis and faster decision-making.","PeriodicalId":41773,"journal":{"name":"Journal of Marine Medical Society","volume":"25 1","pages":"3 - 10"},"PeriodicalIF":0.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47072608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.4103/jmms.jmms_162_22
V. Bhatnagar, R. Rajput, Sudhansu Shekhar, S. Kumar
{"title":"Awake craniotomy for massive intracranial space-occupying lesion: Series of two cases","authors":"V. Bhatnagar, R. Rajput, Sudhansu Shekhar, S. Kumar","doi":"10.4103/jmms.jmms_162_22","DOIUrl":"https://doi.org/10.4103/jmms.jmms_162_22","url":null,"abstract":"","PeriodicalId":41773,"journal":{"name":"Journal of Marine Medical Society","volume":"25 1","pages":"114 - 115"},"PeriodicalIF":0.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42322857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.4103/jmms.jmms_129_22
Bhavni Oberoi, Reetu Agarwal, Gopalsing R Rajput
A range of skin manifestations has been reported since the beginning of the COVID-19 pandemic. These findings earlier thought to be due to direct cytopathic effects of the virus are now predominantly known to be paraviral eruptions due to an immune reaction to the virus. Eruptive pseudoangiomatosis is one such paraviral eruption which has been scarcely reported to be associated with COVID-19 vaccination or infection. We did not find any such association during the first two waves of COVID; however, we found a phenomenal increase in cases of eruptive pseudoangiomatosis with the third wave of COVID-19 in India which coincided with the spread of the Omicron variant. Hereby, we report a case series of ten such cases. All these cases had a temporal correlation with COVID-19 infection and resolved spontaneously without recurrence within 14 days.
{"title":"Eruptive pseudoangiomatosis: An outbreak in the third wave of COVID-19","authors":"Bhavni Oberoi, Reetu Agarwal, Gopalsing R Rajput","doi":"10.4103/jmms.jmms_129_22","DOIUrl":"https://doi.org/10.4103/jmms.jmms_129_22","url":null,"abstract":"A range of skin manifestations has been reported since the beginning of the COVID-19 pandemic. These findings earlier thought to be due to direct cytopathic effects of the virus are now predominantly known to be paraviral eruptions due to an immune reaction to the virus. Eruptive pseudoangiomatosis is one such paraviral eruption which has been scarcely reported to be associated with COVID-19 vaccination or infection. We did not find any such association during the first two waves of COVID; however, we found a phenomenal increase in cases of eruptive pseudoangiomatosis with the third wave of COVID-19 in India which coincided with the spread of the Omicron variant. Hereby, we report a case series of ten such cases. All these cases had a temporal correlation with COVID-19 infection and resolved spontaneously without recurrence within 14 days.","PeriodicalId":41773,"journal":{"name":"Journal of Marine Medical Society","volume":"25 1","pages":"91 - 93"},"PeriodicalIF":0.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46489237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.4103/jmms.jmms_180_22
P. Shihabudheen, Shamsudeen Moideen, N. Uvais
{"title":"Bilateral empyema caused by Acinetobacter Baumanii leading to septic shock and death – A case report","authors":"P. Shihabudheen, Shamsudeen Moideen, N. Uvais","doi":"10.4103/jmms.jmms_180_22","DOIUrl":"https://doi.org/10.4103/jmms.jmms_180_22","url":null,"abstract":"","PeriodicalId":41773,"journal":{"name":"Journal of Marine Medical Society","volume":"25 1","pages":"116 - 117"},"PeriodicalIF":0.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45699461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prashant Panale, A. Jamal, V. Bhat, R. Thergaonkar
A 65-day-old female infant, born to a third-degree consanguineously married couple, was brought to us with neonatal cholestasis and technetium-99 m hepatobiliary iminodiacetic acid scan reporting nonvisualization of the tracer activity in the intestine after 24 h. The neonate had ichthyosis and mild flexion contractures at elbows and knees. Ultrasonography and magnetic resonance cholangiopancreatography did not reveal any evidence of biliary atresia. Liver biopsy showed preserved liver and portal triad architecture with sinusoidal dilatation, giant cell formation, and biliary stasis. The neonate had an episode of enterocolitis complicated by acute kidney injury with persistent renal tubular dysfunction on recovery. Genetic testing revealed a homozygous pathogenic variant c. 201C > A (p. Tyr67Ter) in VPS33B. A diagnosis of arthrogryposis, renal dysfunction, and cholestasis (ARC) syndrome was made, and the neonate managed conservatively with counseling of parents regarding poor prognosis. The neonate died of an intercurrent illness at the age of 7 months. This is possibly the fourth case of ARC syndrome reported from India.
{"title":"ARC syndrome: A rare cause of infantile cholestasis","authors":"Prashant Panale, A. Jamal, V. Bhat, R. Thergaonkar","doi":"10.4103/jmms.jmms_20_22","DOIUrl":"https://doi.org/10.4103/jmms.jmms_20_22","url":null,"abstract":"A 65-day-old female infant, born to a third-degree consanguineously married couple, was brought to us with neonatal cholestasis and technetium-99 m hepatobiliary iminodiacetic acid scan reporting nonvisualization of the tracer activity in the intestine after 24 h. The neonate had ichthyosis and mild flexion contractures at elbows and knees. Ultrasonography and magnetic resonance cholangiopancreatography did not reveal any evidence of biliary atresia. Liver biopsy showed preserved liver and portal triad architecture with sinusoidal dilatation, giant cell formation, and biliary stasis. The neonate had an episode of enterocolitis complicated by acute kidney injury with persistent renal tubular dysfunction on recovery. Genetic testing revealed a homozygous pathogenic variant c. 201C > A (p. Tyr67Ter) in VPS33B. A diagnosis of arthrogryposis, renal dysfunction, and cholestasis (ARC) syndrome was made, and the neonate managed conservatively with counseling of parents regarding poor prognosis. The neonate died of an intercurrent illness at the age of 7 months. This is possibly the fourth case of ARC syndrome reported from India.","PeriodicalId":41773,"journal":{"name":"Journal of Marine Medical Society","volume":"25 1","pages":"94 - 96"},"PeriodicalIF":0.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48121294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.4103/jmms.jmms_135_22
K. Pushkar, S. Bobdey, Rituraj Kotoki, Kunal Koundinya, Priyanka Michael, S. Kaushik
Introduction: Corbevax was introduced by the Government of India in March 2022 for the vaccination of children between 12 and 14 years, however, there is a dearth of literature providing side effect profiles of Corbevax in the real-world/community. Hence, this study was conducted to assess the incidence and types of adverse events following immunization (AEFI) of Corbevax vaccine. Materials and Methods: A prospective observational study was conducted among 358 children between 12 and 14 years of age who had received Corbevax vaccine at a tertiary care center in western Maharashtra from March 16 to May 31, 2022. The participants were followed-up telephonically for side effects at 24 h, 72 h, and 7 days following the first dose and second doses of vaccinations. Results: Out of 358 children of age 12–14 years who received Corbevax vaccine, almost 80% of vaccines developed mild AEFI. Overall, reactogenicity was higher after the second dose and the most common AEFI was pain in the abdomen, followed by headache and pain at the site of injection. Occurrence of AEFI after the first dose (odds ratio: 158.87, 95% confidence interval 46.58–528.28, P < 0.005) was found to be a risk factor for the development of AEFI after the second dose. Conclusion: Corbevax was introduced in India for children between 12 and 14 years, but to the best of our knowledge, till date, there is no study specifically focused of AEFI due to Corbevax in the community setting. The study findings indicate that Corbevax is a safe vaccine with few mild side effects, thus reinforcing faith in the safety profile of the vaccine.
{"title":"Corbevax vaccine side effects in children of age group 12–14 years: A prospective observational study","authors":"K. Pushkar, S. Bobdey, Rituraj Kotoki, Kunal Koundinya, Priyanka Michael, S. Kaushik","doi":"10.4103/jmms.jmms_135_22","DOIUrl":"https://doi.org/10.4103/jmms.jmms_135_22","url":null,"abstract":"Introduction: Corbevax was introduced by the Government of India in March 2022 for the vaccination of children between 12 and 14 years, however, there is a dearth of literature providing side effect profiles of Corbevax in the real-world/community. Hence, this study was conducted to assess the incidence and types of adverse events following immunization (AEFI) of Corbevax vaccine. Materials and Methods: A prospective observational study was conducted among 358 children between 12 and 14 years of age who had received Corbevax vaccine at a tertiary care center in western Maharashtra from March 16 to May 31, 2022. The participants were followed-up telephonically for side effects at 24 h, 72 h, and 7 days following the first dose and second doses of vaccinations. Results: Out of 358 children of age 12–14 years who received Corbevax vaccine, almost 80% of vaccines developed mild AEFI. Overall, reactogenicity was higher after the second dose and the most common AEFI was pain in the abdomen, followed by headache and pain at the site of injection. Occurrence of AEFI after the first dose (odds ratio: 158.87, 95% confidence interval 46.58–528.28, P < 0.005) was found to be a risk factor for the development of AEFI after the second dose. Conclusion: Corbevax was introduced in India for children between 12 and 14 years, but to the best of our knowledge, till date, there is no study specifically focused of AEFI due to Corbevax in the community setting. The study findings indicate that Corbevax is a safe vaccine with few mild side effects, thus reinforcing faith in the safety profile of the vaccine.","PeriodicalId":41773,"journal":{"name":"Journal of Marine Medical Society","volume":"25 1","pages":"64 - 68"},"PeriodicalIF":0.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49427229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: The aim of this study was to determine the incidence of central line-associated bloodstream infections (CLABSIs) in the medical and surgical intensive care units (ICUs) of a tertiary care hospital. Materials and Methods: One hundred and twenty patients admitted to medical and surgical ICU with an indwelling, nontunneled central venous catheter (CVC) inserted at admission in the department of emergency medicine or at medical and surgical ICU for more than 48 h were monitored. The patients were followed up daily for the development of new-onset sepsis after 48 h of insertion of CVC, by analyzing the culture of two sets of blood samples, over a span of 24 h. The data were evaluated statistically using Microsoft Excel version 11 and SPSS version 17 (IBM, USA). Results: Among 120 patients hospitalized for an aggregate of 972 days, 7 patients had acquired CLABSI with an incidence rate of 7.2/1000 central line days. The organisms isolated were Staphylococcus aureus, Acinetobacter spp., Pseudomonas aeruginosa, and Klebsiella pneumoniae. Conclusion: The incidence rate of CLABSI in this study was in line with other studies on the CLABSI rate in India. The study found a significant association of CLABSI with duration of CVC catheterization, underlying comorbid conditions and diseases of patients, and indication of CVC insertion. However, there was no significant association of CLABSI with age of patients, their gender, and site of insertion.
{"title":"Incidence of central line-associated bloodstream infection in the intensive care unit: A prospective observational study","authors":"Shailendra Singh, Punit Yadav, A. Goel, N. Ahuja","doi":"10.4103/jmms.jmms_73_22","DOIUrl":"https://doi.org/10.4103/jmms.jmms_73_22","url":null,"abstract":"Aims: The aim of this study was to determine the incidence of central line-associated bloodstream infections (CLABSIs) in the medical and surgical intensive care units (ICUs) of a tertiary care hospital. Materials and Methods: One hundred and twenty patients admitted to medical and surgical ICU with an indwelling, nontunneled central venous catheter (CVC) inserted at admission in the department of emergency medicine or at medical and surgical ICU for more than 48 h were monitored. The patients were followed up daily for the development of new-onset sepsis after 48 h of insertion of CVC, by analyzing the culture of two sets of blood samples, over a span of 24 h. The data were evaluated statistically using Microsoft Excel version 11 and SPSS version 17 (IBM, USA). Results: Among 120 patients hospitalized for an aggregate of 972 days, 7 patients had acquired CLABSI with an incidence rate of 7.2/1000 central line days. The organisms isolated were Staphylococcus aureus, Acinetobacter spp., Pseudomonas aeruginosa, and Klebsiella pneumoniae. Conclusion: The incidence rate of CLABSI in this study was in line with other studies on the CLABSI rate in India. The study found a significant association of CLABSI with duration of CVC catheterization, underlying comorbid conditions and diseases of patients, and indication of CVC insertion. However, there was no significant association of CLABSI with age of patients, their gender, and site of insertion.","PeriodicalId":41773,"journal":{"name":"Journal of Marine Medical Society","volume":"25 1","pages":"26 - 30"},"PeriodicalIF":0.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46000916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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